*  GTP-binding protein regulators
... regulate G proteins in several different ways. Small GTPases act as molecular switches in ... between the GTP-bound and GDP-bound form, regulated by other regulatory proteins. The inactive form of GTPases (GDP-form) are ... GTP-Binding Protein Regulators at the US National Library of Medicine Medical Subject Headings (MeSH). ... They are active or 'ON' when it is bound to GTP and inactive or 'OFF' when bound to GDP. Activation and deactivation of small ...
*  Gtp binding protein 2
... is a protein that in humans is encoded by the GTPBP2 gene. GTP-binding proteins, or G proteins, ... constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by ... GTP binding protein 2". Retrieved 2017-01-18. This article incorporates text from the United States National Library of ... hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities. GRCh38: ...
*  Rap GTP-binding protein
... also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras ... rap GTP-Binding Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural ... The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ...
*  SAR1B
Takai Y, Sasaki T, Matozaki T (January 2001). "Small GTP-binding proteins". Physiological Reviews. 81 (1): 153-208. PMID ... which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles. Mutations in the SAR1B gene are ... SAR1 gene homolog B (S. cerevisiae), also known as SAR1B, is a protein which in humans is encoded by the SAR1B gene. SAR1B ... Schekman R, Orci L (March 1996). "Coat proteins and vesicle budding". Science. 271 (5255): 1526-33. doi:10.1126/science. ...
*  RHEB
... the protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is ... allowing RHEB to activate the protein. RHEB acts as an activator for mTORC1 in its GTP-bound form, therefore GTP-bound RHEB ... is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the ... The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region. Also present ...
*  RAB14
"Small GTP-binding proteins in human endothelial cells". Br J Haematol. 103 (1): 15-9. doi:10.1046/j.1365-2141.1998.00965.x. ... Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene. GRCh38: Ensembl release 89: ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
*  RAB2A
The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding ... Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in ...
*  GNAI1
"GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin ... Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. Click on ... "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1". Schiaffino MV, ... "Identification of GTP-binding proteins in human glomeruli". Nihon Jinzo Gakkai Shi. 36 (1): 9-12. PMID 8107314. Law SF, Zaina S ...
*  ARF4
Shin OH, Ross AH, Mihai I, Exton JH (1999). "Identification of arfophilin, a target protein for GTP-bound class II ADP- ... A functionally conserved family of GTP-binding proteins". J. Biol. Chem. 266 (4): 2606-14. PMID 1899243. Stearns T, Willingham ... These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera ... "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966-70. doi: ...
*  ARF1
A functionally conserved family of GTP-binding proteins". J. Biol. Chem. 266 (4): 2606-14. PMID 1899243. Stearns T, Willingham ... a novel role for a GTP-binding protein". Cell. 67 (2): 239-53. doi:10.1016/0092-8674(91)90176-Y. PMID 1680566. Kahn RA, Kern FG ... including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized ... The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of ...
*  RAB9A
de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J (1998). "Small GTP-binding proteins ... Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene. RAB9A has been shown to interact with ... Orzaez D, de Jong AJ, Woltering EJ (2001). "A tomato homologue of the human protein PIRIN is induced during programmed cell ... Soldati T, Riederer MA, Pfeffer SR (1993). "Rab GDI: a solubilizing and recycling factor for rab9 protein". Mol. Biol. Cell. 4 ...
*  GTPBP4
Nucleolar GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP4 gene. GTP-binding proteins are GTPases and ... a GTP-binding protein that interacts with the neurofibromatosis 2 protein". Mol. Cell. Biol. 27 (6): 2103-19. doi:10.1128/MCB. ... "Entrez Gene: GTPBP4 GTP binding protein 4". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ... The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, ...
*  GTPBP1
GTP-binding protein 1 is a protein that in humans is encoded by the GTPBP1 gene. This gene is upregulated by interferon-gamma ... "Entrez Gene: GTPBP1 GTP binding protein 1". Goretzki L, Mueller BM (1999). "Low-density-lipoprotein-receptor-related protein ( ... and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has ... interacts with a GTP-binding protein". Biochem. J. 336 (2): 381-6. PMC 1219882 . PMID 9820815. Dunham I, Shimizu N, Roe BA, et ...
*  RALB
Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein". Somat ... "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of ... Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination ... As a Ras GTPase, RalB functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. ...
*  Nucleotide exchange factor
Alfred Wittinghofer's seminar: GTP-BINDING PROTEINS AS MOLECULAR SWITCHES. ... of nucleoside diphosphates for nucleoside triphosphates bound to other proteins. Many cellular proteins cleave (hydrolyze) ... and are often specific to a single protein or class of proteins with which they interact. Nucleoside-diphosphate kinase Guanine ... These changes in turn affect the structural, enzymatic, or signalling properties of the protein. Nucleotide exchange factors ...
*  GNAO1
1994). "Identification of GTP-binding proteins in human glomeruli". Nippon Jinzo Gakkai shi. 36 (1): 9-12. PMID 8107314. ... 1991). "Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two ... Guanine nucleotide-binding protein G(o) subunit alpha is a protein that in humans is encoded by the GNAO1 gene. Mutations in ... Wu HC, Lin CT (1994). "Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis". Lab. Invest. 71 (2): ...
*  OLA1
"Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928-37. doi:10.1074 ... Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...
*  RAB6A
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to ... Goud B, Zahraoui A, Tavitian A, Saraste J (1990). "Small GTP-binding protein associated with Golgi cisternae". Nature. 345 ( ... Karniguian A, Zahraoui A, Tavitian A (1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin- ... Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. Its ...
*  DRG1
Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene. GRCh38: Ensembl ... Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins". Oncogene. ... Sazuka T, Tomooka Y, Ikawa Y, Noda M, Kumar S (Dec 1992). "DRG: a novel developmentally regulated GTP-binding protein". Biochem ... Li B, Trueb B (2000). "DRG represents a family of two closely related GTP-binding proteins". Biochim. Biophys. Acta. 1491 (1-3 ...
*  GTPBP3
"Entrez Gene: GTPBP3 GTP binding protein 3 (mitochondrial)". Li X, Guan MX (2002). "A human mitochondrial GTP binding protein ... The GTPBP3 gene encodes a GTP-binding protein that is evolutionarily conserved from bacteria to mammals and which is localized ... The GTPBP3 gene contains 10 exons, and encodes a ~44 kDa GTP-binding protein that is evolutionarily conserved from bacteria to ... Li X, Guan MX (Nov 2002). "A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic ...
*  RAB15
"Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889-901. doi:10.1006/jmbi.2001.5072. PMID ... Ras-related protein Rab-15 is a protein that in humans is encoded by the RAB15 gene. GRCh38: Ensembl release 89: ... Strick DJ, Elferink LA (2006). "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling ... Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant ...
*  RAB40A
"Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889-901. doi:10.1006/jmbi.2001.5072. PMID ... Ras-related protein Rab-40A is a protein that in humans is encoded by the RAB40A gene. GRCh38: Ensembl release 89: ... "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". J. Biol. Chem ... domain-containing proteins based on their Rab-binding activity". Genes Cells. 11 (9): 1023-37. doi:10.1111/j.1365-2443.2006. ...
*  DNM2
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over ... Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that ... a member of the large GTP-binding protein family". Gene. 163 (2): 301-6. doi:10.1016/0378-1119(95)00275-B. PMID 7590285. Klocke ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238-46. doi: ...
*  RAB21
Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889- ... Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur J Cell Biol. 79 (5): 308-16. ... Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene. GRCh38: Ensembl release 89: ... 2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287- ...
*  RAB25
Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the ... 1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Lab. ... "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889-901. doi:10.1006/jmbi.2001.5072. PMID ... Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene. It is thought to act as a promoter of ...
*  Molybdopterin
... xanthine dehydrogenase from bacteria has been found to contain tungsten-molydopterin and also non-protein-bound selenium (thus ... GTP), to (8S)‑3',8‐cyclo‑7,8‑dihydroguanosine 5'‑triphosphate (3',8‑cH2GTP), (ii) the formation of cyclic pyranopterin ... The monophosphate is adenylated (coupled to ADP) in a step that activates the cofactor toward binding Mo or W. These metals are ... In some enzymes, such as xanthine oxidase, the metal is bound to one molybdopterin, whereas, in other enzymes, e.g., DMSO ...