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*  Granulocyte colony-stimulating factor
hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ... G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate for conditioning regimens. ...
*  Stem cell factor
Nervi B, Link DC, DiPersio JF (October 2006). "Cytokines and hematopoietic stem cell mobilization". J. Cell. Biochem. 99 (3): ... SCF may serve as guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in ... c-Kit is expressed in HSCs, mast cells, melanocytes, and germ cells. It is also expressed in hematopoietic progenitor cells ... promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division". Blood. 86 (5): 1757-64. PMID ...
*  CXCR4
... hematopoietic stem cells into the bloodstream as peripheral blood stem cells. Peripheral blood stem cell mobilization is very ... CXCR4's ligand SDF-1 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem ... It is a very efficient inducer of hematopoietic stem cell mobilization in animal and human studies. In a small human clinical ... To LB, Levesque JP, Herbert KE (October 2011). "How I treat patients who mobilize hematopoietic stem cells poorly". Blood. 118 ...
*  CD117
Mobilization is used clinically as a source of hematopoietic stem cells for hematopoietic stem cell transplantation (HSCT). ... CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of ... It is also a marker for mouse prostate stem cells. In addition, mast cells, melanocytes in the skin, and interstitial cells of ... the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells ...
*  Plerixafor
Peripheral blood stem cell mobilization, which is important as a source of hematopoietic stem cells for transplantation, is ... are important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. The in vivo ... inducer of mobilization of hematopoietic stem cells from the bone marrow to the bloodstream as peripheral blood stem cells. ... is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are ...
*  Hematopoietic stem cell niche
2005). "Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist". J. ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... "Regulation of the HIF-1α level is essential for hematopoietic stem cells". Stem Cell. 7 (3): 391-402. doi:10.1016/j.stem. ... 2010). "The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche". Stem Cell. 7 (3 ...
*  CXC chemokine receptors
Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced ... with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic ... some B cells (B lymphocytes) and NK cells] and is highly induced following cell activation. There are two isoforms, CXCR3-A and ... Langerhans cells and macrophages). In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells ...
*  CXCL2
Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced ... is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The ... CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. Wolpe, S. D., Sherry, B., Juers, D., ... Cell. Biol. 10:5596-5599, 1990. PMID 2078213 Pelus LM, Fukuda S. ...
*  FMS-like tyrosine kinase 3 ligand
... cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to ... B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is ... In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to ... FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of ...
*  Stem cell theory of aging
"Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle". Cell Stem ... mobilization and senescence are detrimental elements. These detrimental effects will eventually cause apoptosis. There are also ... have reviewed evidence that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell ... for stem cell dysfunction with aging. Hematopoietic stem cells (HSCs) regenerate the blood system throughout life and maintain ...
*  Cell isolation
Isolation of Haematopoetic stem cells: Rector K, Liu Y, Van Zant G. "Comprehensive hematopoietic stem cell isolation methods". ... Isolation of Mesenchymal stem cells: Yosupov N, Haimov H, Juodzbalys G. "Mobilization, Isolation and Characterization of Stem ... Isolated cells can also be used for cell culture, in which a single cell multiplies to create a colony of cells.[citation ... Circulating cells such as blood cells or some tumour cells can be isolated by taking a blood sample. As blood samples contain a ...
*  Ancestim
... injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later ... mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683-91. doi:10.1038/sj.bmt ... It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell ... Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to ...
*  CXCR4 antagonist
... to mobilize hematopoietic stem cells). BL-8040 is a CXCR4 antagonist that has undergone clinical trials (e.g. in various ... June 2016 BL-8040, a Peptidic CXCR4 Antagonist, Induces Leukemia Cell Death and Specific Leukemia Cell Mobilization in Relapsed ... important for hindering cancer progression because one of the downstream effects initiated by CXCR4 receptor activation is cell ...
*  Induced stem cells
"Generation of Engraftable Hematopoietic Stem Cells from Induced Pluripotent Stem Cells by Way of Teratoma Formation". Molecular ... improvement of heart function due to mobilization and redirection of epicardial progenitor cells toward cardiovascular cell ... link) Scientists develop 'game changing' stem cell repair system. Stem Cells Portal Could this new stem cell become the game ... "Human Somatic Cell Nuclear Transfer Using Adult Cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03.015. PMID ...
*  Endothelial progenitor cell
Angioblasts are believed to be a form of early progenitor or stem cell which gives rise to the endothelium alone. More recently ... or circulating angiogenic cells (CAC) instead (depending on the method of isolation), highlighting their role as hematopoietic ... the miRNAs miR-10b and miR-196b led to significant defects in angiogenesis-mediated tumor growth by decreasing the mobilization ... Endothelial progenitor cell (or EPC) is a term that has been applied to multiple different cell types that play roles in the ...
*  Colony-stimulating factor
Hematopoietic stem cells were cultured (see cell culture) on a so-called semisolid matrix, which prevents cells from moving ... Promegapoietin Bone marrow stimulation Stem cell mobilization Alberts, Bruce; et al. (2002). Molecular Biology of the Cell (4th ... These are referred to as "colonies". Therefore, it was possible to add various substances to cultures of hemopoietic stem cells ... all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally ...
*  Drug repositioning
"Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 ... it was noticed that the drug induced peripheral blood leukocytosis within which peripheral blood CD34 hematopoietic stem cells ... "The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone". Blood. 106 ... On basis of this observation, the drug has been re-purposed as a stem cell mobilizing drug. Carvedilo and Loratadine are ...
*  Erythropoiesis
... a multipotent hematopoietic stem cell, becomes a common myeloid progenitor or a multipotent stem cell, and then a unipotent ... It appears that this links erythropoietin-driven eyrthropoiesis with the iron mobilization needed for hemoglobin synthesis. ... There are colony forming units that the cells follow during their formation. These cells are referred to as the committed cells ... the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to ...
*  Evans syndrome
The only prospect for a permanent cure is the high-risk option of an allogeneic hematopoietic stem cell transplantation (SCT). ... Martino R, Sureda A, Brunet S (1997). "Peripheral blood stem cell mobilization in refractory autoimmune Evans syndrome: a ... Oyama Y, Papadopoulos EB, Miranda M, Traynor AE, Burt RK (2001). "Allogeneic stem cell transplantation for Evans syndrome". ... Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are ...
*  Stem-cell niche
Vertebrate hematopoietic stem cells niche in the bone marrow is formed by cells subendosteal osteoblasts, sinusoidal ... is also certain degree of similarity in homing-mobilization of normal stem cells and metastasis-invasion of cancer stem cells. ... cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, ... The CSC niche is very similar to normal stem cells niche (Embryonic Stem Cell (ESC), Adult Stem Cell ASC) in function ( ...
*  Human herpesvirus 6
After primary infection, latency is established in salivary glands, hematopoietic stem cells, and other cells, and exists for ... "Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during ... Yoshikawa, Tetsushi (2004). "Human herpesvirus 6 infection in hematopoietic stem cell transplant patients". British Journal of ... "CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion". Glia. 52 (3): 252-8. doi: ...
*  ICD-9-CM Volume 3
Bone marrow or hematopoietic stem cell transplant (41.1) Puncture of spleen (41.2) Splenotomy (41.3) Diagnostic procedures on ... Stapes mobilization (19.1) Stapedectomy (19.2) Revision of stapedectomy (19.3) Other operations on ossicular chain (19.4) ... Magnetic resonance imaging of brain and brain stem (88.92) Magnetic resonance imaging of chest and myocardium (88.93) Magnetic ... 1 bacterial smear 2 culture 3 culture and sensitivity 4 parasitology 5 toxicology 6 cell block and Papanicolaou smear 9 other ...
*  Karen H. Antman
... growth factors and mobilization of peripheral blood derived stem cells for blood and marrow transplant. Her professional ... Granulocyte-macrophage colony stimulating factor expands the circulating hematopoietic progenitor cell compartment in humans, ... Mobilization of peripheral blood progenitor cells by chemotherapy and GM-CSF for hematologic support after high dose ... hematopoietins and stem cells (three editions), Molecular Targeting in Oncology). Dr. Antman's publications also include ...
*  MMP9
Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells ... "Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand". Cell. 109 ( ... "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization". Leukemia & Lymphoma. 43 (2): 233-41. doi: ... Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical ...
*  Muse cell
Muse cells do not express CD34 (markers for hematopoietic stem cells, adipose stem cells, VSELs) and CD117 (hematopoietic stem ... "Mobilization of Pluripotent Multilineage-Differentiating Stress-Enduring Cells in Ischemic Stroke". Journal of Stroke and ... bone marrow-mesenchymal stem cells and adipose-derived stem cells. Muse cells are able to generate cells representative of all ... When mesenchymal cells (sometimes called mesenchymal stem cells) are separated into Muse and non-Muse cells by SSEA-3 cell ...
*  Proteases in angiogenesis
Activated c-kit is then able to recruit hematopoietic, endothelial and mast cell progenitor cells, these cells are then ... Rafii, S; Lyden, D (2003). "Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration". ... promotes tissue revascularization through VEGF release from mast cells and MMP-9 mediated progenitor cell mobilization". J. Exp ... Cathepsins also can be secreted by cells, associate with the cell surface, and degrade the ECM. A study of all 11 members of ...