Arsenic biochemistry
... compound by Glutathione S-Transferase Omega-1 (GTSO1). The other route uses glutathione (GSH) to conjugate with arsenic (III) ... This compound is then converted to a mono-methylated arsenic (III) compound using Glutathione S-Transferase Omega-1 (GSTO1). ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... These sulfur-containing compounds are normally glutathione and the amino acid cysteine. Arsenite derivatives generally have ...
Cyclin-dependent kinase 5
Glutathione S-transferase P enzyme, encoded by the GSTP1 gene, causes a negative regulation, or reduction, of Cdk5 activity. ...
Leukotriene-C4 synthase
... glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11, ... particulate glutathione S-transferase". Arch. Biochem. Biophys. 230 (2): 455-65. doi:10.1016/0003-9861(84)90426-0. PMID 6324687 ... The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common ... glutathione This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. ...
Codling moth
Glutathione-S-transferase is an enzyme that catalyzes a detoxification process involving a conjugation of glutathione into ... This is believed to be caused by increase in the metabolically costly activities of oxidase and glutathione-S-transferase. ...
Flamingo tongue snail
The Role of Glutathione Transferases in Consumer Tolerance of Dietary Prostaglandins. PLOS One 5(1): e8537. doi:10.1371/journal ...
Varicocele
Tobacco smoking and mutations in the gene expressing glutathione S-transferase Mu 1 both put men at risk for infertility; these ...
Pregnane X receptor
In addition, PXR up regulates the expression of phase II conjugating enzymes such as glutathione S-transferase and phase III ... Falkner KC, Pinaire JA, Xiao GH, Geoghegan TE, Prough RA (September 2001). "Regulation of the rat glutathione S-transferase A2 ...
Stephanie J. London
... glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China". The ...
Estradiol sulfate
Although inactive at steroid hormone receptors, E2S has been found to act as a potent inhibitor of glutathione S-transferase, ... Singh D, Pandey RS (1996). "Glutathione-S-transferase in rat ovary: its changes during estrous cycle and increase in its ... an enzyme that contributes to the inactivation of estradiol via conversion of it into an estradiol-glutathione conjugate. As ...
Enzyme promiscuity
Consequently, glutathione S-transferases (GSTs) and cytochrome P450 monooxygenases (CYPs) are termed multispecific or broad- ... including overexpression of the large component of a synthase in the absence of the amine transferase subunit), pathway bypass ...
Detoxification
Sheehan D, Meade G, Foley V, Dowd C (2001). "Structure, function and evolution of glutathione transferases: implications for ... and glutathione S-transferases. These processes are particularly well-studied as part of drug metabolism, as they influence the ...
Cysteinyl leukotriene receptor 1
"Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the ... glutathione) to carbon 6 of the intermediate thereby forming LTC4 synthase. LTC4 then exits its cells of origin through the ...
Methyl-CpG-binding domain protein 2
"Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene ...
Daminozide
... potential was assessed by comparing the number and area of preneoplastic foci positive for the glutathione S-transferase ...
MAPK8
Wang T, Arifoglu P, Ronai Z, Tew KD (June 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase ( ...
Mitochondrial membrane transport protein
Sam37 and Sam35 have a conformation similar to glutathione-S-transferase, except they do not possess residues required for ...
Epididymis
The antioxidant proteins produced include catalase, glutathione peroxidases, glutathione-S-transferases, peroxiredoxins, ...
Cornu aspersum
... under stress have skin-regenerative properties because of antioxidant superoxide dismutase and glutathione S-transferase (GSTs ...
Etacrynic acid
Ethacrynic acid and its glutathione-adduct are potent inhibitors of glutathione S-transferase family members, which are enzymes ...
ERCC1
... and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer". Annals of Oncology. ...
Immunoprecipitation
Examples of tags in use are the green fluorescent protein (GFP) tag, glutathione-S-transferase (GST) tag and the FLAG-tag tag. ...
NDUFV1
... ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13". ...
His-tag
Protein tag Maltose-binding protein-tag SpyTag Glutathione S-transferase-tag Hochuli E, Bannwarth W, Döbeli H, Gentz R, Stüber ...
Constitutive androstane receptor
... and glutathione-S-transferases. Ligands binding to CAR include bilirubin, a variety of foreign compounds, steroid hormones, and ...
Epitalon
... glutathione peroxidase, and glutathione-S-transferase. Epitalon reduced the number of spontaneous tumors and the number of ...
NAD(P)H dehydrogenase (quinone 1)
... glutathione S-transferase M1 and quinone oxidoreductase 1 and 2". Biochem. Biophys. Res. Commun. 288 (4): 887-92. doi:10.1006/ ...
Estrogen receptor alpha
... glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean ...
NFE2L2
The glutathione S-transferase (GST) family includes cytosolic, mitochondrial, and microsomal enzymes that catalyze the ... February 2000). "The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse ... After detoxification by glutathione (GSH) conjugation catalyzed by GSTs, the body can eliminate potentially harmful and toxic ... Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most ...
Triple-negative breast cancer
... cells rely on glutathione-S-transferase Pi1, and an inhibitor (LAS17) shows encouraging results ...
MPGES-1
2003). "Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is ... 2000). "Human glutathione dependent prostaglandin E synthase: gene structure and regulation". FEBS Lett. 471 (1): 78-82. doi: ... The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been ... 1989). "Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a ...