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*  Septic shock
"Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients". The Cochrane Database of ... Type I, cell surface-active toxins, disrupt cells without entering, and include superantigens and heat-stable enterotoxins. ... Septic shock refers specifically to distributive shock due to sepsis as a result of infection. Septic shock may be defined as ... The mortality rate from septic shock is approximately 25-50%. Septic shock is a subclass of distributive shock, a condition in ...
*  Heat shock protein
The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat ... referred hspb7 (cvHSP - cardiovascular Heat shock protein) as cardiac heat shock protein. Gata4 is an essential gene ... Several heat shock proteins function as intra-cellular chaperones for other proteins. They play an important role in protein- ... The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein. A ...
*  Heat shock protein 47
... , also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen. This protein ... of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat ... Autoantibodies to this protein have been found in patients with rheumatoid arthritis. Heat shock protein 47 has been shown to ... heat shock protein 47), member 1, (collagen binding protein 1)". Dafforn TR, Della M, Miller AD (December 2001). "The molecular ...
*  Heat shock protein 90kDa alpha (cytosolic), member A1
Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (Oct 2000). "Heat shock protein 90 mediates protein-protein ... Ciocca DR, Arrigo AP, Calderwood SK (Jan 2013). "Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor ... Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the ... upregulates the heat shock protein Hsp90alpha and enhances transcription of a reporter gene coupled to a single heat shock ...
*  Dnaj heat shock protein family (hsp40) member c12
... is a protein that in humans is encoded by the DNAJC12 gene. This gene encodes ... DnaJ heat shock protein family (Hsp40) member C12". Retrieved 2016-02-22. This article incorporates text from the United States ... Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants ... a member of a subclass of the HSP40/DnaJ protein family. ...
*  Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES)
The heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) is an RNA element that allows cap independent translation ... Page for Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) at Rfam. ... during conditions such as heat shock and stress. It has been shown that the 216 nucleotide long 5' UTR contains internal ...
*  Hsp20
The heat shock protein Hsp20 family, also known as small heat shock proteins (sHSPs), is a family of heat shock proteins. ... Recently, small heat shock proteins (sHSPs) were found in marine viruses (cyanophages). Hsp20, like all heat shock proteins, is ... to heat shock or other environmental stress by inducing the synthesis of proteins collectively known as heat-shock proteins ( ... "Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy". Cell ...
*  University of Miami Division of Surgical Neurooncology
"Heat Shock Protein Vaccine". "HSPCC-96 Vaccine". "Acoustic Neuromas". "Pituitary Tumors". "Skull Base Tumors". Kacl, GM (1999 ...
*  HSPB6
Heat shock protein beta-6 is a protein that in humans is encoded by the HSPB6 gene. HSPB6 also known as hsp20 is a 17-kDa ... "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6". Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano ... Chernik IS, Seit-Nebi AS, Marston SB, Gusev NB (2007). "Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma". ... Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". ...
*  Hsp104
... is a heat-shock protein. It is known to reverse toxicity of mutant α-synuclein, TDP-43, FUS, and TAF15 in yeast cells. " ... "Yeast Chaperone Melts Protein Aggregates". Alzforum.org. Retrieved September 12, 2016. ...
*  Hsp90
However, when cells are heated, the fraction of heat shock proteins increases to 4-6% of cellular proteins. Heat shock protein ... heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat ... Heat shock proteins, as a class, are among the most highly expressed cellular proteins across all species. As their name ... heat shock proteins protect cells when stressed by elevated temperatures. They account for 1-2% of total protein in unstressed ...
*  Leishmania
About 65% of protein-coding genes currently lack functional assignment. Leishmania species produce several different heat shock ... revealing more than 8300 protein-coding and 900 RNA genes. Almost 40% of protein-coding genes fall into 662 families containing ... These proteins play a key role in meiosis. Thus, meiotic events provide the adaptive advantage of efficient recombinational ... L. infantum produces proteins BRCA1 and RAD51 that interact with each other to promote homologous recombinational repair. ...
*  Garo H. Armen
"Heat Shock Proteins: How They Work (animated demonstration)". Archived from the original on January 9, 2008. Retrieved 2008-12- ... The treatment involved removing a patient's tumor cells, isolating and fortifying the cellular proteins that normally alert the ... immune system to disease, and re-injecting the proteins into the patient. In 1994, Armen co-founded Antigenics with Srivastava ...
*  HSP90AB1
... heat shock protein 90 kDa alpha, class A, member 1) HSP90AB1 (heat shock protein 90 kDa alpha, class B, member 1) (this protein ... "Entrez Gene: HSP90AB1 Heat shock protein 90kDa alpha (cytosolic), class B member 1". Lindquist S (June 1986). "The heat-shock ... Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene. HSP90AB1 is a ... Craig EA, Gambill BD, Nelson RJ (Jun 1993). "Heat shock proteins: molecular chaperones of protein biogenesis". Microbiological ...
*  Hsp90 inhibitor
Al Shaer L, Walsby E, Gilkes A, Tonks A, Walsh V, Mills K, Burnett A, Rowntree C (May 2008). "Heat shock protein 90 inhibition ... An Hsp90 inhibitor is a substance that inhibits that activity of the Hsp90 heat shock protein. Since Hsp90 stabilizes a variety ... Luminespib Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM (August 1994). "Inhibition of heat shock protein HSP90- ... Among heat shock proteins the focus on HSP90 has increased due to its involvement in several cellular phenomenon and more ...
*  HSPA6
... heat shock 70kDa protein 6 (HSP70B')". Leung TK, Rajendran MY, Monfries C, et al. (1990). "The human heat-shock protein ... Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene. GRCh38: Ensembl release 89: ... 2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex". ... "Human heat shock factor 1 is predominantly a nuclear protein before and after heat stress". J. Cell Sci. 112. ( Pt 16): 2765-74 ...
*  HSPA1B
Heat shock 70kDa protein 1B, also known as HSPA1B, is a human gene. This intronless gene encodes a 70kDa heat shock protein ... which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes ... "Entrez Gene: HSPA1A heat shock 70kDa protein 1B". Ito Y, Ando A, Ando H, Ando J, Saijoh Y, Inoko H, Fujimoto H (August 1998). " ... Heat shock proteins Hsp70 Milner CM, Campbell RD (1990). "Structure and expression of the three MHC-linked HSP70 genes". ...
*  Lloyd J. Old
... and identified the tumor immunogenicity of heat shock proteins. Old is the author or co-author of more than 800 research ... of the p53 protein, the gene for which is mutated in approximately 50 percent of cancers (1979). Conducting of the most ...
*  Evolution of molecular chaperones
Elevated expression of heat shock proteins is not correlated with chronic environmental stress and is thought to be due to the ... Heat shock proteins (HSPs) are a diverse class of molecular chaperones that assist in folding under stress. While originally ... Feder, ME; Hofmann, GE (1999). "Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological ... "The evolutionary and ecological role of heat shock proteins". Ecology Letters. 6 (11): 1025-1037. doi:10.1046/j.1461-0248.2003. ...
*  Arimoclomol
June 2002). "Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats". Free Radic. Biol. Med ... Brown IR (October 2007). "Heat shock proteins and protection of the nervous system". Ann. N. Y. Acad. Sci. 1113: 147-58. doi: ... Kalmar B, Burnstock G, Vrbová G, Urbanics R, Csermely P, Greensmith L (July 2002). "Upregulation of heat shock proteins rescues ... a coinducer of heat shock proteins, delays disease progression in ALS mice". Nat. Med. 10 (4): 402-5. doi:10.1038/nm1021. PMID ...
*  Ecophysiology
As temperatures fall, production of antifreeze proteins and dehydrins increases. As temperatures rise, production of heat shock ... Heat transfer to the epidermis The rate of evaporation The rate of heat production The hypothalamus plays an important role in ... Heat stress is physiologically combated in four ways: radiation, conduction, convection, and evaporation. Cold stress is ... Long, S. P.; Ort, D. R. (2010). "More than taking the heat: Crops and global change". Current Opinion in Plant Biology. 13 (3 ...
*  Large tumor antigen
The J domain interacts with Hsc70 heat-shock proteins. In many polyomavirus LTags, N-terminal to the J domain is a sequence ... The ATPase domain also contains regions responsible for protein-protein interactions with host cell proteins, most notably ... without affecting these protein-protein interaction sites. LTag is a large protein whose domains can be detected and annotated ... Polyomavirus LTag proteins contain four well-conserved, globular protein domains: from N- to C-terminus, these are the J domain ...
*  Androgen insensitivity syndrome
Before it binds with an androgen, the androgen receptor is bound to heat shock proteins. These heat shock proteins are released ... "Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, ... These misfolded AR proteins form aggregates in the cell cytoplasm and nucleus. Over the course of 30 to 50 years, these ... The human androgen receptor (AR) is a protein encoded by a gene located on the proximal long arm of the X chromosome (locus ...
*  Regeneration (biology)
... heat-shock proteins and regeneration in echinoderms". Journal of Experimental Biology. 204 (5): 843-848. ISSN 0022-0949. PMID ... Neural cells, for example, express growth-associated proteins, such as GAP-43, tubulin, actin, an array of novel neuropeptides ... as the venom volume is replaced before the active proteins are all replenished. Many annelids are capable of regeneration. For ...
*  Paeoniflorin
Yan, D.; Saito, K.; Ohmi, Y.; Fujie, N.; Ohtsuka, K. (2004). "Paeoniflorin, a novel heat shock protein-inducing compound". Cell ...
*  Caspase-activated DNase
Liu QL, Kishi H, Ohtsuka K, Muraguchi A (September 2003). "Heat shock protein 70 binds caspase-activated DNase and enhances its ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ... The protein caspase DNase is an endonuclease involved in the cell apoptotic process that facilitates the DNA breakup. Cell ... Later, it was found out that the way how this protein induces the DNA breakup is explained by its forms CAD and ICAD, which ...
*  Hsp27
Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the ... "Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones". Advances in Protein ... "Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins". Biochemistry. ... Qi Z, Shen L, Zhou H, Jiang Y, Lan L, Luo L, Yin Z (July 2014). "Phosphorylation of heat shock protein 27 antagonizes TNF-α ...