"A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans". The Journal of ...
Advantages due to genetic variation[edit]. See also: Hill-Robertson effect. For the advantage due to genetic variation, there ... Protection from major genetic mutation[edit]. In contrast to the view that sex promotes genetic variation, Heng,[13] and ... Genetic heritability cost of sex[edit]. A sexually reproducing organism only passes on ~50% of its own genetic material to each ... August Weismann picked up the thread in 1889, arguing that sex serves to generate genetic variation, as detailed in the ...
... which are a big part of genetic variation in the human genome, and copy number variation (CNV), pose problems in single cell ... Single-cell resolution can uncover the roles of genetic mosaicism or intra-tumor genetic heterogeneity in cancer development or ... For a gene that is 1kb long, this corresponds to 500 reads and a minimum coefficient of variation (CV) of 4% under the ... "Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites". eLife. 7: e33105. doi:10.7554/eLife.33105 ...
2007: Human genetic variation. *2008: Cellular reprogramming. *2009: Ardipithecus ramidus. *2010: First quantum machine ... "Genetic Engineering & Biotechnology News. Mary Ann Liebert, Inc. p. 13. Retrieved 2008-07-06. (subtitle) Procymal is being ... Using genetic reprogramming with protein transcription factors, pluripotent stem cells with ESC-like capabilities have been ... Without optimal culture conditions or genetic manipulation,[18] embryonic stem cells will rapidly differentiate. ...
2007: Human genetic variation. *2008: Cellular reprogramming. *2009: Ardipithecus ramidus. *2010: First quantum machine ... Some in the press speculated that a contributing factor to Dolly's death was that she could have been born with a genetic age ...
2007: Human genetic variation. *2008: Cellular reprogramming. *2009: Ardipithecus ramidus. *2010: First quantum machine ...
2007: Human genetic variation. *2008: Cellular reprogramming. *2009: Ardipithecus ramidus. *2010: First quantum machine ...
Weiner, Michael P; Gabriel, Stacey B; Stephens, J Claiborne (2007). Genetic Variation: a Laboratory Manual. Cold Spring Harbor ...
Advantages due to genetic variation[edit]. For the advantage due to genetic variation, there are three possible reasons this ... Protection from major genetic mutation[edit]. In contrast to the view that sex promotes genetic variation, Heng,[11] and ... Genetic heritability cost of sex[edit]. A sexually reproducing organism only passes on ~50% of its own genetic material to each ... August Weismann picked up the thread in 1889, arguing that sex served to generate genetic variation, as detailed in the ...
Barnes, Michael R. (2003). "Human Genetic Variation: Databases and Concepts". In Barnes, Michael R.; Gray, Ian C. ... A single nucleotide polymorphism (SNP), a variation at a single site in DNA, is the most frequent type of variation in the ... SNP-based genetic linkage analysis can be used to map disease loci, and determine disease susceptibility genes in individuals. ... The combination of SNP maps and high density SNP arrays allows SNPs to be used as markers for genetic diseases that have ...
"Mechanisms: Genetic Variation: Types of Mutations". Evolution 101: Understanding Evolution For Teachers. University of ... the truncated proteins frequently are unable to function properly or at all and can possibly result in any number of genetic ...
"Model of Genetic Variation in Human Social Networks" (PDF). Proceedings of the National Academy of Sciences. 106 (6): 1720-1724 ... "Genetic Variation in Political Participation" (PDF). American Political Science Review. 102 (2): 233-248. CiteSeerX 10.1.1.165. ... More recently, he has shown evidence that social networks have a partly genetic basis.[28] In 2010, he published a paper ... the study of the genetic basis of political behavior). He is currently Professor of Medical Genetics in the School of Medicine ...
Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID 18096770. Gretchen Vogel ( ... Human genetic variation Reprogramming cells High-energy cosmic rays Receptor visions Beyond silicon: oxide interfaces Quantum ... Genomes Project an international research effort to establish by far the most detailed catalogue of human genetic variation. ...
"What are variants, alleles and haplotypes? , Human genetic variation". Retrieved 16 November 2020. Seltsam A, Hallensleben M, ... and that a great deal of genetic variation is hidden in the form of alleles that do not produce obvious phenotypic differences ... Allelic variation at a locus is measurable as the number of alleles (polymorphism) present, or the proportion of heterozygotes ... It can also refer to different sequence variations for several-hundred base-pair or more region of the genome that codes for a ...
This narrowing of phenotypes causes a reduction in genetic diversity in a population. Maintaining genetic variation is ... "Low genetic variation". evolution.berkeley.edu. Retrieved 2018-05-13. Linnen CR, Hoekstra HE (2009). "Measuring natural ... "Reconciling strong stabilizing selection with the maintenance of genetic variation in a natural population of black field ... "Variation in Clutch Sizes". web.stanford.edu. Retrieved 2018-05-13. "A Simple Definition and Prominent Examples of Stabilizing ...
Pennisi Elizabeth (2007). "Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID ... A set of aAIMs can be used to identify the ancestry of ancient populations and eventually quantify the genetic similarity to ... NGS enables the study of genetic markers by isolating specific gene sequences. One such method for sequence extraction is the ... Though AIM panels can be useful for disease screening, the Genetic Information Nondiscrimination Act (GINA) prevents the use of ...
Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID 18096770. Gretchen Vogel ( ... Human genetic variation 2008: Cellular reprogramming 2009: Ardipithecus ramidus 2010: The first quantum machine Insights of the ...
"European Genetic Variation". Online maps. Archived from the original on 5 December 2006. Collins, Roger (1990). The Basques ( ... Along the same lines, a genetic study carried out in 2001 revealed that the Y-chromosome of Celtic populations do not differ ... Mattias Jakobsson from Uppsala University in Sweden analysed genetic material from eight Stone Age human skeletons found in El ... Throughout this region, which underwent similar cultural developments with some local variation, Aurignacian culture was ...
For continuous variation in biology, see Genetic variability. For other uses, see Distribution. ...
Honjo T, Habu S (1985). "Origin of immune diversity: genetic variation and selection". Annu Rev Biochem. 54 (1): 803-830. doi: ... Several complex genetic mechanisms have evolved that allow vertebrate B cells to generate a diverse pool of antibodies from a ... These gene segments are then joined together using random genetic recombination to produce the paratope. The regions where the ... Susumu Tonegawa showed that genetic material can rearrange itself to form the vast array of available antibodies.[107] ...
O. volvulus has low genetic variation between individuals. This suggests a population bottleneck occurred in the past that ... This pattern of low genetic variation and high haplotype diversity suggests fast population expansion after a bottleneck and ... This is also supported by genetic data that place O. ochengi (a cattle-infecting strain) as the sister group to O. volvulus.[20 ... "Ivermectin Resistance in Onchocerca volvulus: Toward a Genetic Basis". PLOS Neglected Tropical Diseases. 1 (1): e76. doi ...
Combined with archaic admixture this has resulted in significant genetic variation, which in some instances has been shown to ... Townsend G, Richards L, Hughes T (May 2003). "Molar intercuspal dimensions: genetic input to phenotypic variation". Journal of ... gradually converging into the modern human varieties by the mechanism of clinal variation, via genetic drift, gene flow and ... However, genetic evidence from the Sima de los Huesos fossils published in 2016 seems to suggest that H. heidelbergensis in its ...
Recombination between homeologous chromosomes occurs only rarely, if at all.[68] Since production of genetic variation is weak ... Thus little, if any, genetic variation is produced. ... "Genetic damage, mutation, and the evolution of sex". Science. ... van der Beek, S.; Nielen, A.L.; Schukken, Y.H.; Brascamp, E.W. (1999). "Evaluation of genetic, common-litter, and within-litter ... Leroy, G. (August 2011). "Genetic diversity, inbreeding and breeding practices in dogs: results from pedigree analyses". Vet. J ...
"Genetic Variation and Population Structure in Native Americans". PLoS Genet. 3 (11): e185. doi:10.1371/journal.pgen.0030185. ... Observed is both a decreasing genetic diversity as geographic distance from the Bering Strait occurs and a decreasing genetic ... Wells, Spencer; Read, Mark (2002). The Journey of Man - A Genetic Odyssey (Digitised online by Google books). Random House. pp ... Main article: Genetic history of indigenous peoples of the Americas. See also: Y-DNA haplogroups in indigenous peoples of the ...
And we're now confronted with a persisting aberration, but is it an aberration? It's a genetic variation. So what do we do? I ... "LKY Controversial: LGBT - "It's a genetic variation"". The Online Citizen. 26 March 2015. Retrieved 5 December 2020. "Excerpts ... There's a genetic difference, so it's not a matter of choice. They are born that way and that's that. So if two men or two ... They're born with that genetic code, that's that. Dick Cheney didn't like gays but his daughter was born like that. He says, 'I ...
Nonlethal mutations accumulate within the gene pool and increase the amount of genetic variation. The abundance of some genetic ... In the neutral theory of molecular evolution, neutral mutations provide genetic drift as the basis for most variation at the ... Mutation is the ultimate source of all genetic variation, providing the raw material on which evolutionary forces such as ... A 2007 study on genetic variations between different species of Drosophila suggested that, if a mutation changes a protein ...
Genetic variation Georgitsi, Marianthi; Viennas Emmanouil; Antoniou Dimitris I; Gkantouna Vassiliki; van Baal Sjozef; Petricoin ... FINDbase was founded in 2006 to be a relational database for these frequencies of causative genetic variations of inherited ... The Frequency of INherited Disorders database (FINDbase) is a database of frequencies of causative genetic variations worldwide ... a worldwide database for genetic variation allele frequencies updated". Nucleic Acids Res. 39 (Database issue): D926-32. doi: ...
"Selection, nuclear genetic variation, and mtDNA". john hawks weblog. Retrieved 2011-01-05. Thorne, A.G.; Wolpoff, M.H. (2003 ... Thorne, A.G.; Wolpoff, M. H.; Eckhardt, R.B. (1993). "Genetic variation in Africa". Science. 261 (5128): 1507-1508. Bibcode: ... "Variation in NAT1 and NAT2". john hawks weblog. Retrieved 2011-01-04. Garrigan, D.; Mobasher, Z.; Severson, T.; Wilder, J. A.; ... 2010-12-23). "Genetic history of an archaic hominin group from Denisova Cave in Siberia". Nature. 468 (7327): 1053-60. Bibcode: ...
... intra-clonal genetic variation; rapid evolution in insect populations due to various genetic-ecological mechanisms; population ... underwent increased genetic variation, so did that of its parasitoid. This suggested a fine-grained co-evolutionary tracking to ... 2010) Rapid genetic changes in natural insect populations. Ecological Entomology (special issue) 35, 155-164. Biron DG, Loxdale ... Loxdale has written reviews on absence of strict genetic uniformity in populations of clonal organisms such as aphids. This ...
Genetic Variation and the Natural History of Quaking Aspen. BioScience 46, 1, 25-31. JSTOR ... High levels of genetic variation and excesses of heterozygotes are found in [the aspen of] semi-arid environments... Clonal ... DeWoody, J.; Rowe, C.A.; Hipkins, V.D.; Mock, K.E. (2008). ""Pando" Lives: Molecular Genetic Evidence of a Giant Aspen Clone in ... This collection of multiple stems, called ramets, all form one, single, genetic individual, usually termed a clone. ...
基因組圖譜主要可以分成兩種,一種是遺傳圖譜(genetic map),另一種則是物理圖譜(physical map)。遺傳圖譜是利用基因的重組率來做分析,單位是分莫甘(centimorgan)。這種圖譜表現出來的是基因或特定DNA片段之間的相對
Genetic variation in the key bile acid synthesis enzyme, CYP7A1, influenced the effectiveness of UDCA in colorectal adenoma ... "Bile salts of vertebrates: structural variation and possible evolutionary significance". J. Lipid Res. 51 (2): 226-46. doi ...
A Danish study found that substantial genetic variation between ash trees affected their level of susceptibility.[24] However, ... Ash fungus genetic code unravelled - BBC News *^ a b c "Chalara dieback of ash (Chalara fraxinea)". Forestry Commission. ... Gross, A.; Grünig, C. R.; Queloz, V.; Holdenrieder, O. (2012). "A molecular toolkit for population genetic investigations of ... Genetic analysis of the fungus Lambertella albida which grows harmlessly on petioles of the Manchurian ash (Fraxinus ...
... summarized contemporary thinking about the genetic basis of quantitative natural variation: "As genetic studies continued, ever ... The number of QTLs which explain variation in the phenotypic trait indicates the genetic architecture of a trait. It may ... While schizophrenia is widely believed to be multifactorially genetic by biopsychiatrists, no characteristic genetic markers ... then there is a strong chance that the disease is genetic[citation needed] and that the patient will also be a genetic carrier ...
In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq - - ... Many scholars have proposed historical and genetic links between the Marsh Arabs and the ancient Sumerians based on shared ...
... collaborations with both Laboratory Corporation and Quest Diagnostics to develop a solution for scoring genetic variation for ...
There are many regional variations on the rhyme, which means that it is impossible to give a definitive version.[50][52] ... Importance of habitat preference and breeding behavior on genetic structure in China". Molecular Phylogenetics and Evolution. ... The gradual clinal variation over the large geographic range and the intergradation of the different subspecies means that the ... but show much variation in ground and marking.[31] ...
Owing to their highly 'malleable' genetic code, mallards can display a large amount of variation,[36] as seen here with this ... Genetic analysis has shown that certain mallards appear to be closer to their Indo-Pacific relatives while others are related ... Mallards are causing severe "genetic pollution" to South Africa's biodiversity by breeding with endemic ducks[113] even though ... Due to the variability of the mallard's genetic code, which gives it its vast interbreeding capability, mutations in the genes ...
"Mobile Genetic Elements. 3 (4): e25845. doi:10.4161/mge.25845. PMC 3812789. PMID 24195014.. ... Chloroplast transit peptides exhibit huge variation in length and amino acid sequence.[42] They can be from 20-150 amino acids ... It further contends that only a minority of the genetic material is kept in circular chromosomes while the rest is in branched ...
In spite of regional variations, around 80% of the females give birth to their calves within a period of 2-3 weeks after the ... Corbet, S. W.; Robinson, T. J. (November-December 1991). "Genetic divergence in South African Wildebeest: comparative ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... Acne can be a feature of rare genetic disorders such as Apert's syndrome.[15] Severe acne may be associated with XYY syndrome.[ ... Acne appears to be strongly inherited; genetics explain 81% of the variation in the population.[15] Studies performed in ... among others.[19] The 308 G/A single nucleotide polymorphism variation in the gene for TNF is associated with an increased risk ...
They have combined molecular and genetic approaches to answer some of Darwins key questions about the natural variation of ... For his numerous contributions to the exact study of heredity & variation contained in Hereditary Genius, Natural Inheritance, ... of his discovery of somatic recombination in fungi which led to the elucidation of an important type of genetic variation. ... For his important contribution to the theory of organic evolution by his researches on variation and heredity. ...
... we need massive amounts of genetic sequencing. Not just for new cases, but we need to go back and sequence old cases - from ... we can expect a fair amount of temperature dependent variation in this number. For example, at 55 °C, among the hottest ever ...
"Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs". PLOS ONE ... Those variations are called alleles. While some genes have only one allele because there is low variation, others have only one ... Sometimes, one allele is a disease-causing variation while the other allele is healthy. Sometimes, the different variations in ... In cultured mammalian cells, such as the Chinese hamster ovary cell line, a number of genetic loci are present in a functional ...
The genetic network logic responds to signals received from the environment and from internal cell status sensors to adapt the ... There is similar random variation in the rates of progression of all the other subsystem reaction cascades. The net effect is ... The genetic basis of the phenotypic differences between the two strains results from coding, regulatory, and insertion/deletion ... The central feature of the cell cycle regulation is a cyclical genetic circuit-a cell cycle engine-that is centered around the ...
There are variations from country to country regarding which specialties certain subspecialties are in. ... as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in ... transcription and translation of the genetic material. ...
Genetic skeletal dysplasias also known as osteochondrodysplasia usually manifest in short-limbed disproportionate short stature ... From a medical perspective, severe shortness can be a variation of normal, resulting from the interplay of multiple familial ... The deficiency may be genetic. Among children without growth hormone deficiency, short stature may be caused by Turner syndrome ... On the other hand, most genetic skeletal dysplasias are known for short stature that may be proportionate or disproportionate. ...
... complexity allows the parasite to constantly change its surface and thus evade the immune system through antigenic variation.[ ...
Is it a new tick borne disease or Lyme disease variation?". Brazilian Journal of Medical and Biological Research = Revista ... Polymerase chain reaction (PCR) tests for Lyme disease have also been developed to detect the genetic material (DNA) of the ... antigenic variation of the VlsE surface protein, inactivating key immune components such as complement, and hiding in the ... this is more common after infection by certain Borrelia strains in people with certain genetic and immunologic characteristics. ...
Wild Lens species are a significant source of genetic variation for improving the relatively narrow genetic base of this crop. ... Serious genetic improvement for yield has been made, however, the full potential of production and productivity could not yet ... Although lentils have been an important crop for centuries, lentil breeding and genetic research has a relatively short history ...
Darwin, Charles (1868). The Variation of Animals and Plants under Domestication. Volume 1 (1st ed.). London: John Murray. pp. ... Genetic considerationsEdit. The wolf-like canids are a group of large carnivores that are genetically closely related because ... In The Variation of Animals and Plants under Domestication Charles Darwin wrote: ... Documenting Domestication:New Genetic and Archaeological Paradigms. University of California Press. pp. 279-295. ISBN ...
This compares with 25% of Cw7-B7 that extend to A3::DQ6 [4] Of 25 potential genetic recombinants of A1::DQ2, none exceed 10% of ... "Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project". Immunogenetics. 60 (1): 1-18. doi ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ... February 1999). "The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple ...
However, studies examining the incidence of malignant central nervous system (CNS) tumors have shown some variation with ... and follow-up examination of prepared tissues after immunohistochemical staining or genetic analysis. ... with subtle variations in color. Three separate brain areas make up most of the brain's volume: *telencephalon (cerebral ...
"Genetic variation in the progesterone receptor gene and ovarian cancer risk". American Journal of Epidemiology. 161 (5): 442-51 ...
2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk". Thorax. 59 (3): 259 ... Carrell RW, Jeppsson JO, Laurell CB, Brennan SO, Owen MC, Vaughan L, Boswell DR (July 1982). "Structure and variation of human ... a new paradigm for hepatocellular carcinoma in genetic liver disease". Hepatology. 42 (3): 514-21. doi:10.1002/hep.20815. PMID ... Lessons from descriptive studies and analyses of genetic and environmental risk determinants". Clinical and Experimental ...
Van Parijs, Sofie M.; Hastie, Gordon D.; Thompson, Paul M. (2000-03-01). "Individual and geographical variation in display ... the continuance of their genetic line. ...
Ramel, C (1998). "Biodiversity and intraspecific genetic variation". Pure and Applied Chemistry. 70 (11): 2079-2084. CiteSeerX ... "Genetic Evaluation Results". Archived from the original on August 27, 2001.. *^ S1008: Genetic Selection and Crossbreeding to ... With continuous inbreeding, genetic variation is lost and homozygosity is increased, enabling the expression of recessive ... "Genetic diversity and population genetic structure in the South American sea lion (Otaria flavescens)" (PDF). Department of ...
... describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is genes that ... They also propose the idea that pleiotropy increases the phenotypic variation of both traits since a single mutation on a gene ... Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal ... This mathematical model illustrates how evolutionary fitness depends on the independence of phenotypic variation from random ...
By using temperature variations in their surroundings, or by remaining cold when they do not need to move, reptiles can save ... All genetic studies have supported the hypothesis that turtles are diapsids; some have placed turtles within archosauriformes,[ ... This variation in blood flow has been hypothesized to allow more effective thermoregulation and longer diving times for aquatic ... The cladogram below used a combination of genetic (molecular) and fossil (morphological) data to obtain its results.[25] ...
Keller, A; Zhuang, H; Chi, Q; Vosshall, LB; Matsunami, H (2007-09-27). "Genetic variation in a human odorant receptor alters ... ISBN 0-7817-6003-8. Menashe, I; Abaffy, T; Hasin, Y; Goshen, S; Yahalom, V; Luetje, CW; Lancet, D (2007-10-30). "Genetic ... The causes of hyperosmia may be genetic, environmental or the result of benzodiazepine withdrawal syndrome. When odorants enter ... There has not yet been extensive research into the genetic background of those with general hyperosmia, rather than for just a ...