This was in fact the first demonstration of genetic linkage in mammals. Like her father John Scott Haldane and elder brother J ... Their 1915 publication was the first demonstration of genetic linkage in mammals. However, whilst she was a diploma student at ...
"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14". Science. 258 (5082): 668-671. Bibcode: ... His group conducted genetic linking studies identifying loci associated with familial forms of Alzheimer's disease, a discovery ... His later research used genetic engineering in mice to elucidate mechanisms of aging and Alzheimer's disease. Martin was not as ... Martin's major research focus involved using genetic approaches to elucidate the pathobiology of aging and age-related diseases ...
1993). "Genetic linkage of vitelliform macular degeneration (Best's disease) to chromosome 11q13". Nat. Genet. 1 (4): 246-250. ...
"Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14". Science. 258 (5082): 668-671. Bibcode: ... "Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia". Human Molecular Genetics. 16 (3): 295-306. doi ... "Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from ...
1991). "A genetic linkage map of 27 markers on human chromosome 21". Genomics. 9 (3): 407-19. doi:10.1016/0888-7543(91)90406-5 ... 2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by ... Li Y, Youssoufian H (1998). "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups". J ...
Falk, R. (2004). "Applying and extending the notion of genetic linkage: the first fifty years". In Gaudillière, Jean-Paul; ... Karyotypes are used to confirm the presence of specific species and to study genetic diversity in species with a wide range of ... 70 years of genetic research. pp. 203-275. doi:10.1016/S0074-7696(04)41004-3. ISBN 978-0-12-364645-3. PMID 15548421. {{cite ... Rheinberger, Hans-Jörg (eds.). Classical Genetic Research and Its Legacy: The Mapping Cultures of Twentieth-Century Genetics. ...
Genetic factors limiting the attainment of optimality include mutations and genetic linkage. Complementary strategies to ... The degree of optimization in response to natural selection depends on the rate at which genetic structure changes, the amount ... Strict optima may not be reachable due to genetic and environmental changes. ... "Optimal Decoding of Cellular Identities in a Genetic Network". Cell. 176 (4): 844-855.e15. doi:10.1016/j.cell.2019.01.007. PMC ...
"Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14". Arch. Ophthalmol. 113 (5): 671-5. doi: ... "Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM ...
"Genetic linkage evidence for a familial Alzheimer's seasesease locus on chromosome 14". Science. 258 (5082): 668-71. Bibcode: ... These rare genetic variants are autosomal dominant. In addition to its role in Alzheimer's disease, presenilin-1 also found to ...
Molecular genetic testing by linkage analysis or direct mutation screening is clinically available; however, genetic ... in patients requesting genetic counseling, especially in couples wishing a pre-implantation genetic diagnosis. The findings of ... which can be explained to a large extent by its genetic heterogeneity and modifier genes. It is also the most common of the ... Several genetic mechanisms probably contribute to the phenotypic expression of the disease. Although evidence exists for a two- ...
Botstein, D.; White, R.; Skolnick, M.; Davis, R. (1980). "Construction of a genetic linkage map in man using restriction ... Davis proposed a method for constructing a genetic linkage map using restriction fragment length polymorphisms that was used in ...
1997). "Hereditary geniospasm: linkage to chromosome 9q13-q21 and evidence for genetic heterogeneity". Am. J. Hum. Genet. 61 (4 ... It is a benign genetic disorder linked to chromosome 9q13-q21 where there are episodic involuntary up and down movements of the ...
1995). "Products, genetic linkage and limb patterning activity of a murine hedgehog gene". Development. 120 (11): 3339-53. doi: ... Long F, Zhang XM, Karp S, Yang Y, McMahon AP (December 2001). "Genetic manipulation of hedgehog signaling in the endochondral ...
Matise began her career using genetic linkage to identify genes for genetic diseases. Her contribution to the identification of ... "Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map". Nature Genetics ... Matise was the creator of MultiMap, a computer program that automated the construction of genetic linkage maps of the human ... She went on to earn a master's degree in Genetic Counseling in 1988 from the University of Pittsburgh, and a doctorate in 1992 ...
Genetic linkage analysis of Gilles de la Tourette Syndrome in a Colombian family]. Rev Neurol. 2006 Feb 16-28;42(4):211-16. ... in which a genetic predisposition is seen to interact with non-genetic and environmental factors. As the beneficial effects of ... Probabilistic genetic models may yield better clues than the "one gene equals one disorder" approach. One of the most ... Modeled after genetic breakthroughs seen with large-scale efforts in other neurodevelopmental disorders, three groups are ...
... the database concentrated on genetic information such as genetic linkage maps and other Mendalian information. SoyBase genetic ... SoyBase genetic linkage maps were integral to the assembly of the soybean genome. In 2018 the database received approximately ... It contains genetic information about soybeans. It includes genetic maps, information about Mendelian genetics and molecular ... Soybean genetic maps are displayed using the CMap comparative genetic map viewer. Soybean genomic sequence and gene model data ...
His highest cited paper is "Construction of a genetic linkage map in man using restriction fragment length polymorphisms" at ... "Construction of a genetic linkage map in man using restriction fragment length polymorphisms". Am. J. Hum. Genet. 32 (3): 314- ... Finally, Skolnick and his group developed a method called Restriction Fragment Length Polymorphisms (RFLPs) for genetic mapping ...
Botstein, D.; White, R.; Skolnick, M.; Davis, R. (1980). "Construction of a genetic linkage map in man using restriction ... and Ray White developed the method for constructing a genetic linkage map using restriction fragment length polymorphisms that ... In 2013, it was said of Davis that "A substantial number of the major genetic advances of the past 20 years can be traced back ... "A substantial number of the major genetic advances of the past 20 years can be traced back to Davis in some way." He has won ...
"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium ... is an American genetic testing and precision medicine company based in Salt Lake City, Utah, United States. Myriad employs a ... The global search for the genetic basis of breast cancer began when Mary-Claire King, Ph.D., from the University of California ... In August 2016, Myriad announced it would acquire Assurex Health for up to $410 million, expanding the company's genetic ...
Dumsday, J.L; Smith, K.F.; Forster, J.W.; Jones, E. S. (October 2003). "SSR-based genetic linkage analysis of resistance to ... Rayapati, P.J.; Greogry, J.W.; Lee, M; Wise, R.P. (December 1994). "A linkage map of diploid Avena based on RFLP loci and a ...
There are many deviations from the principle of independent assortment due to genetic linkage. Of the 46 chromosomes in a ... Along with crossing over, independent assortment increases genetic diversity by producing novel genetic combinations. ... Genetic characteristics have alternate forms, each inherited from one of two parents. Today these are called alleles. One ... If two parents are mated with each other who differ in one genetic characteristic for which they are both homozygous (each pure ...
In 1994, Ralph Oehlmann's group mapped MED to the peri-centromeric region of chromosome 19, using genetic linkage analysis. ... Oehlmann, R; Summerville, GP; Yeh, G; Weaver, EJ; Jimenez, SA; Knowlton, RG (January 1994). "Genetic linkage mapping of ... "Genetic linkage of mild pseudoachondroplasia (PSACH) to markersin the pericentromeric region of chromosome 19". Genomics. 18 (3 ... In 1995, the group led by Knowlton did a "high-resolution genetic and physical mapping of multiple epiphyseal dysplasia and ...
2003). "Linkage to the CCM2 locus and genetic heterogeneity in familial cerebral cavernous malformation". The Canadian Journal ... 2006). "Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study". Arch. ... 2006). "Cerebral venous malformations have distinct genetic origin from cerebral cavernous malformations". Stroke. 36 (11): ... "Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and ...
Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild ... Briggs MD, Rasmussen IM, Weber JL, Yuen J, Reinker K, Garber AP, Rimoin DL, Cohn DH (Dec 1993). "Genetic linkage of mild ... Oehlmann R, Summerville GP, Yeh G, Weaver EJ, Jimenez SA, Knowlton RG (Jan 1994). "Genetic linkage mapping of multiple ...
Takeda H, Takai A, Inuzuka T, Marusawa H (January 2017). "Genetic basis of hepatitis virus-associated hepatocellular carcinoma ... linkage between infection, inflammation, and tumorigenesis". Journal of Gastroenterology. 52 (1): 26-38. doi:10.1007/s00535-016 ...
Members will often protect and defend young, even if not of direct genetic linkage. Circulus is a Latin based term; one ...
This was the first human disease gene to be found using genetic linkage and the first set of human genetic markers based on ... Summary of Key Discoveries: 1983: Helped localize the Huntington's disease gene via genetic linkage (with James F. Gusella and ... 1987). "The amyloid beta protein gene: cDNA cloning, mRNA distribution, and genetic linkage near the Alzheimer locus". Science ... Discovered genetic linkage of AD to chromosome 10, implicating the gene encoding the insulin degrading enzyme. 2001: Showed ...
In addition, many genetic and epigenetic changes are formed in liver cells during HCV and HBV infection, which is a major ... linkage between infection, inflammation, and tumorigenesis". Journal of Gastroenterology. 52 (1): 26-38. doi:10.1007/s00535-016 ... Genetic conditions: untreated hereditary hemochromatosis, alpha-1-antitrypsin deficiency, glycogen storage diseases, porphyria ... Takeda H, Takai A, Inuzuka T, Marusawa H (January 2017). "Genetic basis of hepatitis virus-associated hepatocellular carcinoma ...
A possible genetic linkage; T. Esposito, R. Uccello, R. Caliendo, G.F. Di Martino, U.A. Gironi Carnevale, S. Cuomo, D. Ronca, B ...
Gorlova OY, Amos CI, Wang NW, Shete S, Turner ST, Boerwinkle E (June 2003). "Genetic linkage and imprinting effects on body ... Although genetic deficiencies are currently considered rare, variations in these genes may predispose to common obesity. Many ... Yang W, Kelly T, He J (2007). "Genetic epidemiology of obesity". Epidemiol Rev. 29: 49-61. doi:10.1093/epirev/mxm004. PMID ... Walley AJ, Asher JE, Froguel P (June 2009). "The genetic contribution to non-syndromic human obesity". Nat. Rev. Genet. 10 (7 ...
Genetic diversity, linkage disequilibrium, and association mapping analyses of Gossypium barbadense L. germplasm. PLoS ONE 12( ... Genetic diversity and population structure of cotton (Gossypium spp.) of the New World were assessed by SSR markers. Botany 91( ... Development, genetic mapping, and QTL association of cotton PHYA, PHYB, and HY5-specific CAPS and dCAPS markers. BMC Genetics. ... "Investigation of genetic and cellular peculiarities of RNA interference of phytochrome A1 gene of cotton (Gossypium ssp) as ...
... with genetic linkage analysis. The authors explain, "While both linkage and expression analyses are powerful on their own, the ... Genomic convergence is a multifactor approach used in genetic research that combines different kinds of genetic data analysis ... identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage". Hum. ... "Genetic Exploration of Alzheimer's and Parkinson's Diseases". eBriefings. The New York Academy of Sciences. Noureddine MA, Li ...