Loading...
*  Adhesion G protein-coupled receptor
This process seems to be similar to those found in other auto-proteolytic proteins such as the Ntn hydrolases and hedgehog ... Since many of these domains have been demonstrated to mediate protein-protein interactions within other proteins, they are ... Adhesion G protein-coupled receptors (adhesion GPCRs) are a class of 33 human protein receptors with a broad distribution in ... Once this protein is cleaved, the pieces are expressed at the cell surface as a heterodimer. This cleavage is thought to happen ...
*  Desert hedgehog (protein)
Desert hedgehog, also Desert hedgehod homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog ... The gene is not specific to desert hedgehogs. This gene encodes a member of the hedgehog family. The hedgehog gene family ... The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene ... "Entrez Gene: desert hedgehog homolog (Drosophila)". DHH protein, human at the US National Library of Medicine Medical Subject ...
*  Indian hedgehog (protein)
The Indian hedgehog protein is one of three proteins in the mammalian hedgehog family, the others being desert hedgehog (DHH) ... This cell signaling protein is in the hedgehog signaling pathway. The several mammalian variants of the Drosophila hedgehog ... Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature. ... Indian hedgehog homolog (Drosophila), also known as IHH, is a protein which in humans is encoded by the IHH gene. ...
*  Paracrine signalling
Hedgehog proteins were first discovered and studied in Drosophila. Hedgehog proteins produce key signals for the establishment ... sonic hedgehog, desert hedgehog, and Indian hedgehog. Sonic hedgehog (SHH) has various roles in vertebrae development, ... Then active Smoothened protein is able to inhibit PKA and Slimb, so that the Ci protein is not cleaved. This intact Ci protein ... The binding of Wnt to a Frizzled protein activates the Dishevelled protein. In its active state the Dishevelled protein ...
*  Hes3 signaling axis
In vivo adult rodent neural stem cells: Increase in cell number; increased expression of Sonic hedgehog (Shh) protein. Delta4 ... These modified proteins may then also be activated and enabled to induce further modifications to other proteins, and so on. ... Cultured adult monkey neural stem cells: Pro-survival effects; increased yield; increased expression of sonic hedgehog protein ... Mice genetically engineered to lack the Hes3 gene exhibit differences in the amount of myelin basic protein (a protein ...
*  Philip A. Beachy
The hedgehog gene's main function is to create protein signals in specific cells. These signals, in turn, allow for the ... He is now still interested in the function of hedgehog proteins. He is also looking for other extracellular signals in pattern ... He is interested in the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and ... Porter, J. A.; Young, K. E.; Beachy, P. A. (1996). "Cholesterol Modification of Hedgehog Signaling Proteins in Animal ...
*  Aorta-gonad-mesonephros
"Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development". Development. 136 (15): ... Notch1 is another protein which has been implicated in the signalling pathway for HSC production. Notch1 knockouts exhibit ...
*  CYP17A1
Bordeau BM, Ciulla DA, Callahan BP (September 2016). "Hedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential ... CYP17A1 is a 57.4 kDa protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508 ... This protein localizes to the endoplasmic reticulum. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key ... CYP17A1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CYP17A1 genome location and ...
*  PTCH2
The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been ... "Characterization of two patched receptors for the vertebrate hedgehog protein family". Proceedings of the National Academy of ... Patched 2 is a protein that in humans is encoded by the PTCH2 gene. This gene encodes a transmembrane receptor of the patched ... Rahnama F, Toftgård R, Zaphiropoulos PG (2004). "Distinct roles of PTCH2 splice variants in Hedgehog signalling". Biochemical ...
*  Smoothened
... is a Class Frizzled (Class F) G protein-coupled receptor that is a component of the hedgehog signaling pathway and ... When the hedgehog pathway is inactive, a complex of Fused (Fu), Supressor of Fused (Sufu), and the kinesin motor protein Costal ... "Characterization of two patched receptors for the vertebrate hedgehog protein family". Proceedings of the National Academy of ... the cleaved Ci goes on to act as a repressor of hedgehog-activated transcription. However, when hedgehog signaling is active, ...
*  Compartment (development)
Tabata T, Kornberg TB (1994). "Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs". Cell. ... Basler K, Struhl G (1994). "Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein". Nature. 368 ... Végh M, Basler K (2003). "A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior ... Blair SS, Ralston A (1997). "Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior ...
*  PTCH1
... is a transmembrane protein that suppresses the release of another protein called smoothened, and when sonic hedgehog binds ... Protein patched homolog 1 is a protein that is the member of the patched family and in humans is encoded by the PTCH1 gene. ... 1998). "Characterization of two patched receptors for the vertebrate hedgehog protein family". Proc. Natl. Acad. Sci. U.S.A. 95 ... PTCH1 is a member of the patched gene family and is the receptor for sonic hedgehog, a secreted molecule implicated in the ...
*  Smith-Lemli-Opitz syndrome
One particular hedgehog signaling protein, sonic hedgehog (SHH), is important in the pattern of the central nervous system, ... Cholesterol is important to this pathway because it undergoes covalent bonding to Hedgehog proteins, resulting in their ... With lower levels of cholesterol, hedgehog proteins would not undergo the necessary covalent modification and subsequent ... Their involvement in regulation stems mostly from their association with proteins; upon binding substrates, some proteins have ...
*  Craniosynostosis
that constraint inside the womb is associated with decreased expression of Indian Hedgehog protein and noggin. These last two ... Jacob S, Wu C, Freeman TA, Koyama E, Kirschner RE (February 2007). "Expression of Indian Hedgehog, BMP-4 and Noggin in ...
*  DHH
Deaf and Hard of Hearing DHH (hedgehog), a human gene that encodes the Desert hedgehog protein. DHH phosphatase family. ...
*  CDON
... protein was shown to bind to all three mammalian isoforms of hedgehog proteins: Sonic Hh, Indian Hh, and Desert Hh. CDON ... Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ (August 2010). "All mammalian Hedgehog proteins interact with cell ... encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors". American ... Cell adhesion molecule-related/down-regulated by oncogenes is a protein that in humans is encoded by the CDON gene. CDON and ...
*  Development of the endocrine system
... patterning and the expression of transcription factors is influenced by the gradients of BMP2 and sonic hedgehog protein (SHH ... This protein is responsible for the development of the initial invagination of the Rathke's pouch. Other essential proteins ... An assortment of genes and proteins - such as WNT4, RSPO1, FOXL2, and various estrogen receptors - have been shown to prevent ... gradient of pituitary morphogenesis is dependent on neuroectodermal signals from the infundibular bone morphogenetic protein 4 ...
*  Cell signaling
For instance, the hedgehog protein activates different genes, depending on the amount of hedgehog protein present.[citation ... The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor ... This phosphorylation can generate a binding site for a different protein and thus induce protein-protein interaction. In Figure ... Bu Z, Callaway DJ (2011). "Proteins MOVE! Protein dynamics and long-range allostery in cell signaling". Advances in Protein ...
*  Simpson-Golabi-Behmel syndrome
... of the transcription factors allows regulation of cellular responses to growth factors such as members of the hedgehog protein ... The function of this gene is to produce a protein that acts as a cell surface receptor that binds to transcription factors. ... GPC3 can no longer negatively regulate Hedgehog signaling during development, therefore increasing cell proliferation and the ... and skeletal development may also go awry when GCP3 mutations inhibit regulations of responses to bone morphogenetic proteins, ...
*  Steroid
Nakiterpiosin-type steroids are active against the signaling pathway involving the smoothened and hedgehog proteins, a pathway ... Stromal cells have been shown to produce steroids in response to Sonic Hedgehog signaling produced by androgen-starved prostate ... "Paracrine Sonic Hedgehog Signaling Contributes Significantly to Acquired Steroidogenesis in the Prostate Tumor Microenvironment ... "Paracrine Sonic Hedgehog Signaling Contributes Significantly to Acquired Steroidogenesis in the Prostate Tumor Microenvironment ...
*  Intein
A protein distantly related to known inteins containing protein, but closely related to metazoan hedgehog proteins, has been ... Schwarzer D, Cole PA (2005). "Protein semisynthesis and expressed protein ligation: chasing a protein's tail". Curr Opin Chem ... This protein isolation can be done using continuous media flow, yielding high amounts of protein, making this process more ... An O-N or S-N shift produces a peptide bond and the functional, ligated protein. Inteins are very efficient at protein splicing ...
*  CRIM1
... by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as ... Cysteine-rich motor neuron 1 protein is a protein that in humans is encoded by the CRIM1 gene. Motor neurons are among the ... Protein Science. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161. Wilkinson L, Kolle G, Wen D, Piper M, ... Scott J, Little M (Sep 2003). "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell ...
*  Holoprosencephaly
Mutations in the gene encoding the Sonic Hedgehog protein, which is involved in the development of the central nervous system ( ... Rash, BG; Grove, EA (24 October 2007). "Patterning the dorsal telencephalon: a role for sonic hedgehog?". The Journal of ... "Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function". Nature. 383 (6599): 407-13. doi:10.1038/ ...
*  HHIP
Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene. This gene encodes a protein ... "Entrez Gene: HHIP hedgehog interacting protein". Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by ... a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins ... 2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in ...
*  Hedgehog signaling pathway
Bürglin, Thomas R. (2008). "Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral ... The steps leading to Ci protein proteolysis include phosphorylation of Ci protein by several protein kinases; PKA, GSK3β and ... Activation of the Hedgehog pathway leads to an increase in Snail protein expression and a decrease in E-cadherin and Tight ... The hedgehog protein appears to have evolved in two sections, the N-terminal domain (hedge) and the C-terminal domain (hog), ...
*  Hibernation
Lundberg, D. A.; Nelson, R. A.; Wahner, H. W.; Jones, J. D. (1976). "Protein metabolism in the black bear before and during ... Obligate hibernators include many species of ground squirrels, other rodents, mouse lemurs, the European hedgehog and other ... Hibernating bears are able to recycle their proteins and urine, allowing them both to stop urinating for months and to avoid ... Nelson, R. A. (1980). "Protein and fat metabolism in hibernating bears". FASEB J. 39 (12): 2955-2958. PMID 6998737. Baker, R. R ...