*  Graft-versus-tumor effect
Kolb HJ (2008). "Graft-versus-leukemia effects of transplantation and donor lymphocytes". Blood. 112 (12): 4371-83. doi:10.1182 ... Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains ... Rezvani AR, Storb RF (2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic ... This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer. It is closely ...
*  David G. Maloney
Maloney, D. G. (2003). Graft-vs.-leukemia effect in various histologies of non-Hodgkin's lymphoma. Leukemia & Lymphoma, 44(sup3 ... Leukemia & Lymphoma Society (2015-09-01). "Our History". www.lls.org. Retrieved 2016-11-01. Horning, Sandra J.; Mocharnuk, ... In addition to his research, he treats patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma and multiple myeloma at ... Aleccia, JoNel (2016-04-25). "New twist on T-cell therapy puts leukemia patients in remission". The Seattle Times. Retrieved ...
*  Forodesine
Facilitation of graft-versus-leukemia effect?". Seminars in Oncology. 34 (6 Suppl 5): S35-9. doi:10.1053/j.seminoncol.2007.11. ... "Forodesine treatment and post-transplant graft-versus-host disease in two patients with acute leukemia: ... Acute lymphoblastic leukemia "From cell biology to therapy: forodesine". Hematology Meeting Reports. 2 (5): 106-111. 2008. Gore ... "Biocryst Initiates Pivotal Fodosine Phase IIb Clinical Trial In Patients With Relapsed/Refractory T-Lymphoblastic Leukemia/ ...
*  Hematopoietic stem cell transplantation
Graft-versus-tumor effect (GVT) or "graft versus leukemia" effect is the beneficial aspect of the Graft-versus-Host phenomenon ... However, in certain leukemias this can coincide with protection against cancer relapse owing to the graft-versus-tumor effect. ... This effect is often accompanied by mild graft-versus-host disease, the appearance of which is often a surrogate marker for the ... Graft versus tumor is mainly beneficial in diseases with slow progress, e.g. chronic leukemia, low-grade lymphoma, and some ...
*  List of MeSH codes (G04)
... graft vs tumor effect MeSH G04.610.555.714.402.320.320 --- graft vs leukemia effect MeSH G04.610.555.714.519 --- ... graft rejection MeSH G04.610.555.714.545.340 --- graft survival MeSH G04.610.575.204 --- blood bactericidal activity MeSH ... bystander effect MeSH G04.335.122.300 --- embryonic induction MeSH G04.335.122.600 --- paracrine communication MeSH G04.335. ... cytopathogenic effect, viral MeSH G04.185.515.880.420 --- hemagglutination, viral MeSH G04.185.515.880.450 --- inclusion bodies ...
*  Minor histocompatibility antigen
Therefore, in order to prevent adverse GVHD effects, immune cell restricted MiHAs are ideal targets for graft-versus- leukemia ... Bleakley M, Riddell SR (2004). "Molecules and mechanisms of the graft-versus-leukaemia effect". Nature Reviews. Cancer. 4 (5): ... As a result, the donor T cells can target the recipients cells called graft-versus-host disease (GVHD). Although graft or bone ... leukemia effect (GVL). The recognition of a mature T cell to this self antigen should not induce an immune response. During ...
*  Cord blood bank
The high relapse rates after autologous or syngeneic transplant and the benefit of a graft-vs.-leukemia effect of an allogeneic ... Bone marrow transplants require a complete match on six key antigens, which are measures of graft-versus-host reaction, known ... especially in cases of childhood cancers and leukemia. Children who develop an immunological disorder often are unable to use ... abnormal cells have been detected in filters containing newborn blood of children who were not diagnosed with acute leukemia ...
*  Robert Peter Gale
... graft-versus-leukemia [GvL]. He has also advanced understanding other complex immune effects of transplants in humans, like ... He is known for research in leukemia and other bone marrow disorders (such as aplastic anemia). Gale received his A.B. degree ... In 1989-2003 Gale chaired the Scientific Advisory Board of the Center for Advanced Studies in Leukemia, a charity funding ... research in bone marrow transplantation where he made contributions to understanding the immune-mediated anti-leukemia effects ...
*  Guo Mei
Factors Influencing Graft versus Leukemia Effect-Review 17(3) Journal of Experimental Hematology. A modified haploidentical ... 2008 Acute graft versus host disease in non-myeloablative allogeneic stem cell transplantation 2007 Effects of mesenchymal stem ... 307 Hospital of PLA Member of the medical team of MST Leukemia Clinic Micro transplantation for treatment of leukemia: "way" to ... This technology opens up new opportunities for treating leukemia in world. From 2010 to 2015, she took part in 12 projects of ...
*  Graft-versus-host disease
... mainly leukemias, donor T-cells have proven to have a valuable graft-versus-tumor effect. A great deal of current research on ... for those that showed little effect after 1 month. Graft-versus-tumor effect Immunosuppression Transplant rejection Paczesny, S ... However, these types of transplants come at a cost of diminished graft-versus-tumor effect, greater risk of engraftment failure ... This is a rather indirect GvHD because it is not directly cells in the graft itself that causes it but cells in the graft that ...
*  Hartmann F. Stähelin
Some metabolic effects in guinea pigs associated with infection with tubercle bacilli". J. Exp. Med. 105 (3): 265-77. doi: ... etoposide as well as cyclosporine are used in the treatment of leukemias or other malignancies; the latter after bone marrow ... transplantation to prevent graft-versus-host disease, the former also being used in conjunction with bone marrow ... Borel JF, Feurer C, Gubler HU, Stähelin H (1976). "Biological effects of cyclosporin A: a new antilymphocytic agent". Agents ...
*  Ibrutinib
... and chronic graft vs host disease. Very common (>10% frequency) adverse effects include pneumonia, upper respiratory tract ... 12, 2014, the FDA expanded the approved use of ibrutinib to chronic lymphocytic leukemia (CLL). It was approved for ... In August 2017 the FDA approved ibrutinib as a second line treatment for graft vs host disease. It was the first drug approved ... Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for ...
*  Donor lymphocyte infusion
Porter D, Levine JE (2006). "Graft-versus-host disease and graft-versus-leukemia after donor leukocyte infusion". Semin. ... The goal of this therapy is to induce a remission of the patient's cancer by a process called the graft-versus-tumor effect ( ... Complications of DLI include acute and chronic graft-versus-host disease and bone marrow aplasia, resulting in ... GVT). The donor T-cells can attack and control the growth of residual cancer cells providing the GVT effect. It is hoped that ...
*  Juvenile myelomonocytic leukemia
Graft versus leukemia: Graft versus leukemia[clarification needed] has been shown many times to play an important role in ... Juvenile myelomonocytic leukemia (JMML) is a serious chronic leukemia (cancer of the blood) that affects children mostly aged 4 ... only in their leukemia cells) Another 35% of patients with a mutation in a gene called PTPN11 (again, only in their leukemia ... "Juvenile myelomonocytic leukemia". Semin Diagn Pathol. 28 (4): 298-303. Nov 2011. PMID 22195407. Bastida P; García-Miñaúr S; ...
*  Genetic engineering
... and then graft healthy skin onto 80 percent of the boy's body which was affected by the illness. Germline gene therapy would ... chronic lymphocytic leukemia (CLL), and Parkinson's disease. In 2012, Alipogene tiparvovec became the first gene therapy ... In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population ... This could be the effect on the phenotype of the organism, where the gene is expressed or what other genes it interacts with. ...
*  Plant hormone
The greatest effects occur at specific stages during the cell's life, with diminished effects occurring before or after this ... In grafting, auxin promotes callus tissue formation, which joins the surfaces of the graft together. In micropropagation, ... Jasmonic acid, a plant stress hormone that belongs to the jasmonate family, induced death in lymphoblastic leukemia cells. ... They are believed to also have a role in seed germination, and affect the storage of protein in seeds, and seem to affect root ...
*  Development of analogs of thalidomide
The effects of these substitutions seem to be mediated by steric effects. For the Y-position, a number of groups have been ... They have also been shown to cause dose dependent G0/G1 cell cycle arrest in leukemia cell lines where the analogs showed 100 ... Orphan indications by the FDA include graft-versus-host disease, mycobacterial infection, recurrent aphthous ulcers, severe ... and S-effects were seen in was not sensitive to the thalidomide teratogenic effects. Later reports in rabbits, which is a ...
*  Shwachman-Diamond syndrome
Insight into the leukemia-associated Shwachman-Diamond Syndrome". J Biol Chem. 280 (19): 19221-9. doi:10.1074/jbc.M414656200. ... Two gene conversion mutations predominate; one is a splice site mutation affecting the 5' splice site of intron two, while the ... However, SDS patients have an elevated occurrence of BMT-related adverse events, including graft-versus-host disease (GVHD) and ... In 2001, linkage analysis in SDS families indicated that affected gene mapped to a large region of human chromosome seven. In ...
*  Gusperimus
Currently, only provisional and preliminary data about side-effects is available. The following side-effects have been noticed ... It is not known if therapy with gusperimus may increase the risk of malignant diseases (lymphoma, leukemia, solid tumors), as ... and the prevention and therapy of transplant rejection or graft-versus-host disease. ...
*  Microtransplantation
... effect combining donor cells' graft-versus-tumor (GVT) effect. Donor's stem cells, which have been processed, will also ... comparing unirradiated to irradiated white blood cell transfusions in acute leukemia patients". Leukemia. 27: 861-5. doi: ... The 6-year leukemia-free survival (LFS) and overall survival (OS) rates were 84.4% and 89.5%, respectively, in the low-risk ... Huisheng Ai and his medical team at MST International Clinic for Leukemia in the 307th Hospital of Chinese People's Liberation ...
*  Fludarabine
... acute myeloid leukemia, and acute lymphocytic leukemia. It is given by injection into a vein or by mouth. Common side effects ... The profound lymphopenia caused by fludarabine renders patients susceptible to transfusion-associated graft versus host disease ... Severe side effects include brain dysfunction, low blood cell counts, and lung inflammation. Use in pregnancy will likely ... Fludarabine, sold under the brand name Fludara among others, is a chemotherapy medication used in the treatment of leukemia and ...
*  Stem cell marker
2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... April 1999). "In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys ... May 2004). "Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice". ... Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (February 2004). "Interleukin-3 receptor in acute leukemia". ...
*  Apheresis
DEHP leaches from the plastic into the blood, and people have begun to study the possible effects of this leached DEHP on ... Leukocytapheresis - removal of malignant white blood cells in people with leukemia and very high white blood cell counts ... Photopheresis - used to treat graft-versus-host disease, cutaneous T-cell lymphoma, and rejection in heart transplantation. ... Immune system effects - "the immediate decreases in blood lymphocyte counts and serum immunoglobulin concentrations are of ...
*  Pablo Rubinstein
Leukemia Article USA TODAY, Young lives get a fighting chance, By Rita Rubin, 7/13/2005"Pablo Rubinstein, director of the New ... and affect susceptibility to certain diseases. He began in as an investigator at the Lindsley F. Kimball Research Institute at ... matched grafts for patients. In 1993, Joanne Kurtzberg, Duke University Medical Center, performed the first two successful ... in freezing of umbilical cord blood or placental blood cells for the use for unrelated donors to treat diseases like Leukemia ...
*  Weekend effect
"Impact of nighttime and weekend liver transplants on graft and patient outcomes". Liver Transpl. 18: 558-65. doi:10.1002/lt. ... "Impact of weekend admissions on quality of care and outcomes in patients with acute myeloid leukemia". Cancer. 116: 3614-20. ... The degree of effect is usually higher for the 'Out-of-Hours Effect' rather than the 'Weekend Effect'. This suggests that the ' ... Weekend Effect'. This suggests that the 'Weekend Effect' may be nothing to do with the weekend per se, but may be an effect ...
*  Prostate cancer
This risk appears to be greater for men with an affected brother than for men with an affected father. In the United States in ... and AR into isolated samples of basal and luminal cells and grafted the treated tissue into mice. After 16 weeks, none of the ... "Lack of evidence for xenotropic murine leukemia virus-related virus (XMRV) in German prostate cancer patients". Retrovirology. ... Essink-Bot ML, de Koning HJ, Nijs HG, Kirkels WJ, van der Maas PJ, Schröder FH (June 1998). "Short-term effects of population- ...