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*  Hepcidin
... is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the ... The structure of hepcidin has been determined through solution NMR. NMR studies showed a new model for hepcidin: at ambient ... Hepcidin is a regulator of iron metabolism. Hepcidin inhibits iron transport by binding to the iron export channel ferroportin ... Hepcidin was first discovered in human urine and serum in 2000. Soon after this discovery, researchers discovered that hepcidin ...
*  Erythropoiesis
The liver produces hepcidin. Hepcidin controls iron absorption in the gastrointestinal tract and iron release from ... The secretion of hepcidin is inhibited by another hormone, erythroferrone, produced by erythroblasts in response to ... Recent studies have also shown that the peptide hormone hepcidin may play a role in the regulation of hemoglobin production, ... "Severe iron deficiency anemia in transgenic mice expressing liver hepcidin". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4596-601. ...
*  Anemia of chronic disease
... the liver produces increased amounts of hepcidin. Hepcidin in turn causes increased internalisation of ferroportin molecules on ... Hepcidin offers an attractive Occam's Razor (parsimonious) explanation for the condition, and more recent descriptions of human ... Before the recent discovery of hepcidin and its function in iron metabolism, anemia of chronic disease was seen as the result ... Over the last few years, however, many investigators have come to feel that hepcidin is the central actor in producing anemia ...
*  HAMP
"Entrez Gene: HAMP hepcidin antimicrobial peptide". Ganz T (2003). "Hepcidin, a key regulator of iron metabolism and mediator of ... Hepcidin is a protein that in humans is encoded by the HAMP gene. The product encoded by this gene is involved in the ... 2003). "Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein". Blood. 101 (7): 2461-3. doi ... 2003). "Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin ...
*  HFE (gene)
Its primary mode of action is the regulation of the iron storage hormone hepcidin. It is possible to delete part or all of a ... Nemeth E, Ganz T (2006). "Regulation of iron metabolism by hepcidin". Annual Review of Nutrition. 26: 323-342. doi:10.1146/ ...
*  Human iron metabolism
Hepcidin causes the internalization of ferroportin, decreasing iron export. Besides, hepcidin seems to downregulate both TFR1 ... Since the liver produces hepcidin in response to inflammatory cytokines, hepcidin levels can increase as the result of non- ... The expression of hepcidin, which only occurs in certain cell types such as hepatocytes, is tightly controlled at the ... Inflammation leading to hepcidin-induced restriction on iron release from enterocytes (see above). The body is able to ...
*  Inflammatory bowel disease
Hepcidin itself is also an anti-inflammatory agent. In the murine model very low levels of iron restrict hepcidin synthesis, ... Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L (July 2011). "Low hepcidin accounts for the ... Due to raised levels of inflammatory cytokines which lead to the increased expression of hepcidin, parenteral iron is the ...
*  Acute-phase protein
August 2009). "ER stress controls iron metabolism through induction of hepcidin". Science. 325 (5942): 877-80. doi:10.1126/ ...
*  Erythroferrone
... is a hormone that regulates iron metabolism through its actions on hepcidin. As shown in mice and humans, it is ... Its mechanism of action is to inhibit the expression of the liver hormone, hepcidin. This process is governed by the renal ... Erythroferrone is produced by erythroblasts, inhibits the action of hepcidin, and so increases the amount of iron available for ... Pasricha, SR; McHugh, K; Drakesmith, H (17 July 2016). "Regulation of Hepcidin by Erythropoiesis: The Story So Far". Annual ...
*  Nancy Andrews (biologist)
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nature Genetics 2006; 38:531-9. 1993-2006, ...
*  Hemojuvelin
... suggesting that hemojuvelin is a positive regulator of hepcidin, the central iron regulatory hormone. As a result, low hepcidin ... Hepcidin levels in the liver are dramatically depressed in these knockout animals. A soluble form of HJV may be a molecule that ... A small number of patients have mutations in the hepcidin (HAMP) gene. The gene was positionally cloned. Hemojuvelin is highly ... Lin L, Goldberg YP, Ganz T (October 2005). "Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin ...
*  Molecular Medicine Partnership Unit
2014). "Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload". Cell Metab. ... 2015). "A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia". Blood. 125 (14): 2265-75. doi:10.1182/ ...
*  African iron overload
Measurement of serum hepcidin levels may be useful in diagnostic for iron overload. MRI can detect the degree of magnetic ... In HEK 293 cells, Q248H was as predisposed to the activities of hepcidin-25 as wild type ferroportin. Ferroportin Q248H also ... "Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin". Blood. 106 (3): 1092-7. doi: ...
*  Juvenile hemochromatosis
Rideau A, Mangeat B, Matthes T, Trono D, Beris P (January 2007). "Molecular mechanism of hepcidin deficiency in a patient with ... There are two forms: "HFE2A" is associated with hemojuvelin "HFE2B" is associated with hepcidin antimicrobial peptide Some ...
*  Siderophore
In addition to these two classes of iron-binding proteins, a hormone, hepcidin, is involved in controlling the release of iron ... Infection leads to inflammation and the release of interleukin-6 (IL-6 ) which stimulates hepcidin expression. In humans, IL-6 ... "Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia". Blood. 105: 1797-1802. doi:10.1182/ ...
*  Iron
Ganz T (August 2003). "Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation". Blood. 102 (3): ... a result of a genetic defect that maps to the HLA-H gene region on chromosome 6 and leads to abnormally low levels of hepcidin ...
*  Ferroportin
... and hepcidin are critical proteins for the regulation of systemic iron homeostasis. Both ferroportin and hepcidin ... This is part of the mechanism that causes anaemia of chronic disease; hepcidin is released from the liver in response to ... Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (December 2004). "Hepcidin regulates cellular ... Ferroportin is inhibited by hepcidin, which binds to ferroportin and internalizes it within the cell. This results in the ...
*  Hemochromatosis type 4
Hepcidin, a protein synthesized in the liver in response to iron or inflammation, is a regulator of ferroportin expression. ... When hepcidin binds ferroportin, ferroportin is phosphorylated, endocytosed, tagged with ubiquitin, and degraded. More than 39 ... or it can involve a failure of ferroportin to respond to negative regulation by hepcidin. Hemochromatosis type 4A is ... mutations are associated with type 4B and lead to production of ferroportin that resists negative regulation by hepcidin. ...
*  Chromosome 19 (human)
Gene map locus 19p13.12 GAPDHS: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 19q13.12 HAMP: Hepcidin antimicrobial ...
*  Noxxon Pharma
March 2013). "The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys". Blood ...
*  Iron metabolism disorder
... they have a deficiency in the action of hepcidin, if not in hepcidin itself. But the exact mechanisms of most of the various ... Hepcidin is the master regulator of iron metabolism and, therefore, most genetic forms of iron overload can be thought of as ... So though many mysteries of iron metabolism remain, the discovery of hepcidin already allows a much better understanding of the ... So, in people with ferroportin proteins that transport iron out of cells without responding to hepcidin's signals to stop, ...
*  Zinc toxicity
... absorption from the small intestine is tightly regulated by hepcidin. Hepcidin is a peptide hormone that is present in higher ... concentrations when body iron is replete [52]. Higher concentrations of hepcidin prevent ingested iron from entering the ...
*  Human disease modifier gene
... those involved in non-HFE GH and those involved in expression of the iron storage hormone hepcidin, and find evidence that ... and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance". American Journal of Human Genetics. ...
*  Mothers against decapentaplegic homolog 4
... and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance". American Journal of Human Genetics. ...
*  Porphyria cutanea tarda
Excess alcohol intake decreases hepcidin production which leads to increased iron absorption from the gut and an increase in ...