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*  CFU-GEMM
... hematopoietic stem cell). In current terminology, CFU-S refers to the pluripotent stem cells that can differentiate into all ... While present in bone marrow, the place where CFU-GEMM is most common is in the umbilical cord between a mother and baby. It ... CFU-GEMM cells are the multipotential progenitor cells for myeloid cells; they are thus also called common myeloid progenitor ... "CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high- ...
*  Endothelial stem cell
CEPs are derived from EPCs within the bone marrow, and the bone marrow is a reservoir of stem and progenitor cells. These cell ... It is characteristic of hematopoietic stem cells, as well as muscle stem cells. The two lineages arising from the EPC and the ... 2 (6). doi:10.1186/2040-2384-2-6. Rafil S, Lyden D (2003). "Therapeutic stem and progenitor cell transplantation for organ ... These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. Progenitor ...
*  CD34
... are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. ... CD34+ cell) are normally found in the umbilical cord and bone marrow as hematopoietic cells, or in mesenchymal stem cells, ... It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. The CD34 ... The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes ...
*  Stem cell marker
March 1997). "Factors predicting morbidity following hematopoietic stem cell transplantation". Bone Marrow Transplantation. 19 ... 2005). "Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors". Stem Cells. 23 (6 ... "Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice". ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ...
*  Granulocyte colony-stimulating factor
"G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 ( ... Thomas J, Liu F, Link DC (May 2002). "Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony- ... hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ...
*  Allen C Eaves
Ernest McCulloch Connie Eaves Stem Cells Hematopoiesis Hematopoietic stem cells Cellular therapy Bone marrow transplantation ... Long-term marrow culture reveals chromosomally normal hematopoietic progenitor cells in patients with Philadelphia chromosome- ... Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow ... on how different types of cancer chemotherapeutic agents killed tumour stem cells while sparing normal stem cells. Working ...
*  Stem cell factor
In the bone marrow, HSCs and hematopoietic progenitor cells are adjacent to stromal cells, such as fibroblasts and osteoblasts ... The expansion of these cells ex-vivo (outside the body) would allow advances in bone marrow transplantation, in which HSCs are ... It causes a significant decrease in the number HSC and other hematopoietic progenitor cells in the bone marrow. This suggests ... SCF may serve as guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in ...
*  CLEC11A
"Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ... and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells". Proceedings ... stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells ... "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106-12. PMID 10807776. ...
*  Hematopoietic stem cell
... subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter HSCs must occur. Stem cell self-renewal ... but is now considered to measure more mature progenitor or transit-amplifying cells rather than stem cells. Hematopoietic stem ... Hematopoiesis Hematopoietic stem cell niche Hematopoietic stem cell transplantation Birbrair, Alexander; Frenette, Paul S. ( ... Lymphoid cells include T cells, B cells, and natural killer cells.) The definition of hematopoietic stem cells has evolved ...
*  Muse cell
Mesenchymal stem cell transplantation: Muse cells exist within cultured MSCs such as bone marrow mesenchymal stem cells and ... Muse cells do not express CD34 (markers for hematopoietic stem cells, adipose stem cells, VSELs) and CD117 (hematopoietic stem ... endothelial progenitor markers). This indicates that Muse cells do not belong to previously investigated stem cell types. Muse ... Bone marrow-derived mesenchymal stem cells Fibroblasts Adipose-derived stem cells Bone marrow: Bone marrow mononucleated cells ...
*  Megakaryocyte
The primary treatment for CAMT is bone marrow transplantation. Bone marrow/stem cell transplant is the only remedy for this ... "Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis ... Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the ... and bone marrow. These multipotent stem cells live in the marrow sinusoids and are capable of producing all types of blood ...
*  Stem cell
"P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ... 16 December 2013 Why Perform a Stem Cell Transplant? Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation ... mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, dental pulp stem cell, etc.). Muse cells (multi- ... Adult stem cells are frequently used in various medical therapies (e.g., bone marrow transplantation). Stem cells can now be ...
*  Bone marrow suppression
Hematopoietic stem cell transplantation Neutropenia, low leukocytes "bone marrow suppression". Retrieved 3 May 2011. ... These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that ... Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency ... Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for ...
*  CD117
... progenitors in the bone marrow. To be specific, hematopoietic stem cells (HSC), multipotent progenitors (MPP), and common ... Mobilization is used clinically as a source of hematopoietic stem cells for hematopoietic stem cell transplantation (HSCT). ... the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells ... CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of ...
*  Clinical uses of mesenchymal stem cells
October 2010). "Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study". J. ... October 2009). "Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risks". Neurol. Sci. 30 ... 2010). "Decreased neural stem/progenitor cell proliferation in mice with chronic/nonremitting experimental autoimmune ... In MSC therapy the cells are extracted from the adult patient's bone marrow via a procedure called bone marrow aspiration. This ...
*  FMS-like tyrosine kinase 3 ligand
... and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in ... Bone Marrow Transplantation. 31 (5): 361-9. doi:10.1038/sj.bmt.1703816. PMID 12634727. FLT3 signaling. ... B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is ... In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to ...
*  Interleukin 7
... hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is ... and increased recovery of T cells after cyclophosphamide administration or after bone marrow transplantation. IL-7 promotes ... IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by ... B cells, T cells and NK cells).[citation needed] It is important for proliferation during certain stages of B-cell maturation, ...
*  Filgrastim
... patients with cancer undergoing bone marrow transplantation; patients undergoing autologous peripheral blood progenitor cell ... of hematopoietic stem cells in the blood before collection by leukapheresis for use in hematopoietic stem cell transplantation ... stimulating the bone marrow to increase production of neutrophils. Causes of neutropenia include chemotherapy and bone marrow ... Increased hematopoietic activity of the bone marrow in response to growth factor therapy has been associated with transient ...
*  Acute biphenotypic leukaemia
If the patients enter fully remission, the consolidation with stem cell transplantation is highly recommended. The prognosis ... Symptoms caused by bone marrow damage Bruising, spotting: the reason is lack of platelets, it is very common in BAL patients, ... Acute biphenotypic leukaemia is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ... Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.: 150-155. Matutes E, Pickl WF, Van't Veer M, et al. ( ...
*  Cell therapy
Wilson A, Trumpp A (2006). "Bone-marrow haematopoietic stem-cell niches". Nature Immunology. 6: 93-106. doi:10.1038/nri1779. ... However, there are two main principles by which cells facilitate therapeutic action: Stem cell or progenitor cell engraftment, ... 2005). "Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis ... the first successful human bone marrow transplantation took place. Bone marrow transplants have been found to be effective, ...
*  Fanconi anemia
2013). "Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the EBMT experience". Blood. 122: 4279-4286. doi: ... blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a ... although more recent published evidence suggests that earlier allogeneic hematopoietic progenitor cell transplantation in ... A more permanent cure is hematopoietic stem cell transplantation. If no potential donors exist, a savior sibling can be ...
*  Stem cell transplantation for articular cartilage repair
... human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow ... The adult stem cell fraction is present in the nucleated cells of the marrow. Most of these cells are CD34+ heme progenitors ( ... Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues including bone marrow, synovial ... The most commonly used source of MSC's is bone marrow aspirate. Most of the adult bone marrow consists of blood cells in ...
*  Roland Mertelsmann
h.c. Roland Mertelsmann R. Mertelsmann: Plasticity of bone marrow-derived stem cells. In: J Hematother Stem Cell Res. 2000 Dec; ... PMID 11177610 A. Spyridonidis, R. Mertelsmann, J. Finke: Hematopoietic stem cell transplantation: more than just hematopoietic ... Efficient serum-free retroviral gene transfer into primitive human hematopoietic progenitor cells by a defined, high-titer, ... An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. In: Bone Marrow ...
*  GATA2
"Young woman with mild bone marrow dysplasia, GATA2 and ASXL1 mutation treated with allogeneic hematopoietic stem cell ... mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, ... transplantation". Leuk Res Rep. 4 (2): 72-5. doi:10.1016/j.lrr.2015.10.001. Kumar MS, Hancock DC, Molina-Arcas M, Steckel M, ... GATA3 expression is restricted to T-lymphocyte cells and some nonhematopoietic cell types, including embryonic stem cells. ...
*  Stem-cell therapy
16 December 2013 Why Perform a Stem Cell Transplant? Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation ... hematopoietic stem and progenitor cells (GM-HSPC). Stem cells are thought to mediate repair via five primary mechanisms: 1) ... Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most ... Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific ...
*  Thymus
... derived from bone marrow resident hematopoietic stem cells). Developing T cells are referred to as thymocytes and are of ... A rare population of hematopoietic progenitor cells enter the thymus from the blood, and expands by cell division to generate a ... The newly formed organ resembled a normal thymus histologically and molecularly, and upon transplantation it was able to ... hematopoietic precursors from the bone-marrow, referred to as thymocytes, mature into T cells. Once mature, T cells emigrate ...
*  Induced stem cells
... of bone marrow-derived cells or human cardiac progenitor cells, isolated from failing myocardium results in durability of ... "Generation of Engraftable Hematopoietic Stem Cells from Induced Pluripotent Stem Cells by Way of Teratoma Formation". Molecular ... This reduces their value as a source for autologous stem cell transplantation therapy, as for the present, it is not clear ... marrow cells in a way that induces marrow stem cells that normally develop into white blood cells to become neural progenitor ...