Rijksen, G; Staal, G E. (August 1978). "Human erythrocyte hexokinase deficiency. Characterization of a mutant enzyme with ...
... (GK) is a hexokinase isozyme, related homologously to at least three other hexokinases. All of the hexokinases can ... Alternative names for this enzyme are: human hexokinase IV, hexokinase D, and ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1 ( ... Glucokinase has a lower affinity for glucose than the other hexokinases do, and its activity is localized to a few cell types, ... This is about half the size of the other mammalian hexokinases, which retain a degree of dimeric structure. Several sequences ...
... is a hexokinase inhibitor. It is a heptose, a monosaccharide with seven carbon atoms. By blocking the enzyme ... "Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence ... hexokinase, it prevents glucose phosphorylation. As a result, the breakdown of glucose is inhibited. It is found as D- ...
Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK2 gene on chromosome 5. Hexokinases ... This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6- ... "Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by ... "Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by ...
GSS Hemolytic anemia due to hexokinase deficiency; 235700; HK1 Hemolytic anemia, nonspherocytic, due to glucose phosphate ...
... which is not inhibited by G-6-P in the way that the hexokinases in other tissues (hexokinase I - III) are affected by this ... The glucose that enters the β-cell is phosphorylated to glucose-6-phosphate (G-6-P) by glucokinase (hexokinase IV) ... Schuit F, Moens K, Heimberg H, Pipeleers D (November 1999). "Cellular origin of hexokinase in pancreatic islets". The Journal ... insulin induces the formation of glycogen by the activation of the hexokinase enzyme, which adds a phosphate group in glucose, ...
Mutations in the hexokinase gene can lead to a hexokinase deficiency which can cause nonspherocytic hemolytic anemia. ... Hexokinase is the most common enzyme that makes use of glucose when it first enters the cell. It converts D-glucose to glucose- ... "Nonspherocytic hemolytic anemia due to hexokinase deficiency". "Phosphofructokinase Deficiency Glycogen Storage Disease". Bauer ...
BUEDING E, MACKINNON JA (1955). "Hexokinases of Schistosoma mansoni". J. Biol. Chem. 215 (2): 495-506. PMID 13242546. Molecular ...
... hexokinase essentially acts to transport glucose into the cells from which it can then no longer escape. Hexokinase is ... Hexokinase responds to the glucose-6-phosphate (G6P) level in the cell, or, in the case of glucokinase, to the blood sugar ... In addition hexokinase and glucokinase act independently of the hormonal effects as controls at the entry points of glucose ... In animals, an isozyme of hexokinase called glucokinase is also used in the liver, which has a much lower affinity for glucose ...
Hexokinase can return the molecule to the glycolysis pathway by phosphorylating fructose to form fructose-6-phosphate. However ... This normally occurs by phosphorylation via the enzyme hexokinase. However, if large amounts of glucose are present (as in ... diabetes mellitus), hexokinase becomes saturated and the excess glucose enters the polyol pathway when aldose reductase reduces ...
Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a ... glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with ... labelled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. ...
Szymona M (1962). "Purification and properties of a new hexokinase utilizing inorganic pyrophosphate". Acta Biochim. Pol. 9: ...
"The association of hexokinase with particulate fractions of brain and other tissue homogenates". Journal of Biological ... "The non-competitive inhibition of brain hexokinase by glucose 6-phosphate and related compounds". Journal of Biological ... "Substrate specificity of brain hexokinase". Journal of Biological Chemistry 210, 1954, pp. 581-595. Robert K. Crane, Richard A ... "The inhibition of brain hexokinase by adenosinediphosphate and sulfhydryl reagents". Journal of Biological Chemistry 206, 1954 ...
TIGAR binds hexokinase 2 and increases its activity by an as yet unknown mechanism. Hexokinase 2 (HK2) carries out the ... TIGAR acts as a direct regulator of fructose-2,6-bisphosphate levels and hexokinase 2 activity, and this can lead indirectly to ... Pastorino JG, Shulga N, Hoek JB (March 2002). "Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release ... a small amount of TIGAR travels to the mitochondria and increases the activity of Hexokinase 2 (HK2) by binding to it During ...
It is able to form Glc-6-Arsenate in vitro; therefore it has been argued that hexokinase could be inhibited. (Eventually this ...
Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. Hexokinases ... This high similarity, along with the existence of a 50-kDa hexokinase (HK4), suggests that the 100-kDa hexokinases originated ... Ahn KJ, Kim J, Yun M, Park JH, Lee JD (Jun 2009). "Enzymatic properties of the N- and C-terminal halves of human hexokinase II ... Ahn KJ, Kim J, Yun M, Park JH, Lee JD (Jun 2009). "Enzymatic properties of the N- and C-terminal halves of human hexokinase II ...
Hexokinase-1 (HK1) is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. Hexokinases phosphorylate glucose ... Okatsu K, Iemura S, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N (Nov 2012). "Mitochondrial hexokinase HKI is a ... Of note, HK1 is the sole hexokinase isoform found in the cells and tissues which rely most heavily on glucose metabolism for ... Murakami K, Blei F, Tilton W, Seaman C, Piomelli S (Feb 1990). "An isozyme of hexokinase specific for the human red blood cell ...
The two most common employed enzymes are glucose oxidase and hexokinase. Average blood glucose concentrations can also be ... More precise blood glucose measurements are performed in a medical laboratory, using hexokinase, glucose oxidase, or glucose ...
Stolz, P; Hammes, WP; Vogel, RE (1996). "Maltose-phosphorylase and hexokinase activity in lactobacilli from traditionally ...
This is notable because in most tissues this reaction is catalyzed by hexokinase (EC 2.7.1.1). Fructokinase has been ... Hepatic fructokinase PFKL PFKM PFKP Glucokinase Hexokinase DBGET ENZYME: 2.7.1.4. Retrieved 2007-05-06 Odanaka S, Bennett AB, ...
"Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria". PLOS ONE. 5 (12): e15230. doi:10.1371/journal.pone. ...
The glucose is subsequently phosphorylated to glucose-6-phosphate by hexokinase. Glycogenolysis takes place in the cells of the ...
Hexokinase II transcription is increased in both red and white skeletal muscle upon treatment with AICAR. With chronic ... This is due in part to the marked increases in the mitochondrial biogenesis, upregulation of GLUT-4, UCP-3, Hexokinase II along ... When glucose is transported into the cell it is phosphorylated by hexokinase. This phosphorylation keeps glucose from leaving ... Ojuka EO, Nolte LA, Holloszy JO (March 2000). "Increased expression of GLUT-4 and hexokinase in rat epitrochlearis muscles ...
The product's inhibition of hexokinase and activation of PFK-1 and pyruvate kinase is indicative of its role in glycolysis. ... The main product, glucose-1,6-bisphosphate, appears to have several functions: 1. inhibition of hexokinase, an enzyme used in ... Glucose-1,6-bisphosphate inhibit hexokinase stopping the production glucose-6-phosphate from D-glucose. Its activation of PFK-1 ...
This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites tumor ...