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*  Guanine nucleotide exchange factor
RCC1 is the guanine nucleotide exchange factor for Ran GTPase. It localizes to the nucleus and catalyzes the activation of Ran ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small ... G proteins Guanine Nucleotide exchange factor Small GTPases Cherfils J, Zeghouf M (January 2013). "Regulation of small GTPases ... Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the ...
*  Ras-GRF1
... is a guanine nucleotide exchange factor. Its function is to release guanosine diphosphate, GDP, from the signaling ...
*  EEF1D
This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and ... "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)". Sang Lee J, Gyu ... "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica et Biophysica ... Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene. This gene encodes a subunit of the ...
*  Centralspindlin
ECT2 is a Guanine nucleotide-exchange factor for RhoA. Cytokinesis is initiated when RhoA is activated by ECT2. RacGAP1 is also ... "Human Ect2 Is an Exchange Factor for Rho Gtpases, Phosphorylated in G2/M Phases, and Involved in Cytokinesis", Journal of Cell ...
*  ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35 is a protein in humans that is encoded by the ARHGEF35 gene. "Entrez Gene: Rho ... guanine nucleotide exchange factor (GEF) 35". Retrieved 2013-02-17. ...
*  RAPGEF2
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. RAPGEF2 is a cyclic AMP ... Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to ... "Entrez Gene: RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2". Pham N, Cheglakov I, Koch CA, de Hoog CL, Moran MF, Rotin ... 2000). "PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2". J. Biol. Chem. 274 (53): 38125-30. doi: ...
*  TRIO (gene)
"The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The ... "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The ... "The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids". The Journal ... "Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell ...
*  RHOA
... conducted simultaneously via guanine nucleotide exchange factors and GTPase activating factor). RhoA is activated primarily by ... Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002). "XPLN, a guanine nucleotide exchange factor for ... "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". J. Biol ... "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. ...
*  ARHGEF5
Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5". Human ARHGEF5 genome location and ARHGEF5 gene details ... 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468-75 ... 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling ...
*  PREX2
... a new guanine-nucleotide exchange factor for Rac". FEBS Lett. 572 (1-3): 172-6. doi:10.1016/j.febslet.2004.06.096. PMID ... specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor ... Rosenfeldt H, Vázquez-Prado J, Gutkind JS (August 2004). "P-REX2, a novel PI-3-kinase sensitive Rac exchange factor". FEBS Lett ... Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 ...
*  ARHGEF4
Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4". "Dysmorphology data for Arhgef4". Wellcome Trust Sanger ...
*  RABGEF1
"Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple ... 1997). "A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and ... and it serves as a specific guanine nucleotide exchange factor for RAB5(RAB5A; MIM 179512) (Horiuchi et al., 1997).[supplied by ... Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene. RABGEF1 forms a complex with rabaptin- ...
*  ARHGEF1
Rho guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the ARHGEF1 gene. Rho GTPases play a ... "Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1". Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, ... "Identification of a novel guanine nucleotide exchange factor for the Rho GTPase". J Biol Chem. 271 (41): 25452-8. doi:10.1074/ ... "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports ...
*  SGEF
... of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF ... It functions as a guanine nucleotide exchange factor (GEF) for RhoG, a small G protein of the Rho family. SGEF was discovered ... "Entrez Gene: Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)". Qi H, Fournier A, Grenier J (May 2003 ... Samson et al 2013 "The Guanine-Nucleotide Exchange Factor SGEF Plays a Crucial Role in the Formation of Atherosclerosis" ...
*  ARHGEF10
Mohl M, Winkler S, Wieland T, Lutz S (Aug 2006). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor ... The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10. Rho GTPases play a fundamental role in ... "Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10". Human ARHGEF10 genome location and ARHGEF10 gene ... "Slowed Conduction and Thin Myelination of Peripheral Nerves Associated with Mutant Rho Guanine-Nucleotide Exchange Factor 10". ...
*  CENTG1
Dunphy JL, Ye K, Casanova JE (2007). "Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2". Traffic. 8 (6): ... "Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE". Nature. 415 (6871 ... phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton". J. Biol. Chem. ...
*  ARHGEF12
"Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor ... Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a ... Chikumi H, Fukuhara S, Gutkind JS (2002). "Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ- ... Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia- ...
*  RAPGEF5
Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene. Members of the RAS (see ... Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to ... Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor ... "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5". de Rooij J, Rehmann H, van Triest M, et al. (2000). " ...
*  ARHGEF7
Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene. Rho GTPase play a ... "Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7". Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, ... a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth ... density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 ...
*  RhoG
The first are known as Guanine nucleotide exchange factors (GEFs) and these facilitate the exchange of GDP for GTP so as to ... Bellanger JM, Lazaro JB, Diriong S, Fernandez A, Lamb N, Debant A (January 1998). "The two guanine nucleotide exchange factor ... Another GEF, known as SGEF (Src homology 3 domain-containing Guanine nucleotide Exchange Factor), is thought to be RhoG- ... a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis". Molecular Biology of the Cell. 15 (7): 3309-19. ...
*  RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) ... Epac2 functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation. Epac2 is ... Zhong N, Zucker RS (Jan 2005). "cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange ... RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4". Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, ...
*  ARHGEF11
"A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the ... Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. Rho GTPases play a ... Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors ... "Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11". Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). " ...
*  ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene. Rho GTPases play a fundamental role in ... Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and ... a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964-72. doi:10.1074/jbc. ... ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3". Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002 ...
*  ARHGEF9
Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene. ARHGEF9 belongs to a ... "Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9". Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly ... a guanine nucleotide exchange factor specific for Cdc42". J Biol Chem. 274 (47): 33587-93. doi:10.1074/jbc.274.47.33587. PMID ... "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering". J. Neurosci. 24 (25): 5816- ...
*  RAPGEF6
Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6". Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in ... 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. ... a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem. 276 (45): 42219-42225. doi: ...
*  Metabolism
The two nucleic acids, DNA and RNA, are polymers of nucleotides. Each nucleotide is composed of a phosphate attached to a ... Ions are also critical for nerve and muscle function, as action potentials in these tissues are produced by the exchange of ... These signals are usually in the form of soluble messengers such as hormones and growth factors and are detected by specific ... Purines are synthesized as nucleosides (bases attached to ribose). Both adenine and guanine are made from the precursor ...