The phosphorylated receptor binds to an adaptor protein (GRB2), which couples the signal to further downstream signaling ... The MAPK protein is an enzyme, a protein kinase that can attach phosphate to target proteins such as the transcription factor ... This phosphorylation can generate a binding site for a different protein and thus induce protein-protein interaction. In this ... The GPCR can then activate an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α ...
SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene. SH2B1 has been shown to interact with: Grb2, ... Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a ... Kong M, Wang CS, Donoghue DJ (Apr 2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A ... Kotani K, Wilden P, Pillay TS (1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the ...
Grb2, MAPK8, TRAF2, UBE2I. TAB1, TNIP1, TNIP2. Signal transducing adaptor molecule, Transforming protein RhoA, RAC1, CDC42, ... and scaffold protein regions that mediate protein-protein interactions. MAP3K1 is highly conserved in Euteleostomi. The ... Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. The ... MAP3K1 contains a protein kinase domain, PHD finger (which has a RING finger domain-like structure) that serves as an E3 ...
SHC dephosphorylation inhibits recruitment of the GRB2 adapter to activated MET. There is evidence of correlation between ... Furge KA, Zhang YW, Vande Woude GF (November 2000). "Met receptor tyrosine kinase: enhanced signaling through adapter proteins ... The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to ... PTEN (phosphatase and tensin homolog) is a tumor suppressor gene encoding a protein PTEN, which possesses lipid and protein ...
... protein interactions of Grb2 and Crk family adaptors". Current Pharmaceutical Design. 12 (5): 529-48. doi:10.2174/ ... linear motifs or minimotifs are short stretches of protein sequence that mediate protein-protein interaction. The first ... In addition, peptides targeting the Grb2 and Crk SH2/ SH3 adaptor domains are also under investigation. There are at present no ... Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories ...
LAT associates with another scaffolding protein Slp-76 via the Grap2 adaptor protein, which provides additional binding sites. ... Molecules that bind the LAT/Slp76 complex include: Phospholipase Cγ1 (PLCγ1), SOS via a Grb2 adaptor, Itk, Vav, Nck1 and Fyb. ... In the plasma membrane the TCR receptor chains α and β associate with six additional adaptor proteins to form an octameric ... The cytoplasmic tail of the TCR is very short, hence the CD3 adaptor proteins containing the signalling motifs needed for ...
Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ...
The BCR protein has been shown to interact with: Abl gene, CD117, CRKL FES, Grb2, GRB10, HCK, MLLT4, PXN, PIK3CG, PTPN6, PTPRT( ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ... The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is ... "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and ...
The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ... "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ...
The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role ... A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of ... STAM-binding protein is a protein that in humans is encoded by the STAMBP gene. Cytokine-mediated signal transduction in the ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene. The protein encoded by this gene is expressed ... Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction ... "Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin ... Iseki M, Takaki S, Takatsu K (2000). "Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins". ...
Morris SM, Tallquist MD, Rock CO, Cooper JA (2002). "Dual roles for the Dab2 adaptor protein in embryonic development and ... Xu XX, Yi T, Tang B, Lambeth JD (1998). "Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2". Oncogene. 16 (12): 1561-9 ... Oleinikov AV, Zhao J, Makker SP (May 2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor ... Oleinikov AV, Zhao J, Makker SP (2000). "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/ ...
"Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature ... The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney ... Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene. Members of this family function as chloride ... He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ...
"Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library ... LY9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene. LY9 has also recently been designated ...
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... 1997). "The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling". J. Biol. Chem. 272 (2 ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... "Guanosine triphosphatase-activating protein-associated protein, but not src-associated protein p68 in mitosis, is a part of ...
... protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochem. ... FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine ... protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochem. ... "Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase ...
"Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". The Journal of Biological Chemistry. 271 (51): 33141-7 ... dynein cargo adaptors, and microtubules. It is involved in a diverse array of cellular functions, including ER-to-Golgi ... "Identification of a novel 135-kDa Grb2-binding protein in osteoclasts". The Journal of Biological Chemistry. 271 (51): 33141-7 ... Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene. This gene encodes the largest subunit of dynactin ...
2001). "HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells". ... ACK1 or TNK2 has been shown to interact with AKT, Androgen receptor or AR, a tumor suppressor WWOX, FYN and Grb2. ACK1 ... The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly ... 1999). "Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK". Nature. 399 (6734): 384-8. Bibcode: ...
An important adaptor protein activated by the Syk phosphorylation step is the linker for activation of T cells (LAT). LAT can ... The tyrosine kinase FYN phosphorylates Grb2-associated-binding protein 2 (Gab2), which binds to phosphoinositide 3-kinase, ... Complement proteins can activate membrane receptors on mast cells to exert various functions as well. Mast cells express a high ... This leads to signal transduction to a G protein and activation of the mast cell. Mast cell activation induces the release of ...
Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... KIT has been shown to interact with: APS, BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ ... Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). "Adaptor protein Lnk associates with Tyr(568) in c-Kit ... Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). "Role for the adaptor protein Grb10 in the activation of Akt ...
SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the ... Motto DG, Musci MA, Ross SE, Koretzky GA (June 1996). "Tyrosine phosphorylation of Grb2-associated proteins correlates with ... SH2B adapter protein 3 is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. It is ubiquitously expressed ... "SH2B3 - SH2B adapter protein 3 - Homo sapiens (Human) - SH2B3 gene & protein". www.uniprot.org. Retrieved 2016-10-11. Morris R ...
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... PDGFRB has been shown to interact with: CRK, Caveolin 1, Grb2, NCK1, NCK2, PDGFR-α, PTPN11, RAS p21 protein activator 1, SHC1 ... yield a PDGFRB-ETV6 fused gene that encodes a fusion protein, PDGFRB-ETV6. This chimeric protein, unlike the PDGFRB protein: a ... a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". J. Biol. ...
ABL/BCR could active several molecular pathways: RAS signaling could be activated by BCR/ABL by GRB2 adaptor which interact ... It has been shown that associates with Host cell factor C1, CREB binding protein, WDR5, CTBP, MEN1, etc. The rearrangement of ... Some focal adhesion complex (PAXILLIN, FAK0 could be activated by BCR/ABL with adaptor molecule CRK-L. BCR/ABL could inactivate ...
2001). "Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2". J. Immunol. 166 (12): 7219-28. doi:10.4049/ ... VAV2 has been shown to interact with CD19 and Grb2. GRCh38: Ensembl release 89: ENSG00000160293 - Ensembl, May 2017 GRCm38: ... "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): ... Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene. VAV2 is the second member of ...
Signal transducing adaptor protein, a helper protein used by major proteins in signalling pathways. Aaronson DS, Horvath CM ( ... Firstly, a protein important for MAPK/ERK signalling, called Grb2, has an SH2 domain, and therefore it can bind to receptors ... proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many ... Phosphorylation then recruits an adaptor protein called Shc, which activates the MAPK/ERK pathway, and this facilitates gene ...
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... "Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2". ... "Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in ... Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to ...
Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. BLNK is ... docking sites necessary for downstream protein-protein interactions between BLNK and the SH2 domain-containing proteins Grb2, ... "Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and ... Tan JE, Wong SC, Gan SK, Xu S, Lam KP (June 2001). "The adaptor protein BLNK is required for b cell antigen receptor-induced ...
2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): ... Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of ... Docking protein 3 is a protein that in humans is encoded by the DOK3 gene. GRCh38: Ensembl release 89: ENSG00000146094 - ... "Entrez Gene: DOK3 docking protein 3". Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family ...
It interacts with TRAF1 and TRAF2 adaptor proteins, which are involved in pathway eventually leading to NFκB translocation to ... and GRB2 and/or activation of phopshoinositol-3-Kinase (PI3K) resulting in Akt kinase activation, promoting T cell ... Signaling through co-stimulatory molecules from TNFRSF often involves the interaction with TRAF adaptor proteins to enhance T ... Its signaling is involved in the recruitment of protein kinase C θ (PKCθ), Ras GEF and Ras GRP to the synapse. Moreover, it ...
1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". ... PTPN12 has been shown to interact with BCAR1, Grb2, PSTPIP1, TGFB1I1, Paxillin and SHC1. GRCh38: Ensembl release 89: ... This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ...