*  AGPAT2
1-acyl-sn-glycerol-3-phosphate acyltransferase beta is an enzyme that in humans is encoded by the AGPAT2 gene. This gene ... Aguado B, Campbell RD (Feb 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene ... lysophosphatidic acid acyltransferase, beta)". Human AGPAT2 genome location and AGPAT2 gene details page in the UCSC Genome ... "Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3". The Journal of ...
*  GPAM
Igal RA, Wang S, Gonzalez-Baró M, Coleman RA (2001). "Mitochondrial glycerol phosphate acyltransferase directs the ... Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene. Glycerol-3- ... phosphate acyltransferase (GPAT; EC 2.3.1.15), which catalyzes the initial and committing step in glycerolipid biosynthesis, is ... "Entrez Gene: GPAM glycerol-3-phosphate acyltransferase, mitochondrial". Skorve J, Ruyter B, Rustan AC, et al. (1990). "Effect ...
*  Glycerol-3-phosphate O-acyltransferase
... glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate ... In enzymology, a glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15) is an enzyme that catalyzes the chemical reaction acyl- ... The systematic name of this enzyme class is acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase. Other names in common use ... Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and ...
*  Glycerol-3-phosphate 2-O-acyltransferase
... at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Glycerol-3-phosphate 2-O-acyltransferase (EC 2.3.1.198, sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O- ... acyltransferase) is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. This enzyme catalyses ... Yang, W.; Pollard, M.; Li-Beisson, Y.; Beisson, F.; Feig, M.; Ohlrogge, J. (2010). "A distinct type of glycerol-3-phosphate ...
*  AGPAT9
... lysophosphatidic acid acyltransferase theta (LPAAT-theta), or lung cancer metastasis-associated protein 1. Glycerol-3-phosphate ... Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known ... Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate ... 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. ...
*  Phospholipid acyltransferase
1-acyl-sn-glycerol-3-phosphate acyltransferase InterPro: IPR004552 AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; AGPAT6; AGPAT7; ... This family contains acyltransferases involved in phospholipid biosynthesis and proteins of unknown function. This family also ... AYTL1; AYTL2; GNPAT; GPAM; GPAT3; LYCAT; TAZ; TMEM68; Neuwald AF (1997). "Barth syndrome may be due to an acyltransferase ...
*  2-acylglycerol-3-phosphate O-acyltransferase
The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase. This enzyme is also ... 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, ...
*  AGPAT5
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene. This gene ... lysophosphatidic acid acyltransferase, epsilon)". Human AGPAT5 genome location and AGPAT5 gene details page in the UCSC Genome ... 2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614. Strausberg RL, Feingold EA, Grouse LH, et al. ( ...
*  AGPAT3
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene. The protein ... Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6: D944-53. doi: ... 2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in ... 474 (7351): 262-3. doi:10.1038/474262a. PMID 21677718. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. ...
*  AGPAT1
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene. This gene ... Aguado B, Campbell RD (1998). "Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major ... Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6 (1): D944-53. ... 1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling ...
*  1-acylglycerol-3-phosphate O-acyltransferase
The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common ... 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. ... 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. ... Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and ...
*  List of EC numbers (EC 2)
... glycerol-phosphate) a-glucosyltransferase EC 2.4.1.53: poly(ribitol-phosphate) b-glucosyltransferase EC 2.4.1.54: undecaprenyl- ... glycerone-phosphate O-acyltransferase EC 2.3.1.43: phosphatidylcholine-sterol O-acyltransferase EC 2.3.1.44: N- ... glucose-1-phosphate cytidylyltransferase EC 2.7.7.34: glucose-1-phosphate guanylyltransferase EC 2.7.7.35: ribose-5-phosphate ... isopentenyl phosphate kinase EC 2.7.4.27: (pyruvate, phosphate dikinase)-phosphate phosphotransferase EC 2.7.4.28: (pyruvate, ...
*  Chromosome 4 (human)
... encoding enzyme Glycerol-3-phosphate acyltransferase 3 a.k.a. 1-acylglycerol-3-phosphate O-acyltransferase 9 ANK2: ankyrin 2, ... ISBN 978-3-318-02253-7. Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. ( ... 329 (5999): 1650-3. Bibcode:2010Sci...329.1650L. doi:10.1126/science.1189044. PMID 20724583. CS1 maint: Multiple names: authors ... ligand 3, scyb3 CXCL4: chemokine (C-X-C motif) ligand 4, Platelet factor-4, PF-4, scyb4 CXCL5: chemokine (C-X-C motif) ligand 5 ...
*  List of MeSH codes (D08)
... diacylglycerol o-acyltransferase MeSH D08.811.913.050.425 --- glycerol-3-phosphate O-acyltransferase MeSH D08.811.913.050.600 ... glucose-6-phosphate isomerase MeSH D08.811.399.475.200.550 --- mannose-6-phosphate isomerase MeSH D08.811.399.475.200.662 --- ... phosphatidylcholine-sterol O-acyltransferase MeSH D08.811.913.050.646 --- retinol O-fatty-acyltransferase MeSH D08.811.913.050. ... UTP-glucose-1-phosphate uridylyltransferase MeSH D08.811.913.696.445.900 --- UTP-hexose-1-phosphate uridylyltransferase MeSH ...
*  Glycerol 3-phosphate
Glycerol 1-phosphate, sometimes called as D-glycerol 3-phosphate, is an enantiomer of glycerol 3-phosphate. Most organisms use ... Acyl-CoA → Lysophosphatidic acid + CoA Glycerol-1-phosphatase removes the phosphate group of glycerol 3-phosphate to generate ... NAD(P)H + H+ → + NAD(P)+ It is also synthesized by phosphorylating glycerol generated upon hydrolyzing fats with glycerol ... glycerol, allowing glycerol fermentation to produce glycerol from glucose through glycolysis pathway. A number of microbes, ...
*  1-Lysophosphatidylcholine
This happens by the migration of the acyl group from the sn-1 position of the glycerol backbone to the sn-2 position. The ... In contrast to these finding from rat liver microsomes, mammalian acyl transferase from dog lungs was found to exhibit no ... 2-acylglycerophosphocholine O-acyltransferase, an enzyme purified in liver microsomes, catalyzes specifically the acylation of ... M. F. Frosolono; Slivka, S; Charms, BL (1971-01-01). "Acyl transferase activities in dog lung microsomes". Journal of Lipid ...
*  Cardiolipin
The hydroxyl groups (-OH and -O−) on phosphate would form a stable intramolecular hydrogen bond with the centered glycerol's ... Two phosphatidic acid moieties connect with a glycerol backbone in the center to form a dimeric structure. So it has four alkyl ... Since there are two phosphates in the molecule, each of them can catch one proton. Although it has a symmetric structure, ... The first step is the acylation of glycerol-3-phosphate by a glycerol-3-phosphate acyltransferase. Then acylglycerol-3- ...
*  Biosynthesis
... all of these steps are catalyzed by the glycerol phosphate acyltransferase enzyme. Phospholipid synthesis continues in the ... High energy molecules, such as ATP, have three phosphates. Often, the terminal phosphate is split off during hydrolysis and ... Phosphate addition to UMP is catalyzed by a kinase enzyme. The enzyme CTP synthase catalyzes the next reaction step: the ... Tetrahydrodipicolinate acyltransferase catalyzes the acetylation reaction that results in ring opening and yields N-acetyl α- ...
*  Platensimycin
An N-acyltransferase reaction of tetracyclic enone and aminobenzoic acid would lead to platensimycin. Because of the ... also glycerol) are part of the glycolytic pathway, varying levels of incorporations are expected. Thus, the terpenoid building ... 1] A first total synthesis of racemic platensimycin has been published.[7] Its structure consists of a 3-amino-2,4- ... the thiol group of FabF Cys163 is activated through the dipole moment of helix N-alpha-3 which lowers the pKa of this ...
*  Phosphatidic acid
PA is a unique phospholipid in that it has a small highly charged head group that is very close to the glycerol backbone. PA is ... This will show whether the phosphate group is newly derived from the kinase activity or whether it originates from the PC. ... Different acyltransferases also have different intracellular distributions, such as the endoplasmic reticulum (ER), the ... PA is degraded by conversion into DAG by lipid phosphate phosphohydrolases (LPPs) or into lyso-PA by phospholipase A (PLA). The ...
*  Chromosome 12 (human)
... encoding protein Glycerol-3-phosphate dehydrogenase 1 GOLT1B: Golgi transport 1B GPN3: encoding enzyme GPN-loop GTPase 3 HNF1A- ... Stuttering Triose Phosphate Isomerase deficiency tyrosinemia Von Willebrand Disease G-banding ideograms of human chromosome 12 ... encoding enzyme Lysophospholipid acyltransferase 5 METTL1: encoding enzyme tRNA (guanine-N(7)-)-methyltransferase MFAP5: ... encoding protein Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma PIWIL1: encoding protein Piwi-like protein 1 POP5: ...
*  Diglyceride
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol ... which is formed in the addition of a third fatty acid to the diacylglycerol under the catalysis of diglyceride acyltransferase ... which is derived primarily from dihydroxyacetone phosphate, a product of glycolysis (usually in the cytoplasm of liver or ... Glycerol-3-phosphate is first acylated with acyl-coenzyme A (acyl-CoA) to form lysophosphatidic acid, which is then acylated ...
*  Alkylglycerophosphate 2-O-acetyltransferase
Lee TC, Malone B, Snyder F (1986). "A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of ... This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl ... The systematic name of this enzyme class is acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase. This enzyme is ... Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen". J. Biol. Chem. 261 ( ...
*  Glycerophospholipid
... the two fatty acid chains and the phosphate group attached to the glycerol backbone. In this Kennedy pathway, Choline is ... Acyltransferases in bacterial glycerophospholipid synthesis". J Lipid Res. 49 (9): 1867-1874. doi:10.1194/jlr.R800005-JLR200. ... enyl residue attached to the glycerol moiety. The alcohol here is glycerol, to which two fatty acids and a phosphoric acid are ... The phosphate serves as a link to another alcohol-usually ethanolamine, choline, serine, or a carbohydrate. The identity of the ...
*  Triglyceride
... s are chemically tri esters of fatty acids and glycerol. Triglycerides are formed by combining glycerol with three ... Diglyceride acyltransferase, enzyme responsible for triglyceride biosynthesis Medium-chain triglycerides Lipid profile Lipids ... via gluconeogenesis by conversion into dihydroxyacetone phosphate and then into glyceraldehyde 3-phosphate, for brain fuel when ... The glycerol molecule has three hydroxyl (HO-) groups. Each fatty acid has a carboxyl group (-COOH). In triglycerides, the ...
*  High-density lipoprotein
FFA and glycerol must be activated prior to the synthesis of TGs into Acyl-CoA and glycerol-3-phosphate respectively. ... Phospholipids: Phospholipids are TGs that are covalently bonded to a phosphate group by an ester linkage. Phospholipids perform ... Niacin (vitamin B3) increases HDL by selectively inhibiting hepatic diacylglycerol acyltransferase 2, reducing triglyceride ... TGs (triglycerides): TGs are formed by combining glycerol with three molecules of fatty acid. TGs, as major components of VLDL ...