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*  GP-100
Ruger GP100, an American revolver glycoprotein 100, a melanoma antigen Gp100:209-217(210M), a peptide cancer vaccine.. ... GP-100 can refer to A model of Suzuki motorcycle The Japanese vintage motorcycle Suzuki GP 100 U is not described fully. A ...
*  Glycoprotein 100
The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. Short fragments of it have been used to develop the ... gp100 cancer vaccine which is or contains gp100:209-217(210M). Hydrophilic recombinant gp100 protein (HR-gp100) has been ... In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ... "Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response". Cell ...
*  Gp100:209-217(210M)
... gp100) melanoma antigen, with a methionine substitution at position 210. It is often referred to as the gp100 cancer vaccine ... for example gp100:280-288(288V) ). It gave good results in a trial for advanced melanoma when used in combination with ... Gp100:209-217(210M) is a synthetic peptide cancer vaccine consisting of amino acid residues 209 through 217 of the glycoprotein ... interleukin-2. Another trial against Ipilimumab in advanced melanoma suggested Ipilimumab may be better than the gp100 vaccine ...
*  Adoptive cell transfer
... encountered in patients who received high-avidity TCRs that recognized either the MART-1 or gp100 melanoma-melanocyte antigens ... In melanoma, a resected melanoma specimen is digested into a single-cell suspension or divided into multiple tumor fragments. ... sarcoma and melanoma. In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with ... that recognized the MART-1 melanoma-melanocyte antigen, mediated tumor regression. In 2010 administration of lymphocytes ...
*  ALECSAT
... gp100 and MART-1) can successfully proliferate if melanoma cell lines are carefully preselected. At the same department, the ... Tumor antigens are typically cancer/testis antigens. Chemically inducing this antigen in T-cells by DNA demethylation allows ... T helper 1 (TH1) cells, when injected with overexpressed tumor antigens, have been shown to enhance migration of antigen- ... After this, the lymphocytes are treated for three days in order to induce the expression of CGL antigen. Next, another set of ...
*  Tumor antigens recognized by T lymphocytes
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma ". The New England Journal of Medicine. 364(22): ... Melanocytic differentiation antigen gp100 has also been used as a vaccine and extended survival has been observed in the group ... A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma ". Science. 254(5038): 1643-1647. van der ... In some patients, the majority of the tumor-specific T cells recognize mutated antigens. The contribution of these antigens to ...
*  SCIB1
... resulting in the development of immune responses against tumour cells expressing the TRP2 and gp100 antigens. The major ... Patients with Stage III or Stage IV melanoma received up to five doses of the SCIB1 vaccine over a 6-month period. In addition ... Scancell's first cancer vaccine, SCIB1, is being developed for the treatment of melanoma and is in Phase I/II clinical trials. ... The induction of high avidity T cells against TRP-2 and gp100 destroys both primary and metastatic tumours, leading to longer ...
*  PMEL (gene)
2003). "Identification of a novel gp100/pMel17 peptide presented by HLA-A*6801 and recognized on human melanoma by cytolytic T ... 1994). "Cloning and expression of the gene for the melanoma-associated ME20 antigen". DNA Cell Biol. 13 (2): 87-95. doi:10.1089 ... 1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas". Am. J. Pathol. 150 ( ... 1994). "Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor ...
*  MLANA
Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the ... 2003). "MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma". Am. J. Pathol. ... at the National Cancer Institute coined the term MART-1, which stands for "melanoma antigen recognized by T-cells." Coulie et ... The same name is also used to refer to the gene which codes for the antigen. The MART-1/melan-A antigen is specific for the ...
*  Jonathan Lewis (oncologist)
Lewis JJ (October 2004). "Therapeutic cancer vaccines: using unique antigens". Proceedings of the National Academy of Sciences ... "Immunization with DNA coding for gp100 results in CD4 T-cell independent antitumor immunity". Surgery. 128 (2): 273-80. doi: ... T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with ...
*  Ipilimumab
"What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?". Oncologist. 14 ... ipilimumab with gp100, and the vaccine alone. Patients had a higher survival rate with ipilimumab alone, however it is not ... These antigens are recognized by dendritic cells that present the antigens to cytotoxic T lymphocytes (CTLs) in the lymph nodes ... The CTLs recognize the cancer cells by those antigens and destroy them. However, along with the antigens, the dendritic cells ...
*  Index of oncology articles
... antigen - antigen-presenting cell - antigen-presenting cell vaccine - antiglobulin test - antihormone therapy - antimetabolite ... melanoma - melanoma vaccine - melphalan - MEN-10755 - MEN1 syndrome - meningeal - meningeal metastases - meningioma - ... gp100 - gp209-2M - GPX-100 - grade IV astrocytoma - graft-versus-host disease - graft-versus-tumor - granisetron - granulocyte ... human leukocyte antigen - human lymphocyte antigen - human papillomavirus - human T-cell leukemia virus type 1 - Hürthle cell ...
*  IRF4
... it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3). In ... gp100 (HMB45), and MelanA". Mod. Pathol. 16 (8): 802-10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225. FactorBook IRF4 ... 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665-76. doi ...