RCC1 is the guanine nucleotide exchange factor for Ran GTPase. It localizes to the nucleus and catalyzes the activation of Ran ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small ... G proteins Guanine Nucleotide exchange factor Small GTPases Cherfils J, Zeghouf M (January 2013). "Regulation of small GTPases ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the ...

In molecular biology, the EF1 guanine nucleotide exchange domain is a protein domain found in the beta and delta chains of ... The beta and delta chains have exchange activity, which mainly resides in their homologous guanine nucleotide exchange domains ... The EF1 guanine nucleotide exchange domain is found in the beta (EF-1beta, also known as EF1B-alpha) and delta (EF-1delta, also ... "The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking ...

Zahniser, Nancy R.; Molinoff, Perry B. (1978-10-05). "Effect of guanine nucleotides on striatal dopamine receptors". Nature. ... and together they examined how the nucleotide guanine could influence the binding of dopamine receptor agonists H-apomorphine ... Their work revealed that the addition of guanine, such as in the molecule guanosine triphosphate, to dopamine binding sites ...

Nucleoside-diphosphate kinase Guanine nucleotide exchange factor Buday, L; Downward J (1993). "Epidermal growth factor ... "Epac is a Rap1 guanine- nucleotide-exchange factor directly activated by cyclic AMP" (PDF). Nature. 396 (6710): 474-477. ... NEFs are specific for the nucleotides they exchange (ADP or GDP, but not both) and are often specific to a single protein or ... Nucleotide exchange factors (NEFs) are proteins that stimulate the exchange (replacement) of nucleoside diphosphates for ...

An enzyme from Entamoeba histolytica selective for guanine nucleotides". Biochem. Biophys. Res. Commun. 58 (4): 1053-7. doi: ...

Cytosine and guanine nucleotides represent 75% of the sequence. Sequence analyses suggest that B virus and HSV types 1 and 2 ...

Haslam RJ, Williams KA, Davidson MM (1985). "Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotides". Mechanisms ... 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231-8. doi: ...

Guanine nucleotide-binding protein subunit alpha-15 is a protein that in humans is encoded by the GNA15 gene. G15α is a member ... GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-15; GNA15 at OMIM. Retrieved JULY 25, 2019. (Articles with short description, Short ...

Guanine nucleotide-binding protein subunit alpha-14 is a protein that in humans is encoded by the GNA14 gene. G14α is a member ... GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-14; GNA14 at OMIM. Retrieved JULY 25, 2019. (Articles with short description, Short ...

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in ... "Entrez Gene: guanine nucleotide binding protein". Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the ...

... binds guanine nucleotides but lacks ADP-ribosylation factor activity. ARL3 has been shown to interact with Protein unc-119 ... "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). ...

It consists of 4 nucleotides: guanine, thymine, cytosine, and adenine. The order of these nucleotides gives the "recipe" for ... Because of this, the changed nucleotide will lose its ability to pair with its original base pair and consequently changing the ... In this model, a nucleotide may spontaneously change its form through a process of quantum tunneling. ...

Childers SR, Snyder SH (1978). "Guanine nucleotides differentiate agonist and antagonist interactions with opiate receptors". ...

... which donates the ribose and phosphate necessary to create a nucleotide. Adenine and guanine are the two nucleotides classified ... The other purine nucleoside, guanosine, is cleaved to form guanine. Guanine is then deaminated via guanine deaminase to form ... ATP, a purine nucleotide, is an activator of pyrimidine synthesis, while CTP, a pyrimidine nucleotide, is an inhibitor of ... Nucleotides are the monomers which polymerize into nucleic acids. All nucleotides contain a sugar, a phosphate, and a ...

"Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)". 139313 GUANINE NUCLEOTIDE-BINDING ... Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with ... Jiang M, Pandey S, Tran VT, Fong HK (1991). "Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells ...

Structural aspects of guanine-nucleotide-binding sites". European Journal of Biochemistry. 155 (1): 167-71. doi:10.1111/j.1432- ...

139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015. "Entrez Gene: GNAQ guanine ... Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with ... Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain ... is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356-62. doi:10.1074/jbc. ...

Structural aspects of guanine-nucleotide-binding sites". European Journal of Biochemistry. 155 (1): 167-171. doi:10.1111/j.1432 ...

Guanine is one of the four nucleotides that makes up DNA. The methylated DNA is prone to breakage, and RNA and protein ... Procarbazine works, in part, as an alkylating agent and methylates guanine at the O-6 position (much like dacarbazine also does ...

It has also been proposed that quinolone antibiotics cause oxidation of guanine nucleotides in the bacterial nucleotide pool, ... Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics. Science. 2012 Apr 20;336(6079):315-9 ... The incorporation of oxidized guanine nucleotides into DNA could be bactericidal. Bacterial cytotoxicity could arise from ...

... is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling ... "Derangement of Ras-Guanine Nucleotide-Releasing Factor 1 (Ras-GRF1) and Extracellular Signal-Regulated Kinase (ERK) Dependent ...

Involvement of a guanine nucleotide binding (Go) protein". J. Immunol. 150 (4): 1524-34. doi:10.4049/jimmunol.150.4.1524. PMID ...

over 2200 citations) Vetter, Ingrid R.; Wittinghofer, Alfred (2001). "The Guanine Nucleotide-Binding Switch in Three Dimensions ... "Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation". Nature ... "Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP". Nature. 396 (6710): 474-477. Bibcode: ...

The process of exchanging the bound nucleotide is facilitated by guanine nucleotide exchange factors (GEFs) and GTPase ... The balance between GEF and GAP activity determines the guanine nucleotide status of Ras, thereby regulating Ras activity. In ... Vetter IR, Wittinghofer A (November 2001). "The guanine nucleotide-binding switch in three dimensions". Science. 294 (5545): ... which releases the nucleotide). Ras also binds a magnesium ion which helps to coordinate nucleotide binding. Ras proteins ...

This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and ... Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange ... "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)". Sang Lee J, Gyu ...

Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans. RALGDS has been shown ... Hofer F, Fields S, Schneider C, Martin GS (December 1994). "Activated Ras interacts with the Ral guanine nucleotide ... Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA (1993). "Characterization of a guanine nucleotide dissociation stimulator ... "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator". Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky ...

"A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Reports. 4 (5): 479-83. doi: ... even calling into question whether MTH1 truly does serve to remove oxidatively damaged nucleotides from a cell's nucleotide ... A single-nucleotide polymorphism that results in the production of an additional, longer isoform has been described. A mouse ... MutT enzymes in non-human organisms often have substrate specificity for certain types of oxidized nucleotides, such as that of ...

Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H (June 2011). "Cleavage of oxidized guanine nucleotide and ADP ... "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Reports. 4 (5): 479-83. doi: ...

"A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479-83. doi:10.1038/sj ... eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their ... McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol ...

the most common methylation site is onto a cystine preceding guanine nucleotides. This methylation is catalyzed by DNA ... DNA Methylation is the addition of a methyl group to the carbon-5 of nucleotides. ... heavy alcohol consumption can cause a decrease in folic acid availability which can decrease the availability of nucleotides ...

Northup, JK; Smigel, MD; Gilman, AG (1982). "The guanine nucleotide activating site of the regulatory component of adenylate ... A family of structurally homologous guanine nucleotide-binding proteins". The Journal of Biological Chemistry. 258 (11): 7059- ... Breckenridge, BM (1971). "Methods of assay of cyclic nucleotides". Annals of the New York Academy of Sciences. 185 (1): 10-17. ... Journal of Cyclic Nucleotide Research. 3 (4): 227-38. PMID 562358. Haga, T; Haga, K; Gilman, AG (1977). "Hydrodynamic ...

ECT2 is a Guanine nucleotide-exchange factor for RhoA. Cytokinesis is initiated when RhoA is activated by ECT2. RacGAP1 is also ...

Rho guanine nucleotide exchange factor (GEF) 35 is a protein in humans that is encoded by the ARHGEF35 gene. ENSG00000288422 ... "Entrez Gene: Rho guanine nucleotide exchange factor (GEF) 35". Retrieved 2013-02-17. v t e (Articles with short description, ...