Glutamate dehydrogenase
Wootton JC (February 1983). "Re-assessment of ammonium-ion affinities of NADP-specific glutamate dehydrogenases. Activation of ... In humans the relevant genes are called GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2), and there are ... L-Glutamate Dehydrogenase, in The Enzymes, Vol VII. Academic Press. pp. 3-24. Frieden C (May 1965). "Glutamate Dehydrogenase. ... as glutamate dehydrogenase equilibrium favours the production of ammonia and α-ketoglutarate. Glutamate dehydrogenase also has ...
John Fincham
NADP-specific glutamate dehydrogenase) gene". Gene. 26 (2-3): 253-260. doi:10.1016/0378-1119(83)90195-6. PMID 6231215. Kinnaird ... glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe". Gene. 20 (3): 387-396. doi: ... using mutants of Neurospora crassa deficient in a specific enzyme called glutamate dehydrogenase. Fincham was appointed first ...
Glutamate-5-semialdehyde dehydrogenase
... semialdehyde dehydrogenase (NADP), the second enzyme in the pathway". Biochimica et Biophysica Acta. 244 (1): 129-34. doi: ... glutamate semialdehyde dehydrogenase, and glutamate-gamma-semialdehyde dehydrogenase. This enzyme participates in urea cycle ... a glutamate-5-semialdehyde dehydrogenase (EC 1.2.1.41) is an enzyme that catalyzes the chemical reaction L-glutamate 5- ... The systematic name of this enzyme class is L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating). Other names in ...
Glutamate dehydrogenase 1
This site binds NAD(H) ~ 10-fold better than NADP(H) with the reduced forms better than the oxidized forms. Although it has ... GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ... "Entrez Gene: glutamate dehydrogenase 1". Won JG, Tseng HS, Yang AH, Tang KT, Jap TS, Lee CH, Lin HD, Burcus N, Pittenger G, ... Smith TJ, Schmidt T, Fang J, Wu J, Siuzdak G, Stanley CA (May 2002). "The structure of apo human glutamate dehydrogenase ...
Nicotinamide adenine dinucleotide phosphate
... isocitrate dehydrogenase (IDH), and glutamate dehydrogenase. In these reactions, NADP+ acts like NAD+ in other enzymes as an ... Bacteria can also use a NADP-dependent glyceraldehyde 3-phosphate dehydrogenase for the same purpose. Like the pentose ... The isocitrate dehydrogenase mechanism appears to be the major source of NADPH in fat and possibly also liver cells. These ... In 2018 and 2019, the first two reports of enzymes that catalyze the removal of the 2' phosphate of NADP(H) in eukaryotes ...
Glutamate-5-semialdehyde
Phosphate-Dependent Glutamate-semialdehyde Dehydrogenase (NADP), the Second Enzyme in the Pathway". Biochim. Biophys. Acta. 244 ... It is synthesized by the reduction of glutamyl-5-phosphate by glutamate-5-semialdehyde dehydrogenase. Reduction of glutamic ... Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in both the biosynthesis and degradation of proline and ... Glutamate-1-semialdehyde Baich A (1971). "The Biosynthesis of Proline in Escherichia coli: ...
Malaria antigen detection tests
Glutamate dehydrogenase provides an oxidizable carbon source used for the production of energy as well as a reduced electron ... Both nicotinamide adenine dinucleotide (NAD) [EC 1.4.1.2] and nicotinamide adenine dinucleotide phosphate (NADP) dependent ... Werner C, Stubbs MT, Krauth-Siegel RL, Klebe G (2005). "The crystal structure of Plasmodium falciparum glutamate dehydrogenase ... 1986). "Antibodies to the glutamate dehydrogenase of Plasmodium falciparum" (PDF). Parasitology. 92 (2): 313-324. doi:10.1017/ ...
Oxidative deamination
... which can be oxidatively deaminated by the enzyme glutamate dehydrogenase (GDH), using NAD or NADP as a coenzyme. This reaction ... Glutamate dehydrogenase play an important role in oxidative deamination LibreTexts, Chemistry (29 August 2020). "Stage II of ... Glutamate can then be regenerated from α-KG via the action of transaminases or aminotransferase, which catalyze the transfer of ... In this manner, an amino acid can transfer its amine group to glutamate, after which GDH can then liberate ammonia via ...
ELFV dehydrogenase
Glutamate dehydrogenases EC 1.4.1.2, EC 1.4.1.3 and EC 1.4.1.4 (GluDH) are enzymes that catalyse the NAD- and/or NADP-dependent ... the ELFV dehydrogenase family of enzymes include glutamate, leucine, phenylalanine and valine dehydrogenases. These enzymes are ... Valine dehydrogenase EC 1.4.1.8 (ValDH) is an NADP-dependent enzyme that catalyses the reversible deamidation of L-valine into ... Benachenhou-Lahfa N, Forterre P, Labedan B (April 1993). "Evolution of glutamate dehydrogenase genes: evidence for two ...
Succinate-semialdehyde dehydrogenase (NADP+)
NADP-dependent succinate-semialdehyde dehydrogenase, GabD) is an enzyme with systematic name succinate-semialdehyde:NADP+ ... 2 H+ This enzyme participates in the degradation of glutamate and 4-aminobutyrate. Bartsch K, von Johnn-Marteville A, Schulz A ... Succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79, succinic semialdehyde dehydrogenase (NADP+), succinyl semialdehyde ... December 1990). "Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate: ...
Dehydrogenase
acetaldehyde dehydrogenase alcohol dehydrogenase Delta12-fatty acid dehydrogenase glutamate dehydrogenase (an enzyme that can ... sorbitol dehydrogenase TCA cycle examples: isocitrate dehydrogenase (uses NAD+, also has an isozyme that uses NADP) alpha- ... ketoglutarate dehydrogenase (uses NAD+) succinate dehydrogenase (uses FAD) malate dehydrogenase (uses NAD+) An IUPAC panel on ... In the above case, the dehydrogenase has transferred a hydride while releasing a proton, H+, but dehydrogenases can also ...
Aldehyde dehydrogenase 3 family, member A1
Aldehyde dehydrogenase, dimeric NADP-preferring is an enzyme that in humans is encoded by the ALDH3A1 gene. Aldehyde ... A water molecule enters the active site and is subsequently activated by a glutamate residue. The activated water then attacks ... Overview of all the structural information available in the PDB for UniProt: P30838 (Aldehyde dehydrogenase, dimeric NADP- ... "Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. ' ...
Gab operon
gabD : encodes an NADP-dependent succinic semialdehyde dehydrogenase, which oxidizes succinic semialdehyde to succinate. gabP ... It is also known to maintain high internal glutamate concentrations under stress conditions. The expression of genes in the ... Succinate semialdehyde is then oxidized into succinate by succinate semialdehyde dehydrogenase which is encoded by the gabP ... that encode for a succinate semialdehyde dehydrogenase, GABA transaminase and a GABA permease respectively. There is a ...
List of MeSH codes (D08)
... glutamate dehydrogenase MeSH D08.811.682.664.500.410 - glutamate dehydrogenase (nadp+) MeSH D08.811.682.664.500.470 - glutamate ... dihydrouracil dehydrogenase (nad+) MeSH D08.811.682.660.350 - dihydrouracil dehydrogenase (nadp) MeSH D08.811.682.660.385 - ... betaine-aldehyde dehydrogenase MeSH D08.811.682.657.163.562 - glutamate-5-semialdehyde dehydrogenase MeSH D08.811.682.657. ... methylenetetrahydrofolate dehydrogenase (nad+) MeSH D08.811.682.662.253 - methylenetetrahydrofolate dehydrogenase (nadp) MeSH ...
Alpha-aminoadipic semialdehyde synthase
Glutamate is an important compound within the body which acts as a neurotransmitter tied to learning and Huntington's disease. ... GCDH is deficient in glutaric aciduria type 1. The intermediate 2-oxoadipate is metabolized by 2-oxoadipate dehydrogenase, ... "Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia". Human ... "About Glutamate Toxicity". Huniting Disease Outreach for Education at Stanford (HOPES). Huntington's Disease Society of America ...
Morpheein
Frieden, C; Colman, R F (1967). "Glutamate dehydrogenase concentration as a determinant in the effect of purine nucleotides on ... Gerald e, Edwards; Carlos s, Andreo (1992). "NADP-malic enzyme from plants". Phytochemistry. 31 (6): 1845-57. doi:10.1016/0031- ... Huang, CY; Frieden, C (1972). "The mechanism of ligand-induced structural changes in glutamate dehydrogenase. Studies of the ... Fisher, Harvey F. (2006). "Glutamate Dehydrogenase-ligand Complexes and Their Relationship to the Mechanism of the Reaction". ...
Flavin adenine dinucleotide
... isovaleryl-CoA dehydrogenase), isoleucine, (short/branched-chain acyl-CoA dehydrogenase), valine (isobutyryl-CoA dehydrogenase ... Glutamate synthase catalyzes the conversion of 2-oxoglutarate into L-glutamate with L-glutamine serving as the nitrogen source ... The FAD of AR is reduced to FADH2 by transfer of two electrons from NADPH that binds in the NADP-binding domain of AR. The ... components of the succinate dehydrogenase complex, α-ketoglutarate dehydrogenase, and a component of the pyruvate dehydrogenase ...
Folate
Each step consumes one molecule of NADPH (biosynthetically derived from vitamin B3) and produces one molecule of NADP. ... The folate molecule is synthesized from pterin pyrophosphate, para-aminobenzoic acid, and glutamate through the action of ... A second enzyme, methylenetetrahydrofolate dehydrogenase (MTHFD2) oxidizes 5,10-methylenetetrahydrofolate to an iminium cation ... Christensen KE, Mackenzie RE (2008). "Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate ...
Cofactor engineering
Inactivating the expression of the enzyme glutamate dehydrogenase, which is NADPH dependent, and over expressing the enzymes ... the researchers found that NADP-dependent alcohol dehydrogenase (YqhD) from E. coli to be effective for the pathway. ... Furthermore, the researchers needed a dehydrogenase to replace the aldehyde dehydrogenase capacity of AdhE2. CoA-acylating ... In 2010, a group of scientists performed cofactor engineering on the enzyme Gre2p, an NADPH-preferring dehydrogenase found in ...
Amphibolic
Phosphofructokinase and pyruvate dehydrogenase". Biochemistry. 7 (11): 4041-4045. doi:10.1021/bi00851a035. PMID 4301881. Pandey ... glutamate and aspartate. The first reaction of the cycle, in which oxaloacetate (a four-carbon compound) condenses with acetate ... with the concomitant reduction of NADP. By conventional glyceraldehyde-3-phosphate oxidation to pyruvate, one NAD is reduced ...
List of EC numbers (EC 5)
NADP-retinol dehydrogenase; EC 2.3.1.135, phosphatidylcholine-retinol O-acyltransferase; EC 3.1.1.64, retinoid isomerohydrolase ... glutamate-1-semialdehyde 2,1-aminomutase EC 5.4.3.9: glutamate 2,3-aminomutase EC 5.4.3.10: phenylalanine aminomutase (L-β- ... EC 5.1.1.1: alanine racemase EC 5.1.1.2: methionine racemase EC 5.1.1.3: glutamate racemase EC 5.1.1.4: proline racemase EC 5.1 ... UDP-N-acetyl-α-D-muramoyl-L-alanyl-L-glutamate epimerase * EC 5.1.1.24: histidine racemase * *No Wikipedia article EC 5.1.2.1: ...
NOXRED1
NADP Dependent Oxidoreductase Domain Containing 1 (NOXRED1) is a human protein encoded by the gene NADP-Dependent ... "ALDH18A1 aldehyde dehydrogenase 18 family member A1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022 ... Ornithine aminotransferase is an enzyme that converts arginine and ornithine into glutamate and GABA. Both of these proteins ... NADP-dependent oxidoreductase domain-containing protein 1 (NOXRED1) is a protein which in humans is encoded by the gene NOXRED1 ...
Tumor metabolome
... which is catalysed by NADP-dependent isocitrate dehydrogenase 1 (IDH1) and IDH2 and have been found linked to tumorigenesis in ... These tumors use glutamine or the structurally related amino acid glutamate as an energy source and a chemotactic sensor in the ... HIF1 then would activate the pyruvate dehydrogenase kinase (PDKs), which inactivate the mitochondrial pyruvate dehydrogenase ... In preclinical studies, drugs such as 6-amino-nicotinamide (6-AN), which inhibits G6P dehydrogenase, the enzyme that initiates ...
List of enzymes
Alcohol dehydrogenase (NAD) EC 1.1.1.1 Alcohol dehydrogenase (NADP) EC 1.1.1.2 Homoserine dehydrogenase EC 1.1.1.3 ... L-glutamate ligase EC 6.2.1.40: 4-hydroxybutyrate-CoA ligase EC 6.2.1.41: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H- ... Acetaldehyde dehydrogenase EC 1.2.1.10 Glyceraldehyde 3-phosphate dehydrogenase EC 1.2.1.12 Pyruvate dehydrogenase EC 1.2.1.51 ... L-xylulose reductase EC 1.1.1.10 Lactate dehydrogenase EC 1.1.1.27 Malate dehydrogenase EC 1.1.1.37 Isocitrate dehydrogenase EC ...
List of EC numbers (EC 1)
... glutamate dehydrogenase EC 1.4.1.3: glutamate dehydrogenase (NAD(P)+) EC 1.4.1.4: glutamate dehydrogenase (NADP+) EC 1.4.1.5: L ... malate dehydrogenase [NAD(P)+)] EC 1.1.1.300: NADP-retinol dehydrogenase EC 1.1.1.301: D-arabitol-phosphate dehydrogenase EC ... L-glutamate-forming) EC 1.5.1.10: saccharopine dehydrogenase (NADP+, L-glutamate-forming) EC 1.5.1.11: D-octopine dehydrogenase ... EC 1.1.1.1: alcohol dehydrogenase EC 1.1.1.2: alcohol dehydrogenase (NADP+) EC 1.1.1.3: homoserine dehydrogenase EC 1.1.1.4: (R ...