Loading...
*  Bemiparin sodium
Bemiparin is an antithrombotic and belongs to the group of low molecular weight heparins (LMWH). Like semuloparin, bemiparin is ... Planès, A. (2003). "Review of bemiparin sodium - a new second-generation low molecular weight heparin and its applications in ... "A common standard is inappropriate for determining the potency of ultra low molecular weight heparins such as semuloparin and ... Enoxaparin has 4500 g/mol) These heparins have lower anti-thrombin activity than classical LMWHs and act mainly on factor Xa, ...
*  Parnaparin sodium
Parnaparin is an antithrombotic and belongs to the group of low molecular weight heparins. parnaparin at the US National ... a low-molecular-weight heparin, prevents P-selectin-dependent formation of platelet-leukocyte aggregates in human whole blood ...
*  Dalteparin sodium
Dalteparin is a low molecular weight heparin. It is marketed as Fragmin by Pfizer Inc. Like other low molecular weight heparins ... "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer ... against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin ... Dalteparin is not superior to unfractionated heparin in preventing blood clots. Heparins are cleared by the kidneys, but ...
*  Tinzaparin sodium
Tinzaparin is an antithrombotic drug in the heparin group. It is a low molecular weight heparin (LMWH) marketed as Innohep ... It was manufactured by Leo pharmaceutical company, who withdrew the product from the US in 2011 due to low sales and a ...
*  Low molecular weight heparin
Natural heparin consists of molecular chains of varying lengths, or molecular weights. Chains of varying molecular weights, ... Heparin and low-molecular-weight-heparin. Thromb Haemost 2008; 99: 807-818. Xu, Y.; Masuko, S.; Takieddin, M.; Xu, H.; Liu, R ... Various methods of heparin depolymerisation are used in the manufacture of low-molecular-weight heparin. These are listed below ... 2007). "Intravenous Low-Molecular-Weight Heparins Compared With Unfractionated Heparin in Percutaneous Coronary Intervention". ...
*  Heparin
A fractionated version of heparin, known as low molecular weight heparin is also available. Heparin is a naturally occurring ... whereas low-molecular-weight heparin's half-life is about four times longer. Lower doses of heparin have a much shorter half- ... "Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following ... Native heparin is a polymer with a molecular weight ranging from 3 to 30 kDa, although the average molecular weight of most ...
*  P-selectin
Lazo-Langner A, Goss GD, Spaans JN, Rodger MA (April 2007). "The effect of low-molecular-weight heparin on cancer survival. A ... Heparin has long been known to represent antiheparanase activity that is to keep an endoglycosidase from degrading heparin ... Despite a striking effect of heparin on tumor progression shown in a number of clinical trials, the use of heparin as anti- ... Cambien B, Wagner DD (2004). "A new role in hemostasis for the adhesion receptor P-selectin". Trends in Molecular Medicine. 10 ...
*  Discovery and development of direct thrombin inhibitors
In the 1980s low molecular-weight heparin (LMWH) were developed. They are derived from heparin by enzymatic or chemical ... Hirsh, Jack; Raschke, Robert (2004). "Heparin and Low-Molecular-Weight Heparin The Seventh ACCP Conference on Antithrombotic ... A few studies indicate that bivalirudin is non-inferior compared to heparin and that bivalirudin is associated with a lower ... HIT is a very serious adverse event related to heparin and occurs with both unfractionated heparin and LMWH, although to a ...
*  Reviparin sodium
Reviparin is an antithrombotic and belongs to the group of low molecular weight heparins. Reviparin is a low molecular weight ... 2005). "Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute ... "Low molecular weight heparin (reviparin) in percutaneous transluminal coronary angioplasty. Results of a randomized, double- ... The average molecular weight is about 3900 daltons. Prevention of blood clots Prophylaxis of perioperative thromboembolism ...
*  Anticoagulant
Low molecular weight heparin, a more highly processed product, is useful as it does not require monitoring of the APTT ... It is a smaller molecule than low molecular weight heparin. Idraparinux Non Vitamin K antagonist oral anticoagulants (NOACs) ... Heparin can be used in vivo (by injection), and also in vitro to prevent blood or plasma clotting in or on medical devices. In ... With low bleeding risk of dental procedures, it is recommended that NOAC medicine still be taken by the patient as per normal, ...
*  Christoph Westphal
Momenta brought the first generic, low-molecular-weight heparin to market. In 2002 he co-founded Alnylam Pharmaceuticals, which ...
*  Enoxaparin sodium
Enoxaparin belongs to the class of drugs known as low molecular weight heparins. Other drugs in this class include dalteparin, ... Enoxaparin is in the low molecular weight heparin family of medications. Enoxaparin was first made in 1981 and approved for ... It has less activity against factor IIa (thrombin) compared to unfractionated heparin (UFH) due to its low molecular weight. ... Updated recommendations to decrease risk of spinal column bleeding and paralysis in patients on low molecular weight heparins ...
*  Heparin-induced thrombocytopenia
Some studies have shown that HIT is less common in those receiving low molecular weight heparin. While heparin was introduced ... "low molecular weight" form that is generally given subcutaneously (administered under the skin). Commonly used low molecular ... Dooley C, Kaur R, Sobieraj DM (2014). "Comparison of the efficacy and safety of low molecular weight heparins for venous ... while those with a low score can safely continue receiving heparin as the likelihood that they have HIT is extremely low. In an ...
*  Essential thrombocytosis
Low-dose low molecular weight heparin (e.g. enoxaparin) may be used. For life-threatening complications, the platelet count can ... Hydroxyurea treated patients had a lower incidence of arterial thrombosis, lower incidence of severe bleeding and lower ... interferon-α and anagrelide can lower the platelet count. Low-dose aspirin is used to reduce the risk of blood clot formation ... People are usually split up into low and high risk for bleeding/blood clotting groups (based on their age, their medical ...
*  Thrombosis prevention
Pre-operatively some patients receive low-molecular-weight heparin once a day. Additional risk factors such as obesity, disease ... Exercise of the lower extremeties is a post-operative method of prophlaxsis. Nursing personnel will often perform range of ... This is due to the observation that not all blood clots form in the lower legs. Most hospitalized medical patients have at ... The benefit of treating those who are at low risk of developing blood clots may not outweigh the higher risks of significant ...
*  Deep vein thrombosis
... low-molecular-weight heparin and low-dose-unfractionated heparin) depending upon the risk of VTE, risk of major bleeding, and ... Typical medications include low-molecular-weight heparin, warfarin, or a direct oral anticoagulant. Wearing graduated ... with low-molecular-weight heparin (LMWH) suggested as a preference. Intermittent pneumatic compression is also an option. ... Heparin is suggested in outpatients with cancer who have solid tumors and additional risk factors for VTE-listed as "previous ...
*  Discovery and development of direct Xa inhibitors
In the 1980s Low molecular weight heparin (LMWH) were developed and they only contain chains with an average molecular weight ... Currently, the main problem with low molecular weight heparin (LMWH) is the administration route, as it has to be given ... They are gradually taking over warfarin usage and low molecular weight heparins (LMWH). Indication for Xa inhibitors is ... During the 1990s several low-molecular-weight substances were developed, such as DX-9065a and YM-60828. DX-9065a was the first ...
*  Hypercoagulability in pregnancy
Unfractionated heparin, low molecular weight heparin, warfarin (not to be used during pregnancy) and aspirin remain the basis ... However, unfractionated heparin and low molecular weight heparin do not cross the placenta. In general, the indications for ... de Vries JI, van Pampus MG, Hague WM, Bezemer PD, Joosten JH, FRUIT Investigators (2012). "Low-molecular-weight heparin added ... chronic anticoagulation may be given the option of conversion to either unfractionated heparin or low molecular weight heparin ...
*  Morpheein
FORMATION OF ACTIVE TRYPTASE MONOMERS IN THE PRESENCE OF LOW MOLECULAR WEIGHT HEPARIN". Journal of Biological Chemistry. 276 ( ... Kim, Sang Suk; Choi, I.-G.; Kim, Sung-Hou; Yu, Y. G. (1999). "Molecular cloning, expression, and characterization of a ... Yang, Zhiru; Lanks, Charles W.; Tong, Liang (2002). "Molecular Mechanism for the Regulation of Human Mitochondrial NAD(P)+- ... Libonati, M. (2004). "Biological actions of the oligomers of ribonuclease A". Cellular and Molecular Life Sciences. 61 (19-20 ...
*  Joseph Kost
Mitragotri, Samir; Kost, Joseph (2001-08-01). "Transdermal Delivery of Heparin and Low-Molecular Weight Heparin Using Low- ... However, the low permeability of the skin limits its applicability. Kost has come up with creative ways to open the skin for ... Terahara, T; Mitragotri, S; Kost, J; Langer, R (2002-03-20). "Dependence of low-frequency sonophoresis on ultrasound parameters ... doi:10.1016/S0378-5173(01)00981-4. Mitragotri, Samir; Kost, Joseph (2004-03-27). "Low-frequency sonophoresis: A review". ...
*  Limb infarction
Low molecular weight heparin is used to reduce or at least prevent enlargement of a thrombus, and is also indicated before any ... Aspirin and low molecular weight heparin should be administered, and possibly warfarin as well. Follow-up includes checking ... Google Translate: Surgical measures in acute ischemia of lower extremities.) Pekka Aho och Pirkka Vikatmaa. Finska ... "Percutaneous aspiration thrombectomy in the treatment of lower extremity thromboembolic occlusions". Diagn Interv Radiol. 16 (1 ...
*  John G. Kelton
"Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin". NEJM. doi: ... heparin-induced thrombocytopenia was significantly more common after unfractionated heparin compared to low molecular weight ... He is an expert on heparin-induced thrombocytopenia. He is known for developing a diagnostic test for heparin-induced ... 2015 Prix Galien Canada Prize with Ted Warkentin for significant advances in pharmaceutical research for work on heparin- ...
*  Thrombophilia
Low molecular weight heparin (LMWH, such as enoxaparin) is generally used as an alternative. Warfarin and LMWH may safely be ... some studies have suggested that low molecular weight heparin reduces the risk of miscarriage. When the results of all studies ... "A meta-analysis of low-molecular-weight heparin to prevent pregnancy loss in women with inherited thrombophilia". Blood. 127 ( ... Heparin-induced thrombocytopenia (HIT) is due to an immune system reaction against the anticoagulant drug heparin (or its ...
*  Certoparin sodium
... is a low molecular weight heparin, primarily active against factor Xa. Like other low molecular weight heparins, it is used to ...
*  Lee Byung-heon (biochemist)
"An apoptosis-homing peptide-conjugated low molecular weight heparin-taurocholate conjugate with antitumor properties". ... The Low Molecular Weight Proteome. Methods in Molecular Biology. 1023. p. 181. doi:10.1007/978-1-4614-7209-4_12. ISBN 978-1- ... Korean Society of Molecular Biology and Biochemistry 1990-present: Korean Society of Molecular Cell Biology 2003-present: ... Lee, M. J.; Wang, K.; Kim, I. S.; Lee, B. H.; Han, H. S. (2011). "Molecular Imaging of Cell Death in an Experimental Model of ...
*  TENM3
Like the Ten-m family, Ten-m3 is a large type II transmembrane glycoprotein that has a molecular weight of ~300 kDa and is ... is expressed throughout the neocortex in a low rostral to high caudal and a high dorsal-medial to low ventral-lateral gradient ... is a neuronal protein with a novel type of heparin-binding domain". Journal of Cell Science. 112 (Pt 12): 2019-32. PMID ... Some Ten-m3 expressions can occur in a high-to-low gradient. At day 7.5 in mouse embryonic development (E7.5), in situ ...