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*  Glucagon-like peptide 1 receptor
The glucagon-like peptide 1 receptor (GLP1R) is a receptor protein found on beta cells of the pancreas. It is involved in the ... 2016). "Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes". Pharmacol ... GLP1R binds glucagon-like peptide-1 (GLP1) and glucagon as its natural endogenous agonists. Receptor agonists: GLP-1 - ... glucagon-like peptide receptor at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Albiglutide
... (trade names Eperzan in Europe and Tanzeum in the US) is a glucagon-like peptide-1 agonist (GLP-1 agonist) drug ... 2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". KEGG: Albiglutide. Matthew Herper for Forbes. 16 July 2012. ... Madsbad, S (2015). "Review of head‐to‐head comparisons of glucagon‐like peptide1 receptor agonists". Diabetes, Obesity & ... a Long-Acting Glucagon-Like Peptide-1 Mimetic, in Patients with Type 2 Diabetes". J. Clin. Endocrinol. Metab. 93 (12): 4810- ...
*  Glucagon-like peptide-1
... intervening peptide-2 (IP-2) and glucagon-like peptide-2 (GLP-2). Initially, GLP-1 was thought to correspond to proglucagon (72 ... 2 producing glicentin-related pancreatic peptide (GRPP), glucagon, intervening peptide-1 (IP-1) and major proglucagon fragment ... 2013). "Glucagon-like peptides 1 and 2 in health and disease: A review". Peptides. 44: 75-86. doi:10.1016/j.peptides.2013.01. ... Glucagon-like peptide-1 (GLP-1) is a 30 amino acid long peptide hormone deriving from the tissue-specific posttranslational ...
*  Glucagon-like peptide-1 receptor agonist
... s also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 ... Baggio LL (2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". Medscape Diabetes & Endocrinology. Ali ES, Hua J, ... "The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2+ signalling in steatotic hepatocytes". BBA ... 2013 "GLP-1 Receptor Agonists vs. DPP-4 Inhibitors for Type 2 Diabetes". Liu, J; Li, L; Deng, K; Xu, C; Busse, JW; Vandvik, PO ...
*  Semaglutide
As a glucagon-like peptide-1 receptor agonist, it lowers the blood sugar level by increasing the production of insulin. It was ... In humans semaglutide is chemically similar to glucagon-like peptide-1 (GLP-1). The only differences are two amino acid ... Kalra, S; Gupta, Y (2015). "Once-weekly glucagon-like peptide 1 receptor agonists". The Journal of the Pakistan Medical ... 2015). "Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide". Journal of Medicinal Chemistry. 58 ...
*  Amylin Pharmaceuticals
Garber, Alan J. (2011-05-01). "Long-Acting Glucagon-Like Peptide 1 Receptor Agonists". Diabetes Care. 34 (Supplement 2): S279- ... which is responsible for regulating insulin and glucagon release. Unlike human GLP-1, however, exendin-4 doesn't degrade for ... "FDA Approves Symlin for Type 1 and Type 2 Diabetes". 2005-03-18. Retrieved 2017-05-26. "Dr. John Eng's Research Found That The ... But adult-onset type 2 diabetes affects far more people than type 1, and pramlintide showed significant benefits only at 6 ...
*  Gastric inhibitory polypeptide
GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins. GIP is derived from ... Thorens B (Dec 1995). "Glucagon-like peptide-1 and control of insulin secretion". Diabète & Métabolisme. 21 (5): 311-8. PMID ... It has traditionally been named gastrointestinal inhibitory peptide or gastric inhibitory peptide and was found to decrease the ... Gastric inhibitory polypeptide (GIP) or gastroinhibitory peptide, also known as the glucose-dependent insulinotropic peptide, ...
*  Taspoglutide
2008). "Glucagon-like Peptide-1 Analogs Other Than Exenatide". "Ipsen's Partner Roche Announces That Taspoglutide Meets Its ... Taspoglutide is a pharmaceutical drug, a glucagon-like peptide-1 agonist (GLP-1 agonist), under investigation for treatment of ... 36-L-argininamide derivative of the amino acid sequence 7-36 of human glucagon-like peptide I. Incretin "Ipsen: Roche Moves ... As of May 2013[update] no new trials had been registered.[needs update] Taspoglutide is the peptide with the sequence H2N-His-2 ...
*  Omarigliptin
Behme, Margaret T; Dupré, John; McDonald, Thomas J (2003). "Glucagon-like peptide 1 improved glycemic control in type 1 ... "Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM". Diabetes. 44 (6): 626-30. doi:10.2337/diabetes.44.6. ... which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying and decreases blood ... Regulatory Peptides. 128 (2): 159-65. doi:10.1016/j.regpep.2004.06.001. PMID 15780435. ...
*  GPR120
"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120". Nat. Med. 11 (1): 90-4. doi:10.1038/ ...
*  Robert Margolskee
"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proceedings of the National Academy ... 28 (1): 58-63. doi:10.1038/88270. PMID 11326277. Perez, C.; Huang, L.; Rong, M.; Kozak, J.A.; Preuss, A.K.; Zhang, H.; Max, M ... "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proceedings of the National ...
*  Hanmi Pharmaceutical
... a long-acting glucagon-like peptide-1 receptor agonist; an insulin intended to be delivered once per week, and a fixed-dosed ... An exclusive license outside of South Korea and China with Sanofi for Hanmi's Glucagon-like peptide-1 receptor agonist drug ... By around 2010, Hanmi's R&D had two areas of interest: developing longer-lasting peptide and protein therapeutics using its " ... Carroll, John (October 1, 2016). "Following lethal tox report, Boehringer scraps plans for high-speed development, kills $730M ...
*  Carboxypeptidase E
"Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice". The Journal of ... CPE is involved in the biosynthesis of most neuropeptides and peptide hormones. The production of neuropeptides and peptide ... although for many peptides the action of the proprotein convertases and CPE is sufficient to produce the bioactive peptide. ... For some peptides, additional processing steps, such as C-terminal amidation, are subsequently required to generate the ...
*  FOXO1
In pancreatic beta cells FOXO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass. When the level of blood ... Buteau J, Spatz ML, Accili D (May 2006). "Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic ... In pancreatic alpha-cells FOXO1 is important in regulating prepro-glucagon expression. ... 11 (1): 6-8. doi:10.1016/S1097-2765(03)00003-0. PMID 12535515. Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon ...
*  GNAT3
2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S. ... 193 (1): 21-34. doi:10.1007/s00359-006-0168-8. PMID 17021831. Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural ... 22 (1-4): 193-203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379. Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. ( ... 2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. ...
*  Anti-obesity medication
de Luis DA, Gonzalez Sagrado M, Conde R, Aller R, Izaola O (2007). "Decreased basal levels of glucagon-like peptide-1 after ... 1-2. Retrieved 11 August 2015. Bray, G. A. (1993). "Use and Abuse of Appetite-Suppressant Drugs in the Treatment of Obesity". ... 99 (1): 156-161. doi:10.1161/01.CIR.99.1.156. PMID 9884392. Retrieved 24 July 2006. Doggrell, SA (2009). "Tesofensine--a novel ... Exenatide (Byetta) is a long-acting analogue of the hormone GLP-1, which the intestines secrete in response to the presence of ...
*  Neointimal hyperplasia
Exendin-4, a glucagon-like peptide-1 receptor (GLP-1) agonist used as drug treatment for type 2 diabetes inhibits neointimal ... a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury. European Journal of ... Circulation, 101(1), 16-26. Kay, I.P., Wardeh, A.J., Kozuman, K., Foley, D.P., Knook, A.H., Thury, A., Sianos, G., van der ... Circulation, 103(1), 14-17. Hirata, Y., Kurobe, H., Nishio, C., Tanaka, K., Fukuda, D., Uematsu, E., Nishimoto, S., Soeki, T., ...
*  Dulaglutide
... is a glucagon-like peptide 1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc ... Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic ... Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E (February 2014). "Glucagon-like peptide-1 receptor agonists and ... Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas, which is known ...
*  Exenatide
... in a similar way to the human peptide glucagon-like peptide-1 (GLP-1); exenatide bears a 50% amino acid homology to GLP-1 and ... Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 ... Exenatide (marketed as Byetta, Bydureon) is a glucagon-like peptide-1 agonist (GLP-1 agonist) medication, belonging to the ... Exenatide binds to the intact human Glucagon-like peptide-1 receptor (GLP-1R) ...
*  Appetite
For example, ghrelin stimulates appetite, whereas cholecystokinin and glucagon-like peptide-1 (GLP-1) suppress appetite. The ... Leptin is a peptide hormone that affects homeostasis and immune responses. Lowering food intake can lower leptin levels in the ... agouti-related peptide (AgRP) [stimulate appetite] and proopiomelanocortin (POMC) [induce satiety] neurons located in the ... 48 (1): 37-45. doi:10.1016/j.appet.2006.06.006. PMC 2045650 . PMID 17000028. Carlson, Neil R.; Donald, Heth C.; Miller, Harold ...
*  Pancreatitis
But, glucagon-like peptide-1 (GLP-1) is more strongly associated with pancreatitis by promoting inflammation. Atypical ... Medical Center). 21 (1): 77-81. PMC 2190558 . Jones, Mark R; Hall, Oliver Morgan; Kaye, Adam M (2015). "Drug-Induced Acute ... 62 (1): 164-74. PMID 10905786. Archived from the original on 2012-10-08. Corfield AP, Cooper MJ, Williamson RC, Mayer AD, ... Retrieved 1 March 2015. Lankisch, PG; Apte, M; Banks, PA (20 January 2015). "Acute pancreatitis". Lancet. 386: 85-96. doi: ...
*  Steatosis
Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 ... 22 (1): 1-10. doi:10.1177/011542650702200101. PMID 17242448. Cotran; Kumar, Collins (1998). Robbins Pathologic Basis of Disease ...
*  Hepatocyte
Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 ... doi:10.1007/978-1-60761-688-7_3. PMID 20645046. Dunn JC, Yarmush ML, Koebe HG, Tompkins RG (Feb 1989). "Hepatocyte function and ... Celton-Morizur, S; Merlen, G; Couton, D; Desdouets, C (1 February 2010). "Polyploidy and liver proliferation: central role of ... typically within 1-3 hr after seeding) and maintenance of the hepatic phenotype. In addition, and overlay with an additional ...
*  Calcium signaling
Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 ... ISBN 978-1-4641-2610-9. Ivannikov, M.; et al. (2013). "Mitochondrial Free Ca2+ Levels and Their Effects on Energy Metabolism in ... ISBN 1-58890-247-1. Berg, Jeremy; Tymoczko, John L.; Gatto, Gregory J.; Stryer, Lubert (2015). Biochemistry (Eighth ed.). New ... 21 (1): 13-26. doi:10.1016/S0896-6273(00)80510-3. PMID 9697848. Petersen, Ole H (2005). "Ca2+ signalling and Ca2+-activated ion ...
*  Cyclic adenosine monophosphate
Ali ES, Hua J, Wilson CH, Tallis GA, Zhou FH, Rychkov GY, Barritt GJ (2016). "The glucagon-like peptide-1 analogue exendin-4 ... Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. ... such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma ...
*  Index of biochemistry articles
... peptide - peptide bond - peptide elongation factor - peptide elongation factor tu - peptide fragment - peptide initiation ... glucagon - glucagon receptor - glucocorticoid receptor - glucose - glutamate - glutamate receptor - Glutamic acid - Glutamine ... calcitonin gene-related peptide - calcitonin gene-related peptide receptor - calcitonin receptor - calcitriol receptor - ... vasoactive intestinal peptide - vasoactive intestinal peptide receptor - vasopressin - vasopressin receptor - venom - ...