Loading...
*  Hypothalamic-pituitary-somatotropic axis
... and ghrelin (GHS) are involved in the control of GH secretion from the pituitary gland. The HPS axis is involved in postnatal ...
*  GHRP-6
... the hormone ghrelin is now considered the receptor's natural endogenous ligand, and it has been renamed as the ghrelin receptor ... Therefore, these GHSR agonists act as synthetic ghrelin mimetics. It has been discovered that when GHRP-6 and insulin are ... Adeghate, E; Ponery, AS (2002). "Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats". Journal ... McGirr, R; McFarland, MS; McTavish, J; Luyt, LG; Dhanvantari, S (2011). "Design and characterization of a fluorescent ghrelin ...
*  Growth hormone
... ghrelin through binding to growth hormone secretagogue receptors (GHSR) sex hormonesincreased androgen secretion during puberty ... "The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion". Endocrinology. 141 (11): 4325-8. ...
*  Ghrelin
Mice with elevated ghrelin swam more than ghrelin deficient mice. These ghrelin-deficient mice exhibited more social avoidance ... In rodents, X/A-like cells produce ghrelin. Ghrelin knock-out mice (who never express ghrelin) have increased anxiety in ... Cord blood levels of active and total ghrelin show a correlation between ghrelin levels and birth weight. Ghrelin gene products ... and C-ghrelin(acylated). Obestatin is presumed to be cleaved from C-ghrelin. Ghrelin only becomes active when caprylic ( ...
*  Ghrelin O-acyltransferase
Heppner KM, Tong J, Kirchner H, Nass R, Tschöp MH (February 2011). "The ghrelin O-acyltransferase-ghrelin system: a novel ... "The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes". ... "Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa". Journal ... "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O- ...
*  Pralmorelin
It acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist, and was the first of this class of drugs to be ... Moulin, Aline; Brunel, Luc; Verdie, Pascal; Gavara, Laurent; Martinez, Jean; Fehrentz, Jean-Alain (2014). "Ghrelin Receptor ... "Ghrelin". Molecular Metabolism. 4 (6): 437-460. doi:10.1016/j.molmet.2015.03.005. ISSN 2212-8778. ...
*  Growth hormone secretagogue receptor
The binding of ghrelin to GHS-R1a in pituitary cells stimulates the secretion of growth hormone (GH) by the pituitary gland. ... However, ghrelin may also play a role in behavioral reinforcement. Studies in animal models, found that food intake increased ... Building on this, it was found that there are growth hormone secretagogue receptors in the VTA and that ghrelin acts on the VTA ... The second transcript (1b) retains the intron and does not function as a receptor for ghrelin; however, it may function to ...
*  Obestatin
... and C-ghrelin(acylated). Obestatin is presumed to be cleaved from C-ghrelin. It was originally proposed that GPR39 functioned ... "Meta-analysis of the relationship between obestatin and ghrelin levels and the ghrelin/obestatin ratio with respect to obesity ... a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science. 310 (5750): 996-9. doi:10.1126/ ... Ghrelin Nesfatin-1 PDB: 2JSH​; Scrima M, Campiglia P, Esposito C, Gomez-Monterrey I, Novellino E, D'Ursi AM (November 2007). " ...
*  Gastrectomy
Another side effect is the loss of ghrelin production, which has been shown to be compensated after a while. The first ... "After Stomach Cancer Surgery - Complications : Diet". Masayasu Kojima; Kenji Kangawa (2005). "Ghrelin: Structure and Function ...
*  Cyril Y. Bowers
... ghrelin receptor antagonists for overnutrition, i.e., obesity; 3) use of ghrelin agonists in diabetes; 4) use of ghrelin ... A New Obesity Related Peptide Unnatural Growth Hormone-Releasing Peptide Begets Natural Ghrelin Octanoyl Ghrelin Is ... In: Ghrelin, Ghigo E, ed, Klerwer Academic Publishers, Boston/London; 2004, pg 1-13. 21. Iranmanesh A, Bowers CY, Veldhuis JD. ... Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid M, Fujimiya M. Ghrelin, Appetite, and Growth-The Emerging Role of ...
*  Ipamorelin
... (INN) (developmental code name NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone ... Moulin, Aline; Ryan, Joanne; Martinez, Jean; Fehrentz, Jean-Alain (2007). "Recent Developments in Ghrelin Receptor Ligands". ... proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients ...
*  Adrenergic receptor
Increase ghrelin secretion from the stomach. The β2 receptor "binds epinephrine and is involved in the fight or flight response ... Sep 2010). "Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice". ...
*  Four Fs (evolution)
Sakata, Ichiro; Sakai, Takafumi (2010). "Ghrelin cells in the gastrointestinal tract". International Journal of Peptides. 2010 ... and ghrelin, which is commonly described as "the hunger hormone". Species from other phyla than vertebrates, such as arthropods ...
*  Examorelin
These GH-releasing peptides have no sequence similarity to ghrelin, but mimic ghrelin by acting as agonists at the ghrelin ... 117-. ISBN 978-94-011-4439-1. Moulin A, Ryan J, Martinez J, Fehrentz JA (2007). "Recent developments in ghrelin receptor ... Carpino, Philip A (2002). "Recent developments in ghrelin receptor (GHS)". Expert Opin. Ther. Patents. Informa Healthcare. 12 ( ... and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue which ...
*  Hedonic hunger
Eating disorder Ghrelin Glucagon-like peptide-1 agonist Melanin-concentrating hormone Peptide YY Specific appetite Witt AA, ... Hedonic hunger show a positive correlation between plasma of the endocannabinoid 2-arachidonoyl glycerol (2-AG) and ghrelin ... "Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in ...
*  Vagotomy
... may have an impact upon ghrelin. In an open-label, prospective study of 30 obese patients (26 women), response has ... and long-term controls of circulating ghrelin". Endocrinology. 144 (12): 5184-7. doi:10.1210/en.2003-1059. PMID 14525914. Boss ...
*  Appetite
For example, ghrelin and leptin are released from the stomach and adipose cells, respectively, into the blood stream. Ghrelin ... It has been found that ghrelin-reactive IgG immunoglobulins affect ghrelin's orexigenic response. Other than genetically- ... "Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans". Nature ... "How The Hormones Ghrelin and Leptin Affect Appetite". The Monterey Diet. Sader, S; Nian, M; Liu, P (2003). "Leptin: a novel ...
*  Butyrylcholinesterase
Chen VP, Gao Y, Geng L, Parks RJ, Pang YP, Brimijoin S (Feb 2015). "Plasma butyrylcholinesterase regulates ghrelin to control ... It was recently indicated that butyrylcholinesterase could be a physiological ghrelin regulator. Click on genes, proteins and ...
*  N-Acylphosphatidylethanolamine
Ghrelin Leptin Dunham, Will (Nov 26, 2008). "Gut chemical may inspire new way to fight obesity". Reuters Accessed 27 Nov. 2008 ...
*  Cholecystokinin
The stimulatory effects of CCK oppose those of ghrelin, which has been shown to inhibit the vagus nerve. The effects of CCK ... "CCK inhibits the orexigenic effect of peripheral ghrelin". American Journal of Physiology. Regulatory, Integrative and ...
*  Ingestive behaviors
Ghrelin antibodies or ghrelin receptor antagonists inhibit eating. Ghrelin also stimulates energy production and signals ... 2005). "Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls ... 2003). "Plasma ghrelin concentrations are not regulated by glucose or insulin: A double-blind, placebo-controlled crossover ... Inui, Akio (2001). "Ghrelin: An orexigenic and somatotrophic signal from the stomach". Nature Reviews Neuroscience. 2: 551-60. ...
*  Brianna Stubbs
"A Ketone Ester Drink Lowers Human Ghrelin and Appetite". Obesity: n/a-n/a. doi:10.1002/oby.22051. ISSN 1930-739X. "The startup ...
*  Motilin
This domain is also found in ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin ... ISBN 0-07-022001-8. Kangawa K, Matsuo H, Kojima M, Hosoda H (2001). "Ghrelin: discovery of the natural endogenous ligand for ... termed ghrelins, can bring about similar effects to motilin agonists. Camicinal is a Motilin agonist under development. ...
*  GHRLOS
In molecular biology, ghrelin opposite strand (non-protein coding), also known as GHRLOS, is a long non-coding RNA. It is ... Seim I, Carter SL, Herington AC, Chopin LK (2008). "Complex organisation and structure of the ghrelin antisense strand gene ... "Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural ... antisense to the GHRL gene, which encodes ghrelin. In humans, it is located on chromosome 3p25. It is alternatively spliced ...
*  Enteroendocrine cell
Other hormones produced include somatostatin, pancreatic polypeptide, amylin and ghrelin. Rare and slow growing carcinoid and ...