Glycogen synthase
The control of glycogen synthase is a key step in regulating glycogen metabolism and glucose storage. Glycogen synthase is ... Glycogen synthase is also regulated by protein phosphatase 1 (PP1), which activates glycogen synthase via dephosphorylation. ... Insulin stimulates glycogen synthase by inhibiting glycogen synthase kinases or/and activating protein phosphatase 1 (PP1) ... Wikimedia Commons has media related to Glycogen synthase. Glycogen Synthase at the U.S. National Library of Medicine Medical ...
glycogen-synthase-D) phosphatase
... glycogen synthase phosphatase, glycogen synthase D phosphatase, Mg2+ dependent glycogen synthase phosphatase, and phosphatase ... The enzyme [glycogen-synthase-D] phosphatase ({EC 3.1.3.42) catalyzes the reaction [glycogen-synthase D] + H2O ⇌ {\displaystyle ... UDP-glycogen glucosyltransferase phosphatase, UDPglucose-glycogen glucosyltransferase phosphatase, glycogen glucosyltransferase ... "Studies on glycogen synthase D phosphatase of rat liver-multiple nature". Biochim. Biophys. Acta. 350 (2): 383-91. doi:10.1016/ ...
Glycogen synthase kinase-3 beta
... , (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is ... "Entrez Gene: GSK3B glycogen synthase kinase 3 beta". Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, et ... Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a ... Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR (July 2000). "Requirement for glycogen synthase kinase-3beta in cell ...
Ribosomal s6 kinase
Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion ...
PKC alpha
Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ...
GSK3A
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. Glycogen synthase kinase 3-alpha EC ... "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput ... Glycogen synthase kinase 3 GRCh38: Ensembl release 89: ENSG00000105723 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ...
PRKD3
2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 ( ... "Entrez Gene: PRKD3 protein kinase D3". Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, ... 2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and ... 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK ...
SGK3
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB (2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by ... Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB (2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase ... Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8 ... phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. ...
PRKCD
Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8 ...
PRKCB1
Ali A, Hoeflich KP, Woodgett JR (August 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ...
PRKCG
Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8 ...
Glycogen storage disease type 0
Glycogen storage disease due to liver glycogen synthase deficiency Glycogen storage disease due to muscle and heart glycogen ... "Glycogen-Storage Disease Type 0" "Orphanet: Glycogen storage disease due to hepatic glycogen synthase deficiency". www.orpha. ... Glycogen storage disease type 0 is a disease characterized by a deficiency in the glycogen synthase enzyme (GSY). Although ... "Orphanet: Glycogen storage disease due to muscle and heart glycogen synthase deficiency". www.orpha.net. Retrieved 2017-05-31. ...
TPPP
Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta ...
Phosphorylation
... stimulates glycogen synthase, and glucose 6 phosphate may inhibit the phosphorylation of glycogen synthase by cyclic AMP- ... Glycogen is a long-term store of glucose produced by the cells of the liver. In the liver, the synthesis of glycogen is ... Villar-Palasí C, Guinovart JJ (June 1997). "The role of glucose 6-phosphate in the control of glycogen synthase". FASEB Journal ... Glucose 6-phosphate has role in regulating glycogen synthase. High blood glucose releases insulin, stimulating the ...
Notch 1
Foltz DR, Santiago MC, Berechid BE, Nye JS (June 2002). "Glycogen synthase kinase-3beta modulates notch signaling and stability ...
Anabolism
Glycogen synthase adds this UDP-glucose to a glycogen chain. Glucagon is traditionally a catabolic hormone, but also stimulates ... During periods of high blood sugar, glucose 6-phosphate from glycolysis is diverted to the glycogen-storing pathway. It is ...
Mania
Li X, Liu M, Cai Z, Wang G, Li X (2010). "Regulation of glycogen synthase kinase-3 during bipolar mania treatment". Bipolar ...
DNM1L
Hong YR, Chen CH, Cheng DS, Howng SL, Chow CC (August 1998). "Human dynamin-like protein interacts with the glycogen synthase ...
Cyclin D
Glycogen synthase kinase three beta, GSK3β, causes Cyclin D degradation by inhibitory phosphorylation on threonine 286 of the ... Diehl JA, Cheng M, Roussel MF, Sherr CJ (November 1998). "Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and ... October 2000). "The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP- ...
Phyllis Gardner (clinical pharmacologist)
Gardner, Phyllis (1997-03-28). "Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3". Science. 275 (5308): 1930- ...
NFATC1
Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR (Mar 1997). "Nuclear export of NF-ATc enhanced by glycogen synthase ...
Glucose 1-phosphate
It can then return to the greater glycogen structure via glycogen synthase. β-Glucose 1-phosphate is found in some microbes. It ... A deficiency of muscle glycogen phosphorylase is known as glycogen storage disease type V (McArdle Disease). To be utilized in ... In glycogenolysis, it is the direct product of the reaction in which glycogen phosphorylase cleaves off a molecule of glucose ... One reason that cells form glucose 1-phosphate instead of glucose during glycogen breakdown is that the very polar ...
Protein phosphatase 1
This dissociation activates glycogen synthase and converts phosphorylase a to phosphorylase b. Phosphorylase b does not bind ... In the end, phosphorylase is kept in its active form and glycogen synthase in its inactive form. In Alzheimer's, ... PP1 is important to the reciprocal regulation of glycogen metabolism by ensuring the opposite regulation of glycogen breakdown ... "Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism". The Journal of Biological ...
DYRK1A
Skurat AV, Dietrich AD (January 2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". ...
Tideglusib
... (NP-12, NP031112) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. There ... "Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib". The Journal of Biological Chemistry. 287 (2 ... "Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib". The Journal of Biological Chemistry. 287 (2 ...
DYRK2
Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol ... potential role for DYRK as a glycogen synthase kinase 3-priming kinase". Biochem. J. 355 (Pt 3): 609-15. doi:10.1042/bj3550609 ...
Polymer backbone
Buschiazzo, Alejandro (2004). "Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and ... Generally, carbohydrates which our bodies break down are alpha-linked (example: glycogen) and those which have structural ...
CRACD-like protein
Glycogen Synthase Kinase 3 Beta (GSK3B) GSK3B is a protein kinase that regulates transcription factors and microtubules. As ... "GSK3B - Glycogen synthase kinase-3 beta - Homo sapiens (Human) - GSK3B gene & protein". www.uniprot.org. Retrieved 2017-04-23. ...
MTORC1
Activation of the Wnt pathway inhibits glycogen synthase kinase 3 beta (GSK3B). When the Wnt pathway is not active, GSK3B is ...
CTP synthase 1
Higgins MJ, Graves PR, Graves LM (October 2007). "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase ... CTP synthase 1 is an enzyme that is encoded by the CTPS1 gene in humans. CTP synthase 1 is an enzyme in the de novo pyrimidine ... "Entrez Gene: CTP synthase". Kursula P, Flodin S, Ehn M, Hammarström M, Schüler H, Nordlund P, Stenmark P (July 2006). " ... June 2014). "CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation". Nature. 510 (7504): 288 ...