... region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two ... is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3". Cancer Res. 62 (16 ... gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor ... interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription". Mol. Cancer Res. 4 (9): 655-65. doi: ...

Gossage L, Eisen T, Maher ER (January 2015). "VHL, the story of a tumour suppressor gene". Nature Reviews. Cancer. 15 (1): 55- ... Searching for developmentally regulated genes the authors used gene trap screen analysis and identified mouse Jade1 as gene ... "Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma". Human ... "Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease ...

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene. It has been associated with ... large tumor suppressor, homolog 1 (Drosophila)". Hao Y, Chun A, Cheung K, Rashidi B, Yang X (February 2008). "Tumor suppressor ... 1995). "Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase". ... 2002). "WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis". FEBS Lett. 529 (2-3): 319- ...

Lee YS, Dutta A (2007). "The tumor suppressor microRNA let-7 represses the HMGA2 oncogene". Genes Dev. 21 (9): 1025-30. doi: ... Let-7 also inhibits several components of DNA replication machinery, transcription factors, even some tumor suppressor genes ... "Epigenetic Down-Regulation of the Tumor Suppressor Gene PRDM1/Blimp-1 in Diffuse Large B Cell Lymphomas : A Potential Role of ... let-7 is closely associated with human cancer and acts as a tumor suppressor. Numerous reports have shown that the expression ...

The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116-33. PMID 11085536 ... definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034-41. ... identification and evaluation of the resident candidate tumor suppressor genes. ... RBM6 human gene location in the UCSC Genome Browser. RBM6 human gene details in the UCSC Genome Browser. v t e (Articles with ...

... and/or tumor development. The CYLD gene is classified as a tumor suppressor gene, i.e. a gene that regulates cell growth and ... turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene". Nature ... The CYLD lysine 63 deubiquitinase gene, also termed the CYLD gene, CYLD is an evolutionary ancient gene found to be present as ... on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas". Oncogene. 12 (6): 1375-7 ...

This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is known to interact with TNNI3K in the ... Huynh HT, Larsson C, Narod S, Pollak M (Jun 1995). "Tumor suppressor activity of the gene encoding mammary-derived growth ... gene: genomic structure and mutation analysis in human breast tumors". Genomics. 34 (1): 63-8. doi:10.1006/geno.1996.0241. PMID ... "Entrez Gene: FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)". Kleine AH, Glatz JF, Van ...

"Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer". Cancer Research. 71 (2): ... "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research ... "Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities". Biochemical and Biophysical Research ... "Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling". Cancer Cell. 16 ...

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle ... As a tumor suppressor BANP negatively regulates p53 transcription in recombination. It can be expressed in various tissues in ... Jalota A, Singh K, Pavithra L, Kaul-Ghanekar R, Jameel S, Chattopadhyay S (Apr 2005). "Tumor suppressor SMAR1 activates and ... Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by ...

... pituitary tumors miR-26b has been found to directly target and regulate the expression of the PTEN tumour suppressor gene, ... emerging as critical regulators in carcinogenesis and tumor progression by acting either as oncogenes or tumor suppressor genes ... Glioma miR-26b may act as a tumor suppressor in glioma. Low level expression of miR-26b has been found in glioma cells. The ... Burkitt lymphoma miR-26a plays a role as a potential tumor-suppressor in MYC-induced lymphoma. miR-26a is found to be ...

The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. ... Hsieh SY, Hsieh PS, Chiu CT, Chen WY (December 2004). "Dickkopf-3/REIC functions as a suppressor gene of tumor growth". ... January 2002). "Reduced expression of the REIC/Dkk-3 gene by promoter-hypermethylation in human tumor cells". Gene. 282 (1-2): ... Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene. This gene encodes a ...

... including the vast majority of tumor suppressor proteins. For tumor suppressor genes to carry out their normal function ( ... These compounds work by blocking the export of tumor suppressor genes from the cell's nucleus to the cell's cytoplasm, where ... a tumor suppressor gene), CDK4 and CDK6, thyroid hormone receptor beta, and nuclear receptor coactivator 1, among others. ... "SMARCB1/INI1 Tumor Suppressor Gene Is Frequently Inactivated in Epithelioid Sarcomas". Cancer Research. 65 (10): 4012-9. doi: ...

Through loss-of-function and gain-of-function mutations in tumor suppressor genes as well as the K-ras oncogene, mouse models ... The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. PNAS,104(9):3261-3266. Ventura, A, Kirsch DG, ... He has pioneered the use of gene-targeting technology in mice to study cancer-associated genes and to construct mouse models of ... Genes & Development, 21(6):694-707. McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, and ...

2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271-4. doi:10.1006/geno. ... deleted in tumors)". Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor ... Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene. LRP1B belongs to ... Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is ...

"MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy". eLife. 2: e00825. doi:10.7554/eLife.00825. PMC ... of MYB duplications in T-ALL Discovery of FBXW7 mutations in T-ALL Discovery of MYBL2 as the crucial 20q tumor suppressor in ... "Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study ... MYC-induced T-ALL in the zebrafish Use of gene expression profiling to define distinct oncogenic subgroups in T-ALL Discovery ...

These processes are orchestrated by proteins known as tumor suppressor genes. These genes take information from the cell to ... This limit can be overcome by disabling their pRB and p53 tumor suppressor proteins, which allows them to continue doubling ... these tumour suppressor proteins are altered so that they don't effectively prevent cell division, even when the cell has ... An expanding tumour requires new blood vessels to deliver adequate oxygen to the cancer cells, and thus exploits these normal ...

In 1992 oncomice with tumor suppressor genes knocked out were generated. Creating Knockout rats is much harder and only became ... By removing the genes in the plasmid that caused the tumor and adding in novel genes researchers were able to infect plants ... The ability to partially reduce gene function has allowed the study of genes that are lethal when completely knocked out. Other ... With the introduction of the gene gun in 1987 it became possible to integrate foreign genes into a chloroplast. Genetic ...

"Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma". Oncogene. 29 (27): 3908-20. doi:10.1038/onc.2010.143. PMID ... IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer. IRX1 is a member of the Iroquois ... "Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma". Cancer Res. 68 (12): 4494-9. doi: ... "Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma". Cancer Res. 68 (12): 4494-9. doi: ...

"Evolutionary history of the reprimo tumor suppressor gene family in vertebrates with a description of a new reprimo gene ... Hence, it has been proposed as a novel tumor suppressor gene. In colorectal cancer cells, RPRML is a target of Wnt/β-catenin ... "The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of ... "The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties". International Journal of ...

In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene ... A candidate tumor suppressor gene involved in multiple tumor types". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11417-22. Bibcode: ... the FRA16D gene, behaves as a suppressor of tumor growth". Cancer Res. 61 (22): 8068-73. PMID 11719429. Kuroki T, Trapasso F, ... "The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis". Clin. Cancer Res. 10 (7): 2459-65. doi: ...

Tumor suppressor genes are genes that inhibit cell division, survival, or other properties of cancer cells. Tumor suppressor ... The tumor types are typical for each type of tumor suppressor gene mutation, with some mutations causing particular cancers, ... Proto-oncogenes are genes that promote cell growth and mitosis, whereas tumor suppressor genes discourage cell growth, or ... On the other hand, loss of function mutations need to happen in both copies of a tumor suppressor gene to render that gene ...

2006). "Identification of RASSF8 as a candidate lung tumor suppressor gene". Oncogene. 25 (28): 3934-3938. doi:10.1038/sj.onc. ... "Entrez Gene: RASSF8 Ras association (RalGDS/AF-6) domain family 8". Falvella FS, Spinola M, Manenti G, et al. (2007). "Common ... Ras association domain-containing protein 8 is a protein that in humans is encoded by the RASSF8 gene. GRCh38: Ensembl release ... 2002). "The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly". J. Med. Genet ...

1996). "Identification of two candidate tumor suppressor genes on chromosome 17p13.3". Cancer Res. 56 (9): 1997-2002. PMID ... 1999). "Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells". ... a candidate tumor suppressor". Genomics. 69 (1): 54-62. doi:10.1006/geno.2000.6315. PMID 11013075. Chen CM, Behringer RR (2001 ... "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)". Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ ...

"Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes". Nature Medicine. 7 (3): 437-443. ... and hypoxia-inducible factor 1 alpha in tumor growth and metastasis". J Natl Cancer Inst. 102 (6): 426-442. doi:10.1093/jnci/ ...

Hypermethylation of tumor suppressor gene promoter regions can result in silencing of those genes. This type of epigenetic ... When mutation results in loss of heterozygosity at tumor suppressor gene sites, these genes may become inactive. Single base ... These histone modifications can silence tumor suppressor genes despite the drop in methylation of the gene's CpG island (an ... The tumor suppressor gene p53 regulates DNA repair and can induce apoptosis in dysregulated cells. E Soto-Reyes and F Recillas- ...

Among the most common are mutations in tumor suppressor PTEN gene. PTEN phosphatase negatively affects mTOR signalling through ... In 2009 the FRAP1 gene name was officially changed by the HUGO Gene Nomenclature Committee (HGNC) to mTOR, which stands for ... and colleagues independently cloned genes that mediate the toxicity of rapamycin in fungi, known as the TOR/DRR genes. However ... HUGO Gene Nomenclature Committee. September 1, 2020. Retrieved 2020-12-17. Tokunaga C, Yoshino K, Yonezawa K (January 2004). " ...

Higuchi E, Chandraratna RA, Hong WK, Lotan R (2003). "Induction of TIG3, a putative class II tumor suppressor gene, by retinoic ... 2005). "Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase- ... 2000). "Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin ... 1999). "Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene". Proc. Natl ...

Comparative oncology Tumor suppressor gene Metabolic theory of ecology Peto, R.; Roe, F. J. C.; Lee, P. N.; Levy, L.; Clack, J ... The TP53 tumor suppressor gene specifies a protein that senses damaged sites in DNA, or a cell experiencing stress. The TP53 ... In October 2015, two independent studies showed that African elephants have 20 copies of tumor suppressor gene TP53 in their ... Callaway, E. (8 October 2015). "How elephants avoid cancer: Pachyderms have extra copies of a key tumour-fighting gene". Nature ...

Nonetheless, it is suspected to act as a tumor suppressor gene. GRCh38: Ensembl release 89: ENSG00000078725 - Ensembl, May 2017 ... 2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): ... 2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes ... "Entrez Gene: DBC1 deleted in bladder cancer 1". Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour ...

The mutated DNA affects genes involved with the cell cycle, classified as either oncogenes or tumor suppressor genes. Oncogenes ... Tumor suppressor genes prevent cells with erroneous cell cycles from replicating. Cancer cells ignore cell cycle regulators ... Hemangiosarcomas are tumors that form on the blood vessels, and can occur all over the body. These tumors can develop on the ... The tumors occur around the area of external genitalia and can grow up to 15 cm in area. Canine transmissible venereal tumors ...