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*  ATP-binding cassette transporter
... different types of drugs can be used or the ABC transporters themselves must be inhibited. For other types of drugs to work ... "Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and ... The type II ABC importer fold is observed in the twenty TM helix-domain of BtuCD and in Hi1471, a homologous transporter from ... Nickel Uptake Transporter (NiT) Methionine Uptake Transporter (MUT) 2.A.52 Nickel/Cobalt Uptake Transporter (NiCoT) 3.A.1.106 ...
*  Glucose transporter
GLUT is a type of uniporter transporter protein. Most non-autotrophic cells are unable to produce free glucose because they ... Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. ... Each glucose transporter isoform plays a specific role in glucose metabolism determined by its pattern of tissue expression, ... Thorens B (1996). "Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes". Am. J. Physiol. 270 ...
*  GLUT3
Glucose Transporter Type 3 at the US National Library of Medicine Medical Subject Headings (MeSH). ... GLUT3 is considered the main but not the exclusive neuronal glucose transporter, whereas other glucose transporters have also ... 1998). "Glucose transporter expression in brain: relationship to cerebral glucose utilization". Dev. Neurosci. 20 (4-5): 369-79 ... Vannucci SJ, Maher F, Simpson IA (September 1997). "Glucose transporter proteins in brain: delivery of glucose to neurons and ...
*  Nerve tissue protein
Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 Protein Glucose Transporter Type 3 Hu ... There are two types of myelin the first is ogliodendrocyte- Myelin which can be found in the mammalian Central Nervous System ( ... In caspase-3 the 'hook' and 'sinker' attach. Both the BIR2 and BIR3 have a groove that is predominately negatively charged. ... 3 (6): 401-10. doi:10.1038/nrm830. PMID 12042762. Lindholm, Dan; Mercer, Eric A; Yu, Li-Ying; Chen, Yuming; Kukkonen, Jyrki; ...
*  SLC37A4
1999). "Mutations in the glucose-6-phosphate transporter (G6PT) gene in patients with glycogen storage diseases type 1b and 1c ... 1999). "Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b". J. Biol. Chem. 274 (9): ... 1999). "Glycogen storage disease type Ib: structural and mutational analysis of the microsomal glucose-6-phosphate transporter ... 1999). "The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type ...
*  Blood-brain barrier
"Facilitated glucose transporter protein type 1 (GLUT1) deficiency syndrome: impaired glucose transport into brain-a review". ... Genetic defects in glucose transporter type 1 (GLUT1) appears to be the primary cause of De Vivo disease. Some evidence ... including carrier-mediated transporters such as glucose and amino acid carriers; receptor-mediated transcytosis for insulin or ... "GLUT1 deficiency and other glucose transporter diseases". European Journal of Endocrinology. 150 (5): 627-33. doi:10.1530/eje. ...
*  Human T-lymphotropic virus 2
HTLV-II entry in target cells is mediated by the glucose transporter GLUT1. HTLV-II has not been clearly linked to any disease ... Roucoux DF, Murphy EL (2004). "The epidemiology and disease outcomes of human T-lymphotropic virus type II". AIDS Rev. 6 (3): ... Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL (November 2003). "The ubiquitous glucose transporter GLUT-1 is a ... November 2008). "Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection". Blood. 112 ...
*  Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
"Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes". Cell. ... It has been proposed that the MGAT4A isoenzyme acts as a toggle for developing of type 2 diabetes. Mice that lack MGAT4A are ... If this mechanism also operates in human islets, MGAT4A may represent a link between type 2 diabetes and high-fat diet. GRCh38 ... Thorens B (Apr 2006). "A toggle for type 2 diabetes?". The New England Journal of Medicine. 354 (15): 1636-8. doi:10.1056/ ...
*  Major facilitator superfamily
These include a fungal phosphate transporter PiPT, plant nitrate transporter NRT1.1, and the human glucose transporter GLUT1. ... Atypical MFS Transporter Families), suggesting there are at least 64 different families including SLC proteins of MFS type. Pao ... Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N (June 2014). "Crystal structure of the human glucose transporter GLUT1". Nature. ... Pascual JM, Wang D, Lecumberri B, Yang H, Mao X, Yang R, De Vivo DC (May 2004). "GLUT1 deficiency and other glucose transporter ...
*  Tumor hypoxia
"Synergistic up-regulation of Hexokinase-2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose ... GLUT1 is the most abundantly expressed of the family thought to maintain basal glucose transport in almost all cell types. ... "Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes." Science 235.4795 (1987 ... "Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc." Journal of Biological Chemistry 275.29 (2000): ...
*  Insulin
Glucose enters the β-cells through the glucose transporters, GLUT2. These glucose transporters have a relatively low affinity ... This results in type 1 diabetes mellitus, which is characterized by abnormally high blood glucose concentrations, and ... If the carbohydrates include glucose, then that glucose will be absorbed into the bloodstream and blood glucose level will ... at high blood glucose concentrations large quantities of glucose enter these cells. The glucose that enters the β-cell is ...
*  SLC2A10
2001). "Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome ... 2003). "Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary ... SLC2A10 is a member of the facilitative glucose transporter family, which plays a significant role in maintaining glucose ... Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene. ...
*  Astrocyte
Marty N (2005). "Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors ... GluT type: these express glutamate transporters (EAAT1/SLC1A3 and EAAT2/SLC1A2) and respond to synaptic release of glutamate by ... astrocytes can fuel neurons with glucose during periods of high rate of glucose consumption and glucose shortage. Recent ... GluR type: these express glutamate receptors (mostly mGluR and AMPA type) and respond to synaptic release of glutamate by ...
*  Bioenergetics
Half a century later this idea has turned into one of the most studied of all transporter proteins (SGLT1), the sodium-glucose ... Peter Mitchell (1961). "Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism". ... Glycolysis is the process of breaking down glucose into pyruvate, producing two molecules of ATP (per 1 molecule of glucose) in ... Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose ...
*  Red blood cell
... glucose and L-dehydroascorbic acid transporter; Kidd antigen protein - urea transporter; RhAG - gas transporter, probably of ... The blood type (A, B, AB, or O) or the blood product is identified. This relates to the presence of antigens on the cell's ... interaction with the Glut1 glucose transporter. The zeta potential is an electrochemical property of cell surfaces that is ... The blood types of humans are due to variations in surface glycoproteins of red blood cells. Disorders of the proteins in these ...
*  GLUT2
Glucose Transporter Type 2 at the US National Library of Medicine Medical Subject Headings (MeSH). ... Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a ... GLUT2 could reasonably be referred to as the "diabetic glucose transporter" or a "stress hyperglycemia glucose transporter." ... It is the principal transporter for transfer of glucose between liver and blood, and has a role in renal glucose reabsorption. ...
*  Sodium-glucose transport proteins
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found ... SGLT2 inhibitors, also called gliflozins, are used in the treatment of type 2 diabetes. Examples include dapagliflozin (Farxiga ... glucose is excreted in urine (glucosuria) because SGLT are saturated with the filtered glucose. Glucose is never secreted by a ... These co-transporters are an example of secondary active transport. Members of the GLUT family of glucose uniporters then ...
*  Glucose 6-phosphatase
... glucose-6-phosphatase-α), glucose-6-transporter (G6PT), and glucose-6-phosphatase-β (glucose-6-phosphatase-β or G6PC3) subunits ... The third type of glucose-6-phosphatase deficiency, glucose-6-phosphatase-β deficiency, is characterized by a congenital ... resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter ... Glucose-6-phosphatase is a complex of multiple component proteins, including transporters for G6P, glucose, and phosphate. The ...
*  MsiK RNA motif
MsiK, the protein encoded by msiK genes, is the ATPase subunit within certain ABC-type membrane transporter proteins. MsiK is ... it was suggested that msiK RNAs are probably not involved in sensing glucose themselves, but are more likely a part of a ... 11 (3): R31. doi:10.1186/gb-2010-11-3-r31. PMC 2864571 . PMID 20230605. Bertram R, Schlicht M, Mahr K, Nothaft H, Saier MH, ...
*  Symporter
... a type of cotransporter. The transporter is called a symporter, because the molecules will travel in the same direction in ... If this symporter did not exist, individual sodium channels and glucose uniporters would not be able to transfer glucose ... A symporter is an integral membrane protein that is involved in the transport of many differing types of molecules across the ... This is in contrast to the antiport transporter. Typically, the ion(s) will move down the electrochemical gradient, allowing ...
*  Autoinducer-2
AI-2 is actively transported by the Lsr ABC-type transporter into the cell in Enterobacteriaceae and few other bacterial taxa ( ... AI-2 signalling is also regulated by glucose and cAMP/CRP via the lsr operon. In the presence of glucose, low levels of cAMP/ ... Without glucose, cAMP-CRP is needed to stimulate the lsr expression, while LsrR represses its expression in the absence of the ... "Detection of AI-2 receptors in genomes of Enterobacteriaceae suggests a role of type-2 quorum sensing in closed ecosystems". ...
*  Membrane transport protein
Excitatory amino acid transporters (EAATs) EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 Glucose transporter Monoamine transporters, including ... ATP-binding cassette transporter (ABC transporter), such as MDR, CFTR V-type ATPase ; ( "V" related to vacuolar ). P-type ... Dopamine transporter (DAT) Norepinephrine transporter (NET) Serotonin transporter (SERT) Vesicular monoamine transporters (VMAT ... The two main types of proteins involved in such transport are broadly categorized as either channels or carriers. The solute ...
*  Glut1 deficiency
... the protein that transports glucose across the blood brain barrier also known as Glucose transporter type 1 deficiency syndrome ... Because glucose is the primary source of fuel for the brain, patients with Glut1 Deficiency have insufficient cellular energy ... Other seizure types may occur, including generalized tonic clonic, focal, myoclonic, atypical absence, atonic, or unclassified ... The Glut1 protein that transports glucose across the blood brain barrier is made by the SLC2A1 gene, located on chromosome 1. ...
*  Human T-lymphotropic virus 1
Manel N, Kim FJ, Kinet S, Taylor N, Sitbon M, Battini JL (November 2003). "The ubiquitous glucose transporter GLUT-1 is a ... The most widespread genotype is type A. Types B, D, E, F and G have only been isolated from Central Africa. Type C is only ... Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma ... a glucose transporter, on target cells. HTLV-1 is also associated with adult T-cell leukemia/lymphoma and has been quite well ...
*  List of proteins
... receptor GABAa receptors Voltage-gated ion channels Potassium channels Calcium channels Sodium channels Glucose transporter ... For more information about categorizing protein types, see List of types of proteins. Arp2/3 Coronin Dystrophin FtsZ Keratin ...
*  Prostaglandin-endoperoxide synthase 2
Legan M (August 2010). "Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of ... Consequently, inhibiting PTGS2 (COX-2) may have benefit in the prevention and treatment of these types of cancer. COX-2 ... 73 (3-4): 141-62. doi:10.1016/j.plefa.2005.05.002. PMID 16005201. Wang Q1, He Y, Shen Y, Zhang Q, Chen D, Zuo C, Qin J, Wang H ... 51 (3): 575-85. doi:10.1194/jlr.M001719. PMC 2817587 . PMID 19752399. Serhan CN (2005). "Lipoxins and aspirin-triggered 15-epi- ...
*  Glyceroneogenesis
Glucose transporter 4, also known as GLUT 4 (Figure 6) is the transporter protein of glucose which intakes extracellular ... Type 2 diabetes is a metabolic disorder caused by high level of blood glucose and blood lipid. Type2 diabetes can be caused by ... is usually synthesized from glucose through glycolysis. Glucose will be degraded though glycolysis until fructose 1,6- ... However, when the glucose level of in the cell drops in situations like fasting, white adipose tissue generates glycerol 3- ...