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*  Soil-transmitted helminthiasis
Soil-transmitted helminths can also cause loss of appetite. These nutritional "knock on" effects of STH can have a significant ... In fact it is the leading cause of anaemia and protein deficiency in developing nations, affected an estimated 740 million ... Its main cause, like for many types of helminth infections, is lack of sanitation, such as the practice of open defecation and ... Soil-transmitted helminths are essentially intestinal parasites and their eggs are liberated along the faeces of infected ...
*  Helminth protein
... helminth proteins have potential to be co-opted to treat a number of other human diseases. Helminth proteins modulate the ... A helminth protein, or helminthic antigen, is a protein derived from a parasitic worm that causes an immune reaction. When ... The Helminth Secretome Database (HSD) is a repository for helminth proteins predicted using expressed sequence tags (ESTs). ... Garg G, Ranganathan S (2012-01-01). "Helminth secretome database (HSD): a collection of helminth excretory/secretory proteins ...
*  Index of biochemistry articles
70 kDa heat shock proteins) - Hsp90 (90 kDa heat shock proteins) - heavy-chain immunoglobulin - Hela cell - helminth protein - ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ... proto-oncogene protein C-kit - proto-oncogene proteins c-abl - proto-oncogene proteins c-bcl-2 - Proto-oncogene proteins c-fos ...
*  Heligmosomoides polygyrus
17 October 2017). "HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33". Immunity. 47 (4): 739-751. doi: ... Another factor might be the production of H. polygyrus Alarmin Release Inhibitor (HpARI), an IL-33-suppressive 26-kDa protein, ... as it is used as a model of human helminth infection to which there is a spectrum of natural resistance to parasite infection. ... "Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection". ...
*  Basophil
... pollen proteins or helminth antigens. Recent studies in mice suggest that basophils may also regulate the behavior of T cells ... Basophils have protein receptors on their cell surface that bind IgE, an immunoglobulin involved in macroparasite defense and ... Voehringer D (December 2009). "The role of basophils in helminth infection". Trends Parasitol. 25 (12): 551-6. doi:10.1016/j.pt ...
*  Guard theory
One proposed mechanism by which this may take place is that proteases secreted by the helminths cleave proteins which act as ... This model is best illustrated by RIN4 protein in A. thaliana. RIN4 forms a complex with the NB-LRR proteins RPM1 and RPS2. ... The interaction between pathogen and accessory protein results in some modification of the accessory protein, which allows for ... In short, this example elucidates how one NBS-LRR protein is able to recognize the effects of more than one virulence factor or ...
*  Effects of parasitic worms on the immune system
Some helminth-products, like a protein of the nematode Acanthocheilonema viteae, didn't have any effect. Another infectious ... In the past, helminths were thought to simply suppress T-helper Type 1 (Th1) cells while inducing T-helper Type 2 (Th2) cells. ... Rook says that such helminths "are all either things that really do us no harm, or things where the immune system is forced to ... However, helminths also regulate Th2-caused diseases, such as allergy and asthma. Professor Rook postulates that different ...
*  Fc receptor
... against which helminths are not resistant. The interaction of the FcεRI receptor with the Fc portion of helminth bound IgE ... This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ... This receptor is called the Fc-alpha/mu receptor (Fcα/μR) and is a type I transmembrane protein. With one Ig-like domain in its ... An Fc receptor is a protein found on the surface of certain cells - including, among others, B lymphocytes, follicular ...
*  Tegument (helminth)
In fact it is a living structure consisting of proteins, lipids, carbohydrates and RNA. It forms the protective layer and the ...
*  Major basic protein
PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic ... Major basic protein has been shown to interact with Pregnancy-associated plasma protein A. arylsulfatase GRCh38: Ensembl ... Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen ... Weller PF, Ackerman SJ, Smith JA (1988). "Eosinophil granule cationic proteins: major basic protein is distinct from the ...
*  Helminths
... the inner layer is composed of lipids and proteins and is useful to protect eggs from desiccation, strong acid and bases, ... The word helminth comes from Greek hélmins, a kind of worm. There is no consensus on the taxonomy of helminths. It is simply a ... Helminths are a group of organisms which share a similar form but are not necessarily related as part of evolution. Helminths ... The most important helminths in the sanitation field are the human parasites, which is why most people relate the term helminth ...
*  Structural parasitology
More importantly, it is hoped that structures of parasite proteins will lead to faster discovery of drugs for diseases ... Parasites of interest include Plasmodium, Trypanosoma, Leishmania, Giardia, Entamoeba, Cryptosporidium, Helminth and Toxoplasma ... This is a challenging field because parasite proteins are often more difficult to express using a heterologous system. The ... Structural parasitology is the study of the structures of proteins of parasites. It applies the techniques of structural ...
*  The Collapse of Nature
Citing examples of the Schistosoma mansoni, a parasitic worm whose eggs release a protein which can bind to DNA and replicate ... alongside it, and Helminths, parasitic worms which have been used to treat autoimmune disorders, as possibilities for ...
*  Hookworm infection
A hookworm is a type of parasitic worm (helminth). There are no specific symptoms or signs of hookworm infection, but they give ... Signs of advanced severe infection are those of anemia and protein deficiency, including emaciation, cardiac failure and ... Knowles SC (August 2011). "The effect of helminth co-infection on malaria in mice". Int. J. Parasitol. 41 (10): 1041-51. doi: ... Hartgers FC, Yazdanbakhsh M (October 2006). "Co-infection of helminths and malaria: modulation of the immune responses to ...
*  Pathogen
This expels the pathogen's DNA, making it incapable of producing proteins and causing the bacteria to die. A class of bacteria ... Some eukaryotic organisms, including a number of protozoa and helminths, are human parasites (i.e., they cause various ... These abnormally folded proteins are found characteristically in some diseases such as scrapie, bovine spongiform ...
*  Mast cell
An important adaptor protein activated by the Syk phosphorylation step is the linker for activation of T cells (LAT). LAT can ... Mast cells are activated in response to infection by pathogenic parasites, such as certain helminths and protozoa, through IgE ... Complement proteins can activate membrane receptors on mast cells to exert various functions as well. Mast cells express a high ... September 2002). "Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE- ...
*  Eosinophil
... cationic protein and eosinophil-derived neurotoxin are ribonucleases with antiviral activity. Major basic protein ... They also fight helminth (worm) colonization and may be slightly elevated in the presence of certain parasites. Eosinophils are ... These include: major basic protein (MBP) eosinophil cationic protein (ECP) eosinophil peroxidase (EPX) eosinophil-derived ... Eosinophil cationic protein creates toxic pores in the membranes of target cells allowing potential entry of other cytotoxic ...
*  Degranulation
In a similar mechanism, activated eosinophils release preformed mediators such as major basic protein, and enzymes such as ... following interaction between their Fc receptors and IgE molecules that are bound to large parasites like helminths. Four kinds ...
*  WormBase
The protein products of gene are created by translating the CDS sequences. Each unique protein sequence is given a unique ... WormBase ParaSite is a sub-portal for approximately 100 draft genomes of parasitic helminths (nematodes and platyhelminthes) ... Protein-protein interaction Interactome data; Genetic regulatory relationships; Details of intra- and inter-specific sequence ... Examples of the protein identifier names for each species in WormBase is given in the table, below. It is possible for two CDS ...
*  HIV disease progression rates
Entry inhibitors bind to the CCR5 protein to block HIV from binding to the CD4 cell. Coinfections or immunizations may enhance ... Frequent exposure to helminth infections, which are endemic in Africa, activates individual immune systems, thereby shifting ... 2004). "The glutamine-rich region of HIV-1 Tat protein involved in T cell apoptosis". Journal of Biological Chemistry. 279 (46 ... Baeuerle, P.A. (1991). "The inducible transcription activator NF-kappa B: regulation by distinct protein subunits". Biochimica ...
*  Bridget Ogilvie
access-date= requires ,url= (help) Philipp, M.; Parkhouse, R. M. E.; Ogilvie, B. M. (1980). "Changing proteins on the surface ... Ogilvie, B. M. (1964). "Reagin-like Antibodies in Animals Immune to Helminth Parasites". Nature. 204 (4953): 91. Bibcode: ...
*  Human pathogen
Prions are abnormal proteins whose presence causes some diseases such as scrapie, bovine spongiform encephalopathy (mad cow ... Some eukaryotic organisms, such as protists and helminths, cause disease. One of the best known diseases caused by protists in ...
*  Chitinase
Elias JA, Homer RJ, Hamid Q, Lee CG (Sep 2005). "Chitinases and chitinase-like proteins in T(H)2 inflammation and asthma". The ... Hunter MM, McKay DM (Jan 2004). "Review article: helminths as therapeutic agents for inflammatory bowel disease". Alimentary ... Some parts of chitinase molecules, almost identical in structure to hevein or other proteins in rubber latex due to their ... Recklies AD, White C, Ling H (Jul 2002). "The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates ...
*  Wellcome Sanger Institute
Pfam, a protein family database Rfam, an RNA family database TreeFam, a database of phylogenetic trees for animal genes Vega, a ... WormBase ParaSite, a database for the genomics for parasitic helminths (both Nematodes and Platyhelminthes). Since 2000, the ... The Institute houses genome resources, RNA, protein and other family resources and functional annotation databases and ... The protein families database". Nucleic Acids Research. 42 (Database issue): D222-30. doi:10.1093/nar/gkt1223. PMC 3965110 . ...
*  Cysteine protease
The protease is activated by removal of an inhibitory segment or protein. Activation occurs once the protease is delivered to a ... the development of resistance is thought to be unlikely because it would require a complete change of structure of the helminth ... Each superfamily uses the catalytic triad or dyad in a different protein fold and so represent convergent evolution of the ... In plants they are important in growth and development and in accumulation and mobilization of storage proteins such as in ...
*  WormBook
Capitalizing on the World Wide Web, WormBook links in-text references (e.g. genes, alleles, proteins, literature citations) ... expanding to enable helminth genomic research". Nucleic Acids Research. Oxford: Oxford University Press. 44 (D1): D774-D780. ...
*  Peritrophic matrix
Many helminth microfilaria and arboviruses (arthropod borne viruses) are transmitted to the mosquito in their infective form ... However, heme groups ingested in a blood meal bind to proteins on the peritrophic matrix, enabling insects to safely feed on ... In addition, some smaller toxins bind with specific surface proteins present in the peritrophic matrix. This binding is ... Heme groups, which are components of hemoglobin, an oxygen carrying protein present in vertebrate blood, act as strong ...