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*  Directed differentiation
A limited number of signaling factors such as growth factors or small molecules, controlling cell differentiation, is applied ... Cell differentiation involves a transition from a proliferative mode toward differentiation mode. Directed differentiation ... Proper differentiation of the cell type of interest is verified by analyzing cell type specific markers, gene expression ... Cell differentiation and tissue organogenesis involve a limited set of developmental signaling pathways. It is thus possible to ...
*  Bone morphogenetic protein 3
The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone ... "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and ... BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured ... Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (October 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign ...
*  Folliculogenesis
van den Hurk R, Zhao J (2005). "Formation of mammalian oocytes and their growth, differentiation and maturation within ovarian ... is mediated by the counterbalance of various stimulatory and inhibitory hormones and locally produced growth factors. During ... At this point, the majority of the group of follicles that started growth have died. This process of follicle death is known as ... Follicles that have fewer FSH-receptors will not be able to develop further; they will show retardation of their growth rate ...
*  Ovarian follicle
... growth factors and three-dimensional extracellular matrix support. Molecular methods and immunoassay can evaluate stage of ... maturation and guide adequate differentiation. Animal studies have generally showed correct imprinted DNA methylation ... For in vitro culture of follicles, there are various techniques to optimize the growth of follicles, including the use of ... ISBN 978-0-321-61655-5 "What Is an Ovarian Follicle?". wiseGEEK.org. wiseGEEK. Retrieved 24 May 2015. Luijkx, Tim. "Ovarian ...
*  Growth differentiation factor
Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily ... Andersson O, Reissmann E, Ibáñez C (2006). "Growth differentiation factor 11 signals through the transforming growth factor- ... "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic ... "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following ...
*  Bone morphogenetic protein 5
You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the ... The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally ... This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta ... "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". ...
*  GDF5
Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. The protein encoded by this gene is ... Growth differentiation factor 5 (GDF5) is a protein belonging to the transforming growth factor beta superfamily that is ... "Entrez Gene: GDF5 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1)". O'Keeffe G, Dockery P, Sullivan ... Sullivan A, O'Keeffe G (2005). "The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain ...
*  Ovarian follicle activation
... growth differentiation factor 9 (GDF9) and bone morphogenic protein 15 (BMP15). Follicular activation rate is increased in ... nerve growth factor (NGF) and its tyrosine receptor kinase (NTRK1), neurotrophin 4 (NT4), brain-derived neurotrophic factor ( ... AMH (Anti-mullerian Hormone) is a member of the transforming growth factor beta (TGF-b), that has a very important role in ... Additional ligands have a role in facilitating primordial follicle activation such as transforming growth factor-beta (TGF-B), ...
*  FGF9
A mutation in Noggin (NOG) and the Growth Differentiation Factor 5 (GDF5) are the other two causes of SYNS. The S99N mutation ... Tsai SJ, Wu MH, Chen HM, Chuang PC, Wing LY (July 2002). "Fibroblast growth factor-9 is an endometrial stromal growth factor". ... "Entrez Gene: FGF9 fibroblast growth factor 9 (glia-activating factor)". Sánchez L, Chaouiya C (May 2016). "Primary sex ... tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured ...
*  Growth differentiation factor-9
Growth differentiation factor 9 (GDF9) is an oocyte derived growth factor in the transforming growth factor ß (TGF-ß) ... Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 ... pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ... Growth Differentiation Factor-9 Promotes the Growth, Development, and Survival of Human Ovarian Follicles in Organ Culture. The ...
*  ACVR2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ... "Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11". Nat. Genet. 22 (3): 260 ... "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone". J. Biol. Chem. 276 (22): 19495-502. doi: ...
*  BMPR1A
You L, Kruse FE, Pohl J, Völcker HE (1999). "Bone morphogenetic proteins and growth and differentiation factors in the human ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ... Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation. Signals tranduced by ... BMPR1A has also been designated as CD292 (cluster of differentiation 292). The bone morphogenetic protein (BMP) receptors are a ...
*  Bone morphogenetic protein 4
The superfamily includes large families of growth and differentiation factors. BMP4 is highly conserved evolutionarily. BMP4 is ... of hair is through restricting growth factor expression in the hair matrix and antagonism between growth and differentiation ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ... BMP4, a paracrine growth factor, has been found in rat ovaries. BMP4, in conjunction with BMP7, regulate early ovarian follicle ...
*  ACVR2A
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ... Lux A, Attisano L, Marchuk DA (1999). "Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the ... D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM (1999). "Mutational analysis of activin/transforming growth factor-beta ...
*  Nerve guidance conduit
BPE contains the cytokines GDNF, basic fibroblast growth factor and platelet-derived growth factor, which cause differentiation ... The neurotrophic factors used were epidermal growth factor (EGF), fibroblast growth factor-2 (FGF-2), nerve growth factor (NGF ... Many factors promote the growth of MSCs including: platelet-derived growth factor, epidermal growth factor β, and insulin-like ... Neurotrophic factors such as NGF and growth differentiation factor 5 (GDF-5), however, are well established as promoters of ...
*  North Sichuan Medical University
Feng G, Wan Y, Balian G, Laurencin CT, Li X (2008). "Adenovirus-mediated expression of growth and differentiation factor-5 ... Growth Factors. 26 (3): 132-42. doi:10.1080/08977190802105917. PMC 3034080 . PMID 18569021. Peng B, Wang YP, Shang Y, Guo Y, ... 18 (5): 457-9. doi:10.1177/0961203308098188. PMID 19318401. Zhang XM, Mitchell DG, Byun JH, Verma SK, Bergin D, Witkiewicz A ( ... In recent years, the college has undertaken 8 national research projects, 5 projects from the Ministry of Education, Ministry ...
*  Midkine
1992). "Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor". J. Biochem. 111 (5 ... 1996). "Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway ... 2002). "Midkine, a heparin-binding growth factor, promotes growth and glycosaminoglycan synthesis of endothelial cells through ... Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK ...
*  GDF6
Growth differentiation factor 6 (GDF6) is a regulatory protein associated with growth and differentiation of developing embryos ... Growth differentiation factor 6 (GDF6) is a protein that in humans is encoded by the GDF6 gene. GDF6 belongs to the ... 1997). "Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF- ... 2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ...
*  GDF7
Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene. GDF7 belongs to the ... 1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, ... 2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ... transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is ...
*  GDF1
Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene. GDF1 belongs to the ... "Human PubMed Reference:". "Mouse PubMed Reference:". Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the ... Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". ... 2007). "Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in ...
*  GDF11
"Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior- ... "Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy". Cell. 153 (4): 828-39 ... Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... Liu JP (Aug 2006). "The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing ...
*  Ae binding protein 1
... enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways ... The protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation ... 289 (5): 2526-36. doi:10.1074/jbc.M113.502617. PMC 3908388 . PMID 24344132. Lyons PJ, Muise AM, Ro HS (2005). "MAPK modulates ... 343 (2): 341-5. doi:10.1042/0264-6021:3430341. PMC 1220559 . PMID 10510298. Feldkamp ML, Bowles NE, Botto LD (2012). "AEBP1 ...
*  PURA
"Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". Journal of Neurovirology. 8 ... Cell Growth & Differentiation. 9 (8): 651-65. PMID 9716182. Gallia GL, Safak M, Khalili K (December 1998). "Interaction of the ... Following the identification of a Pur factor, which specifically bound a purine-rich sequence in the control region of the c- ... Bergemann AD, Johnson EM (March 1992). "The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene ...
*  Donald E. Ingber
Ingber, Donald (July 1, 1989). "Mechanochemical Switching between Growth and Differentiation during Fibroblast Growth Factor- ... The major focus is on angiogenesis-the growth of blood capillaries-a process that is critical for the growth of cancer and many ... Ingber's group extended this technology to develop a human gut-on-a-chip that undergoes peristalsis and supports growth of a ... "On Growth and Form" at the Textile Museum of Canada in Toronto. Ingber lives with his wife in Boston and in Chilmark, ...
*  FRS2
"Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation". Mol ... "Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling". FASEB J. ... of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ...
*  MAPK8IP3
2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". ... binding protein that functions as a Scaffold factor in the JNK signaling pathway". Mol Cell Biol. 19 (11): 7539-48. doi:10.1128 ... 32 (5): 787-800. doi:10.1016/S0896-6273(01)00532-3. PMID 11738026. Matsuura H, Nishitoh H, Takeda K, et al. (2002). " ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Brandenberger R, Wei H, Zhang S, et al. ( ...
*  CEBPD
Choy L, Derynck R (Mar 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with ... "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): ... Xia C, Cheshire JK, Patel H, Woo P (Dec 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the ... The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA ...