*  BCAR1
"Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins". Oncogene. 12 (12): 2491-8. PMID 8700507. ... of adaptor proteins which is characterized by the presence of multiple conserved motifs for protein-protein interactions, and ... p130Cas/BCAR1 belongs to the Cas family of adaptor proteins and can act as a docking protein for several signalling partners. ... Brinkman A, van der Flier S, Kok EM, Dorssers LC (Feb 2000). "BCAR1, a human homologue of the adapter protein p130Cas, and ...
*  IRS1
Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein". The Journal of Biological Chemistry ... is a signaling adapter protein that in humans is encoded by the IRS-1 gene. It is a 131 kDa protein with amino acid sequence of ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ...
*  RET proto-oncogene
"The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins". Oncogene. 9 (6): 1661-8. PMID ... "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". J. Biol. ... resulting in the juxtaposition of the C-terminal region of the RET protein with an N-terminal portion of another protein, can ...
*  Tropomyosin receptor kinase A
MacDonald JI, Gryz EA, Kubu CJ, Verdi JM, Meakin SO (June 2000). "Direct binding of the signaling adapter protein Grb2 to the ... "The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins". Oncogene. 9 (6): 1661-8. PMID ... The levels of distinct proteins can be regulated by the "ubiquitin/proteasome" system. In this system, a small (7-8 kd)protein ... Geetha T, Wooten MW (February 2003). "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve ...
*  PTPN1
Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein". J. Biol. Chem. 275 (6): 4283-9. doi ... Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the ... The pTyr loop and Tyr46 residue are located on the surface of the protein, and thus help to determine the depth a substrate can ... PTP1B was first isolated from a human placental protein extract, but it is expressed in many tissues. PTP1B is localized to the ...
*  Nucleotide exchange factor
Grb2 adapter protein, and Sos nucleotide exchange factor". Cell. 73 (3): 611-620. doi:10.1016/0092-8674(93)90146-H. PMID ... and are often specific to a single protein or class of proteins with which they interact. Nucleoside-diphosphate kinase Guanine ... of nucleoside diphosphates for nucleoside triphosphates bound to other proteins. Many cellular proteins cleave (hydrolyze) ... These changes in turn affect the structural, enzymatic, or signalling properties of the protein. Nucleotide exchange factors ...
*  GRAP
GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2/ ... "Entrez Gene: GRAP GRB2-related adaptor protein". Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE (Jan 1998). "LAT ... "Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients ... "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological ...
*  Annexin A2
Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (Mar 1994). "A complex of Grb2 adaptor protein, Sos exchange ... This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a ... Becker T, Weber K, Johnsson N (Dec 1990). "Protein-protein recognition via short amphiphilic helices; a mutational analysis of ... It is a calcium-dependent phospholipid-binding protein whose function is to help organize exocytosis of intracellular proteins ...
*  SOS1
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange ... Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... Park RK, Izadi KD, Deo YM, Durden DL (September 1999). "Role of Src in the modulation of multiple adaptor proteins in FcalphaRI ...
*  GRB2
... Adaptor Protein at the US National Library of Medicine Medical Subject Headings (MeSH) The Grb2 protein page on The SH2 ... In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal ... Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell ... "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and ...
*  Epidermal growth factor receptor
"Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange ... a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth ...
*  GRAP2
GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans ... This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein ( ... Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 ... "Entrez Gene: GRAP2 GRB2-related adaptor protein 2". Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a ...
*  Grb2 associated binding protein 3
... and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage ... GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. This gene is a member of the GRB2- ... associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth ... GRB2 associated binding protein 3". Retrieved 2016-07-26. Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud ...
*  List of MeSH codes (D12.644)
... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... wnt2 protein MeSH D12.644.360.011 --- activating transcription factor 6 MeSH D12.644.360.024 --- adaptor proteins, signal ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  Platelet-derived growth factor receptor
The adaptor protein Grb2 forms a complex with Sos by the Grb2 SH3 domain. Grb2 (or the Grb2/Sos complex) is recruited to the ... Whereas the interaction between Grb2 and PDGFR occurs through interaction with the SHP2 protein, Grb2 instead binds to ... another adaptor protein that forms a complex with many receptors via its PTB domain. Once activated, Ras interacts with several ... Similarly to other SH2 domain-containing proteins, PI-3 kinase forms a complex with PY sites on activated receptors. The main ...
*  Adapter molecule crk
"Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades". J. Biol. Chem ... Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins ...
*  BAG3
... coupling to the adaptor protein GRB2". Arch. Biochem. Biophys. 345 (1): 103-10. doi:10.1006/abbi.1997.0245. PMID 9281317. Nel ... Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ (February 1996). "A Grb2-associated docking protein in EGF- and ... BAG3 balances protein synthesis and protein degradation under mechanical stress. PLCG1 has been shown to interact with: FGFR1, ... Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein ...
*  PLCG1
... coupling to the adaptor protein GRB2". Archives of Biochemistry and Biophysics. 345 (1): 103-10. doi:10.1006/abbi.1997.0245. ... Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ (February 1996). "A Grb2-associated docking protein in EGF- and ... Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. The protein encoded by ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ...
*  Amide ring
An amide ring is employed in the specificity of the adaptor protein GRB2 for a particular asparagine within proteins it binds. ... GRB2 binds strongly to the pentapeptide EYINQ (when the tyrosine is phosphorylated); in such structures a 9-atom amide ring ... Amide Rings are small motifs in proteins and polypeptides. They consist of 9-atom or 11-atom rings formed by two CO...HN ... Rahuel, J; Gay B (1996). "Structural basis for specificity of GRB-2-SH2 revealed by a novel ligand binding mode". Nat Struct ...
*  Joseph Schlessinger
One of the seminal findings in this work was his laboratory's cloning of Grb2 and other Adaptor proteins. Another is the lab's ...
*  Lymphocyte cytosolic protein 2
Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (June 2000). "GRID: a novel Grb-2-related adapter protein ... "The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ... "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors ...
*  Receptor for activated C kinase 1
Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (June 2000). "GRID: a novel Grb-2-related adapter protein ... Koehler JA, Moran MF (May 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP". ... RACK1 was originally isolated and identified as an intracellular protein receptor for protein kinase C, noting the significant ... RAS p21 protein activator 1, ST7, STAT1, Src, and Tyrosine kinase 2. Eukaryotic small ribosomal subunit (40S) Protein kinase C ...
*  CD28
Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (June 2000). "GRID: a novel Grb-2-related adapter protein ... Okkenhaug K, Rottapel R (August 1998). "Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain- ... The N172 residue (as part of the YMNM) is important for the binding of Grb2 and Gads and seems to be able to induce IL-2 mRNA ... However, mutation of the final amino acid of the motif, M173, which is unable to bind PI3K but is able to bind Grb2 and Gads, ...
*  SH3 domain
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually ... Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other ... Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the ...
*  MTORC1
... the adaptor protein GRB2 binds with its SH2 domains. This recruits the GEF called Sos, which activates the Ras G protein. Ras ... Even if a cell has the proper energy for protein synthesis, if it does not have the amino acid building blocks for proteins, no ... TSC2 is a GTPase activating protein (GAP). Its GAP activity interacts with a G protein called Rheb by hydrolyzing the GTP of ... Almost all of the variables required for protein synthesis affect mTORC1 activation by interacting with the TSC1/TSC2 protein ...
*  ABL (gene)
Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... GRB2, MDM2, NCK1, NEDD9, NTRK1, P73, PAG1, PAK2, PSTPIP1, RAD9A, RAD51, RB1, RFX1, RYBP, SHC1, SORBS2, SPTA1, SPTAN1, TERF1, ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ...