Graft-versus-tumor effect
... (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains ... Rezvani AR, Storb RF (May 2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic ... Graft-versus-leukemia (GvL) is a specific type of GvT effect. As the name of this effect indicates, GvL is a reaction against ... March 2005). "Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning ...
Graft-versus-host disease
However, these types of transplants come at a cost of diminished graft-versus-tumor effect, greater risk of engraftment failure ... Graft-versus-tumor effect Immunosuppression Transplant rejection Williamson, Lorna M. (1998-09-01). "Transfusion associated ... Falkenburg JH, Jedema I (December 2017). "Graft versus tumor effects and why people relapse". Hematology. American Society of ... to separate the undesirable graft-vs-host disease aspects of T-cell physiology from the desirable graft-versus-tumor effect. ...
T-cell depletion
These veto cells can also exert graft vs tumor effect. HIV has been confirmed to target CD4+ T cells and destroy them, making T ... it can cause a delay in recovery of the immune system of the transplanted individual and a decreased Graft-versus-tumor effect ... Depletion post infection has no effect on the NK cells. A preliminary study of the effect on TCD in arthritis in mice models ... Ex vivo techniques enable a more accurate count of the T cells in a graft and also has the option to 'addback' a set number of ...
Hematopoietic stem cell transplantation
Graft-versus-tumor effect (GVT), or "graft versus leukemia" effect, is the beneficial aspect of the GvHD phenomenon. For ... In certain leukemias, though, this can coincide with protection against cancer relapse owing to the graft-versus-tumor effect. ... March 2005). "Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning ... Memorial Sloan-Kettering Cancer Center > Blood & Marrow Stem Cell Transplantation > The Graft-versus-Tumor Effect Archived 4 ...
Veto cells
Anti-3rd party veto cells have also been shown to have Graft-versus-tumor effect Ophir, Eran; Reisner, Yair (2012-05-02). "The ... These are the same T-cells that mediate graft rejection. This means that the addition of donor-veto cells to the donor graft ... Graft rejection is the main problem. Addition of donor-veto cells to the graft can provide one solution to this problem. Veto ... The large number of veto cells helped overcome the graft rejection that was mediated by the host CD8 T-cell precursors. An ...
Ameloblastic fibroma
This kind of treatment also requires reconstruction of the affected area, with bone grafts often being the preferred choice for ... This is done when the tumour is large or is deemed to have a high chance of malignant transformation. In some cases the fibroma ... Enucleation is the removal of an organ or tumor in such a way that it comes out clean and whole. Thorough enucleation is ... An ameloblastic fibroma is a fibroma of the ameloblastic tissue, that is, an odontogenic tumor arising from the enamel organ or ...
Entolimod
November 2012). "A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus- ... effects. Tissue protective effects of TLR5 agonists are limited to normal tissues and do not involve protection of tumors from ... Preclinical studies have shown that entolimod has a suppressive effect on growth of TLR5 expressing tumors. Entolimod has also ... Clinical trial number NCT01527136 for "Entolimod in Treating Patients With Locally Advanced or Metastatic Solid Tumors That ...
Beverly Torok-Storb
... replacing high-dose cytotoxic therapy with graft-versus-tumor effects". Blood. 97 (11): 3390-3400. doi:10.1182/BLOOD.V97.11. ...
Immunotransplant
Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating ... That study uses a whole-cell, CpG-activated, autologous tumor vaccine to induce anti-tumor immunity followed by leukapheresis ... tumor-associated antigens, or whole tumor cells, can induce specific T-cell mediated immune responses. A number of approaches ... Because of the logistic difficulty of obtaining tumor-specific T cells via the ex vivo expansion of tumor-infiltrating cells, a ...
Transplant rejection
Graft-versus-host disease Graft-versus-tumor effect Immunosuppression Transplant engineering Frohn C, Fricke L, Puchta JC, ... whereas acute rejection episodes with return to function back to baseline do not have major effects on graft survival. Chronic ... Graft failure secondary to hyperacute rejection has significantly decreased in incidence as a result of improved pre-transplant ... The greater the difference in MHC between donor and recipient, the more cytotoxic T-cells are recruited to damage the graft, ...
Foetal brain cell graft
A patient with Huntington disease was treated with foetal brain cells which led to a brain tumour due to graft overgrowth. Due ... As PD progresses, these pharmaceutical interventions lose efficacy and result in greater side-effects. Foetal brain cell graft ... instead grafted cells homogenised with the environment and developed morphological and functional features of the affected PD ... Grafting is a surgical procedure involving the replacement of damaged or missing body tissues from a healthy body, in which ...
NKG2
... match can also prevent graft versus leukemia effect (GvL) as well as the graft versus host disease (GvHD). NKG2D is an ... Many tumors avoid the cytotoxicity by excreting soluble NKG2D ligands or secreting TGF-β, leading to the downregulation of the ... The level of expression of NKG2 genes is not constant, rather it is affected by cytokine environment (mainly interleukin-2 (IL- ...
Nancy Flournoy
Her work in this time on the graft-versus-tumor effect become "the first major application of the proportional hazards model ... and in particular on the graft-versus-tumor effect. She is Curators' Distinguished Professor Emeritus of Statistics at the ...
Benign tumor
The health effects of benign tumor growth may be more prominent if the tumor is contained within an enclosed space such as the ... Treatment of enchondromas involves surgical curettage and grafting. Lipomas are benign, subcutaneous tumors of fat cells ( ... Some forms of benign tumors may be harmful to health. Benign tumor growth causes a mass effect that can compress neighboring ... Bowel intussusception can occur with various benign colonic tumors. Cosmetic effects can be caused by tumors, especially those ...
CDC42
Ye H, Zhang Y, Geng L, Li Z (February 2015). "Cdc42 expression in cervical cancer and its effects on cervical tumor invasion ... Wilson JM, Menkhaus P, Gustin BW (May 1987). "Volume and outcome of coronary artery bypass graft surgery". JAMA. 257 (18): 2434 ... Another study found that Cdc42 drives the process of initiating a metastatic tumor in a new tissue by promoting the expression ... In mice, systemic AZA197 treatment in vivo reduced primary tumor growth and prolonged survival. Therapy targeting Rho GTPase ...
Donor lymphocyte infusion
The goal of this therapy is to induce a remission of the patient's cancer by a process called the graft-versus-tumor effect ( ... Porter D, Levine JE (2006). "Graft-versus-host disease and graft-versus-leukemia after donor leukocyte infusion". Semin. ... GVT). The donor T-cells can attack and control the growth of residual cancer cells providing the GVT effect. It is hoped that ... to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. These donated white blood cells ...
Sulfatide
Chemokines are implicated in: Angiogenesis HIV-1 infection Tumour metastasis Haematopoiesis Graft rejection Embryonic ... Autoimmunity also affects sulfatide levels. When an enhanced antibody response against myelin lipids occurs, including ... Sulfatide also has a direct inhibitory effect on thrombosis. On the other hand, sulfatide also helps to improve blood ... Other cancers such as Wilms' tumor show no expression of sulfatide. Therefore, it appears that such increased levels of ...
Trauma Center (video game series)
Operation types range from organ repair and tumor extraction to skin grafts and bone repair. The DS titles make use of the ... Its effects vary between individuals, with demonstrated abilities including slowing time, healing patients, and stopping a ...
Minor histocompatibility antigen
Therefore, in order to prevent adverse GVHD effects, immune cell restricted MiHAs are ideal targets for graft-versus- leukemia ... CD8+ T cells that are specific for a MiHA can target these antigens when they are expressed specifically on tumor cells, which ... Bleakley M, Riddell SR (2004). "Molecules and mechanisms of the graft-versus-leukaemia effect". Nature Reviews. Cancer. 4 (5): ... As a result, the donor T cells can target the recipients cells called graft-versus-host disease (GVHD). Although graft or bone ...
Sumiteru Taniguchi
... stochastic effects of radiation exposure during and after the bombings manifested in the growth of numerous burn keloid tumors ... Taniguchi also had multiple skin grafting surgeries on his back and left arm. Taniguchi devoted his life to informing people of ...
Caspase-9
The inhibitor affects the dimerization of caspase-9 and causes a conformational change that affects the substrate-binding cleft ... In the context of graft versus host disease, caspase-9 can be introduced as an inducible switch. In the presence of a small ... CAR T cells are genetically modified T cells that exhibit cytotoxicity to tumor cells. Evidence shows that CAR T cells are ... A deficiency in caspase-9 largely affects the brain and its development. The effects of having a mutation or deficiency in this ...
Microtransplantation
... and will play a role as recipient-versus-tumor (RVT) effect combining donor cells' graft-versus-tumor (GVT) effect. Donor's ... Microtransplantation (MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients ... Practices of microtransplantation has shown none graft-versus-host disease (GVHD) till present, thus immunosuppressive drugs ... hematological disorder or tumor Not allergic to G-CSF Not pregnant or lactating In a randomized controlled trial from 2004 to ...
List of women in statistics
American statistician known for the design of adaptive clinical trials and for the graft-versus-tumor effect in bone marrow ... studied effects of air quality and racial inequality on health Elizabeth Stasny, American expert on missing data in surveys ... introduced random-effects meta-analysis and its application in clinical trials Jill Dever, American survey statistician Susan J ... studied contagion effect of mass shootings Andrea Troxel, American biostatistician, expert in behavioral economics in public ...
List of MeSH codes (G04)
... graft vs host reaction MeSH G04.610.555.714.402.320 - graft vs tumor effect MeSH G04.610.555.714.402.320.320 - graft vs ... host vs graft reaction MeSH G04.610.555.714.545.328 - graft rejection MeSH G04.610.555.714.545.340 - graft survival MeSH ... plant tumors MeSH G04.742.800.400 - gravitropism MeSH G04.742.800.700 - phototropism The list continues at List of MeSH codes ( ... bystander effect MeSH G04.335.122.300 - embryonic induction MeSH G04.335.122.600 - paracrine communication MeSH G04.335.122.850 ...
Treatment of cancer
... since the donor's immune cells will often attack the tumor in a phenomenon known as graft-versus-tumor effect. For this reason ... Since chemotherapy affects the whole body, it can have a wide range of side effects. Patients often find that they start losing ... Fetal tumors are sometimes diagnosed while still in utero. Teratoma is the most common type of fetal tumor, and usually is ... which can bind to cell surface receptors or affected extracellular matrix surrounding the tumor. Radionuclides which are ...
GVT
... a Brazilian television channel Glyn Valley Tramway in Wales Graft-versus-tumor effect in transplantation medicine Grand Valley ...
Bone tumor
Instead of amputation, the affected bone is removed and replaced in one of two ways: (a) bone graft, in which bone is taken ... This newer classification categorises bone tumors into cartilage tumors, osteogenic tumors, fibrogenic tumors, vascular tumors ... Clinical features of a bone tumor depend on the type of tumor and which part of which bone is affected. Symptoms and signs ... Primary tumors of bone can be divided into benign tumors and cancers. Common benign bone tumors may be neoplastic, ...
Index of immunology articles
Fragment crystallizable region Freund's adjuvant Gc-MAF Gluten immunochemistry Glycoprotein 130 Graft versus tumor effect ... TPBG Transfer factor TRIF TRIM5alpha Trogocytosis Tuberculin Tumor necrosis factor alpha Tumor necrosis factor receptor Tumor ...
Vascular anomaly
Vascular tumors, include hemangiomas, the most common tumors in infants, occurring in 1-2%, and higher in 10% of premature ... Moreover, adult onset has been described too with mainly males being affected. Both sexes are affected equally in children. ... Involuted RICH may leave behind atrophic tissue, which can be reconstructed with autologous grafts. It is often best to ... vascular tumors and vascular malformations. Although vascular tumors and vascular malformations can resemble each other, there ...
Cyclophosphamide
... and/or Enhanced grafting of adoptively transferred, tumor-reactive effector T cells by the creation of an immunologic space ... Most people develop side effects. Common side effects include low white blood cell counts, loss of appetite, vomiting, hair ... Graft-versus-host disease (GVHD) is a major barrier for allogeneic stem cell transplant because of the immune reactions of ... GVHD can often be avoided by T-cell depletion of the graft. The use of a high dose cyclophosphamide post-transplant in a half ...