doi:10.1002/hep.22736. PMC 2665925. PMID 19185000. Nakamura M, Takii Y, Ito M, Komori A, Yokoyama T, Shimizu-Yoshida Y, et al ... March 2006). "Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis". Journal ... doi:10.1002/hep.22906. PMID 19554543. S2CID 439839. The AASLD Practice Guideline Floreani A, Franceschet I, Cazzagon N (August ... doi:10.1002/hep.21472. PMID 17187436. S2CID 19225707. Nesher G, Margalit R, Ashkenazi YJ (April 2001). "Anti-nuclear envelope ...
In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role ... "Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and ... of the Hepatitis C virus and thus influences viral reproduction rate. ...
He is a specialist in HIV vaccine design and the sequence evolution and diversity of HIV and hepatitis C virus (HCV). More ... including chimeric antigen receptor (CAR) T cell immunotherapy and gene editing approaches capable of protecting against HIV ... His laboratory at the Ragon Institute is focused on identifying protective immunity to HIV and Hepatitis C virus (HCV). He is a ...
November 1988). "Hepatitis B Variant in Europe". The Lancet. 332 (8620): 1132-1133. doi:10.1016/s0140-6736(88)90541-7. ISSN ... Bordetella pertussis because not all serotypes were targeted and later because acellular vaccines targeted only a few antigens ... Sheldon, J.; Soriano, V. (2008-02-04). "Hepatitis B virus escape mutants induced by antiviral therapy". Journal of ... "Hepatitis B vaccination". Human Vaccines & Immunotherapeutics. 11 (1): 53-57. doi:10.4161/hv.34306. ISSN 2164-5515. PMC 4514213 ...
... regardless of their antigen specificity, causing liver cell damage through NKG2D-mediated cytotoxicity. This study demonstrated ... Innate-like cytotoxic function of bystander-activated CD8+ T cells is associated with liver injury in acute hepatitis A. ... "Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A". ... of bystander T cell activation in human viral disease by studying T cell responses in patients infected with hepatitis A virus ...
Later, furthering his earlier researches, he worked on designing new synthetic peptide vaccines for Hepatitis B which were ... B lymphocytes which helped in a wider understanding of antigen-specific B cell selection and amplification. ... plasticity controlling mechanisms in receptor-initiated signaling pathways based on the systems level analysis of the antigen ...
It consists of a suspension of diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliomyelitis (DTaP-IPV- ... A branded formulation with a 3-antigen pertussis component, Infanrix hexa, is manufactured by GlaxoSmithKline. In October 2000 ... "Public statement on Hexavac [diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis b (recombinant) and ... and hepatitis b [recombinant] vaccine. The liquid vaccine is also known in abbreviated form as DTaP-HepB-IPV-Hib or DTPa-HepB- ...
... such as hepatitis C Primary Immunodeficiencies, such as DADA2, GATA2, and RAG deficiency Exposure to chemicals and drugs, such ... extractable nuclear antigens, RNP = ribonucleoproteins; VDRL = Venereal Disease Research Laboratory Treatments are generally ... as amphetamines, cocaine, and anthrax vaccines which contain the Anthrax Protective Antigen as the primary ingredient. ...
... human hepatitis delta virus 4 (HDV-4)] (host: H. sapiens) Species: Deltavirus togense [human hepatitis delta virus 5 (HDV-5)] ( ... Additional common features include a rod-like structure, an RNA-binding "delta antigen" encoded in the genome, and animal hosts ... human hepatitis delta virus 7 (HDV-7)] (host: Homo sapiens) Species: Deltavirus carense [human hepatitis delta virus 6 (HDV-6 ... human hepatitis delta virus 2 (HDV-2)] (host: H. sapiens) Species: Deltavirus peruense [human hepatitis delta virus 3 (HDV-3 ...
... as well as predicting treatment complications in hepatitis B and hepatitis C patients. AI has been used to identify causes of ... and improved point-of-care testing of Lyme disease based on antigen detection. Additionally, AI has been investigated for ... hepatitis B, gastric cancer, and colorectal cancer. AI has also been used to predict genetic mutations and prognosticate ...
"HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella". Tissue Antigens. ... Some diseases found associated with A1 actually link to the extended A1-B8 haplotype, viral induced hepatitis and accelerated ... "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 ... HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody ...
... yet the scheme did not include infection with hepatitis B because blood donors were screened for hepatitis B from 1972, which ... Testing to screen for the Australia antigen was introduced for all blood donations in the rest of the UK from December 1972. CN ... A and Others v National Blood Authority and Another (Consumer law case involving claimants infected with hepatitis C) M.C. and ... Instructed by a claimant infected with Hepatitis B in the 1980s who seeks to challenge the discriminatory (art 14 ECHR) failure ...
This substrate has largely been superseded by the use of HEp-2 cells. Hep-2 cells, originally of laryngeal carcinoma origin, ... Mice that have T cells directed towards the nucleosome can elicit a response to other antigens such as dsDNA and histone via a ... HEp-2 cells provide a greater ability to differentiate patterns of ANA than animal sections, due to the large nuclei and high ... Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is ...
... is a spherical, enveloped virus. The core particle, or nucleocapsid, contains e antigen, viral ... Mature ground squirrel hepatitis sAg (GSHsAg) had 90% amino acid homology with woodchuck hepatitis sAg and is believed to be ... Feitelson, M A; Marion, P L; Robinson, W S (August 1982). "Core particles of hepatitis B virus and ground squirrel hepatitis ... Two are for the genes encoding the structural proteins (surface antigens and core antigens), and the other two are unassigned. ...
Further tests like ELISA can be used to detect the antigen. Virus can be grown in cell culture also.[citation needed] Marquis ... hepatosplenomegaly and jaundice due to hepatitis Lung - pneumonitis (interstitial pneumonitis) Heart - myocarditis ...
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary ... The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence (IIF) on Hep-2 cells ... "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from ...
Tarmogens activate T cells to specifically target and eliminate diseased cells with the same target antigen. The company has ... Their collaboration with Gilead for the development of therapeutic vaccines for the treatment of hepatitis B was terminated in ... Tarmogens are made from genetically modified yeast that express one or more disease-associated antigens. ...
Rh factor, also known as Rh D antigen, is an antigen found on red blood cells; individuals that are Rh-positive (Rh+) have this ... while IgG is elevated in viral hepatitis, autoimmune hepatitis and cirrhosis. Autoimmune disorders can often be traced to ... This occurs before the antigen can stimulate maternal B cells to "remember" Rh antigen by generating memory B cells. Therefore ... This means binding between antibody and antigen is reversible, and the antibody's affinity towards an antigen is relative ...
Antigen-Antibody binding hypothesis (John Marrack) 1940 - Identification of the Rh antigens (Karl Landsteiner and Alexander ... Hepatitis B vaccine produced by genetic engineering 1986 - Th1 vs Th2 model of T helper cell function (Timothy Mosmann) 1988 - ... Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow- ... Antigen-specific NK cell memory first reported by Ulrich von Andrian's group after discovery by Mahmoud Goodarzi 2010 - The ...
There is an association with the HLA-B27 histocompatibility antigen, which is present in 65% of patients with erythema nodosum ... Rogerson, S J; Nye, F J (1990). "Hepatitis B vaccine associated with erythema nodosum and polyarthritis". BMJ. 301 (6747): 345 ... Erythema nodosum is probably a delayed hypersensitivity reaction to a variety of antigens. Although circulating immune ... Medications associated with EN include: Omeprazole Sulfonamides Penicillins Bromides Hepatitis B vaccination Cancers associated ...
Mamiya N, Worman HJ (May 1999). "Hepatitis C virus core protein binds to a DEAD box RNA helicase". The Journal of Biological ... "An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility ... This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in ... Owsianka AM, Patel AH (May 1999). "Hepatitis C virus core protein interacts with a human DEAD box protein DDX3". Virology. 257 ...
Chimeric antigen receptors (CARs) are genetically modified receptors targeting cell surface antigens that provide a valuable ... 2017). "Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis ... which subsequently enables antigen-specific T and B cell responses. Instead of acting via antigen-specific receptors, lysis of ... In contrast to NKT cells, NK cells do not express T-cell antigen receptors (TCR) or pan T marker CD3 or surface immunoglobulins ...
... antigen of Salmonella typhi Motility of flagellated salmonella strains used to study phage transduction First description of ... First anti-D immunoglobulin for treating rhesus negative mothers Development of radio immunoassay to screen blood for hepatitis ... H and Lewis blood group antigens, their biosynthesis and genetic control Invented the ether method for fractionating blood ... Devised a method for identifying the blood meals of insect vectors Discovered that sequential mutations in surface antigens ...
Genetic vaccines deliver nucleic acid that codes for an antigen into host cells, which then produce that antigen, stimulating ... Examples are vaccines against flu, cholera, plague, and hepatitis A. Most vaccines of this type are likely to require booster ... A characteristic example is the subunit vaccine against Hepatitis B virus. In addition, there are some newer types of vaccines ... Artificially acquired active immunity can be induced by a vaccine, a substance that contains antigen. A vaccine stimulates a ...
"Long-term follow-up of antimitochondrial antibody-positive autoimmune hepatitis". Hepatology. 48 (2): 550-6. doi:10.1002/hep. ... Of the mitochondrial antigens that can generate autoantibody reactivity in PBC patients, the E2 subunit of the pyruvate ... 49 (3): 871-9. doi:10.1002/hep.22736. hdl:2434/55031. PMC 2665925. PMID 19185000. Bellucci R, Oertelt S, Gallagher M, Li S, ... There is also evidence of anti-PDC-E2 antibodies in autoimmune hepatitis (AIH) patients. Pyruvate dehydrogenase deficiency (PDH ...
The hepatitis delta virus of humans has an RNA genome similar to viroids but has a protein coat derived from hepatitis B virus ... Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, Moore PS, Chang Y (October 2008). "T antigen mutations are a human tumor- ... Although hepatitis delta virus genome may replicate independently once inside a host cell, it requires the help of hepatitis B ... This is common in hepatitis B virus and hepatitis C virus infections. People chronically infected are known as carriers, as ...
DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens. The ... DQB1*0301 haplotype is associated with hepatitis B virus persistence HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) ... Tissue Antigens. 40 (2): 90-7. doi:10.1111/j.1399-0039.1992.tb01965.x. PMID 1357780. Chou HT, Chen CH, Chen JY, Chang KC (2007 ... "Human leukocyte antigen class II and cervical cancer risk: a population-based study". J Infect Dis. 186 (11): 1565-74. doi: ...
"Gilead's Hepatitis C Drug Sofosbuvir Offers Upside". Seeking Alpha. Retrieved 12 October 2013. Rubin, Rita. "PSA Screening: New ... task force released a guideline advising against routine screening for prostate cancer using the prostate-specific antigen test ... in anticipation of release of the hepatitis C drug sofosbuvir. On May 22, 2012, the United States preventive services ...
DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens. ... Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease. DRB1*1302:DQA1*0102:DQB1 ...
One such application is the identification of hepatitis C virus (HCV) peptides that bind to HLA, and that can be recognized by ... For example, genetically modified mice may be born with human leukocyte antigen genes in order to provide a more realistic ...