... (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small ... Glial cell line-derived neurotrophic factor has been shown to interact with GFRA1 and GDNF family receptor alpha 1. The ... Glial+Cell+Line-Derived+Neurotrophic+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles ... January 2005). "Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine ...

... belongs to the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors, which regulate the ... "Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR- ... a relative of glial-cell-line-derived neurotrophic factor". Nature. 384 (6608): 467-70. Bibcode:1996Natur.384..467K. doi: ... "Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic ...

Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (May 1993). "GDNF: a glial cell line-derived neurotrophic factor for midbrain ... March 2006). "An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression ... Glial cell-derived neurotrophic factor (GDNF) is a protein that aids in the survival and differentiation of dopaminergic ... Brain-derived neurotrophic factor (BDNF) is a neurotrophic growth factor that plays an important role in memory, learning, and ...

It is associated with an increase in glial cell line derived neurotrophic factor. rTMS (repetitive transcranial magnetic ... "Electroconvulsive therapy increases glial cell-line derived neurotrophic factor (GDNF) serum levels in patients with drug- ... Some factors that contribute to inadequate treatment are: a history of repeated or severe adverse childhood experiences, early ... Another factor is that medications used to treat comorbid medical disorders may lessen the effectiveness of antidepressants or ...

The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), ... 2002). "Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulfate glycosaminoglycan". J. Cell ... "Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol ... "Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease". Nat Med. 9 (5): 589-95. doi:10.1038 ...

... is a neurotrophic factor in the glial cell line-derived neurotrophic factor family of ligands which are a group of ... a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. ... a glial cell line-derived neurotrophic factor family receptor". Proceedings of the National Academy of Sciences of the United ... convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083-92. doi:10.1016/j.str.2006.05. ...

"Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor". Biological ... In-vitro rat studies show a direct inhibitory effect of cabergoline on the prolactin secretion in the lactotroph cells of the ... Cabergoline is frequently used as a first-line agent in the management of prolactinomas due to its higher affinity for D2 ...

"Glial cell line-‐derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells". Neuroscience ... recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor". ... "Exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor enhances survival in two patients with ... He also pioneered the use of Glial Derived Neurotrophic Factor (GDNF) in combination with fetal cells in humans. Mendez ...

... is a neurotrophic factor in the glial cell line-derived neurotrophic factor (GDNF) family. Persephin shares around a ... The mRNA levels of persephin in developing neurons has been low compared to other neurotrophic factors, but relatively higher ... February 1998). "Persephin, a novel neurotrophic factor related to GDNF and neurturin". Neuron. 20 (2): 245-53. doi:10.1016/ ... Neurotrophic factors, All stub articles, Biochemistry stubs). ...

1997). Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development124,4077 ... in the kidney as glial cell line-derived neurotrophic factors, neurturin and persephin. The term has now passed into general ... As such, the use of the glial-cell-line neurotrophic factor (GDNF) has been found to contribute to uterine tissues. The ... The term ramogen refers to a biological factor, typically a growth factor or other protein, that causes a developing biological ...

McGee Sanftner LH, Abel H, Hauswirth WW, Flannery JG (December 2001). "Glial cell line derived neurotrophic factor delays ... were also carried out to study whether supplying AAV2 vectors with cDNA for glial cell line-derived neurotrophic factor (GDNF) ... 2001). "Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization". J Cell Physiol. 188 (2): 253-263 ... Intravitreal AAV targets retinal ganglion cells and a few Muller glial cells. Subretinal AAV efficiently targets photoreceptors ...

... convergent recognition of glial cell line-derived neurotrophic factors". Structure. 14 (6): 1083-92. doi:10.1016/j.str.2006.05. ... expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3)". ... The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF ...

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic ... "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory ... "Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors ... It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the ...

Glial cell line-derived neurotrophic factor (GDNF) may have the ability to chemoprotect the cells of the substantia nigra. A ... "P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38- ... The increase in p38 MAPK signaling leads to greater microglial release of brain-derived neurotrophic factor (BDNF). BDNF ... Crosstalk between tumor cells and TAMs is characterized by the release of growth factors and cytokines by TAMs in response to ...

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic ... "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory ... Yoong LF, Too HP (May 2007). "Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate ... mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a ...

... brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF). These neurotrophic factors are ... GDNF is the glial cell lined derived neurotrophic factor, which is involved in the survival and differentiation of dopaminergic ... Additionally, vitamin D is associated with the up regulation of neurotrophic factors: GDNF and TN3. These neurotrophic factors ... A second mechanism is through the association of neurotrophic factors like nerve growth factor (NGF), ...

"Selective glial cell line-derived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after ... Retinal pigment epithelial cells synthesize dopamine and secrete the neurotrophic factors glial-cell derived neurotrophic ... Based on their ability to secrete dopamine and also glial cell-derived neurotrophic factor (GDNF), these cells have been ... It includes two populations of cells; glomus (type I) cells and sustentacular (type II) cells. Glomus cells are derived from ...

Glial cell line-derived neurotrophic factor (GDNF) was originally detected as survival promoter derived from a glioma cell. ... Most neurotrophic factors belong to one of three families: (1) neurotrophins, (2) glial cell-line derived neurotrophic factor ... The GDNF family of ligands includes glial cell line-derived neurotrophic factor (GDNF), artemin, neurturin, and persephin. ... The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), ...

Glial cell line-derived neurotrophic factor (GDNF) has been discovered to play an especially important role in all layers of ... The differentiation into these two classes is regulated by complex interactions between several neurotrophic factors, and all ... Among this pool-specific combination of transcription factors, Hox factors play an especially important role. Hox transcription ... followed by a pruning process that is mediated by cell death mechanisms and survival factors. Some researchers have speculated ...

... "c-Src Is Required for Glial Cell Line-Derived Neurotrophic Factor (GDNF) Family Ligand-Mediated Neuronal Survival via a ... The GDNF family of ligands (GFL) are neurotrophic factors found to be important in neuron survival, so Tansey and her ... XPro 1595 Attenuates Nigral Cell Loss and Glial Activation in 6-OHDA Hemiparkinsonian Rats". Journal of Parkinson's Disease. 4 ... and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells". Journal of Biological Chemistry. 272 (15): ...

"Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament ... During the process of creating new queens, the workers construct special queen cells. The larvae in these cells are fed with ... These are the only cells in which large amounts are deposited. This is because when royal jelly is fed to worker larvae, it is ... Therefore, only in queen cells is the harvest of royal jelly practical. A well-managed hive during a season of 5-6 months can ...

... glial cell line-derived neurotrophic factor), the regulation of the α-synuclein and Parkin gene expression. Currently the main ... cells cannot be used because these cells are difficult to obtain and modifications of cell can only be made on somatic cells, ... GNDF is a factor of the TGFß superfamily, is secreted by astrocytes (glia cells that are in charge of the survival of the ... The first one is the neurotrophic factors gene delivery. In this therapy, GNDF or NTN are used to protect the system. ...

In mice, Sertoli cells have been shown to secrete Glial cell line-derived neurotrophic factor (GDNF) which has a stimulatory ... Various other somatic cells in the interstitial tissue support Sertoli cells such as Leydig cells and peritubular myoid cells ... This factor is thought to be expressed in the peritubular cells in human testes. Fibroblast growth factor (FGF2) is another ... molecule crucial for the regulation of stem cell renewal and is expressed in Sertoli cells, Leydig cells, and germ cells. FGF2 ...

... glial cell-line derived neurotrophic factor). Additionally, GAS1 has been proved can largely influence the developmental state ... "Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling". The Journal ... "Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling". The Journal ... "Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines". International Journal of Cancer ...

One of the gene therapy based approach involves gene delivery of neurturin and glial cell line-derived neurotrophic factor ( ... This may be due to the distribution factor; the trophic factor was not distributed sufficiently throughout the target place. ... cells survive and improve behavioral abnormalities of the animals. Nevertheless, use of fetal stem cells is controversial. Some ... Stem cell transplants are a main research recent target: they are easy to manipulate and when transplanted into the brains of ...

... glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, leukemia inhibitory factor, insulin-like growth ... Other neurotrophic molecules produced by Schwann cells and fibroblasts together include brain-derived neurotrophic factor, ... Schwann cells upregulate the production of cell surface adhesion molecule ninjurin further promoting growth. These lines of ... During their proliferation phase, Schwann cells begin to form a line of cells called Bands of Bungner within the basal laminar ...

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF ... Airaksinen MS, Titievsky A, Saarma M (May 1999). "GDNF family neurotrophic factor signaling: four masters, one servant?". ... found to be rearranged within a 3T3 fibroblast cell line following its transfection with DNA taken from human lymphoma cells. ... Murakami H, Yamamura Y, Shimono Y, Kawai K, Kurokawa K, Takahashi M (September 2002). "Role of Dok1 in cell signaling mediated ...

... which is a transmembrane signaling component that allows the expression of glial cell line-derived neurotrophic factor (GDNF). ... which is a receptor to nerve growth factor (NGF). However, transcription factors that determine the type of nociceptor remain ... The cell bodies of these neurons are located in either the dorsal root ganglia or the trigeminal ganglia. The trigeminal ... Nociceptors: the cells that sense pain. "Pain Pathway". Retrieved 2008-06-02.[dead link] Hall, Michael E.; Hall, John E. (2021 ...

Glial cell line-derived neurotrophic factor (GDNF) Vascular endothelial growth factor (VEGF) Brain-derived neurotrophic factor ... "Neurotrophic factors". Nature Publishing Group. Retrieved 31 May 2016. Neurotrophic factors are molecules that enhance the ... Examples of notable neurotrophic factors include: Insulin-like growth factor-1 (IGF-1) ... Neurotrophic factors are polypeptides or small proteins that support the growth, differentiation, and survival of neurons. They ...

... and the COX-2-glial cell line-derived neurotrophic factor (GDNF) pathways. A recent theory of Sonkodi et al., that incorporates ... Mizumura, Kazue; Taguchi, Toru (2016). "Delayed onset muscle soreness: Involvement of neurotrophic factors". The Journal of ... Cheung, K; Hume, P; Maxwell, L (2003). "Delayed onset muscle soreness: treatment strategies and performance factors". Sports ... these ruptures are microscopic lesions at the Z-line of the muscle sarcomere. The soreness has been attributed to the increased ...