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*  Serum protein electrophoresis
A decreased level of albumin, however, is common in many diseases, including liver disease, malnutrition, malabsorption, ... There are typically low levels in haemolytic anaemia (haptoglobin is a suicide molecule which binds with free haemoglobin ... chronic liver disease, rheumatoid arthritis, systemic lupus erythematosus and other connective tissue diseases. A narrow spike ... Some variants give rise to a wide band or two bands of unequal intensity but none of these variants is associated with disease ...
*  Fetal hemoglobin
The fetal hemoglobin's reduction in the severity of the disease comes from its ability to inhibit the formation of hemoglobin ... Most types of normal hemoglobin, including hemoglobin A, hemoglobin A2, as well as hemoglobin F, are tetramers composed of four ... primary form of hemoglobin switches from embryonic hemoglobin to fetal hemoglobin. At birth, fetal hemoglobin comprises 50-95% ... Fetal hemoglobin, or foetal haemoglobin, (also hemoglobin F, HbF, or α2γ2) is the main oxygen transport protein in the human ...
*  Hemoglobin Constant Spring
Hemoglobin variants Hemoglobinopathy Thalassemia What is Thalassemia? Hemoglobin H Disease and its Variants Hemoglobinopathiesm ... It is the most common nondeletional alpha-thalassemia mutation associated with hemoglobin H disease. The quantity of hemoglobin ... Hemoglobin Constant Spring is a variant of Hemoglobin in which a mutation in the alpha globin gene produces an alpha globin ... Hemoglobin Constant Spring is renamed after Constant Spring district in Jamaica. ...
*  Beta thalassemia
... is a hereditary disease affecting hemoglobin. As with about half of all hereditary diseases, an inherited ... In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease. The ... Brissot, Pierre; Cappellini, Maria Domenica (2014). "LIVER DISEASE". "WHO , Global epidemiology of haemoglobin disorders and ... Normal adult hemoglobin contains 2 alpha and 2 beta subunits. Thalassemias typically affect only the mRNAs for production of ...
*  Sickle Cell Anemia, a Molecular Disease
... the task of finding differences in hemoglobin that might explain sickle cell disease. After failing to find any differences in ... to show that the key difference between normal hemoglobins and sickle cell hemoglobins was a single difference in one chain of ... a glutamic acid residue on the normal hemoglobin in place of a valine residue on the sickle cell hemoglobin. The molecular ... They also estimated that blood from those with sickle cell trait was a mixture of 60 percent normal hemoglobin and 40 percent ...
*  Hemoglobinopathy
... well-known hemoglobin variants such as sickle-cell anemia and congenital dyserythropoietic anemia are responsible for diseases ... Methemoglobinemia: The iron in the heme portion of hemoglobin is easily oxidised and this reduces the ability of hemoglobin to ... Joseph Bonavetura and Austin Riggs, March 1968, "Hemoglobin Kansas, A Human Hemoglobin with a Neutral Amino Acid Substitution ... Hemoglobin functions: Transport of oxygen from the lungs to the tissues: This is due to the peculiar cooperation of the globin ...
*  Management of thalassemia
This build-up of iron may be due to the disease itself, from irregular hemoglobin not properly incorporating adequate iron into ... It beneficially affects cardiac disease, such as myocardial disease which occurs as a result of iron accumulation in the heart ... The child was born from an embryo screened to be free of the disease before implantation with In vitro fertilization. The ... In Iran as a premarital screening, the man's red cell indices are checked first, if he has microcytosis (mean cell hemoglobin ...
*  Hemoglobin H disease
... is a type of alpha thalassemia caused by impaired production of three of the four alpha globins, coded by ...
*  Alpha-thalassemia
"Hemoglobin H disease". Orphanet. Retrieved 22 September 2016. Vichinsky, Elliott P. (2009-01-01). "Alpha thalassemia major-new ... More specifically, HbH disease is seen in Southeast Asia and the Middle East, while Hb Bart hydrops fetalis is acknowledged in ... The excess β chains form unstable tetramers called hemoglobin H or HbH of four beta chains. The excess γ chains form tetramers ... Online Mendelian Inheritance in Man (OMIM) Hemoglobin-Alpha locus 1; HBA1 -141800 Online Mendelian Inheritance in Man (OMIM) ...
*  Max Perutz
In addition Perutz studied the structural changes in a number of haemoglobin diseases and how these might affect oxygen binding ... Haemoglobin was a subject which was to occupy him for most of his professional career. He completed his Ph.D. under William ... He demonstrated that the onset of Huntington disease is related to the number of glutamine repeats as they bind to form what he ... After 1959, Perutz and his colleagues went on to determine the structure of oxy- and deoxy- haemoglobin at high resolution. As ...
*  HBAP1
Safaya S, Rieder RF (1988). "Dysfunctional alpha-globin gene in hemoglobin H disease in blacks. A dinucleotide deletion ... Hemoglobin, alpha pseudogene 1, also known as HBAP1, is a human gene. "Human PubMed Reference:". "Entrez Gene: HBAP1 hemoglobin ... Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 ...
*  Hemoglobin, alpha 2
Zhu C, Yu W, Xie J, Chen L, Ding H, Shang X, Xu X (Oct 2010). "Hemoglobin H disease due to a de novo mutation at the α2-globin ... Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin. The human alpha ... Deletion of all 4 alleles is lethal because it renders the body unable to make fetal hemoglobin (HbF), adult hemoglobin (HbA) ... "Hemoglobin H disease in Guangxi province, Southern China: clinical review of 357 patients". Acta Haematologica. 124 (2): 86-91 ...
*  Munib Shahid
with G.I. Abu-Haydar and N.A. Abu-Haydar) "Thalassemia Hemoglobin E. Disease. A Case Report from Quatar." Persian Gulf, Man., ... "The Use of Nitrogen Mustard in Neoplastic Diseases of the Bone Marrow," Rev. Med. Liban. I (1961?): 45-51. (with E. Stephan) " ... with N.A. Abu-Haydar) "Sickle Cell Disease in Lebanon and Syria." Acta Haemat., Basel XXVII (1962):268-273. ( ...
*  Anemia
They are not recommended in people with chronic kidney disease unless hemoglobin levels are less than 10 g/dL or they have ... Rh disease, one of the causes of hemolytic disease of the newborn Transfusion reaction to blood transfusions Mechanical trauma ... Iron is an essential part of hemoglobin, and low iron levels result in decreased incorporation of hemoglobin into red blood ... In anemias of chronic disease, associated with chemotherapy, or associated with renal disease, some clinicians prescribe ...
*  Human genetic resistance to malaria
In West Africa, they account for as great a reduction in disease incidence as the sickle-cell hemoglobin variant. The studies ... Hb (HbC, HbE, HbS, etc.) hemoglobin (hemoglobin polymorphisms: hemoglobin type C, hemoglobin type E, hemoglobin type S) ... hemoglobin) - subcomponents of the hemoglobin molecule; two α-chains and two β-chains make up normal hemoglobin (HbA) alveolar ... May J, Evans JA, Timmann C, Ehmen C, Busch W, Thye T, Agbenyega T, Horstmann RD (2007). "Hemoglobin variants and disease ...
*  Derek Enlander
1969 Jul 24;281(4):205." " Hemoglobin S-C disease presenting as acute cor pulmonale. Rowley PT, Enlander D. Am Rev Respir Dis. ... He worked on the relationship of Epstein-Barr virus and Hodgkin's disease and also worked at Dr Lennete's Clinical virology Lab ...
*  Hemoglobin
Variant forms that cause disease: Hemoglobin D-Punjab - (α2βD2) - A variant form of hemoglobin. Hemoglobin H (β4) - A variant ... Hemoglobin S (α2βS2) - A variant form of hemoglobin found in people with sickle cell disease. There is a variation in the β- ... Hemoglobin AS - A heterozygous form causing sickle cell trait with one adult gene and one sickle cell disease gene Hemoglobin ... Many of these mutant forms of hemoglobin cause no disease. Some of these mutant forms of hemoglobin, however, cause a group of ...
*  NT5C3
... nucleotidase deficiency is also linked to the conversion of hemoglobin E disease into an unstable hemoglobinopathy-like disease ...
*  Chukwuedu Nwokolo
Nwokolo C (September 1957). "A case of sickle cell haemoglobin 'C' disease in Eastern Nigeria". The West African Medical ... Lehmann H, Nwokolo C (June 1959). "The River Niger as a barrier in the spread eastwards of haemoglobin C: a survey of ... Nwokolo founded SICREP: Sickle Cell Research Programme to effectively fight the disease in Nigeria and globally. Nwokolo was a ... He did major research in endomyocardial fibrosis, endemic goitre, sickle-cell disease and other areas of national need. ...
*  Helsinki Challenge
... team leader Laura Visapää Genetic Correction of Inherited Hemoglobin Disease, team leader Kirmo Wartiovaara In October 2015, ...
*  Mean corpuscular hemoglobin concentration
MCHC can be elevated ("polychromatic") in hereditary spherocytosis, sickle cell disease and homozygous haemoglobin C disease, ... The Mean corpuscular hemoglobin concentration, a measure of the concentration of haemoglobin in a given volume of packed red ... A low MCHC can be interpreted as identifying decreased production of hemoglobin. MCHC can be normal even when hemoglobin ... haemoglobin. Haemolysis: Will falsely increase the MCHC (measured haemoglobin is proportionally higher than HCT or PCV) and ...
*  Hemoglobin, alpha 1
2008). "Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease ... Hemoglobin, alpha 1, also known as HBA1, is a hemoglobin protein that in humans is encoded by the HBA1 gene. The human alpha ... 2007). "Clinical and molecular analysis of haemoglobin H disease in Sardinia: haematological, obstetric and cardiac aspects in ... 1992). "Six rare hemoglobin variants found in Sicily". Hemoglobin. 15 (5): 431-7. doi:10.3109/03630269108998862. PMID 1802885. ...
*  Sickle cell-beta thalassemia
Ashley-Koch, A; Yang, Q; Olney, R. S. (2000). "Sickle hemoglobin (HbS) allele and sickle cell disease: A HuGE review". American ... "Hemoglobin S- β -Thalassemia Disease - Hematology and Oncology". Retrieved 2015-06-18. "Newborn Screening Program - Sickle Cell ... Ashley-Koch, A; Yang, Q; Olney, R. S. (2000). "Sickle hemoglobin (HbS) allele and sickle cell disease: A HuGE review". American ... The disease may range in severity from being relatively benign and like sickle cell trait to being similar to sickle cell ...
*  Mirror syndrome
Ballantyne syndrome can result from the maternal reaction to a fetus that has hemoglobin Bart's disease due to inherited double ...
*  Hodgkin's lymphoma
45 years Stage IV disease Hemoglobin < 10.5 g/dl Lymphocyte count < 600/µl or < 8% Male Albumin < 4.0 g/dl White blood count ≥ ... heart disease, or lung disease over the subsequent decades. In 2015 about 574,000 people had Hodgkin's lymphoma, and 23,900 ... announced in August 2015 that he was diagnosed with Hodgkin's disease. He later died of the disease in October 2015. Eric Berry ... in which he called the disease "Hodgkin's disease" in honor of his predecessor. Theodor Langhans and WS Greenfield first ...
*  Metabolism
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabási AL (May 2007). "The human disease network". Proc. Natl. Acad. Sci. U.S. ... as cofactors and are essential for the activity of enzymes such as catalase and oxygen-carrier proteins such as hemoglobin. ... These models are now used in network analysis, to classify human diseases into groups that share common proteins or metabolites ... Csete M, Doyle J (2004). "Bow ties, metabolism and disease". Trends Biotechnol. 22 (9): 446-50. doi:10.1016/j.tibtech.2004.07. ...
*  C. Lockard Conley
His hematology research included important work on blood coagulation, blood platelets, hemorrhagic diseases, and hemoglobins. ... In 1953 he and a research fellow, Ernest W. Smith, described a simple method of separating the components of hemoglobin on ... "In Memory - Dr C Lockard Conley A Pioneer in Sickle Cell Disease". Sickle Cell Information Center. Archived from the original ... Smith, Ernest W.; Conley, C. Lockard (August 1953). "Filter paper electrophoresis of human hemoglobins with special reference ...