... acts by blocking thiol residues in the cell membrane. Gliotoxin also activates a member of the Bcl-2 family called ... Gliotoxin is also believed to interfere with T-cell activation. Additionally, gliotoxin acts as an inhibitor of farnesyl ... Acute symptoms of gliotoxin start rapidly after ingestion. Understanding the mechanisms behind the toxicity of gliotoxin can ... The chemical structure of gliotoxin was resolved in 1958 by Bell et al. by treatment of gliotoxin on alkaline alumina. Bell and ...

43, p. 40 (1963). (Article) Johnson, J. R.; Hasbrouck, R. B.; Dutcher, J. D. & Bruce, W. F. (1945). "Gliotoxin. V. The ...

Aspergillus synthesizes immunosuppressants gliotoxin and endocrocin. Subglutinols are immunosuppressants isolated from Fusarium ...

LaeA regulated toxins, besides gliotoxin, likely have a role in virulence since loss of gliotoxin production alone did not ... Neutrophils are the principal targets of gliotoxin. Gliotoxin interrupts the function of leukocytes by inhibiting migration and ... Gliotoxin disrupts the proinflammatory response through inhibition of NF-κB. LaeA and GliZ are transcription factors known to ... February 2008). "Gliotoxin production in Aspergillus fumigatus contributes to host-specific differences in virulence". The ...

Gliotoxin is a metabolite of G. (now Trichoderma) deliquescens. The significance of gliotoxin has not yet been determined. ...

Ciclosporin, mycophenolic acid, mizoribine, FR901483, and gliotoxin, are immunosuppressant fungal isolates. Penicillin, ...

It also acts as a neurotoxin, gliotoxin, proinflammatory mediator, and pro-oxidant molecule. While quinolinic acid cannot pass ...

It has been reported to produce asperfuran, cytochalasin-like compounds, fiscalin-like compounds, pyripyropens, and gliotoxin. ...

Gliotoxin is a sulfur-containing mycotoxin produced by several species of fungi under investigation as an antiviral agent. ...

... gliotoxin, patulin, terrein, terreic acid, and terretonin. The fungus also produces a secondary metabolite called lovastatin, a ...

... gliotoxin, and aspergillic acid. In humans, A. flavus aflatoxin production can lead to acute hepatitis, immunosuppression, ...

Other Biologically active 2,5-Diketopiperazine Natural Products Bicyclomycin Gliotoxin Phenylahistin Roquefortine C 2,5- ... in animals while the thio derivatives such as the cytotoxic bridged epipolythiodioxopiperazine are represented by gliotoxin. ...

... gliotoxin MeSH D03.438.473.385 - hydroxytryptophol MeSH D03.438.473.390 - ibogaine MeSH D03.438.473.391 - indapamide MeSH ...

... produces gliotoxin, acetylgliotoxin G, fiscalin B and xanthocillin X. A. cejpii has been cultivated on both ...

Mycotoxins: Aflatoxin, Cytochalasin, Fumonisins, Gliotoxin, Patulin, Penicillic acid, Zearalenone, Tentoxin, Deoxynivalenol, ...

... gliotoxin MeSH D23.946.587.475 - ibotenic acid MeSH D23.946.587.587 - muscimol MeSH D23.946.587.697 - ochratoxins MeSH D23.946. ...