Philadelphia 76ers, NBA'de Atlantik Grubu'nda yer alan Philadelphia takımıdır. 1949 yılında kurulmuştur. NBA de üç kez şampiyonluğa ulaşmıştır. Şampiyonlukları 1955,1967 ve 1983 yılındadır. En son 2000-2001 sezonunda final oynamış ama finalde L.A. Lakers takımına kaybetmiştir. 2006 yılında playofflara girememiştir. Takımın ünlü oyuncusu Allen Iverson, 2006-07 sezonunda takas edilmiş ve Denver Nuggets'a gönderilmiştir. Bu oyuncunun ayrılmasından sonra takım büyük bir düşüşe geçmiştir. Özellikle yıldız oyuncu eksikliği yaşamaktadır. Fakat Philadelphia 76ers 2007-2008 sezonunda yıldızsız kadrosuna rağmen büyük bir başarı göstererek, doğu konferansını 7. bitirip playofflara girmiştir. Playoff ilk turunda güçlü rakibi Detroit Pistons'ı zorlamasına rağmen 4-2 elenmiştir. Takım 2008 off sezonunda beklenen hamleyi yapmış ve takıma Los Angeles Clippers'tan Elton Brand'i katmıştır. Son olarak kısa bir süre önce basketbolu ...
... , sold under the brand name Tasigna, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.[2] It may be used both in initial cases of chronic phase CML as well as in accelerated and chronic phase CML that has not responded to imatinib.[2][3] It is taken by mouth.[3] Common side effects may include low platelets, low white blood cells, anemia, rashes, vomiting, diarrhea, and joint pains.[3] Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems.[3] It is not safe for use during pregnancy.[3] Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell.[3] Nilotinib was approved for medical use in the United States in 2007.[3] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[4] In the United Kingdom it costs the NHS £2,432.85 per month as of 2018.[5] In ...
The chromosomal defect in the Philadelphia chromosome is a translocation, in which parts of two chromosomes, 9 and 22, swap places. The result is that a fusion gene is created by juxtaposing the ABL1 gene on chromosome 9 (region q34) to a part of the BCR (breakpoint cluster region) gene on chromosome 22 (region q11). This is a reciprocal translocation, creating an elongated chromosome 9 (termed a derivative chromosome, or der 9), and a truncated chromosome 22 (the Philadelphia chromosome, 22q-).[3][4] In agreement with the International System for Human Cytogenetic Nomenclature (ISCN), this chromosomal translocation is designated as t(9;22)(q34;q11). The symbol ABL is derived from Abelson, the name of a leukemia virus which carries a similar protein.. Translocation results in an oncogenic BCR-ABL gene fusion that can be found on the shorter derivative 22 chromosome. This gene encodes for a Bcr-abl fusion protein. Depending on the precise location of fusion, the molecular weight of this protein ...
M2 is a subtype of AML (Acute Myeloid Leukemia). It is also known as "Acute Myeloblastic Leukemia with Maturation". Acute myeloid leukemia (AML) is a type of cancer affecting blood cells that eventually develop into non-lymphocyte white blood cells. The disease originates from the bone marrow, the soft inner portion of select bones where blood stem cells develop into either lymphocyte or in this particular condition, myeloid cells. This acute disease prevents bone marrow cells from properly maturing, thus causing an accumulation of immature myeloblast cells in the bone marrow. Acute myeloid leukemia is more lethal than chronic myeloid leukemia, a disease that affects the same myeloid cells, but at a different pace. Many of the immature blast cells in acute myeloid leukemia have a higher loss of function and thus, a higher inability to carry out normal functions than those more developed immature myeloblast cells in chronic myeloid leukemia (O'Donnell et al. 2012). Acute in acute myeloid leukemia ...
... were the first human immortalised myelogenous leukemia line to be established. K562 cells are of the erythroleukemia type, and the line is derived from a 53-year-old female chronic myelogenous leukemia patient in blast crisis. The cells are non-adherent and rounded, are positive for the bcr:abl fusion gene, and bear some proteomic resemblance to both undifferentiated granulocytes and erythrocytes. In culture they exhibit much less clumping than many other suspension lines, presumably due to the downregulation of surface adhesion molecules by bcr:abl. However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. K562 cells can spontaneously develop characteristics similar to early-stage erythrocytes, granulocytes and monocytes and are easily killed by natural killer cells as they lack the MHC complex required to inhibit NK activity. They also lack any trace of Epstein-Barr virus and other herpesviruses. In addition to the ...
... (rINN/USAN; codenamed SKI-606, marketed under the trade name Bosulif) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer. Originally synthesized by Wyeth, it is being developed by Pfizer. Bosutinib received US FDA and EU European Medicines Agency approval on September 4, 2012 and 27 March 2013 respectively for the treatment of adult patients with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance, or intolerance to prior therapy. Adverse effects by incidence:Very common (>10% frequency): Diarrhoea (~82%) Nausea Myelosuppression Vomiting (~37%) Abdominal pain Raised ALT Raised AST Rash Arthralgia (joint pain) Fever Oedema Fatigue Cough Headache Reduced appetite Respiratory tract infection Common (1-10% frequency): Drug hypersensitivity Dehydration Hyperkalaemia (high blood potassium) Hypophosphataemia (low blood phosphate) Dizziness Dysgeusia (distorted sense of taste) Pericardial effusion Pleural effusion QT ...
... (also called neutrophil leukocytosis or occasionally neutrocytosis) is leukocytosis of neutrophils, that is, a high number of neutrophil granulocytes in the blood. Neutrophils are the primary white blood cells that respond to a bacterial infection, so the most common cause of neutrophilia is a bacterial infection, especially pyogenic infections. Neutrophils are also increased in any acute inflammation, so will be raised after a heart attack, other infarct or burns. Some drugs, such as prednisone, have the same effect as cortisol and adrenaline (epinephrine), causing marginated neutrophils to enter the blood stream. Nervousness will very slightly raise the neutrophil count because of this effect.[citation needed] A neutrophilia might also be the result of a malignancy. Chronic myelogenous leukemia (CML or chronic myeloid leukaemia) is a disease where the blood cells proliferate out of control. These cells may be neutrophils. Neutrophilia can also be caused by appendicitis and ...
Numerous TKIs aiming at various tyrosine kinases have been generated by the originators of these compounds and proven to be effective anti-tumor agents and anti-leukemic agents.[4][5] Based on this work imatinib was developed against chronic myelogenous leukemia (CML)[6] and later gefitinib and erlotinib aiming at the EGF receptor. Sunitinib, an inhibitor of the receptors for FGF, PDGF and VEGF is also based on early studies on TKIs aiming at VEGF receptors.[7] Adavosertib is a Wee1 kinase inhibitor that is undergoing numerous clinical trials in the treatment of refractory solid tumors.[8] However, toxicities such as myelosuppression, diarrhea, and supraventricular tachyarrhythmia have arisen while attempting to determine the toxicity and effectiveness of the drug.[9] Lapatinib, FDA approved for treatment in conjunction with chemotherapy or hormone therapy, is also currently undergoing clinical trials in the treatment of HER2-overexpressing breast cancers as it is suggested intermittent ...
Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1. CRKL has been shown to interact with: Abl gene, BCAR1, BCR gene, CBLB, CD117, CD34, Cbl gene, Dock2, EPOR, GAB1, GAB2, INPP5D, MAP4K1, MAP4K5, NEDD9, PIK3R2, Paxillin RAPGEF1, RICS, STAT5A, Syk, and WAS. Crk GRCh38: Ensembl release 89: ENSG00000099942 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000006134 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". ten Hoeve J, Morris C, Heisterkamp N, Groffen J (September 1993). "Isolation and ...
The cast lived in a building at 249-251 Arch Street at 3rd Street in Old City Philadelphia 39°57′08″N 75°08′43″W / 39.9522°N 75.1453°W / 39.9522; -75.1453. The 14,494-square-foot (1,346.5 m2), three-story building, which is adjacent to the Betsy Ross House, was built in 1902, and known as the Union Bank of Philadelphia Building until 1970, when it was sold to Seamen's Church Institute to house global seafarers. It was placed on the Philadelphia Register of Historic Places in January 1977,[5] and purchased in 2003 by Yaron Properties, Inc for $2.2 million USD. $3 million more went into renovating and furnishing the building for production of the series, which included 42 mounted cameras for filming. The interior was designed by Norm Dodge of Norm Dodge & Associates. In March 2004, producers ceased construction after completing two thirds of the project, and announced they were leaving Philadelphia because of disputes with Philadelphia trade unions. Joey Carson, CEO of ...
Philadelphia 76ers, NBA'de Atlantik Grubu'nda yer alan Philadelphia takımıdır. 1949 yılında kurulmuştur. NBA de üç kez şampiyonluğa ulaşmıştır. Şampiyonlukları 1955,1967 ve 1983 yılındadır. En son 2000-2001 sezonunda final oynamış ama finalde L.A. Lakers takımına kaybetmiştir. 2006 yılında playofflara girememiştir. Takımın ünlü oyuncusu Allen Iverson, 2006-07 sezonunda takas edilmiş ve Denver Nuggets'a gönderilmiştir. Bu oyuncunun ayrılmasından sonra takım büyük bir düşüşe geçmiştir. Özellikle yıldız oyuncu eksikliği yaşamaktadır. Fakat Philadelphia 76ers 2007-2008 sezonunda yıldızsız kadrosuna rağmen büyük bir başarı göstererek, doğu konferansını 7. bitirip playofflara girmiştir. Playoff ilk turunda güçlü rakibi Detroit Pistons'ı zorlamasına rağmen 4-2 elenmiştir. Takım 2008 off sezonunda beklenen hamleyi yapmış ve takıma Los Angeles Clippers'tan Elton Brand'i katmıştır. Son olarak kısa bir süre önce basketbolu ...
ଲିଉକେମିଆ (ଆମେରିକିୟ ଇଂରାଜୀରେ Leukemia ଓ ଇଂଲିସ ଇଂରାଜୀରେ leukaemia) ଏକ କର୍କଟ ଦଳର ନାମ ଯାହା ଅସ୍ଥିମଜ୍ଜାରେ ଆରମ୍ଭ ହୁଏ ଓ ଏହା ଯୋଗୁ ଶ୍ୱେତ ରକ୍ତ କଣିକା ସଂଖ୍ୟ ବଢ଼ିଯାଏ । [୧] ଏହି ରକ୍ତ କଣିକାଗୁଡ଼ିକ ସମ୍ପୁର୍ଣ୍ଣଭାବେ ତିଆରି ହୋଇ ନ ଥାଆନ୍ତି, ତେଣୁ ଏମାନଙ୍କର ନାମ ପ୍ରିକର୍ସର ଜୀବକୋଷ ବା ବ୍ଲାଷ୍ଟ ଜୀବକୋଷ ବା ଲିଉକେମିଆ ଜୀବକୋଷ ଦିଆଯାଇଥାଏ ।[୨] ରକ୍ତସ୍ରାବ ଅସୁବିଧା, ଥକ୍କାଣ ଓ ଜ୍ୱର ହୁଏ ତ‌ଥା ସଂକ୍ରମଣ ସଂକଟ ଅଧିକ ରହେ । [୨] ସାଧାରଣ ରକ୍ତ କଣିକା ଅଭାବ ...
The touchdown polymerase chain reaction or touchdown style polymerase chain reaction is a method of polymerase chain reaction by which primers avoid amplifying nonspecific sequences. The annealing temperature during a polymerase chain reaction determines the specificity of primer annealing. The melting point of the primer sets the upper limit on annealing temperature. At temperatures just above this point, only very specific base pairing between the primer and the template will occur. At lower temperatures, the primers bind less specifically. Nonspecific primer binding obscures polymerase chain reaction results, as the nonspecific sequences to which primers anneal in early steps of amplification will "swamp out" any specific sequences because of the exponential nature of polymerase amplification. The earliest steps of a touchdown polymerase chain reaction cycle have high annealing temperatures. The annealing temperature is decreased in increments for every subsequent set of cycles (the number of ...