Recombinant proteins, such as insulin, hepatitis B vaccine, interferon, granulocyte colony-stimulating factor, streptokinase ... One-factor-at-a-time (OFAT) is the preferential choice that researchers use for designing a medium composition. This method ... Growth factors and trace nutrients are included in the fermentation broth for organisms incapable of producing all of the ... Several other factors must be measured and controlled such as pressure, temperature, agitator shaft power, and viscosity. An ...
"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, ... This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of ... and cloned from mouse EL4 thymoma cells and the bioactivity of IL-17A was confirmed by stimulating the transcriptional factor ... Kolls JK, Khader SA (December 2010). "The role of Th17 cytokines in primary mucosal immunity". Cytokine & Growth Factor Reviews ...
1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine- ... 1996). "Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. ... 1994). "Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130". ... "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth ...
... expression in heart muscle is up-regulated by estrogen and down-regulated by granulocyte-macrophage colony-stimulating factor. ... while simultaneously stimulating the transcription factors normally activated by reelin. This binding of THBS1, however, does ... In addition, being that apoE, a major ligand of VLDLR, is a leading genetic risk factor for Alzheimer's disease, VLDLR may play ... However, in this case phosphorylation of transcription factors, usually performed by reelin, is also blocked. VLDLR is found ...
... and 9 and granulocyte-macrophage colony stimulating factor. LECT2 is conserved in zebrafish, chicken, rat, mouse, cow. dog, ... Larsen CP, Ismail W, Kurtin PJ, Vrana JA, Dasari S, Nasr SH (2016). "Leukocyte chemotactic factor 2 amyloidosis (ALECT2) is a ... Hutton, H.L.; DeMarco, M.L.; Magil, A.B.; Taylor, P. (2014). "Renal leukocyte chemotactic factor 2 (LECT2) amyloidosis in first ... Murphy, C. L.; Wang, S.; Kestler, D.; Larsen, C.; Benson, D.; Weiss, D. T. (2010). "Leukocyte chemotactic factor 2 (LECT2)- ...
Brú, Antonio; S. Albertos; F. García-Hoz; I. Brú (2005). "Regulation of neutrophilia by granulocyte colony-stimulating factor: ... a granulocyte colony-stimulating factor (G-CSF) routinely used in Oncology in order to recover the level of these blood cells ... Due to the above, the success on the male hepatic patient was reported in a magazine with no impact factor; such factor, ... Measuring the objective quality of an article by means of the impact factor of a journal. Publishing results on scientific ...
... granulocyte colony-stimulating factor, and interleukin 6". Proc. Natl. Acad. Sci. U.S.A. 88 (19): 8641-5. Bibcode:1991PNAS... ... Ichihara M, Hara T, Kim H, Murate T, Miyajima A (July 1997). "Oncostatin M and leukemia inhibitory factor do not use the same ... OSM is a major growth factor for Kaposi's sarcoma "spindle cells", which are of endothelial origin. These cells do not express ... OSM is synthesized by stimulated T-cells and monocytes. The effects of OSM on endothelial cells suggest a pro-inflammatory role ...
In a select subset of high risk patients, granulocyte colony stimulating factors (G-CSF) can be used to aid immune system ... July 2006). "2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice ... Africa CW, Nel J, Stemmet M (July 2014). "Anaerobes and bacterial vaginosis in pregnancy: virulence factors contributing to ... They can be caused by a variety of factors, including: Malnutrition Fatigue Recurrent infections Immunosuppressing agents for ...
... developed improved versions of interferon beta, granulocyte colony-stimulating factor, TNF inhibitors, factor ...
"Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft ...
January 2001). "Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer ... Tumor cells modified with a gene for immune growth factors such as GM-CSF, had been used many years previously and continue to ...
Therapies such as granulocyte colony-stimulating factor (G-CSF), interferons, imiquimod and cellular membrane fractions from ... Dendritic cells (DC) can be stimulated to activate a cytotoxic response towards an antigen. Dendritic cells, a type of antigen- ... The cells are expanded non-specifically and/or stimulated. The cells are then reinfused and produce an immune response against ... September 2019). "Enhanced early immune response of leptospiral outer membrane protein LipL32 stimulated by narrow band mid- ...
... a granulocyte colony-stimulating factor (G-CSF) is sometimes administered along with chemotherapy. This has been shown to ... "The impact of the granulocyte colony-stimulating factor on chemotherapy dose intensity and cancer survival: a systematic review ... Determining the appropriate regimen to use depends on many factors; such as, the character of the tumor, lymph node status, and ... Most adjuvant breast cancer chemotherapy regimens do not routinely require growth factor support except for those associated ...
December 2009). "Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation ... granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma". ... a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in ... The drug works by replicating in cancer cells, causing them to burst; it was also designed to stimulate an immune response ...
"Long-term clinical outcome after intramuscular transplantation of granulocyte colony stimulating factor-mobilized CD34 positive ... Delivery of these factors demonstrated successful reprogramming in-vivo and signals propagated from the epidermis to the dermis ... This chip is then connected to an electrical source capable of delivering an electrical field to drive the factors from the ... Using a patented cocktail of plasmids (Etv2, Fli1, Foxc2, or EFF), these factors were delivered to the tissue above the surgery ...
... monocytes can differentiate into dendritic cells by adding the cytokines granulocyte macrophage colony-stimulating factor (GM- ... a neurologic disease associated with mutations in the macrophage colony-stimulating factor receptor gene. Complete blood count ... Many factors produced by other cells can regulate the chemotaxis and other functions of monocytes. These factors include most ... Non-classical monocytes produce high amounts of pro-inflammatory cytokines like tumor necrosis factor and interleukin-12 after ...
... granulocyte colony stimulating factor. Maxygen filed a certificate of dissolution on August 29, 2013. The company has ceased ... In 2008, the company sold its MAXY-VII candidate drug, a recombinant form of clotting factor VIIa, to Bayer HealthCare. 2009 ...
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor ... Cytokine and Growth Factor Reviews 18, pp. 171-182 Shimizu, J., Yamazaki, S. and Sakaguchi, S., 1999. Induction of tumor ... In conjuncture with TNF (Tumor Necrosis Factors), IFN-γ can have direct cytotoxic effects on tumor cells (Franzen et al., 1986 ... 137-148 Fransen, L., Van der Heyden, J., Ruysschaert, R and Fiers, W., 1986 Recombinant tumor necrosis factor: its effect and ...
... such as granulocyte macrophage colony-stimulating factor (GM-CSF). The most common source of antigens used for dendritic cell ... The interleukins stimulate these CAR T cells to proliferate, and the CAR T cells exit the MASTER to attack the cancer. The ... Oncolytic viruses are thought not only to cause direct destruction of the tumour cells, but also to stimulate host anti-tumour ... For example, beta-glucans such as lentinan have been shown in laboratory studies to stimulate macrophage, NK cells, T cells and ...
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor ... that have been stimulated in vitro) can mediate anti-tumor immunity when transferred back into tumor-bearing hosts; furthermore ... stimulates potent, specific, and long-lasting anti-tumor immunity. Proceedings of the National Academy of Sciences, 90(8), pp. ...
... has been shown to interact with: ADAM15 BCR gene, Cbl gene, ELMO1, Granulocyte colony-stimulating factor receptor, RAPGEF1 ... "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF ... Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87-94. doi: ... "Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro". J. Biol. ...
June 2011). "Low dose of homoharringtonine and cytarabine combined with granulocyte colony-stimulating factor priming on the ... September 2009). "Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on ...
... with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, ... granulocyte-macrophage colony-stimulating factor (GM-CSF), and then irradiated to prevent further cell division. The product ...
The Granulocyte Macrophage colony Stimulating Factor(GM-CSF) is superior to other cytokines, and the addition of GM-CSF in ... with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, ... When administered to the patients, these molecules will stimulate the immune system of the patient. The whole-cell vaccine ... GM-CSF recruits dendritic cells to the site of irradiated cells and stimulates the antigen uptake, processing and presentation ...
... after in vivo application of recombinant human granulocyte colony-stimulating factor". Blood. 78 (4): 885-9. doi:10.1182/blood. ...
"Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative ... Ram PA, Waxman DJ (Dec 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms ... "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". ... "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochemical and Biophysical Research ...
Gaudreau S, Guindi C, Ménard M, Besin G, Dupuis G, Amrani A (September 2007). "Granulocyte-macrophage colony-stimulating factor ... CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of ... Once stimulated, the dendritic cells migrate to the draining lymph node and present antigens to T cells via interaction of MHC ... "Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice ...
"Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by ...
... a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1". FEBS Lett. 282 (1): 95-7. doi: ... 2006). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but ... C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of ... Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site". J. ...
... granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor for priming leukocyte-mediated ... Several notable factors are water damage in buildings, the use of building materials which provide a suitable substrate and ... While mold and related microbial agents can be found both inside and outside, specific factors can lead to significantly higher ... Bhattacharya A, Derecki NC, Lovenberg TW, Drevets WC (May 2016). "Role of neuro-immunological factors in the pathophysiology of ...