... transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins ... The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition ... Albers JJ, Cheung MC (2004). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin ... Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis". Front. Biosci. 7 ...

APOM is partly responsible for producing pre beta-high-density lipoprotein and cholesterol, and APM1 is responsible for ... abnormal low-density lipoprotein and high-density lipoprotein cholesterol levels). However, there is growing evidence that T2DM ... Additionally, mice with deficiencies in TLR4 signaling were protected from insulin resistance caused by high-fat diet and from ... As CDKN2A and B regulate the pancreatic beta-cell replication, and HNF1B is homeodomain containing transcription factor that ...

"Relation between plasma high-density lipoprotein cholesterol and sex hormone concentrations in men". The American Journal of ... Testosterone replacement therapy in men diagnosed with pre-existing heart disease has been related to an increased risk of ... in elevating the HDL fraction can be attributed to its conversion via aromatase activity in adipose tissue into 17-beta ... "Physiological testosterone replacement therapy attenuates fatty streak formation and improves high-density lipoprotein ...

Keene D, Price C, Shun-Shin MJ, Francis DP (July 2014). "Effect on cardiovascular risk of high density lipoprotein targeted ... Aspirin, ACE inhibitors, beta-blockers, and statins used together for secondary CVD prevention in the same regions showed ... Men are at greater risk of heart disease than pre-menopausal women. Once past menopause, it has been argued that a woman's risk ... A diet high in trans fatty acids is associated with higher rates of cardiovascular disease, and in 2015 the Food and Drug ...

"Estrogen induction of liver proteins and high-density lipoprotein cholesterol: comparison between estradiol valerate and ... and sex-hormone-binding globulin during simultaneous vaginal administration of 17 beta-oestradiol and progesterone in the pre- ... Oestrogens at high doses (i.e. polyoestradiol phosphate + oral ethinyl oestradiol or high doses of diethyl stilboestrol ... including in transgender women on hormone therapy and pre-hormone therapy transgender men acutely challenged with a high dose ...

Law MR, Wald NJ, Rudnicka AR (June 2003). "Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic ... In people with acute coronary syndrome, high-dose atorvastatin treatment may play a plaque-stabilizing role. At high doses, ... Prior to contrast medium (CM) administration, pre-treatment with atorvastatin therapy can reduce the risk of contrast-induced ... as well as various beta-oxidation metabolites. The ortho- and parahydroxylated metabolites are responsible for 70% of systemic ...

Anacetrapib is a cholesteryl ester transfer protein inhibitor that raises high-density lipoprotein (HDL) cholesterol and ... Only 10-25% of patients survive rupture due to large pre-and postoperative mortality. Annual mortality from ruptured aneurysms ... use of statins and occasionally beta blockers. Ultrasound studies are obtained on a regular basis (i.e. every 6 or 12 months) ... November 2012). "Elevation of plasma high-density lipoproteins inhibits development of experimental abdominal aortic aneurysms ...

Lipoprotein lipase is downregulated by high levels of insulin, and upregulated by high levels of glucagon and adrenaline. ... of digestive enzyme that helps regulate the uptake of triacylglycerols from chylomicrons and other low-density lipoproteins ... Organisms can either by alpha-hemolytic, beta-hemolytic, or gamma-hemolytic (non-hemolytic). Amylases are a group of ... different classes of microbial exoenzymes have been used by humans since pre-historic times for such diverse purposes as food ...

... low density lipoprotein-receptor, and the neural cell adhesion molecule". The Journal of Biological Chemistry. 266 (34): 22939- ... This role for perlecan in beta-amyloid plaque generation is supported by an earlier study showing that perlecan and beta- ... One theory states that high glucose in circulation could lead to a decrease in GAG chain attachment to perlecan, but not ... Pre-implantation blastocyst development is a controlled cascade of gene regulation and intercellular signaling. Extracellular ...

Eren E, Yilmaz N, Aydin O (2013). "Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial ... Calcium channel blockers and selective beta 1 antagonists may also improve endothelial dysfunction. Life style modifications ... "Role of nitric oxide deficiency and its detection as a risk factor in pre-hypertension". JASH. 1 (1): 45-56. doi:10.1016/j.jash ... Since NO maintains low tone and high compliance of the small arteries at rest, a reduction of age-dependent small artery ...

At the time of pre-ovulation (a period of about 24 to 48 hours), estradiol levels briefly surge and reach their highest ... 17-beta-estradiol (E2) is considered the most potent estrogen found in humans. E2 influences vascular function, apoptosis, and ... Bone density is also affected, resulting in early osteopenia and osteoporosis. Low levels of estradiol may also predict ... It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood ...

Oxidized Low-density lipoprotein-induced chemokine expression was associated with H3KAc and phosphorylation, and recruitment of ... This leads to higher accessibility of pathological gene expression products and activation of pathological genes. Being in this ... The defects in pancreatic beta cell function and insulin resistance in peripheral tissues were thought to be the result of ... HATs along with NF-κB in endothelial cells, and these were reversed by pre-treatment with statins. Studies show alterations in ...

... particularly high low-density lipoprotein, low high-density lipoprotein, and high triglycerides. Many risk factors for ... The dose should be increased to the highest tolerated. Contrary to what was long believed, the use of beta blockers does not ... Pre-hospital thrombolysis reduces time to thrombolytic treatment, based on studies conducted in higher income countries; ... and total cholesterol and high-density lipoprotein levels. Many risk factors of myocardial infarction are shared with coronary ...

The glycogen is stored in the liver, but the triglycerides are secreted into the blood as very low-density lipoprotein (VLDL) ... In mammals, the primary sensors for this are the beta cells of the pancreatic islets. The beta cells respond to a rise in the ... For example, high glycine concentration disrupts temperature and blood pressure control, and high CSF pH causes dizziness and ... An autopilot operates the steering controls of an aircraft or ship in response to deviation from a pre-set compass bearing or ...

... has been shown to cause high levels of 'bad' cholesterol via low-density lipoprotein (LDL), increasing heart disease ... The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular ... Each protein subunit comprises a carboxy-terminal disulfide-rich beta sandwich "head" domain and an amino-terminal alpha- ... The seminal concentrations of resistin were significantly higher in cases of leukocyte spermia or if the patients were smokers ...

... high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein). It is also associated ... Based on gene knockout studies in murine models, it has been suggested that, among many other pathogenic factors, TGF beta ... However, transient elastography can fail for people with pre-hepatic portal hypertension. Although no drugs are approved to ... high blood pressure, high blood sugar, high serum triglycerides, and low serum HDL cholesterol), a diet high in fructose, and ...

... the anti-inflammatory effect does not appear to correlate with reduction in low-density lipoprotein levels. These new insights ... December 2001). "beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies". The Journal of ... Pre-sensitised mast cells respond by degranulating, releasing vasoactive chemicals such as histamine. These chemicals propagate ... C-reactive protein (CRP) is generated at a higher level in obese people, and may increase the risk for cardiovascular diseases ...

... in the low density lipoproteins isolated from individuals with rheumatoid arthritis, in the high-density lipoprotein fraction ... While much further work is needed, these pre-clinical studies allow that 13(S)-HODE, made at least in part by eosinophils and ... 13(S)-HODE (and 9(S)-HODE) also stimulate the activation of peroxisome proliferator-activated receptor beta (PPARβ) in a model ... a scavenger receptor for oxidized low density lipoproteins, native lipoproteins, oxidized phospholipids, and long-chain fatty ...

... very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), low density lipoprotein (LDL) and high density ... beta blockers, retinoic acid, antipsychotics), certain anticonvulsants and medications for HIV as well as interferons. Genetic ... and are effective in reducing the risk of cardiovascular disease in both people with and without pre-existing cardiovascular ... Trans fats have been shown to reduce levels of high-density lipoprotein while increasing levels of LDL. A 2016 review found ...

... decreased high-density plasma lipoprotein levels, increased low-density lipoprotein levels, and increased prothrombin time. No ... In pre-clinical models, testosterone XHT has been shown to lead to adverse cardiovascular effects, but adding a low-dose ... a nonselective beta blocker used in the management of cardiovascular conditions; Increases the effect of some oral medicines ... Higher bone mineral density in males is associated with higher serum estrogen.) Bone is not static. It is constantly being ...

Women's level of testosterone is higher when measured pre-intercourse vs. pre-cuddling, as well as post-intercourse vs. post- ... Non-specific binding proteins include albumin and lipoprotein. The part of the total hormone concentration that is not bound to ... Ajayi AA, Mathur R, Halushka PV (June 1995). "Testosterone increases human platelet thromboxane A2 receptor density and ... interleukin 1 beta, interleukin 6, TNF alpha and endotoxin concentration, as well as leukocyte count. As demonstrated by a meta ...

... in the low-density lipoprotein receptor (LDLR). In December 2020, Novartis announced that positive results from phase III ... Some pre-miRNAs do undergo A→I RNA editing and this mechanism may regulate the processing and expression of mature miRNAs. ... SBEIIa and SBEIIb genes in wheat have been targeted in wheat in order to produce higher levels of amylose in order to improve ... Studies in cells and in mouse have shown that specifically targeting Amyloid beta-producing genes (e.g. BACE1 and APP) by RNAi ...

... and serum lipoprotein concentrations increase with age. Infants and young children have a higher risk of being below the ... Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (April 1994). "The effect of vitamin E and beta carotene on the ... where it can be incorporated into newly created very low density lipoprotein (VLDL) molecules. These convey α-tocopherol to ... The HOPE/HOPE-TOO trial, which enrolled people with pre-existing vascular disease or diabetes into a multi-year trial of 400 IU ...

... modestly reduces low density lipoprotein and triglyceride levels. In individuals with prediabetes, a 2019 systematic ... High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe ... Alqudah A, McKinley MC, McNally R, Graham U, Watson CJ, Lyons TJ, McClements L (February 2018). "Risk of pre-eclampsia in women ... Sulfonylureas act by increasing insulin release from the beta cells in the pancreas. A 2019 systematic review suggested that ...

... cholesterol-associated High density lipoprotein) which are niacin's therapeutic targets for treating primary hyperlipidemia and ... lower levels of brain amyloid-beta precursor protein and amyloid-β protein; and higher levels of neprilysin, an enzyme that ... mice fed a diet that greatly reduced the levels of butyric acid in the colon developed colitis and numerous potentially pre- ... higher numbers of inflammation-suppressing M2 macrophages, and higher levels of messenger RNA encoding an inflammation- ...

There are several types of cholesterol but the main two are high-density lipoprotein (HDL) and low-density lipoprotein (LDL). ... "Women taking beta blockers for hypertension may have higher risk of heart failure with acute coronary syndrome". medicalxpress. ... Hypertensive disorders in pregnancy such as pre-eclampsia can be seen in 10% of pregnancies and has been recognized as a risk ... anything higher can lead to a higher CVD risk. When there is a high level of LDL cholesterol in the blood it is up-taken by ...

... high-density lipoprotein (HDL) variation, found by Eric Brunner (epidemiologist) of UCL; Sir Richard Way; fibrinogen variation ... so thirty pre-existing engines would be deployed, and the pre-burner which powered the rocket pumps would become a closed cycle ... the amyloid beta protein of dementia, and research on marmosets. Narrated by Libby Purves, directed by John Bird, produced by ... who claimed that the Earth's temperature would be 2 degrees higher by 2000, 3 degrees higher by 2010, and 4 to 7 degrees warmer ...

The c-miRNAs are transported by exosomes, high-/low-density lipoproteins, apoptotic bodies, and RNA-binding proteins. A bout of ... The amyloid beta plaque causes the microglia and astrocytes regulatory components to be improperly activated resulting in ... Subsequent processing of the pre-miRNA generates mature-miRNA, which binds to 3'UTR "seed sequence" of target mRNAs, a process ... Higher generalized glutamate levels in the prefrontal cortex results in atypically high signaling at AMPA receptors. Abnormal ...

The most common adverse events include transient decreases in high-density lipoprotein and increases blood triglycerides. ... "Coronavirus (COVID-19) Update: FDA Authorizes New Long-Acting Monoclonal Antibodies for Pre-exposure Prevention of COVID-19 in ... lopinavir-ritonavir combined with interferon-beta, 3) remdesivir or 4) (hydroxy)chloroquine in separate trials and hospital ... "The COVID-19 High Performance Computing Consortium". The COVID-19 High Performance Computing Consortium. 2020. Archived from ...

... that have taken up oxidized low-density lipoprotein (LDL).[citation needed] After they accumulate large amounts of cytoplasmic ... CT scans using state of the art higher resolution spiral, or the higher speed EBT, machines have been the most effective method ... "2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed ... The sudden nature of the complications of pre-existing atheroma, vulnerable plaque (non-occlusive or soft plaque), have led, ...