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*  TRPC
... of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells". ... It has long been proposed that TRPC channels underlie the store-operated channels (SOC) observed in many cell types. These ... TRPC1 channels are found on cardiomyocytes, smooth muscle, and endothelial cells. Upon stimulation of these channels in ... Smith, Richard (2009). "Excitatory actions of noradrenaline and metabotropic glutamate receptor activation in granule cells of ...
*  HEK 293 cells
As a consequence, HEK 293 cells should not be used as an in vitro model of typical kidney cells. HEK 293 cells have a complex ... Human embryonic kidney cells 293, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a ... HEK 293 Transfection and Selection Data @ Cell-culture Database A HEK293 Cell Database 293 Cells (CRL-1573) in the ATCC ... HEK 293 cells have been widely used in cell biology research for many years, because of their reliable growth and propensity ...
*  PHLDA2
2007). "Upregulation of PHLDA2 in Dicer knockdown HEK293 cells". Biochim. Biophys. Acta. 1770 (5): 820-5. doi:10.1016/j.bbagen. ...
*  ASAH2C
"Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochemical and Biophysical Research ...
*  SLC7A11
Shih AY, Murphy TH (April 2001). "xCt cystine transporter expression in HEK293 cells: pharmacology and localization". ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. This article incorporates text from the United States ... The dimer cystine gets taken up by glial cells and the monomer of cystine, cysteine, is taken up by neurons.[citation needed] ... N-acetylcysteine works by increasing levels of cysteine in cells, leading to an increase in system Xc- activity. This increase ...
*  ASAH2
2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun. 331 (1 ... 2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". ...
*  Sirtuin 7
Knock down of SIRT7 in HEK293 cells resulted in decreased rRNA levels. This same study found that this SIRT3 knockdown ... In humans cells, SIRT7 has only been shown to interact with two other molecules: RNA polymerase I (RNA Pol I) and upstream ... Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D (Mar 2015). "Stem cell aging. A mitochondrial UPR-mediated ... These features include premature curvature of the spine, reduced weight and fat content, compromised hematopoietic stem cell ...
*  PRDX4
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells". Mol. Med. 8 (2): 95- ...
*  CCT7
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, ... "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". ... 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell ...
*  SUMO4
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ...
*  KCNK13
2006). "Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells". Adv. Exp. Med. Biol. ADVANCES IN ... 2008). "Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney". Cell. Physiol. ...
*  PAFAH1B3
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Cell. 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, ...
*  STRAP
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... Cell. Biol. 20 (9): 3157-67. doi:10.1128/MCB.20.9.3157-3167.2000. PMC 85610 . PMID 10757800. Zhang QH, Ye M, Wu XY, Ren SX, ... Cell. Biol. 20 (9): 3157-67. doi:10.1128/mcb.20.9.3157-3167.2000. PMC 85610 . PMID 10757800. Datta PK, Chytil A, Gorska AE, ... "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621-5. doi:10.1126/science. ...
*  SF3B4
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Molecular Cell. 5 (5): 779-87. doi:10.1016/S1097-2765(00)80318-4. PMID 10882114. Will CL, Schneider C, MacMillan AM, Katopodis ... "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94-101. doi:10.1038/ ...
*  EIF3I
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad ... "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94-101. doi:10.1038/nbt1046. ...
*  CCT6A
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. ... "Identification of candidate radioresistant genes in human squamous cell carcinoma cells through gene expression analysis using ... Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. Higo M, Uzawa K, Kouzu Y, Bukawa H, Nimura Y, Seki N, Tanzawa H ( ... Cell. Proteomics. 4 (11): 1725-40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Human CCT6A genome location and CCT6A gene ...
*  Nav1.8
"Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells". The Journal of ... Voltage clamp methods have been used to show how action potentials in DRG cells are shaped by TTX-resistant sodium channels. ... Lipid rafts organise the cell membrane, which includes trafficking and localising ion channels. Removal of lipid rafts in the ... Okuse K (2007). "Pain signalling pathways: from cytokines to ion channels". The International Journal of Biochemistry & Cell ...
*  IDH1
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Within cells, IDH1 has been observed to localize to the cytoplasm, peroxisome, and endoplasmic reticulum. Under hypoxic ... In addition, IDH1 is key to β-oxidation of unsaturated fatty acids in the peroxisomes of liver cells. IDH1 also participates in ... Zhao S, Guan KL (Dec 2010). "IDH1 mutant structures reveal a mechanism of dominant inhibition". Cell Research. 20 (12): 1279-81 ...
*  ZNF259
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... "The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells". Molecular Biology of the Cell. 9 ... "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells". The Journal of Cell Biology. 143 (6): ... Gangwani L (December 2006). "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle ...
*  Phosphoglycerate dehydrogenase
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... Given that PHGDH represents the committed step in the production of serine in the cell, flux through the pathway must be ... This finding suggests that pathways providing an outlet for diverting carbon out of glycolysis may be beneficial for rapid cell ... Cytogenetics and Cell Genetics. 89 (1-2): 6-7. doi:10.1159/000015577. PMID 10894924. Cho HM, Jun DY, Bae MA, Ahn JD, Kim YH ( ...
*  CCT2 (gene)
"Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical ... "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". ... 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell ...
*  IMPDH2
2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... 2008). "Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells". Cell Cycle. 7 (15): 2392-400 ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... doi:10.1016/j.cell.2006.03.032. PMID 16713569. He Y, Mou Z, Li W, et al. (2009). "Identification of IMPDH2 as a tumor- ...
*  Aggresome
When expressed in naïve HEK293 cells, synphilin 1 forms multiple small highly mobile aggregates. However, proteasome or Hsp90 ... In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein- ... Consequently, elaborate systems have evolved to protect cells from the deleterious effects of misfolded proteins. Cells mainly ... An aggresome forms around the microtubule organizing center in eukaryotic cells, adjacent to or enveloping the cell's ...
*  TUBA1C
2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... Cell. 16 (11): 5445-5454. doi:10.1091/mbc.E05-04-0354. PMC 1266439 . PMID 16148047. Guo D, Han J, Adam BL, et al. ( ... doi:10.1016/j.cell.2006.09.026. PMID 17081983. Frum R, Busby SA, Ramamoorthy M, et al. (2007). "HDM2-binding partners: ... 2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197- ...
*  TXNL1
2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ...
*  Halostachine
Using a β2 adrenergic receptor preparation derived from transfected HEK 293 cells, Liappakis and co-workers found that in wild- ... Measurements of cAMP accumulation in intact transfected HEK 293 cells, after treatment with EEDQ to inactivate 98-99% of the ...
*  Kua-UEV
2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. ... in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells". Mol. Cell. Biol. 18 (1): 576- ... 1998). "Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines". Oncogene. 17 ( ... Cell. 96 (5): 645-53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880. Deng L, Wang C, Spencer E, et al. (2000). "Activation ...