Low-molecular-weight heparin
Natural heparin consists of molecular chains of varying lengths, or molecular weights. Chains of varying molecular weights, ... "Low Molecular Mass FEPAFUNS". Pharmeuropa. 3: 161-165. Gray E, Mulloy B, Barrowcliffe TW. Heparin and low-molecular-weight- ... Various methods of heparin depolymerisation are used in the manufacture of low-molecular-weight heparin. These are listed below ... January 2001). "Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing, monitoring, efficacy ...
Heparin
A fractionated version of heparin, known as low molecular weight heparin, is also available. Heparin was discovered by Jay ... whereas low-molecular-weight heparin's half-life is about four times longer. Lower doses of heparin have a much shorter half- ... Unfractionated heparin is used in hemodialysis. Comparing to low-molecular-weight heparin, unfractionated heparin does not have ... Handoll HH, Farrar MJ, McBirnie J, Tytherleigh-Strong G, Milne AA, Gillespie WJ (2002). "Heparin, low molecular weight heparin ...
Heparin-induced thrombocytopenia
... "low molecular weight" form that is generally given subcutaneously. Commonly used low molecular weight heparins are enoxaparin, ... Some studies have shown that HIT is less common in those receiving low molecular weight heparin. While heparin was introduced ... Dooley C, Kaur R, Sobieraj DM (2014). "Comparison of the efficacy and safety of low molecular weight heparins for venous ... while those with a low score can safely continue receiving heparin, as the likelihood that they have HIT is extremely low. In ...
Vitamin K antagonist
... with unfractionated or low-molecular-weight heparin... [which] was not mandated by the study protocol during either temporary ...
Dalteparin sodium
Dalteparin is a low molecular weight heparin. It is marketed as Fragmin. Like other low molecular weight heparins, dalteparin ... "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer ... against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin ... Dalteparin is not superior to unfractionated heparin in preventing blood clots. Heparins are cleared by the kidneys, but ...
Tinzaparin sodium
Tinzaparin is an antithrombotic drug in the heparin group. It is a low molecular weight heparin (LMWH) marketed as Innohep ... Infobox-drug molecular-weight unexpected-character, Chemical pages without DrugBank identifier, Articles without InChI source, ... It was manufactured by Leo pharmaceutical company, who withdrew the product from the US in 2011 due to low sales and a ...
Jian Liu (academic)
Homogeneous and reversible low-molecular weight heparins with reversible anticoagulant activity. Nat Chem Biol. 2014;10:248-50 ... Chemoenzymatic synthesis of homogeneous ultra-low molecular weight heparin. Science. 2011;334:498-501. Xu Y, Cai C, ... Jian Liu also participated in the effort organized by the US FDA and US Pharmacopeia to define the purity standards for heparin ... He served as a member of Unfractionated Heparins Ad Hoc Advisory Panel for US Pharmacopeia from 2010 to 2012. "Jian Liu, Ph.D ...
P-selectin
Lazo-Langner A, Goss GD, Spaans JN, Rodger MA (April 2007). "The effect of low-molecular-weight heparin on cancer survival. A ... Despite a striking effect of heparin on tumor progression shown in a number of clinical trials, the use of heparin as anti- ... Heparin has long been known to represent antiheparanase activity that is to keep an endoglycosidase from degrading heparan ... Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin". Trends in Molecular Medicine. 10 ...
Reviparin sodium
Reviparin is a low molecular weight heparin obtained by nitrous acid depolymerization of heparin extracted from porcine ... Reviparin is an antithrombotic and belongs to the group of low molecular weight heparins (LMWH). Prevention of blood clots ... 2005). "Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute ... "Low molecular weight heparin (reviparin) in percutaneous transluminal coronary angioplasty. Results of a randomized, double- ...
Antithrombin III deficiency
Low molecular weight heparin at full weight based dosing is effective; however, measurements of peak anti-Xa levels may not ... If large quantities of unfractionated heparin are required e.g. greater than 35000 units per day, this would point towards ... Antithrombin concentrates have been used, though with risk of bleeding at large doses of unfractionated heparin. ... In patients with antithrombin deficiency, they may develop resistance to unfractionated heparin, especially with continuous ...
Christoph Westphal
Momenta brought to market the first generic, low-molecular-weight heparin. To expand the portfolio of treatments for autoimmune ...
Spinal cord stroke
Protamine is used to reverse heparin and low-molecular-weight heparin. Vitamin K is a reversal agent for warfarin. It is ... including axial and sagittal T1 and T2-weighted sequences and diffusion-weighted imaging (DWI). As the non-contrast CT and ... Bhole, R.; Caplan, L. R. (2017-01-01), Caplan, Louis R.; Biller, José; Leary, Megan C.; Lo, Eng H. (eds.), "Chapter 89 - Spinal ... Neurological examination should be conducted after anesthesia to test the motor function of the low extremity of patients. By ...
Enoxaparin sodium
Enoxaparin belongs to the class of drugs known as low molecular weight heparins. Other drugs in this class include dalteparin, ... Enoxaparin is in the low molecular weight heparin family of medications. Enoxaparin was first made in 1981 and approved for ... It has less activity against factor IIa (thrombin) compared to unfractionated heparin (UFH) due to its low molecular weight. ... Updated recommendations to decrease risk of spinal column bleeding and paralysis in patients on low molecular weight heparins ...
Trousseau sign of malignancy
"Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin". Journal of Thrombosis and ... "Pharmacokinetics of low molecular weight heparin in patients with malignant tumors". Anti-Cancer Drugs. 26 (1): 106-111. doi: ... Heparin therapy is recommended to prevent future clots. The Trousseau sign of malignancy should not be confused with the ... an enzyme that degrade heparan sulfate and endogenous heparin, and thus contribute to the hypercoagulable state in cancer ...
Subcutaneous administration
This includes heparin and low molecular weight heparin products such as enoxaparin. There is some low certainty evidence that ... Subcutaneous heparin-based anticoagulation may also lead to necrosis of the surrounding skin or lesions, most commonly when ... Heparin-based anticoagulants injected subcutaneously may cause hematoma and bruising around the injection site due to their ... A 90-degree angle is always used for medications such as heparin. If administered at an angle, the skin and underlying tissue ...
Essential thrombocythemia
Low-dose low molecular weight heparin (e.g. enoxaparin) may be used. For life-threatening complications, the platelet count can ... Hydroxyurea treated patients had a lower incidence of arterial thrombosis, lower incidence of severe bleeding and lower ... Hydroxycarbamide, interferon-α and anagrelide can lower the platelet count. Low-dose aspirin is used to reduce the risk of ... Low risk individuals are usually treated with aspirin, whereas those at high risk are treated with hydroxycarbamide, interferon ...
Certoparin sodium
It is a low molecular weight heparin, primarily active against factor Xa. Like other low molecular weight heparins, it is used ... Heparins, All stub articles, Blood and blood forming organ drug stubs). ...
Hypercoagulability in pregnancy
Unfractionated heparin, low molecular weight heparin, warfarin (not to be used during pregnancy) and aspirin remain the basis ... However, unfractionated heparin and low molecular weight heparin do not cross the placenta. In general, the indications for ... de Vries JI, van Pampus MG, Hague WM, Bezemer PD, Joosten JH, FRUIT Investigators (2012). "Low-molecular-weight heparin added ... chronic anticoagulation may be given the option of conversion to either unfractionated heparin or low molecular weight heparin ...
Drugs in pregnancy
A common low molecular weight heparin drug is called enoxaparin (brand name Lovenox). Enoxaparin is listed as Pregnancy ... Deruelle P, Coulon C (December 2007). "The use of low-molecular-weight heparins in pregnancy--how safe are they?". Current ... Women who use opioids during pregnancy in a non-medical fashion are at a higher risk for premature birth, lower birth weight, ... Iron deficiency anemia in pregnancy can lead to an increased risk of premature delivery, low birth weight and increased risk of ...
Morpheein
FORMATION OF ACTIVE TRYPTASE MONOMERS IN THE PRESENCE OF LOW MOLECULAR WEIGHT HEPARIN". Journal of Biological Chemistry. 276 ( ... Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology ... Kim, Sang Suk; Choi, I.-G.; Kim, Sung-Hou; Yu, Y. G. (1999). "Molecular cloning, expression, and characterization of a ... Koshland, D.E. (1970). "7 The Molecular Basis for Enzyme Regulation". The Enzymes Volume 1. The Enzymes. Vol. 1. pp. 341-396. ...
Joseph Kost
Mitragotri, Samir; Kost, Joseph (2001-08-01). "Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low- ... However, the low permeability of the skin limits its applicability. Kost has come up with creative ways to open the skin for ... Terahara, T; Mitragotri, S; Kost, J; Langer, R (2002-03-20). "Dependence of low-frequency sonophoresis on ultrasound parameters ... Mitragotri, Samir; Kost, Joseph (2004-03-27). "Low-frequency sonophoresis: A review". Advanced Drug Delivery Reviews. Breaking ...
Deep vein thrombosis
... low-molecular-weight heparin and low-dose-unfractionated heparin) depending upon the risk of VTE, risk of major bleeding, and ... Critically ill hospitalized patients are recommended to either receive unfractionated heparin or low-molecular weight heparin ... These parenteral (non-oral) medicines include low-molecular-weight heparin, fondaparinux, and unfractionated heparin. Some oral ... "Compression and walking versus bed rest in the treatment of proximal deep venous thrombosis with low molecular weight heparin ...
Limb infarction
Low molecular weight heparin is used to reduce or at least prevent enlargement of a thrombus, and is also indicated before any ... Aspirin and low molecular weight heparin should be administered, and possibly warfarin as well. Follow-up includes checking ... Google Translate: Surgical measures in acute ischemia of lower extremities.) Pekka Aho och Pirkka Vikatmaa. Finska ... "Percutaneous aspiration thrombectomy in the treatment of lower extremity thromboembolic occlusions". Diagnostic and ...
John G. Kelton
"Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin". NEJM. 332 ( ... heparin-induced thrombocytopenia was significantly more common after unfractionated heparin compared to low molecular weight ... He is an expert on heparin-induced thrombocytopenia. He is known for developing a diagnostic test for heparin-induced ... 2015 Prix Galien Canada Prize with Ted Warkentin for significant advances in pharmaceutical research for work on heparin- ...
Thrombophilia
Low molecular weight heparin (LMWH, such as enoxaparin) is generally used as an alternative. Warfarin and LMWH may safely be ... some studies have suggested that low molecular weight heparin reduces the risk of miscarriage. When the results of all studies ... "A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia". Blood. 127 ( ... Heparin-induced thrombocytopenia (HIT) is due to an immune system reaction against the anticoagulant drug heparin (or its ...
Lee Byung-heon (biochemist)
"An apoptosis-homing peptide-conjugated low molecular weight heparin-taurocholate conjugate with antitumor properties". ... The Low Molecular Weight Proteome. Methods in Molecular Biology. Vol. 1023. pp. 181-9. doi:10.1007/978-1-4614-7209-4_12. ISBN ... Korean Society of Molecular Biology and Biochemistry 1990-present: Korean Society of Molecular Cell Biology 2003-present: ... Lee, M. J.; Wang, K.; Kim, I. S.; Lee, B. H.; Han, H. S. (2011). "Molecular Imaging of Cell Death in an Experimental Model of ...
Protamine sulfate
It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin ... It is a highly cationic peptide that binds to either heparin or low molecular weight heparin (LMWH) to form a stable ion pair, ... Dosage for heparin reversal is 0.5mg to 1.0 mg mg protamine sulfate IV for every 100 IU of active heparin. Partial ... Protamine works by binding with heparin. Protamine sulfate was approved for medical use in the United States in 1969. It is on ...
Discovery and development of direct Xa inhibitors
In the 1980s Low molecular weight heparin (LMWH) were developed and they only contain chains with an average molecular weight ... Currently, the main problem with low molecular weight heparin (LMWH) is the administration route, as it has to be given ... They are gradually taking over warfarin usage and low molecular weight heparins (LMWH). Indication for Xa inhibitors is ... During the 1990s several low-molecular-weight substances were developed, such as DX-9065a and YM-60828. DX-9065a was the first ...
Venous thrombosis
If heparin is used for initial treatment of VTE, fixed doses with low-molecular-weight heparin (LMWH) may be more effective ... "Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization". The Cochrane ... The initial treatment for VTE is typically either low-molecular-weight heparin (LMWH) or unfractionated heparin, or ... "Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for the initial treatment of ...
Ciraparantag
... and heparins (including fondaparinux, low molecular weight heparins (LMWH), and unfractionated heparin). Ciraparantag ... Costin JC, Laulicht B, Bakhru S, Steiner S (March 2015). "PER977 reverses low molecular weight heparin in addition to IIa and ...