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*  Transmission disequilibrium test
A specificity of the TDT is that it will detect genetic linkage only in the presence of genetic association. While genetic ... as a family-based association test for the presence of genetic linkage between a genetic marker and a trait. It is an ... Blackwelder WC, Elston RC (1985). "A comparison of sib-pair linkage tests for disease susceptibility loci". Genetic ... McGinnis RE, Ewens WJ, Spielman RS (1995). "The TDT reveals linkage and linkage disequilibrium in a rare disease". Genet ...
*  Recombination hotspot
Linkage disequilibrium has identified more than 30,000 hotspots within the human genome. In humans, the average number of ... Evolution Genetic recombination Jeffreys AJ, Kauppi L, Neumann R (October 2001). "Intensely punctate meiotic recombination in ... The PRDM9 gene encodes a histone methyltransferase in the Dsbc1 region, providing evidence of a non-random, genetic basis for ... Auton, Adam; Fledel-Alon, Adi; Pfeifer, Susanne; Venn, Oliver; Ségurel, Laure (2012). "A fine-scale chimpanzee genetic map from ...
*  Genetic recombination
For any fixed set of genetic and environmental conditions, recombination in a particular region of a linkage structure ( ... In eukaryotes, genetic recombination during meiosis can lead to a novel set of genetic information that can be passed on from ... The shuffling of genes brought about by genetic recombination produces increased genetic variation. It also allows sexually ... During meiosis, synapsis (the pairing of homologous chromosomes) ordinarily precedes genetic recombination. Genetic ...
*  Ancestry-informative marker
SLC24A5 Race and genetics Elizabeth Pennisi, Human Genetic Variation, Science 21 December 2007: Vol. 318. no. 5858, pp. 1842 - ... way to discover novel genes underlying complex diseases in a technique called admixture mapping or mapping by admixture linkage ...
*  Amplified fragment length polymorphism
AFLP-PCR or just AFLP is a PCR-based tool used in genetics research, DNA fingerprinting, and in the practice of genetic ... and in linkage studies to generate maps for quantitative trait locus (QTL) analysis. There are many advantages to AFLP when ... As a result, AFLP has become widely used for the identification of genetic variation in strains or closely related species of ...
*  Homologous recombination
This represents linkage between the two genes greater than would be expected from genes that independently assort during ... Lobo I, Shaw K (2008). "Thomas Hunt Morgan, genetic recombination, and gene mapping". Nature Education. 1 (1). Coe E, Kass LB ( ... These new combinations of DNA represent genetic variation in offspring, which in turn enables populations to adapt during the ... The SSA pathway is considered mutagenic since it results in such deletions of genetic material. During DNA replication, double- ...
*  Genetic linkage
Recombination frequency is a measure of genetic linkage and is used in the creation of a genetic linkage map. Recombination ... Genetic maps help researchers to locate other markers, such as other genes by testing for genetic linkage of the already known ... A linkage map (also known as a genetic map) is a table for a species or experimental population that shows the position of its ... Linkage maps were first developed by Alfred Sturtevant, a student of Thomas Hunt Morgan. A genetic map is a map based on the ...
*  Genetic heterogeneity
Initial research on genetic heterogeneity was conducted using genetic linkage analyses, which map genetic loci of related ... 8 (1): 6. doi:10.1016/S1672-2930(13)50002-X. Teare, Dawn; Barrett, Jennifer (September 15, 2005). "Genetic linkage studies". ... Genetic heterogeneity occurs through the production of single of similar phenotypes through different genetic mechanisms. There ... Disorders on the Autism spectrum have high levels of genetic heterogeneity and result from multiple genetic pathways including ...
*  Gene map
They found that the CF gene resides around 7q31-q32 (see chromosomal nomenclature). Genetic linkage Nussbaum, Robert L.; ... Pulst, Stefan M. (June 1999). "Genetic Linkage Analysis". JAMA Neurology. 56 (6): 667-672. doi:10.1001/archneur.56.6.667. ... Genetic mapping on the other hand uses genetic techniques to indirectly find association between genes. Techniques can include ... These sites usually contain genetic polymorphisms making them sources of viable genetic markers (as they differ from other ...
*  Domestic rabbit
The Early genetic research focused on linkage distance between various gross phenotypes using linkage analysis. Between 1924 ... "Genetic linkage in the rabbit". Genetics. 27: 519-523. doi:10.1073/pnas.27.11.519. Retrieved July 24, 2015. "Genome of ... Most genetic defects in the domestic rabbit (such as the Holland Lop breed's tendency to develop dental problems) are due to ... Populations in New Zealand have bounced back after developing a genetic immunity, and the disease has no effect on native wild ...
*  Rex mutation
Castle, WE; Sawin, PB (1941). "Genetic linkage in the rabbit". Genetics. 27: 519-523. doi:10.1073/pnas.27.11.519. Retrieved 24 ... Of the 3 genetic sources of rex rabbits, the one due to the gene r1 is the most popular with fanciers and has the simple ... It was not linked with any other genes known at the time although it was eventually found to be in the same linkage group as r2 ... The diversity of genetic factors results in variable coat thickness/density and fur length. A great variety exists within rex ...
*  Gene
This is known as genetic linkage. DNA replication is for the most part extremely accurate, however errors (mutations) do occur ... The genetic variation in relative frequencies of different alleles in a population is due to both natural selection and genetic ... Lobo, Ingrid; Shaw, Kelly (2008). "Discovery and Types of Genetic Linkage". Nature Education Knowledge. SciTable. Nature ... The related term synthetic biology is sometimes used to refer to extensive genetic engineering of an organism. Genetic ...
*  Heritability of autism
The Autism Genome Project database contains genetic linkage and CNV data that connect autism to genetic loci and suggest that ... Genetic linkage analysis has been inconclusive; many association analyses have had inadequate power. For each autistic ... Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13. Journal of ... Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet. 2007;39(3):319-28. doi:10.1038/ng1985 ...
*  Neurogenetics
This process is referred to sometimes as linkage analysis. By the 1990s ever advancing technology had made genetic analysis ... Tanzi, R.E. (Oct 1991). "Genetic linkage studies of human neurodegenerative disorders". Curr Opin Neurobiol. 1 (3): 455-461. ... focusing in particular how the genetic code an organism carries affects its expressed traits. Mutations in this genetic ... The discovery of linkages could then lead to therapeutic drugs, which could reverse brain degeneration. One of the most ...
*  Gametic phase
... is influenced by genetic linkage. Excoffier, Laurent (1 November 2003). "Gametic phase estimation over large ...
*  VPS13A
... genetic linkage to chromosome 9q21". American Journal of Human Genetics. 61 (4): 899-908. doi:10.1086/514876. PMC 1715977 . ... clinical and genetic findings in three families from the Arabian peninsula". Movement Disorders. 18 (4): 403-7. doi:10.1002/mds ...
*  PTPN14
"The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246-339. doi:10.1038/ng0694supp-246. PMID ...
*  Family-based QTL mapping
Genetic linkage is the phenomenon where by alleles at different loci cosegregate in families. The strength of cosegregation is ... CRC Press, Boca Raton, pp 145-161 Lander, E. S.; Green, P. (1987). "Construction of multilocus genetic linkage maps in humans ... Extended pedigree are attractive for linkage-based analysis. Linkage and association analysis are primary tools for gene ... In linkage studies, we seek to identify the loci that cosegregate with a specific genomic region, tagged by polymorphic markers ...
*  SLURP1
Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J (1999). "Genetic linkage of Meleda disease to ...
*  XRCC1
"The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246-339. doi:10.1038/ng0694supp-246. PMID ... Hung RJ, Hall J, Brennan P, Boffetta P (Nov 2005). "Genetic polymorphisms in the base excision repair pathway and cancer risk: ...
*  Human disease modifier gene
Genetic linkage analysis and association studies are widely used methods of identifying modifier loci. The advent of new ... Pulst SM (1999). "Genetic linkage analysis". Archives of Neurology. 56 (6): 667-72. PMID 10369304. Milet J, Dehais V, Bourgain ... In an example of a familial linkage study, genotyping and linkage analysis conducted in a population of 197 sibpairs and their ... Genetic Modifiers of Huntington's Disease (GeM-HD) Consortium (2015). "Identification of Genetic Factors that Modify Clinical ...
*  Phycomyces blakesleeanus
A genetic linkage map was developed for P.blakesleeanus. This genetic map was constructed from 121 progeny of a cross between ... Chaudhary S, Polaino S, Shakya VP, Idnurm A (2013). "A new genetic linkage map of the zygomycete fungus Phycomyces ...
*  F13B
1987). "Coagulation factor XIII: genetic linkage studies with F13B". Genet. Epidemiol. 4 (1): 43-9. doi:10.1002/gepi.1370040106 ... 1993). "Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII". Blood. 82 (1 ...
*  Elston-Stewart algorithm
It is used in the analysis of genetic linkage. Elston, R. C., Stewart, J. (1970) "A new test of association for continuous ... variables", Biometrics, 26, 305-314 Elston, R. C., Stewart, J. (1971) "A general model for the genetic analysis of pedigree ...
*  Helen Donis-Keller
"A Genetic Linkage Map of the Human Genome" (PDF). Cell. 51: 319-337. doi:10.1016/0092-8674(87)90158-9. Cook-Deegan, Robert ( ... During her time at Collaborative Research, her research group created the first genetic map of the human genome. Donis-Keller ...
*  HLA-A36
HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in ... Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in ... 2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue ...
*  George Davis Snell
His doctoral thesis was on genetic linkage in mice. Upon receiving the Ph.D from Harvard, George Snell was employed as a ... Snell studied the genetic effects of x-rays on mice with Muller. This experience "served to convince me that research was my ... "discovered the genetic factors that determine the possibilities of transplanting tissue from one individual to another. It was ...