"Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis". The ... Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to ... originating from heme via heme oxygenase and ~14% from non-heme sources including: photooxidation, lipid and keto acid ... A controversial third heme oxygenase (HO-3) is considered to be catalytically inactive and has been speculated to work in heme ...

... originating from heme via heme oxygenase and ~14% from non-heme sources including: photooxidation, lipid peroxidation, and ... thereby identifying the heme oxygenase (HMOX) enzyme. HMOX is a heme-containing member of the heat shock protein (HSP) family ... Some PPIX analogs such as tin PPIX, tin mesoporphyrin, and zinc PPIX, are heme oxygenase inhibitors. HMOX is regarded as the ... Based on the synergism of the heme oxygenase system and CO delivery, a new molecular hybrid-CORM (HYCO) class emerged ...

Implication for heme oxygenase-1 gene regulation". The Journal of Biological Chemistry. 276 (24): 20858-20865. doi:10.1074/jbc. ... 14 (1): 87. doi:10.1186/s12915-016-0301-2. PMC 5054600. PMID 27717342. Carracedo A, Gironella M, Lorente M, Garcia S, Guzmán M ... 189 (1-4): 144-152. doi:10.1159/000151747. PMC 3512205. PMID 18728356. Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, ... 299 (1): 36-38. doi:10.1016/0014-5793(92)80094-W. PMID 1371974. S2CID 34097395. Karpinski BA, Morle GD, Huggenvik J, Uhler MD, ...

Poss, K. D., & Tonegawa, S. (1997). Reduced stress defense in heme oxygenase 1-deficient cells. Proceedings of the National ... Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992). RAG-1-deficient mice have ... Annual review of immunology, 11(1), 637-685. Tsien, Joe Z.; Huerta, Patricio T.; Tonegawa, Susumu (1996). "The Essential Role ... Skeletal and CNS defects in Presenilin-1-deficient mice. Cell, 89(4), 629-639. Nakazawa, K., Quirk, M. C., Chitwood, R. A., ...

ZnPP is a competitive inhibitor of heme oxygenase. Heme oxygenase is a cytoprotective enzyme that copes with oxidative stress ... and leukemia all show a susceptibility to ZnPP due to increase expression of heme oxygenase. The inhibition of heme oxygenase ... ZnPP suppression of heme oxygenase reduces cell viability of cancer cells and increases cytotoxicity in cancer cells. ZnPP ... A targeted delivery system is needed to fully exploit the uses of ZnPP as a therapeutic agent and heme oxygenase inhibitor due ...

The Bach1-sMaf heterodimer regulates the heme oxygenase-1 gene. The contribution of individual sMafs to the transcriptional ... "Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene ... 285 (1): 183-95. doi:10.1006/jmbi.1998.2316. PMID 9878398. Kobayashi A, Ito E, Toki T, Kogame K, Takahashi S, Igarashi K, ... and syntenin-1, which play roles in neuronal function". Journal of Biomedical Science. 17: 18. doi:10.1186/1423-0127-17-18. PMC ...

Heme oxygenase-1 (HMOX1, HO-1) is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti- ... NRF2 induces the expression of heme oxygenase 1 in vitro leading to an increase in phase II enzymes. NRF2 also inhibits the ... Heme oxygenase Carbon monoxide-releasing molecules GRCh38: Ensembl release 89: ENSG00000116044 - Ensembl, May 2017 GRCm38: ... Wang J, Doré S (June 2007). "Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage". Brain. 130 (Pt 6 ...

Stocker R, Perrella MA (2006). "Heme oxygenase-1: a novel drug target for atherosclerotic diseases?". Circulation. 114 (20): ... "Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging". J Exp ... the understanding of how antioxidants and heme oxygenase-1 protect against atherosclerosis, the role of myeloperoxidase to ... 1): 45-9. Bibcode:1993PNAS...90...45I. doi:10.1073/pnas.90.1.45. PMC 45596. PMID 8419943. Stocker R, Bowry VW, Frei B (1991). " ...

The Bach1-sMaf heterodimer regulates the heme oxygenase-1 gene. In particular, it has been reported that Bach1-MafG ... 276 (1): 819-26. doi:10.1074/jbc.M007643200. PMID 11036080. Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). " ... 44 (1): 147-9. doi:10.1006/geno.1997.4847. PMID 9286713. Dhakshinamoorthy S, Jaiswal AK (Dec 2000). "Small maf (MafG and MafK) ... "Oxidative stress induces the levels of a MafG homolog in hamster HA-1 cells". Free Radical Biology & Medicine. 21 (4): 521-5. ...

The Bach1-sMaf heterodimer is critical for heme metabolism. Knockout mouse studies showed that heme oxygenase-1 gene expression ... Sun, J (2002). "Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene". EMBO J. 21 (19): 5216-24. doi: ... These data show that the Bach1-sMaf heterodimer negatively regulates heme oxygenase-1 gene. The Bach2-sMaf heterodimers are ... 1). The first member of the Maf family is c-Maf, which was cloned as a cellular counterpart of the v-Maf oncogene isolated from ...

The Bach1-sMaf heterodimer regulates the heme oxygenase-1 gene. In particular, it has been reported that MafF regulates the ... 449 (1-2): 87-93. doi:10.1016/j.abb.2006.02.011. PMID 16549056. Massrieh W, Derjuga A, Doualla-Bell F, Ku CY, Sanborn BM, Blank ... 276 (1): 819-26. doi:10.1074/jbc.M007643200. PMID 11036080. Kimura T, Ivell R, Rust W, Mizumoto Y, Ogita K, Kusui C, Matsumura ... 264 (1): 86-92. doi:10.1006/bbrc.1999.1487. PMID 10527846. Johnsen O, Skammelsrud N, Luna L, Nishizawa M, Prydz H, Kolstø AB ( ...

... peroxo-heme intermediates--the central bus station in heme oxygenase catalysis". Biochem. Biophys. Res. Commun. 338 (1): 346-54 ... The oxygenases form a class of oxidoreductases; their EC number is EC 1.13 or EC 1.14. Most oxygenases contain either a metal, ... SW, Ryter; J, Alam (April 2006). "Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications". Physiol ... Oxygenases constitute a major intracellular source of iron and carbon monoxide Two types of oxygenases are recognized: ...

... the best understood of which is the catabolic action of heme oxygenase on the heme derived from hemoproteins such as hemoglobin ... Ryter, Stefan W.; Alam, Jawed; Choi, Augustine M. K. (2006-04-01). "Heme Oxygenase-1/Carbon Monoxide: From Basic Science to ... Shimizu, Toru; Lengalova, Alzbeta; Martínek, Václav; Martínková, Markéta (2019-12-09). "Heme: emergent roles of heme in signal ... "Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon Monoxide Therapeutics?". Current Pharmaceutical Design. 24 (20 ...

The most extensively studied source is the catabolic action of heme oxygenase (HMOX) which has been estimated to account for 86 ... Hopper, C. P.; Meinel, L.; Steiger, C.; Otterbein, L. E. (October 2018). "Where is the Clinical Breakthrough of Heme Oxygenase- ... 2020-07-22). "Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia". Frontiers in Physiology. 11: ... Shimizu T, Lengalova A, Martínek V, Martínková M (December 2019). "Heme: emergent roles of heme in signal transduction, ...

The most extensively studied pathway is the metabolism of heme by heme oxygenase which occurs throughout the body with ... Hemoglobin contains a globin protein unit with four prosthetic heme groups (hence the name heme -o- globin); each heme is ... Hopper CP, Meinel L, Steiger C, Otterbein LE (2018-05-31). "Where is the Clinical Breakthrough of Heme Oxygenase-1 / Carbon ... "Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia". Frontiers in Physiology. 11: 886. doi:10.3389 ...

Liao, Wang; Yang, Wanbao; Shen, Zheng; Ai, Weiqi; Pan, Quan; Sun, Yuxiang; Guo, Shaodong (2021). "Heme Oxygenase-1 Regulates ...

"Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells". The Journal of Biological ... a transcriptional repressor of heme oxygenase-1 gene". The Journal of Biological Chemistry. 278 (49): 49246-53. doi:10.1074/jbc ... focusing on the Bach1/heme oxygenase-1 pathway". Current Pharmaceutical Biotechnology. 7 (2): 87-93. doi:10.2174/ ... Tahara T, Sun J, Nakanishi K, Yamamoto M, Mori H, Saito T, Fujita H, Igarashi K, Taketani S (Feb 2004). "Heme positively ...

Velmurugan, Kalpana; Alam, Jawed; McCord, Joe M.; Pugazhenthi, Subbiah (2009). "Synergistic induction of heme oxygenase-1 by ... The claims were deemed to be in violation of Section 201(g)(1)(B) of the Federal Food, Drug, and Cosmetic Act [21 U.S.C. § 321( ... December 1, 2003. Archived from the original on April 13, 2016. Retrieved 2012-08-19. "The Uncertain Antiaging Pill (press ... December 1, 2004. Retrieved 2012-08-19. Alison McCook (February 2006). "Your Money for Your Life". The Scientist. 20 (3): 33. " ...

Research topics include the enzyme placental heme oxygenase (HO), carbon monoxide (CO), and soluble Flt-1. "Asif Ahmed". ... "Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation". ... Ahmed, A; Dunk, C; Kniss, D; Wilkes, M (1997). "Role of VEGF receptor-1 (Flt-1) in mediating calcium-dependent nitric oxide ... Ahmad, S; Ahmed, A (2004). "Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in ...

Velmurugan K, Alam J, McCord JM, Pugazhenthi S (February 2009). "Synergistic induction of heme oxygenase-1 by the components of ...

... a transcriptional repressor of heme oxygenase-1 gene". The Journal of Biological Chemistry. 278 (49): 49246-49253. doi:10.1074/ ... 487 (1-2): 67-71. doi:10.1016/s0921-8777(01)00104-5. PMID 11595410. Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman ... 85 (1): 207-221. doi:10.3233/JAD-215305. PMID 34776453. S2CID 244078679. Sun X, Brieño-Enríquez MA, Cornelius A, Modzelewski AJ ... Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. The ...

Biliverdin also is replenished in the cycle with its formation from heme units through heme oxygenase (HO) localized from the ... and causes its dissociation from heme oxygenase (HO) (which catalyzes reaction of ferric heme --> biliverdin), causing the ... Wang J, de Montellano PR (May 2003). "The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin ... a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1". The Journal of Biological Chemistry ...

Wang J, de Montellano PR (May 2003). "The binding sites on human heme oxygenase-1 for cytochrome p450 reductase and biliverdin ... BLVRB binds to human heme oxygenase-1 (hHO-1) in conjunction with cytochrome p450 reductase to catalyzes the NADPH-cytochrome ... The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24). ... P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron. GRCh38: Ensembl release 89: ENSG00000090013 - ...

Subsequent analysis showed an increase in expression of heme oxygenase-1, a protein induced during oxidative stress. The ... doi:10.1111/j.1365-2621.1986.tb13136.x. 康雄, 小笠原; 豊, 肥田野; 陽治, 加藤 (1 January 2006). "アピオスの塊茎および花の炭水化物組成". 日本食品科学工学会誌 (in Japanese ... 9 (1). doi:10.5539/mas.v9n1p103. Wilson, PW; JR Gorney; WJ Blackmon; BG Reynolds (1986). "Fatty acids in the American groundnut ... 1 January 2015). "Investigation of the Safety and Antihyperglycemic Effect of Apios americana Flower

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene. GRCh38: Ensembl release 89: ENSG00000139644 - ... 2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Hillier LD, Lennon G, Becker M, et al. (1997). "Generation ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression ...

In the first step, heme is converted to biliverdin by the enzyme heme oxygenase (HO). NADPH is used as the reducing agent, ... Thus cytochrome oxidase, which has two A hemes (heme a and heme a3) in its structure, contains two moles of heme A per mole ... The most common type is heme B; other important types include heme A and heme C. Isolated hemes are commonly designated by ... Heme S is related to heme B by having a formal group at position 2 in place of the 2-vinyl group. Heme S is found in the ...

"Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein ... 115 (1): 84-88. doi:10.1254/jphs.10239SC. PMID 21258167. Kim, RG; Shin, KM; Kim, YK; Jeong, HJ; Ha, J; Choi, JW; Park, HJ; Lee ... Saururus chinensis, commonly known as Asian lizard's tail, is an herb that grows in low, damp places to more than 1 meter high ... 1 (2): 100-104. doi:10.4162/nrp.2007.1.2.100. PMC 2882583. PMID 20535394. Wikimedia Commons has media related to Saururus ...

"Prenylated chalcone from Sophora flavescens suppresses Th2 chemokine expression induced by cytokines via heme oxygenase-1 in ... Sophora flavescens is an evergreen slow growing shrub growing to 1.5 m (4.9 ft) by 1 m (3.3 ft). It is hardy to 0-10 °F (−18 ... and purification by high-speed counter-current chromatography" (PDF). Journal of Chromatography A. 1145 (1-2): 123-127. doi: ...

36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of ... 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of ... 490 (1-2): 32-8. doi:10.1016/S0014-5793(01)02132-9. PMID 11172806. Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). " ... 2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma ...

Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes ... Heme oxygenase (abbreviated HMOX or HO) mediates the first step of heme catabolism, it cleaves heme to form biliverdin. The ... Zhang Z, Song Y, Zhang Z, Li D, Zhu H, Liang R, Gu Y, Pang Y, Qi J, Wu H, Wang J (2016). "Distinct role of heme oxygenase-1 in ... HMOX1 (heme oxygenase 1 gene) is a human gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). ...