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*  Beta thalassemia
Transmission is autosomal recessive; however, dominant mutations and compound heterozygotes have been reported. Genetic ...
*  Heterozygote advantage
A heterozygote advantage describes the case in which the heterozygous genotype has a higher relative fitness than either the ... Heterozygote advantage is a major underlying mechanism for heterosis, or "hybrid vigor", which is the improved or increased ... The heterozygote expressed none of the disadvantages of homozygotes, yet gained improved viability. The homozygote wild type ... The specific case of heterozygote advantage due to a single locus is known as overdominance. Overdominance is a condition in ...
*  Mutation
When the new allele is created, a heterozygote containing the newly created allele as well as the original will express the new ... "Compound heterozygote". MedTerms. New York: WebMD. 14 June 2012. Archived from the original on 4 March 2016. Retrieved 9 ... confers HIV resistance to homozygotes and delays AIDS onset in heterozygotes. One possible explanation of the etiology of the ...
*  Compound heterozygosity
Compound heterozygotes are often observed only through subclinical symptoms such as excess iron. Disease is rarely observed in ... That is, an organism is a compound heterozygote when it has two recessive alleles for the same gene, but with those two alleles ... This means that many cases of disease arise in individuals who have two unrelated alleles, who technically are heterozygotes, ... As a result, compound heterozygotes often become ill later in life, with less severe symptoms. Although compound heterozygosity ...
*  Glycogen storage disease type I
Heterozygote carriers are asymptomatic. As for other autosomal recessive diseases, the recurrence risk for each subsequent ...
*  ΔF508
... and heterozygotes may be at risk for poor pulmonary function. Heterozygotes with wheeze have been shown to be at higher risk ... Heterozygote advantage Bobadilla, JL; Macek Jr, M; Fine, JP; Farrell, PM (2002). "Cystic fibrosis: a worldwide analysis of CFTR ... Cystic fibrosis ΔF508 heterozygotes may be overrepresented among individuals with asthma and may have poorer lung function than ... Another theory posits that CF carriers (heterozygotes for ΔF508) are more resistant to typhoid fever, since CFTR has been shown ...
*  Eugenics
The heterozygote test is used for the early detection of recessive hereditary diseases, allowing for couples to determine if ... "Heterozygote test / Screening programmes - DRZE". Drze.de. Retrieved 19 October 2017. "Fatal Gift: Jewish Intelligence and ... although not influencing the prevalence of heterozygote carriers of those diseases. The elevated prevalence of certain ...
*  Host-parasite coevolution
Overdominance occurs if the heterozygote phenotype has a fitness advantage over both homozygotes (heterozygote advantage, ... Hence, homozygote and heterozygote genotypes for the sickle-cell disease allele show malaria resistance, while the homozygote ... As a consequence, the heterozygote genotype is selectively favored in areas with a high incidence of malaria. If an allele ... overdominance caused by heterozygote advantage; and directional selective sweeps near an advantageous mutation. Theories of ...
*  Phenylketonuria
Woolf, LI (1986). "The heterozygote advantage in phenylketonuria". American Journal of Human Genetics. 38 (5): 773-5. PMC ... being a heterozygote is advantageous. The PAH gene is located on chromosome 12 in the bands 12q22-q24.1. More than 400 disease- ...
*  Synalpheus regalis
Furthermore, many colonies show heterozygote excesses. This led researchers to conclude that outbreeding is common in the S. ...
*  Medical genetics of Jews
One of the first genetic testing programs to identify heterozygote carriers of a genetic disorder was a program aimed at ... However, most populations contain hundreds of alleles that could potentially cause disease and most people are heterozygotes ... This effect is called heterozygote advantage. Familial dysautonomia (Riley-Day syndrome), which causes vomiting, speech ... effect of drift on decay of linkage disequilibrium and evidence for heterozygote selection". Blood Cells Mol. Dis. 26 (4): 348- ...
*  Hartnup disease
Heterozygotes are normal. Consanguinity is common. The failure of amino-acid transport was reported in 1960 from the increased ...
*  Microsatellite
Amos W, Rubinsztein DC (1996). "Microsatellites show mutational bias and heterozygote instability". Nature Genetics. 13: 390- ...
*  Erythropoietic protoporphyria
Most heterozygotes are asymptomatic. Symptoms do not occur unless FECH activity is less than 30% of normal, but such low levels ...
*  Bilateral frontoparietal polymicrogyria
Heterozygotes (carriers) are asymptomatic. Sibs of a proband At conception, each sibling of an affected individual has a 25% ... Once an at-risk sibling is known to be unaffected, the risk of his/her being a carrier is 2/3. Heterozygotes (carriers) are ... Parents of a proband The parents of an affected individual are obligate heterozygotes and therefore carry one mutant allele. ... Offspring of a proband Offspring of a proband are obligate heterozygotes and will therefore carry one mutant allele. In ...
*  Quantitative genetics
Heterozygotes (Aa) can arise in two ways: when p male (A allele) randomly fertilize q female (a allele) gametes, and vice versa ... Heterozygotes can arise only from the allozygous component, and its frequency in the sample bulk is just (1-f): hence this must ... The heterozygote deviation from the same midpoint can be named "d", this being the "dominance" effect referred to above. The ... Previously, it was noted that the decline in heterozygotes was f ( 2 p 0 q 0 ) {\textstyle f\left(2p_{0}q_{0}\right)} . This ...
*  Polymorphism (biology)
Heterosis (or heterozygote advantage): "Heterosis: the heterozygote at a locus is fitter than either homozygote". Frequency ... homozygote and also the heterozygote is normal (though heterozygote individuals will suffer periodic problems). The sickle-cell ... Because the heterozygote survives, so does the HgbS allele survive at a rate much higher than the mutation rate (see and refs ... The heterozygote has a permanent advantage (a higher fitness) so long as malaria exists; and it has existed as a human parasite ...
*  Polymorphism in Lepidoptera
Now, assuming equal viability of the genotypes 1,209 heterozygotes would be expected, so the field results do not suggest any ... This is sufficient to maintain the system despite the fact that in this case the heterozygote has slightly lower viability. ... and the heterozygote (medionigra). It was studied there by E. B. Ford, and later by P. M. Sheppard and their co-workers over ...
*  Leopard complex
However, one study used ERG findings to diagnose all the homozygous Lp subjects with CSNB, while all heterozygotes and non-Lp ... A proposed gene, PATN-1, may be responsible for the most familiar expressions of white: heterozygotes possessing common-size " ... While both heterozygous and homozygous Lp horses possess the aforementioned characteristics, heterozygotes and homozygotes ... A heterozygote may eventually show conspicuous leopard spots. Base colors are overlain by various spotting patterns, which are ...
*  Genetic carrier
Carriers are also known to be resistant to malaria, suggesting there is a heterozygote advantage in certain regions of Africa. ... This resistance leads to increased fitness of the carriers, known as a heterozygote advantage, and thereby increases the ... Rodman, D.M.; Zamudio, S. (1991). "The Cystic Fibrosis Heterozygote--Advantage in Surviving Cholera?". Medical Hypotheses. 36: ...
*  NSUN2
In addition, heterozygote mutants displayed premature hair follicle exogen. GRCh38: Ensembl release 89: ENSG00000037474 - ...
*  PTS (gene)
Unusual gene dosage effect in heterozygotes". Hum. Genet. 77 (2): 168-71. doi:10.1007/BF00272386. PMID 3308682. Oppliger T, ... 1999). "Dominant negative allele (N47D) in a compound heterozygote for a variant of 6-pyruvoyltetrahydropterin synthase ...
*  Heterosis
Certain combinations of alleles that can be obtained by crossing two inbred strains are advantageous in the heterozygote. The ... According to Crow, the demonstration of several cases of heterozygote advantage in Drosophila and other organisms first caused ... F1 hybrid Genetic admixture Heterozygote advantage George Harrison Shull (1948). "What Is "Heterosis"?". Genetics. 33 (5): 439- ... overdominance hypothesis attributes the heterozygote advantage to the survival of many alleles that are recessive and harmful ...
*  Merle (dog coat)
Merle is actually a heterozygote of an incompletely dominant gene. If two such dogs are mated, on the average one quarter of ...
*  Polysomy
... mis-segregation from multivalents in interchange heterozygotes." Incidences of polysomy have been identified in many species of ...