"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet. 372 ...
Second, genome wide association studies have reported a significant association of chromosome 9p21 with coronary artery disease ... A multi-locus genetic risk score study based on a combination of 27 loci, including the CDKN2A gene, identified individuals at ... The study was based on a community cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled ... Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S (July 2008). "Association of genetic variation on chromosome 9p21 with ...
... null mice exhibit behaviors consistent with autism and multiple genetic studies have found significant evidence for association ... This same association was replicated in the longitudinal studies. Children prenatally exposed to VPA or with fetal valproate ... Folate pathways have been studied to be potential predictors of ASD. A few genetic polymorphisms such as folate hydrolase 1 and ... SHANK 3 is the most studied gene from the SHANK gene family. Several studies have found that disruptions to SHANK 3 cause more ...
Indeed, a wide range of studies on irregularities in the noncoding genes discovered several associations to genetic diseases. ... One of the most studied gene deserts is the 8q24 region. Early genome wide association studies were focused on the 8q24 region ... For example, in a study on chromosomes 2 and 4, which have been linked to several genetic diseases, there were elevated GpC ... is perhaps the most studied oncogene due to its association with a myriad of diseases. Normal functioning of the MYC promoter ...
She has primarily investigated the genetic association of Varicella zoster virus, Herpes simplex virus and human parainfluenza ... She eventually studied medicine at the Middlesex Hospital medical school. During her doctoral degree Breuer studied the genes ... She also studies how viral evolution impacts public health practises and policy. Breuer demonstrated a methodology that enables ... Breuer was the first to identify a latency associated genetic transcript, which can persist in the neurons of almost all adults ...
... studying the genetic basis for macular telangiectasia type 2. She directed the most recent Genome Wide Association Study (GWAS ... Her work has "led to the discovery of new genes involved in genetic diseases such as deafness and epilepsy". She is a member of ... "New genetic cause of epilepsy found". medicalxpress.com. Retrieved 27 February 2020. "King's Birthday 2023 Honours - the full ... 2023 Member of the Order of Australia in the 2023 King's Birthday Honours for "significant service to genetic and infectious ...
In association studies, detecting the presence of genetic structure is considered a necessary preliminary step to avoid ... In evolutionary biology and bio-medicine, the model is used to detect the presence of structured genetic variation in a group ... The model assumes that alleles carried by individuals under study have origin in various extant or past populations. The model ... to estimate the allele frequencies in those source populations and the origin of alleles carried by individuals under study. ...
Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (June 2005). "Developmentally restricted genetic ... gene resequencing and functional genomics studies". The Journal of Biological Chemistry. 281 (11): 7364-73. doi:10.1074/jbc. ... determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". ... Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (April 2007). "Genetic polymorphisms influencing ...
The biochemical association towards crime must acknowledge psychophysiology, brain mechanism and genetic factors that ... He studied unobservable behaviour, parts of the personality that are not visibly noticeable within one's nature and on a basic ... A study conducted in 2018 reviewed 17 patients with brain lesions in research of identifying common characteristics of the ... The study into the unconscious motive for criminal behaviour takes into account the uncontrollable variables human possesses ...
A decade later, hundreds of genome-wide association studies have shown beyond any doubt that the genetic architecture of human ... This resource for genetic epidemiological studies was established in a series of genetic isolate islands off the coast of ... He co-led the study that first identified associations between SLC2A9 genetic variants, uric acid levels and gout; and ... Using inbreeding studies and very elegant designs within his PhD research, Rudan and his colleagues showed that the genetic ...
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008 ... the Rotterdam Study and the Generation R study. Data collection for these studies started in 1990 and 2002, respectively. These ... Genomewide association studies of stroke. N Engl J Med. 2009 Apr 23;360(17):1718-28. Newton-Cheh C, et al. Common variants at ... A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet. 2010 ...
Zheng W, Rao S (August 2015). "Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies ... These associations are mostly obtained from genome wide association studies. Common neurodegenerative diseases associated with ... "Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and ... "STRING: functional protein association networks". string-db.org. Retrieved 6 May 2019. Zeytuni N, Zarivach R (March 2012). " ...
Most importantly, these associations occurred after adjusting for lifestyle factors, implying a genetic basis for onset of ... "The association of fetal and childhood growth with risk of schizophrenia. Cohort study of 720,000 Swedish men and women". ... evidence for an association that may be mediated by genetic factors". Calcif. Tissue Int. 67 (4): 304-8. doi:10.1007/ ... A germ-line study reported paternal rats fed a high-fat diet led to insulin dysfunction in the F1 offspring. While this likely ...
Some methods, such as genetic burden tests, have been specifically developed to study genetic association of rare variants. ... In addition, compared to a genome-wide association study, a region or gene based test performs much fewer tests resulting in a ... effectively boost the power of genetic association of rare variants analysis of whole exome and whole genome sequencing studies ... Lee, Seunggeung; Abecasis, Gonçalo R.; Boehnke, Michael; Lin, Xihong (July 2014). "Rare-Variant Association Analysis: Study ...
... and one study estimated that as of 2018 there were more than 68,000 genetic tests on the market. Genetic testing is "the ... "Genetic testing". American Medical Association. Retrieved 2019-10-03. "Paternity Testing". American Pregnancy Association. 2012 ... Direct-to-consumer (DTC) genetic testing (also called at-home genetic testing) is a type of genetic test that is accessible ... Additionally, a study by Khalifa University has identified, for the first time, four genetic markers associated with type 2 ...
Kalopissis AD, Pastier D, Chambaz J (Apr 2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and ... advances in the study of an enigmatic protein". Journal of Lipid Research. 42 (11): 1727-39. doi:10.1016/S0022-2275(20)31499-1 ...
... "genetic association studies [of HTR2A gene variants with psychiatric disorders] report conflicting and generally negative ... One study found that the common genetic variant rs6311 regulates expression of HTR2A transcripts containing the extended 5' UTR ... July 2008). "Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts". American Journal ... A number of other studies were devoted to finding an association of the gene with schizophrenia, with diverging results. These ...
For Population-based Association Studies. Springer. p. 250. ISBN 978-0-387-89553-6. Stone; et al. (2007). "Glossary of Terms". ... Genetic admixture occurs when previously diverged or isolated genetic lineages mix. Admixture results in the introduction of ... Climatic cycles facilitate genetic admixture in cold periods and genetic diversification in warm periods. Natural flooding can ... The method attempts to correlate the degree of ancestry near a genetic locus with the phenotype or disease of interest. Genetic ...
... suggesting a possible genetic association between the two disorders. Fibrochondrogenesis is quite rare. A 1996 study from Spain ... The study also included the high rate of consanguinous marriages as a prevailing factor for these disorders, as well as the ... Out of 38,048 newborns in Al Ain, over the course of the study period, fibrochondrogenesis was found to be the most common of ... Currently, no specific genetic mutation has been established as the cause of fibrochondrogenesis. Omphalocele is a congenital ...
2009). "Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the ... DAMAGE study". Eur. J. Hum. Genet. 17 (8): 1056-62. doi:10.1038/ejhg.2009.4. PMC 2986549. PMID 19209188. Gerhard DS, Wagner L, ...
Genetic associations studies have suggested that the short "S" allele is associated with impulsive antisocial behavior and ASPD ... Research into genetic associations in antisocial personality disorder suggests that ASPD has some or even a strong genetic ... Twin studies, which are designed to discern between genetic and environmental effects, have reported significant genetic ... Some studies suggest this increase in suicidality is in part due to the association between suicide and symptoms or trends ...
"Genetic Association and Brain Morphology Studies and the Chromosome 8p22 Pericentriolar Material 1 (PCM1) Gene in ... Immunolabeling studies performed found that PCM1 was present in centriolar satellites and in electron dense granules between 70 ... This means that it may now be possible to offer very limited genetic counselling to a small proportion of people with ... These were originally thought to be scattered only around the centrosomes, but further studies proved that PCM1 was also found ...
However, other studies show no association with elevated FSH levels and genetic quality of embryos after adjusting for age. The ... There was no significant difference in genetic embryo quality between same aged women regardless of FSH levels. A 2008 study ... One study has shown AMH to be a better marker than basal FSH for women with proven (prior) fertility in measuring age related ... One study showed an elevated basal day-three FSH is correlated with diminished ovarian reserve in women aged over 35 years and ...
2007). "Case-control genetic association study of fibulin-6 (FBLN6 or HMCN1) variants in age-related macular degeneration (AMD ...
... a meta-analysis showed no association between LUM polymorphism and high myopia susceptibility in all genetic models studied. ... Li M, Zhai L, Zeng S, Peng Q, Wang J, Deng Y, Xie L, He Y, Li T (Jul 2014). "Lack of association between LUM rs3759223 ...
... performed a genome-wide association study, testing millions of genetic markers to find any associated with ... The study of DNA heritability was enhanced through the use of rich genealogical data available in Utah. Over the course of the ... AIS genetic testing is the process of analyzing the DNA of a patient who has been diagnosed with adolescent idiopathic ... "Genetic markers for scoliosis are ID'd". Deseret News. 2008-09-14. Archived from the original on 2009-10-15. Retrieved 2009-10- ...
"A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes". ... Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A (2007). "Association analysis of genetic variants in IL23R, ... Dec 2006). "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene". Science. 314 (5804): 1461- ... "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene". Science. 314 (5804): 1461-3. Bibcode: ...
Genome-wide association studies have found 27 genetic variants that are associated with an increased risk of myocardial ... Aspirin has been studied extensively in people considered at increased risk of myocardial infarction. Based on numerous studies ... The strongest association of MI has been found with chromosome 9 on the short arm p at locus 21, which contains genes CDKN2A ... Previous studies suggested a benefit from omega-3 fatty acid supplementation but this has not been confirmed. Following a heart ...
... have shown genetic association with schizophrenia in several schizophrenia case control studies. Resequencing of the genomic ... "Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in ... Although, recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level ... Linkage studies in extended families multiply affected with bipolar disorder also provide evidence for DISC1 as a genetic ...
Many studies have used TCI for examining whether genetic variants in individual genes have an association with personality ... Self-directedness has a strong negative association with neuroticism and a positive association with conscientiousness. Self- ... although it also has a moderate positive association with openness to experience and a moderate negative association with ... A study examining relationships between character dimensions and aspects of health and happiness found that self-directedness ...