Steroid-induced osteoporosis
The synthetic glucocorticoid prescription drug prednisone is a main candidate after prolonged intake. Bisphosphonates are ... Steroid-induced osteoporosis is osteoporosis arising from the use of glucocorticoids (a class of steroid hormones) analogous to ... All patients on long term glucocorticoids (≥3 months) should be encouraged to do weightbearing exercise, avoid smoking and ... It is also known as glucocorticoid-induced osteoporosis. Mechanisms of SIOP include: Direct inhibition of osteoblast function ...
Phenylethanolamine N-methyltransferase
Glucocorticoids have also been shown to increase the biological half life of the enzyme in vitro. In animals who have had their ... PNMT is known to be regulated by glucocorticoids made in the adrenal gland. One way that it can regulate PNMT expression is by ... Wong DL, Lesage A, Siddall B, Funder JW (November 1992). "Glucocorticoid regulation of phenylethanolamine N-methyltransferase ... elevation by stress in a glucocorticoid-dependent manner". American Journal of Physiology. Heart and Circulatory Physiology. ...
Phyllodes tumor
Certain receptors include estrogen/progesterone, glucocorticoid, and HER2. The most well-studied cell signal transduction ...
11-Ketoprogesterone
However, it is non-toxic even in high dosages, suggesting that it lacks conventional glucocorticoid activity, and it does not ... Harrison RW, Balasubramanian K, Yeakley J, Fant M, Svec F, Fairfield S (1979). "Heterogeneity of AtT-20 Cell Glucocorticoid ... 11-Ketoprogesterone may act through membrane glucocorticoid receptors. 11-Ketoprogesterone is reportedly devoid of androgenic, ...
Golfer's elbow
A more invasive treatment is the injection into and around the inflamed and tender area of a glucocorticoid (steroid) agent. ... Jacobs, J.W.G.; Michels-van Amelsfort, J.M.R. (April 2013). "How to perform local soft-tissue glucocorticoid injections?". Best ...
GAS5
Garabedian MJ, Logan SK (2010). "Glucocorticoid receptor DNA binding decoy is a gas". Sci Signal. 3 (108): pe5. doi:10.1126/ ... acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene ... "Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor". Sci Signal. 3 (107 ...
Pattern hair loss
Van Rossum, E. F. C.; Lamberts, S. W. J. (2006). "Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach". ...
Trevor K. Archer
Hoffman, Jackson A; Trotter, Kevin W; Ward, James M; Archer, Trevor K (2018-05-24). "BRG1 governs glucocorticoid receptor ... Fryer CJ; Trevor K Archer (1 May 1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex". ... Fryer, Christy J.; Archer, Trevor K. (May 1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 ... Trotter, Kevin W.; Archer, Trevor K. (2004-04-01). "Reconstitution of Glucocorticoid Receptor-Dependent Transcription In Vivo ...
Corticosteroid receptor
They include the following two nuclear receptors: Glucocorticoid receptor (type I) - glucocorticoids like cortisol ... 267-. ISBN 978-0-08-053415-2. Groeneweg FL, Karst H, de Kloet ER, Joëls M (2012). "Mineralocorticoid and glucocorticoid ... Tasker JG, Di S, Malcher-Lopes R (2006). "Minireview: rapid glucocorticoid signaling via membrane-associated receptors". ... including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized ...
Ergogenic use of anabolic steroids
Hickson RC, Czerwinski SM, Falduto MT, Young AP (June 1990). "Glucocorticoid antagonism by exercise and androgenic-anabolic ...
Norgestimate
This includes estrogenic, glucocorticoid, antimineralocorticoid, and neurosteroid activity. However, levonorgestrel has been ...
Cushing's syndrome
Dexamethasone is a glucocorticoid and simulates the effects of cortisol, including negative feedback on the pituitary gland. ... Baek JH, Kim SK, Jung JH, Hahm JR, Jung J (March 2016). "Recovery of Adrenal Function in Patients with Glucocorticoids Induced ... Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs ... The most common cause of Cushing's syndrome is the use of prescribed glucocorticoids to treat other diseases (iatrogenic ...
Laron syndrome
GH release is inhibited by somatostatin (GHIH), IGF-1, hyperglycemia, and glucocorticoids. Once released, the GH molecules ...
Lactation
Glucocorticoids play a complex regulating role in the maintenance of tight junctions. Thyroid-stimulating hormone (TSH) and ... Adrenocorticotropic hormone (ACTH) and glucocorticoids such as cortisol have an important lactation inducing function in ...
Atrophy
The adrenal glands atrophy during prolonged use of exogenous glucocorticoids like prednisone. Atrophy of the breasts can occur ...
Whale feces
Glucocorticoid levels were highest in the fall when there was a shortage of prey and maximum during August at the height of ... Glucocorticoids in orcas rise when the animal faces psychological tension or starvation. The study found that prey is maximum ...
Luteal support
Glucocorticoids such as cortisol has limited evidence of efficacy as luteal support. Farquhar, Cindy; Marjoribanks, Jane (2018 ...
Oxytocin
... oxytocin has been shown to promote neural growth in the hippocampus in rats even during swim stress or glucocorticoid ... "Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids". Hippocampus. 22 (4): 861- ...
Hepatotoxicity
Glucocorticoids are so named due to their effect on the carbohydrate mechanism. They promote glycogen storage in the liver. An ... In the past, glucocorticoids in allergic features and ursodeoxycholic acid in cholestatic cases had been used, but there is no ...
Epigenetics of depression
Glucocorticoid receptors (GR) are receptors to which cortisol (and other glucocorticoids) bind. The bound receptor is involved ... It is also known that increased glucocorticoid receptor expression has been shown to modulate the HPA pathway by increasing ... Increased NGFI-A binding, and the resulting increase in glucocorticoid receptor (GR) expression, leads to a decrease in ...
Additive effect
Although NSAIDs and glucocorticoids have different mechanisms of action, the drugs are able to diminish the protective effect ... As a result, the concomitant use of NSAIDs and glucocorticoids increases the risk of gastric bleeding and worsens peptic ulcer ... For example, co-administration of non-steroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids increases the risk of ... As a result, the combination of NSAIDs and glucocorticoids is not recommended. Antibiotic synergy Government of Canada, ...
Postoperative nausea and vomiting
Glucocorticoids have direct antiemetic effects and can reduce need for postoperative opioids. Adverse effects include a ...
Ecoimmunology
Stress through the release of stress hormones, such as glucocorticoids, influence immune function. Glucocorticoids, like ...
Aggression
Glucocorticoids are released by the hypothalamic pituitary adrenal (HPA) axis in response to stress, of which cortisol is the ... Glucocorticoid hormones have an important role in regulating aggressive behavior. In adult rats, acute injections of ... In addition, glucocorticoids affect development of aggression and establishment of social hierarchies. Adult mice with low ...
Malnutrition in Peru
Food intake reductions can affect the growth of cytokines, glucocorticoids, and insulin. When levels of food intake are low for ...
Psychic numbing
Once the HPA axis is activated, it triggers an increase in glucocorticoids. Once these hormones cross the blood-brain barrier, ... Adrenocorticotropin (ACTH) is released from the anterior pituitary, which triggers the release of glucocorticoids from the ...
Carcinogenesis
Busillo JM, Azzam KM, Cidlowski JA (November 2011). "Glucocorticoids sensitize the innate immune system through regulation of ...
Post-traumatic stress disorder
Glucocorticoids may be useful for short-term therapy to protect against neurodegeneration caused by the extended stress ... Yehuda R, Halligan SL, Grossman R, Golier JA, Wong C (September 2002). "The cortisol and glucocorticoid receptor response to ... Additionally, one study found that soldiers whose leukocytes had greater numbers of glucocorticoid receptors were more prone to ... Serotonin also contributes to the stabilization of glucocorticoid production. Dopamine levels in a person with PTSD can ...
Stress (biology)
Glucocorticoids can increase the concentration of glucose, fat, and amino acid in blood. In high doses, one glucocorticoid, ... There is also some activation of the HPA axis, producing glucocorticoids (cortisol, aka the S-hormone or stress-hormone). ... This secretion is made up of glucocorticoids, including cortisol, which are steroid hormones that the adrenal gland releases, ... Steroid hormones bind to glucocorticoid receptors in the brain, providing negative feedback by reducing ACTH release. Some ...
Development of the nervous system in humans
Stress activates the HPA axis, and results in the production of glucocorticoids. Increased glucocorticoid production results in ... Brain regions with a high density of glucocorticoid receptors are especially vulnerable to the effects of early life stress, ... Some examples of brain regions with high glucocorticoid receptor density are the hippocampus and cerebellar vermis. ... likely because glucocorticoids bind to these receptors during stress exposure, facilitating the development of survival ...