Upstream stimulatory factor 1 (USF1) is another basic helix-loop-helix zipper (bHLHZ) transactivator. Hepatic nuclear factor 6 ... Levels of F2,6P 2 play other amplifying roles in glycolysis in hepatocytes. Other transacting factors suspected of playing a ... Hepatic nuclear factor-4-alpha (HNF4α) is an orphan nuclear receptor important in the transcription of many genes for enzymes ... Pdx-1 is a homeodomain transcription factor involved in the differentiation of the pancreas. PPARγ is a nuclear receptor that ...

2004). "SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic ... "Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase-Ibeta expression by PGC-1". J. Biol. Chem ... by Nuclear Respiratory Factors (NRF-1 and NRF-2) and PGC-1 Family Coactivators". Mol. Cell. Biol. 25 (4): 1354-66. doi:10.1128/ ... a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 ( ...

Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is ... Sun Q, Yu X, Degraff DJ, Matusik RJ (December 2009). "Upstream stimulatory factor 2, a novel FoxA1-interacting protein, is ... These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and ... Lee HJ, Chattopadhyay S, Yoon WH, Bahk JY, Kim TH, Kang HS, Lee K (March 2010). "Overexpression of hepatocyte nuclear factor- ...

"Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human ... Data suggest that nuclear translocation of NF-κB regulates IL-6 overexpression in SP-stimulated cells. This is of key interest ... Recent work has shown that both upstream and downstream signalling pathways for IL-6 differ markedly between myocytes and ... IL-6 is commonly found in the senescence-associated secretory phenotype (SASP) factors secreted by senescent cells (a toxic ...

Alternatively, targeting their upstream activating mediators (IL-23, IL-1B, or IL-6), or their survival factors (IL-7) could be ... Both cell types produce IFN-γ as their principle cytokine and require the transcription factor T-bet to do so. Both cells can ... Their production of IFN-γ promotes the survival of hepatocytes. The production of IFN-γ by ILC1s is dependent on the expression ... Although they can present antigens, via MHC class II receptors, ILCs lack co-stimulatory molecules, and therefore play a role ...

In general, the A-boxes bind to Pdx1 factors, E-boxes bind to NeuroD, C-boxes bind to MafA, and cAMP response elements to CREB ... This protein works as a transcription factor for MafA in an unknown manner and MafA is transported out of the cell. MafA is ... Insulin also has stimulatory effects on gonadotropin-releasing hormone from the hypothalamus, thus favoring fertility. Once an ... In hepatocytes, insulin binding acutely leads to activation of protein phosphatase 2A (PP2A)[citation needed], which ...

This induced production happens through the activation of nuclear factor-κB downstream of the mitochondrial antiviral signaling ... These locations include positions upstream of the N gene, between the N and P genes, between P and M, M and F, F and HN, HN and ... There are multiple factors that are responsible for this variability. For example, an inverse correlation was observed between ... Schirrmacher V, Haas C, Bonifer R, Ertel C (July 1997). "Virus potentiation of tumor vaccine T-cell stimulatory capacity ...