Mutations in the ATPase domain render the protein inactive; however, the method of controlling this ADP-ATP exchange is unclear ... The ATPase domain belongs to the AAA+ family of ATPases; this family is known for its ability to link to other ATPase domains ... creating an ATPase domain that is part of the AAA+ family of ATPases. There is a super helical domain (HD2) present in the ... It has been determined through mass spectrometry that in the autoinhibited, or "locked" state, ADP is bound to the ATPase ...
"Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange". Biochemistry. 31 (39): 9406-12 ... Non-chaperonin molecular chaperone ATPase (EC 3.6.4.10, molecular chaperone Hsc70 ATPase) is an enzyme with systematic name ATP ... Li X, Su RT, Hsu HT, Sze H (January 1998). "The molecular chaperone calnexin associates with the vacuolar H(+)-ATPase from oat ... Blond-Elguindi S, Fourie AM, Sambrook JF, Gething MJ (June 1993). "Peptide-dependent stimulation of the ATPase activity of the ...
Hendricks JK, Mobley HL (1997). "Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity ... In enzymology, a nickel-transporting ATPase (EC 3.6.3.24) is an enzyme that catalyzes the chemical reaction ATP + H2O + Ni2+out ...
"Na+/Ca2+ exchange and Na+/K+-ATPase in the heart". The Journal of Physiology. 593 (6): 1361-1382. doi:10.1113/jphysiol. ... An example of active transport of ions is the Na+-K+-ATPase (NKA). NKA is powered by the hydrolysis of ATP into ADP and an ... Aperia, Anita; Akkuratov, Evgeny E.; Fontana, Jacopo Maria; Brismar, Hjalmar (2016-04-01). "Na+-K+-ATPase, a new class of ... potential difference Action potential Cell potential Electrodiffusion Galvanic cell Electrochemical cell Proton exchange ...
The gastric hydrogen potassium ATPase or H+/K+ ATPase is the proton pump of the stomach. It exchanges potassium from the ... H+/K+ ATPase is a P2-type ATPase, a member of the eukaryotic class of P-type ATPases. Like the Ca2+ and the Na+/K+ ATPases, the ... The H+/K+ ATPase is a heterodimeric protein, the product of 2 genes. The gene ATP4A encodes the H+/K+ ATPase α subunit, and is ... The H+/K+ ATPase β subunit stabilizes the H+/K+ ATPase α subunit and is required for function of the enzyme. The β subunit ...
... is a nucleotide exchange factor that regulates the ATPase activity of BiP". The Journal of Biological Chemistry. 277 (49): ... Nucleotide exchange factor SIL1 is a protein that in humans is encoded by the SIL1 gene. This gene encodes a resident ... Ichhaporia VP, Sanford T, Howes J, Marion TN, Hendershot LM (February 2015). "Sil1, a nucleotide exchange factor for BiP, is ... This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene ...
DeMarco SJ, Chicka MC, Strehler EE (2002). "Plasma membrane Ca2+ ATPase isoform 2b interacts preferentially with Na+/H+ ... exchange to Na+/H+ exchange". Biochemistry. 41 (41): 12336-42. doi:10.1021/bi0259103. PMID 12369822. Overview of all the ... Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY ... Sodium-hydrogen exchange regulatory cofactor 2 has been shown to interact with SGK, Actinin alpha 4, Parathyroid hormone ...
These proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins (Hsp70). ... DNAJC5 is a guanine nucleotide exchange factor for Gα proteins. CSPα plays a role in membrane trafficking and protein folding, ...
The sodium-calcium exchanger passively removes one calcium ion from the cell in exchange for three sodium ions. As a passive ... The calcium ATPase removes calcium from the cell actively, using energy derived from adenosine triphosphate (ATP). In order to ... 2021). "Beat-by-Beat Cardiomyocyte T-Tubule Deformation Drives Tubular Content Exchange". Circ. Res. 128 (2): 203-215. doi: ... calcium ATPases and Beta adrenoceptors. T-tubules are found in both atrial and ventricular cardiac muscle cells (cardiomyocytes ...
To facilitate phosphorus exchange an array of genes are upregulated; Pi transporter genes such as MtPT4 and StPT3 are up ... regulated in orchids plants along with H+ ATPase transporters. Fungal partners upregulated Pi transporter genes as well as ... This highly convoluted and transporter rich membrane expertly performs the duties of nutrient exchange between the plant and ... Typically in arbuscular mycorrhizal interactions the plants will unidirectionally supply the fungi with carbon in exchange for ...
Hydrogen ions are pumped out of the cell into the canaliculi in exchange for potassium ions, via the H+/K+-ATPase. These pumps ... The enzyme hydrogen potassium ATPase (H+/K+ ATPase) is unique to the parietal cells and transports the H+ against a ... The bicarbonate ion (HCO3−) is exchanged for a chloride ion (Cl−) on the basal side of the cell and the bicarbonate diffuses ... Protein kinase A phosphorylates proteins involved in the transport of H+/K+-ATPase from the cytoplasm to the cell membrane. ...
"Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK". Science. ... These eukaryotic nucleotide exchange factors are all heat-shock inducible meaning that they serve a similar function as GrpE, ... GrpE is a nucleotide exchange factor that causes the release of bound ADP from DnaK, a heat shock protein important in de novo ... Other nucleotide exchange factors that interact with heat-shock proteins in eukaryotes include, Sse1p, Sil1p, Hip, and HspBP1. ...
Three Na+ ions are extruded from the cell in exchange for two K+ ions entering through the intramembrane enzyme Na+/K+-ATPase; ... of glucose with sodium from the lumen does not directly require ATP hydrolysis but depends upon the action of the ATPase, this ...
The formation of a ternary complex may result in cis-interaction of the J-domain of DnaJ with the ATPase domain of DnaK. An ... Dimeric GrpE is the co-chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000- ... Besides stimulating the ATPase activity of DnaK through its J-domain, DnaJ also associates with unfolded polypeptide chains and ... DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the ...
An ATPase removes protons in exchange for ATP from the vacuole, allowing the formation of carbon dioxide, a mechanism linking ... V- and P-type Ca2+-stimulated ATPases in a calcifying strain of Pleurochrysis sp. (Haptophyceae). Journal of Phycology 34(1):79 ... Effects of nitrogen and phosphorus availability on the expression of the coccolith-vesicle V-ATPase (subunit c) of ... Localization of Ca2+-stimulated ATPase in the coccolith-producing compartment of cells of Pleurochrysis sp. (Prymnesiophyceae ...
The Na+/K+-ATPase is a P-type pump that extrudes 3Na+ ions in exchange for 2K+ ions for each hydrolytic cleavage of ATP. This ... Temperature also modulates the activity of the Na+/K+-ATPase. ...
The depolarization triggers a reverse sodium/calcium exchange, which will cause calcium-mediated axon degeneration. The liver ... Glycidamide inhibits the sodium/potassium ATPase protein present in the plasma membrane of nerve cells. Intracellular sodium ...
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H+/K+ ATPase) and inhibit gastric acid secretion. ... Hydrolysis of one ATP molecule is used to catalyse the electroneutral exchange of two luminal potassium ions for two ... That is, they block the action of the H+/K+ ATPase by binding to or near the site of the K+ channel. Since the binding is ... All PPIs react with cysteine 813 in the loop between TM5 and TM6 on the H+/K+ ATPase, fixing the enzyme in the E2 configuration ...
kAE1 exchanges bicarbonate for chloride on the basolateral surface, essentially returning bicarbonate to the blood. Here it ... The hydrogen ions are pumped into the collecting duct tubule by vacuolar H+ ATPase, the apical proton pump, which thus excretes ... The bicarbonate is then excreted (in exchange for a chloride) from the cell by band 3. Physical linkage of the plasma membrane ... Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of ...
... use may be found in many cellular fundamental metabolic activities such as acidosis and alkalosis and respiratory gas exchange ... Together with V-ATPases and A-ATPases, F-ATPases belong to superfamily of related rotary ATPases. F-ATPase consists of two ... F-ATPase, also known as F-Type ATPase, is an ATPase/synthase found in bacterial plasma membranes, in mitochondrial inner ... They form a distinct group that is further apart from usual F-ATPases than A-ATPases are from V-ATPases. Lodish H (2008). ...
... yeast Sse1p has little ATPase activity but is a chaperone on its own as well as a nucleotide exchange factor for Hsp70, while ... The exchange of ATP and ADP leads to conformational changes in the other two domains. Substrate binding domain - is composed of ... Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many ... However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow ...
ATPase." Adenosine-tetraphosphatase Adenosine methylene triphosphate ATPases ATP test Creatine Cyclic adenosine monophosphate ( ... The inner membrane contains an antiporter, the ADP/ATP translocase, which is an integral membrane protein used to exchange ... ISBN 978-0-471-19350-0. Abrahams, J.; Leslie, A.; Lutter, R.; Walker, J. (1994). "Structure at 2.8 Å resolution of F1-ATPase ... as it results in the movement of about 4 negative charges out across the mitochondrial membrane in exchange for 3 negative ...
Exchange of ADP for ATP results in the opening of the SBDα lid and subsequent release of the substrate, which then is free to ... ATPase mutants of BiP were found to cause a block in translocation of a number of proteins (invertase, carboxypeptidase Y, a- ... The activity of BiP is regulated by its allosteric ATPase cycle: when ATP is bound to the NBD, the SBDα lid is open, which ... ATPase mutants (including allosteric mutants) of BiP have been shown to significantly slow down the degradation rate of CPY*. ...
VAChT is able to transport ACh into vesicles by relying on an exchange between protons (H+) that were previously pumped into ... Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. PET imaging of the VAChT may provide ...
This is because the calcium-sodium exchange pump's activity decreases. The calcium-sodium exchange pump exchanges Ca2+ and Na+ ... Na+/K+-ATPase is an ion transport system of sodium and potassium ions and requires energy. It is often used in many types of ... Cerberin is able to bind to the extracellular part of the Na+/K+-ATPase pump and can block the dephosphorylation step. Due to ... Cerberin, as a cardiac glycoside, is seen as binding to and inhibiting the cellular Na+/K+ -ATPase, because it binds to the ...
ATP3 H+/K+ exchanging: ATP4A H+ transporting, mitochondrial: ATP5A1, ATP5B, ATP5C1, ATP5C2, ATP5D, ATP5E, ATP5F1, ATP5G1, ... The number of peripheral stalks is dependent on the type of ATPase: F-ATPases have one, A-ATPases have two, and V-ATPases have ... and A-ATPases contain rotary motors) and in the type of ions they transport. Rotary ATPases F-ATPases (F1FO-ATPases) in ... A-ATPases (A1AO-ATPases) are found in Archaea and some extremophilic bacteria. They are arranged like V-ATPases, but function ...
H+ ions are first extruded through the electron transport chain in respiring cells and to some extent through an ATPase in ... establishes a proton gradient that drives electrogenic antiporters-which drive intracellular Na+ out of the cell in exchange ... increase in charge causes the production of greater amounts of ATP by each translocated proton when driven through an ATPase. ...
... works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions ... transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell ... in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves ...
H+/K+-exchanging ATPase * EC 7.2.2.20: ABC-type Zn2+ transporter * EC 7.2.2.21: Cd2+-exporting ATPase * EC 7.2.2.22: P-type ... Na+/K+-exchanging ATPase * EC 7.2.2.14: P-type Mg2+ transporter * EC 7.2.2.15: P-type Ag+ transporter * EC 7.2.2.16: ABC-type ... mitochondrial protein-transporting ATPase * EC 7.4.2.4: chloroplast protein-transporting ATPase * EC 7.4.2.5: bacterial ABC- ... arsenite-transporting ATPase * * No Wikipedia article EC 7.4.2.1: ABC-type polar-amino-acid transporter * EC 7.4.2.2: ABC-type ...
... which is raised by ClC-5 in exchange for protons accumulated by the V-ATPase, may play a role in endocytosis independently from ... ClC-5 is located in early endosomes of PTCs where it co-localizes with the electrogenic vacuolar H+‐ATPase (V‐ATPase). ClC-5 in ... Scheel O, Zdebik AA, Lourdel S, Jentsch TJ (July 2005). "Voltage-dependent electrogenic chloride/proton exchange by endosomal ... Novarino G, Weinert S, Rickheit G, Jentsch TJ (June 2010). "Endosomal chloride-proton exchange rather than chloride conductance ...