*CFU-GEMM

... hematopoietic stem cell). In current terminology, CFU-S refers to the pluripotent stem cells that can differentiate into all ... CFU-GEMM cells are the multipotential progenitor cells for myeloid cells; they are thus also called common myeloid progenitor ... researchers were in search of molecules to stimulate the proliferation of long-term hematopoietic stem cells (LT-HSC). They ... "Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal". Blood. 124 (21). ...

*Endothelial stem cell

It is characteristic of hematopoietic stem cells, as well as muscle stem cells. The two lineages arising from the EPC and the ... These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. Progenitor ... Hematopoietic stem cells can of course undergo self-renewal, and are multipotent cells that give rise to erythrocytes (red ... Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. They are multipotent, which describes ...

*Embryoid body

Wiles, M. V.; Keller, G. (1991). "Multiple hematopoietic lineages develop from embryonic stem (ES) cells in culture". ... Scalable Embryonic Stem Cell Differentiation Culture". Stem Cells. 22 (3): 275-282. doi:10.1634/stemcells.22-3-275. PMID ... and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood". Cell Stem Cell. 2 ... Cell Stem Cell. 3 (5): 508-518. doi:10.1016/j.stem.2008.09.013. PMC 2683270 . PMID 18983966. Shukla, S.; Nair, R.; Rolle, M. W ...

*Hematopoietic stem cell

Lymphoid cells include T cells, B cells, and natural killer cells.) The definition of hematopoietic stem cells has evolved ... Hematopoietic stem cells (HSCs) are the stem cells that give rise to blood cells through the process of haematopoiesis. They ... Schroeder T (2010). "Haematopoietic Stem Cell Heterogeneity: Subtypes, Not Unpredictable Behavior". Cell Stem Cell. 6 (3): 203- ... Hematopoiesis Hematopoietic stem cell niche Hematopoietic stem cell transplantation Birbrair, Alexander; Frenette, Paul S. ( ...

*Hematopoietic stem cell transplantation

... (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ... Peripheral blood stem cells are now the most common source of stem cells for HSCT. They are collected from the blood through a ... It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from ... of haematopoietic stem cells (HSC) from the patient and storage of the harvested cells in a freezer. The patient is then ...

*Hematopoietic stem cell niche

... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... "Regulation of the HIF-1α level is essential for hematopoietic stem cells". Stem Cell. 7 (3): 391-402. doi:10.1016/j.stem. ... 2010). "The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche". Stem Cell. 7 (3 ... "Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and ...

*List of conditions treated with hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. Malignancies ... "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation". N Engl J Med. 360 (7): 692-698. doi:10.1056/ ... Immunodeficiencies T-cell deficiencies Ataxia-telangiectasia DiGeorge syndrome Combined T- and B-cell deficiencies Severe ... globoid cell leukodystrophy) Mucopolysaccharidoses Hurler syndrome (MPS I H, α-L-iduronidase deficiency) Scheie syndrome (MPS I ...

*Clonal hematopoiesis

Acute myeloid leukemia Haematopoiesis Hematopoietic stem cell Hematopoietic stem cell transplantation Hematology ... Clonal hematopoiesis is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell ... A fourth possibility is that the mutation makes the progenitor cells and cells derived from them more like stem cells in their ... "Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia". Cancer Cell ...

*National Kidney Registry

Berz; McCormack; Winer; Colvin; Quesenberry (12 Nov 2007). "Cryopreservation of Hematopoietic Stem Cells" (PDF). Am. J. Hematol ...

*Monocyte

... bipotent cells that differentiated from hematopoietic stem cells. Monocytes circulate in the bloodstream for about one to three ... "Chronic variable stress activates hematopoietic stem cells". Nature Medicine. 20 (7): 754-758. doi:10.1038/nm.3589. ISSN 1078- ... Vacuolization may be present in a cell that has recently phagocytized foreign matter. Many factors produced by other cells can ... "Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal". Cell. 153: 362-375. doi:10.1016/j. ...

*Reticular dysgenesis

Hematopoietic stem cells give rise to blood cells. Differentiation and proliferation of hematopoietic stem cells require a lot ... Hematopoietic Stem Cell Transplantation (HSCT) involves intravenous infusion of stem cells to those who have either a damaged ... Stem cells are taken from an affected child's blood or bone marrow. Then in laboratory conditions the stem cells are ... hematopoietic stem cells will not be able to differentiate or proliferate. The immune system consists of specialized cells that ...

*CDCP1

"Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells". Leukemia. 20 (9): 1551-6. doi: ... "CDCP1 is a novel marker for hematopoietic stem cells". Annals of the New York Academy of Sciences. 996 (1): 222-6. doi:10.1111/ ... "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic ... Stem Cells. 22 (3): 334-43. doi:10.1634/stemcells.22-3-334. PMID 15153610. Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, ...

*Beckman Center for Molecular and Genetic Medicine

Their technology enabled Irving Weissman to isolate hematopoietic stem cells. Patrick O. Brown and Ronald W. Davis developed ... The bedrock of what it means to be a living entity is an understanding of how a cell or tissue functions as an integrated ... Philip A. Beachy has examined the Hedgehog signaling pathway and its role in embryonic development and cell formation. Matthew ... These include a Computer Services and Bioinformatics Facility (CSBF), a Cell Sciences Imaging Facility (CSIF), a Fluorescence ...

*MYST3

... is important for proper development of hematopoietic stem cells. GRCh38: Ensembl release 89: ENSG00000083168 - Ensembl, ... Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408- ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of ...

*Mothers against decapentaplegic homolog 4

"Smad4 is critical for self-renewal of hematopoietic stem cells". The Journal of Experimental Medicine. 204 (3): 467-74. doi: ... If the SMAD 4 mutation is acquired, it will only exist in certain somatic cells. Indeed, SMAD 4 is not synthesized by all cells ... expression of the genes involved in cell growth is no longer regulated and cell proliferation can go on without any inhibition ... PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells". Experimental Cell Research. ...

*KSL cells

... is the receptor of Stem Cell Factor. Sca-1 is a murine hematopoietic stem cell antigen. Lin is a series of lineage marker ... KSL cells are an early form of hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). Kit (CD117) ... antigens that identify mature murine blood cells.. ...

*CXCR4

... hematopoietic stem cells into the bloodstream as peripheral blood stem cells. Peripheral blood stem cell mobilization is very ... CXCR4's ligand SDF-1 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem ... It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. In a small human clinical ... To LB, Levesque JP, Herbert KE (October 2011). "How I treat patients who mobilize hematopoietic stem cells poorly". Blood. 118 ...

*Zinc finger nuclease

CCR5-targeted hematopoietic stem cell gene approaches for HIV disease: Current progress and future prospects Current Stem Cell ... Hütter G, Ganepola S (2011). "Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells". The Scientific ... After editing the stem cell genome, the cells could be expanded in culture and reinserted into the patient to produce ... Both ex-vivo (manipulation of stem or autologous T cell precursors) and in-vivo delivery platforms are being explored. It is ...

*CXCR4 antagonist

... to mobilize hematopoietic stem cells). BL-8040 is a CXCR4 antagonist that has undergone clinical trials (e.g. in various ... June 2016 BL-8040, a Peptidic CXCR4 Antagonist, Induces Leukemia Cell Death and Specific Leukemia Cell Mobilization in Relapsed ... important for hindering cancer progression because one of the downstream effects initiated by CXCR4 receptor activation is cell ...

*NSG mouse

2007). "Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells". Nat. Immunol. 8 (12): 1313-23. doi: ... "SCID mouse models of human stem cell engraftment". Stem Cells. 16 (3): 166-177. doi:10.1002/stem.160166. PMID 9617892. Blunt T ... Cell Stem Cell. 1 (6): 635-645. doi:10.1016/j.stem.2007.10.001. PMC 2292126 . PMID 18371405. Kumar P, Ban HS, Kim SS, et al. ( ... 2008). "T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice". Cell. 134 (4): 577-86. doi:10.1016/j.cell ...

*Gero Hütter

117 (10). Hütter G, Ganepola S (2011). "Eradication of HIV by transplantation of CCR5-deficient hematopoietic stem cells". The ... "Man appears free of HIV after stem cell transplant". CNN. 2009-02-11. Retrieved 2009-03-08. Glass WG, McDermott DH, Lim JK, et ... March 10, 2011). "Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation". Blood. ... "Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation". N Engl J Med. 360 (7): 692-698. doi:10.1056/ ...

*Haematopoiesis

One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c- ... Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to ... As a stem cell matures it undergoes changes in gene expression that limit the cell types that it can become and moves it closer ... 2006). Hematopoietic stem cell development. Springer. ISBN 978-0-306-47872-7. CS1 maint: Uses editors parameter (link) ...

*Penelope Jeggo

7 June 2007). "DNA repair is limiting for haematopoietic stem cells during ageing". Nature. 447 (7145): 686-690. doi:10.1038/ ... Jeggo studied aging and stem cells. She found that the inability of DNA Ligase IV to repair breaks in stem cell DNA contributes ... in the stem cell DNA come from genetics as well as environmental stress which increase inhibits the lifespan of stem cells and ... "DNA repair is limiting for haematopoietic stem cells during ageing". Nature. 447 (7145): 686-690. doi:10.1038/nature05875. ISSN ...

*LIG4

... haematopoietic stem cells to lig4 deficiency suggests that lig4-mediated NHEJ is a key determinant of the ability of stem cells ... Lig4 deficiency in the mouse causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during aging. ... This interaction stabilizes LIG4 protein in cells; cells that are deficient for XRCC4, such as XR-1 cells, have reduced levels ... "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age". Nature. 447 (7145): 725-9. doi: ...

*Jeff Bradstreet

Siniscalco, D.; Bradstreet, J. J.; Antonucci, N. (2013). "Therapeutic Role of Hematopoietic Stem Cells in Autism Spectrum ... "Stem cells and autism: one year later" (PDF). Autism Science Digest. Autism One. Retrieved 25 August 2013. Joshua Sharpe (June ... In an article for an anti-vaccine magazine, Bradstreet endorsed stem cell therapy as an autism treatment. Bradstreet was found ... is Up-Regulated in Peripheral Blood Mononuclear Cells of Children Affected by Autistic Disorders". Journal of Autism and ...

*Follicular dendritic cells

... are not dendritic cells (DCs). Unlike DCs, FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of ... Follicular dendritic cells (FDCs) are cells of the immune system found in primary and secondary lymph follicles of the B cell ... and differentiation into high-affinity plasma cells and memory B cells. Adhesion between FDCs and B cells is mediated by ICAM-1 ... Activated B-cells with low affinity to antigen captured on FDCs surface as well as autoreactive B-cells undergo apoptosis, ...

*PRDM1

Blimp-1 is also considered a 'master regulator' of hematopoietic stem cells. Blimp1 (also known as Prdm1), a known ... The increased expression of the Blimp-1 protein in B lymphocytes, T lymphocytes, NK cell and other immune system cells leads to ... Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the ... cells originating from the proximal posterior epiblast cells are indeed the lineage-restricted primordial germ cell precursors ...