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*  C-Raf
Nantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY (April 1998). "Interaction of the Grb10 adapter protein with the Raf1 ... 14-3-3 proteins also contribute to the autoinhibition. As 14-3-3 proteins are all known to form constitutive dimers, their ... Raf kinases A-Raf kinase B-Raf kinase KSR1 protein KSR2 protein GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May ... Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid ...
*  GRB10
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... Bai, R Y; Jahn T; Schrem S; Munzert G; Weidner K M; Wang J Y; Duyster J (Aug 1998). "The SH2-containing adapter protein GRB10 ... Nantel, A; Mohammad-Ali K; Sherk J; Posner B I; Thomas D Y (Apr 1998). "Interaction of the Grb10 adapter protein with the Raf1 ...
*  MAP2K1
Nantel, A; Mohammad-Ali K; Sherk J; Posner B I; Thomas D Y (Apr 1998). "Interaction of the Grb10 adapter protein with the Raf1 ... The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated ... MAP2K1 has been shown to interact with C-Raf, Phosphatidylethanolamine binding protein 1, MAP2K1IP1, GRB10, MAPK3, MAPK8IP3, ... a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway". ...
*  PIK3CG
"The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941-8. doi:10.1038/sj.onc.1202024. PMID ... This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that ... In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the ... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. ...
*  BCR (gene)
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ... The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is ... BCR protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human BCR genome location and BCR ... The protein has serine/threonine kinase activity and is a guanine nucleotide exchange factor for Rho family GTPases including ...
*  CD117
Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). "Role for the adaptor protein Grb10 in the activation of Akt ... Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... Gueller S, Gery S, Nowak V, Liu L, Serve H, Koeffler HP (October 2008). "Adaptor protein Lnk associates with Tyr(568) in c-Kit ... ISBN 1-84110-100-1. Wollberg P, Lennartsson J, Gottfridsson E, Yoshimura A, Rönnstrand L (March 2003). "The adapter protein APS ...
*  ABL (gene)
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ... Yamanashi Y, Baltimore D (January 1997). "Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein ...
*  CRKL
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ... related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ...
*  GRB2
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". The Journal of Biological ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (Aug 1998). "The SH2-containing adapter protein GRB10 ... GRB2 Adaptor Protein at the US National Library of Medicine Medical Subject Headings (MeSH) The Grb2 protein page on The SH2 ...
*  RET proto-oncogene
"The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): ... "The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins". Oncogene. 9 (6): 1661-8. PMID ... "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". J. Biol. ... resulting in the juxtaposition of the C-terminal region of the RET protein with an N-terminal portion of another protein, can ...
*  BPS domain
... domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/,Grb10/Grb14. It mediates ... "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325-33. doi:10.1016/j ...
*  List of MeSH codes (D12.644)
... grb2 adaptor protein MeSH D12.644.360.024.298 --- grb7 adaptor protein MeSH D12.644.360.024.300 --- grb10 adaptor protein MeSH ... wnt2 protein MeSH D12.644.360.011 --- activating transcription factor 6 MeSH D12.644.360.024 --- adaptor proteins, signal ... rap gtp-binding proteins MeSH D12.644.360.525.475.100 --- rap1 gtp-binding proteins MeSH D12.644.360.525.500 --- ras proteins ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  TNRC15
... receptors by the Grb10 adapter and modulate IGF-I signaling". J Biol Chem. 278 (34): 31564-73. doi:10.1074/jbc.M211572200. PMID ... PERQ amino acid-rich with GYF domain-containing protein 2 is a protein that in humans is encoded by the GIGYF2 gene. GRCh38: ... X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169-76 ... Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (Aug 2003). "Two novel proteins that are linked to insulin- ...
*  Cordon-bleu protein
COBL_HUMAN (O75128) Uniprot entry COBL_HUMAN SMART entry Eija Paunola et al., WH2 domain: a small, versatile adapter for actin ... Megan P. Hitchins et al., DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed, Mamm Genome. 13 ... Cordon-bleu protein (Cobl) is an actin nucleator protein, which seems to have a pivotal role in morphogenetic processes of the ... and is present in at least 6 classes of proteins WIP/Verprolin, Cibulot, Svv2/CAP, β-Thymosines, WAVE/Scar. WH2 proteins occur ...
*  GRB14
2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein ... of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10- ... The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor ... Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein ...
*  PTPN11
"Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J (June 1998). "Grb10 identified as a potential regulator of growth ... Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to ... PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs ...
*  NEDD4
The NDFIP1 and NDFIP2 proteins function as adaptor proteins that can facilitate NEDD4 binding to substrates that lack PY motifs ... Murdaca J, Treins C, Monthouël-Kartmann MN, Pontier-Bres R, Kumar S, Van Obberghen E, Giorgetti-Peraldi S (2004). "Grb10 ... The WW domains interact with proline rich PPxY motifs in target proteins to mediate interactions with substrates and adaptors. ... NEDD4 protein is widely expressed, and a large number of proteins have been predicted or demonstrated to bind in vitro. In vivo ...
*  SH2 domain
... s are commonly found in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways. ... GRB10; GRB14; GRB2; GRB7 HCK; HSH2D INPP5D; INPPL1; ITK; JAK2; LCK; LCP2; LYN MATK; NCK1; NCK2 PIK3R1; PIK3R2; PIK3R3; PLCG1; ... Protein-protein interactions play a major role in cellular growth and development. Modular domains, which are the subunits of a ... SH2 domains allow proteins containing those domains to dock to phosphorylated tyrosine residues on other proteins. ...
*  Insulin receptor
These changes facilitate the recruitment of specific adapter proteins such as the insulin receptor substrate proteins (IRS) in ... Langlais P, Dong LQ, Hu D, Liu F (June 2000). "Identification of Grb10 as a direct substrate for members of the Src tyrosine ... Kotani K, Wilden P, Pillay TS (October 1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts ... Grb2 is then able to bind SOS, which in turn catalyzes the replacement of bound GDP with GTP on Ras, a G protein. This protein ...
*  IRS1
... is a signaling adapter protein that in humans is encoded by the IRS-1 gene. It is a 131 kDa protein with amino acid sequence of ... and Grb10". Molecular Endocrinology. 10 (6): 631-41. doi:10.1210/mend.10.6.8776723. PMID 8776723. Mañes S, Mira E, Gómez-Mouton ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ... Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV (March 2007). "Oncogenic transformation by the signaling adaptor proteins insulin ...