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*  Von Hippel-Lindau tumor suppressor
"Entrez Gene: VHL von Hippel-Lindau tumor suppressor". Czyzyk-Krzeska MF, Meller J (April 2004). "von Hippel-Lindau tumor ... The von Hippel-Lindau tumor suppressor also known as pVHL is a protein that in humans is encoded by the VHL gene. Mutations of ... Kaelin WG (September 2004). "The von Hippel-Lindau tumor suppressor gene and kidney cancer". Clinical Cancer Research. 10 (18 ... Kaelin WG (September 2004). "The von Hippel-Lindau tumor suppressor gene and kidney cancer". Clinical Cancer Research. 10 (18 ...
*  Tumor suppressor gene
Tumor suppressor genes can be grouped into categories including caretaker genes, gatekeeper genes, and landscaper genes; the ... Tumor Suppressor Genes, published in 2012 Tumor Suppressor Gene Database, published in 2012. ... A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene ... Another important tumor suppressor is the p53 tumor-suppressor protein encoded by the TP53 gene. Homozygous loss of p53 is ...
*  Marc Lacroix (biochemist)
"An Update on Tumor Suppressor Genes in Breast Cancer". In Katherine R. Polinsky (ed.). Tumor Suppressor Genes. Commack, N.Y: ... CS1 maint: Extra text: editors list (link) Lacroix M. Tumor suppressor genes in breast cancer (2008). Nova Science Publishers, ... Lacroix, M; Leclercq G. (2004). "About GATA3, HNF3A, and XBP1, three genes co-expressed with the oestrogen receptor-alpha gene ... Lacroix, M; Querton G; Hennebert P; Larsimont D; Leclercq G. (2001). "Estrogen receptor analysis in primary breast tumors by ...
*  Head and neck cancer
Gendicine is a gene therapy that employs an adenovirus to deliver the tumor suppressor gene p53 to cells. It was approved in ... HPV can induce tumor by several mechanisms: E6 and E7 oncogenic proteins. Disruption of tumor suppressor genes. High-level DNA ... Viral integration tends to occur in or near oncogenes or tumor suppressor genes and it is for this reason that the integration ... The incidence of second primary tumors ranges in studies from 9% to 23% at 20 years. Second primary tumors are the major threat ...
*  KLF6
Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene. This gene ... Jeng YM, Hsu HC (Jul 2003). "KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas". International Journal ... a candidate tumor suppressor gene mutated in prostate cancer". Science. 294 (5551): 2563-6. doi:10.1126/science.1066326. PMID ... is a tumor-suppressor gene frequently inactivated in colorectal cancer". Gastroenterology. 126 (4): 1090-103. doi:10.1053/j. ...
*  CDH1 (gene)
E-cadherin acts as an invasion suppressor and a classical tumor suppressor gene in pre-invasive lobular breast carcinoma. 1. E- ... CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene. Cadherin-1 is a ... Shibata T, Gotoh M, Ochiai A, Hirohashi S (August 1994). "Association of plakoglobin with APC, a tumor suppressor gene product ... Semb H, Christofori G (December 1998). "The tumor-suppressor function of E-cadherin". Am. J. Hum. Genet. 63 (6): 1588-93. doi: ...
*  TGF beta receptor 2
TGFBR2 is its human gene. It is a tumor suppressor gene. This gene encodes a member of the serine/threonine protein kinase ... "Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)". Yao D, Ehrlich M, Henis YI, Leof EB (Nov 2002). " ... Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu ... which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. ...
*  P16
This gene is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene. ... multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the ... Hypermethylation of tumor suppressor genes has been implicated in various cancers. In 2013, a meta-analysis of 39 articles ... Liggett WH, Sidransky D (March 1998). "Role of the p16 tumor suppressor gene in cancer". Journal of Clinical Oncology. 16 (3): ...
*  TUSC3
Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. This gene is a candidate tumor ... "Entrez Gene: TUSC3 tumor suppressor candidate 3". Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of ... suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in ... Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at ...
*  MTUS1
Mitochondrial tumor suppressor 1 is a protein that in humans is encoded by the MTUS1 gene. This gene encodes a protein which ... a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP". Gene. 380 ... "Entrez Gene: MTUS1 mitochondrial tumor suppressor 1". Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di ... Seibold S, Rudroff C, Weber M, Galle J, Wanner C, Marx M (Jun 2003). "Identification of a new tumor suppressor gene located at ...
*  TUSC2
Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene. This gene is a highly conserved lung ... "Entrez Gene: TUSC2 tumor suppressor candidate 2". Prudkin L, Behrens C, Liu DD, et al. (2008). "Loss and reduction of FUS1 ... The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116-33. PMID 11085536 ... "Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest ...
*  CDKN2A
The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors ... Kanellou P, Zaravinos A, Zioga M, Spandidos DA (June 2009). "Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), ... Rayess H, Wang MB, Srivatsan ES (April 2012). "Cellular senescence and tumor suppressor gene p16". International Journal of ... Asokan GS, Jeelani S, Gnanasundaram N (October 2014). "Promoter hypermethylation profile of tumour suppressor genes in oral ...
*  Von Hippel-Lindau disease
The disease is caused by mutations of the von Hippel-Lindau tumor suppressor (VHL) gene on the short arm of chromosome 3 (3p25- ... It is a type of phakomatosis that results from a mutation in the von Hippel-Lindau tumor suppressor gene on chromosome 3p25.3. ... Kondo, K; Kaelin Jr, WG (10 March 2001). "The von Hippel-Lindau Tumor Suppressor Gene". Experimental Cell Research. 264 (1): ... of mutations in the VHL gene consist of 50-250kb deletion mutations that remove either part of the gene or the whole gene and ...
*  GAS1
... is a putative tumor suppressor gene. GRCh38: Ensembl release 89: ENSG00000180447 - Ensembl, May 2017 GRCm38: Ensembl ... Evdokiou A, Cowled PA (1998). "Tumor-suppressive activity of the growth arrest-specific gene GAS1 in human tumor cell lines". ... 1994). "The human growth-arrest-specific gene GAS1 maps outside the candidate region of the gene for nevoid basal cell ... "Entrez Gene: GAS1 growth arrest-specific 1". Del Sal G, Ruaro ME, Philipson L, Schneider C (1992). "The growth arrest-specific ...
*  PTCH1
This gene functions as a tumor suppressor. The PTCH1 gene product, is a transmembrane protein that suppresses the release of ... 1996). "The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog". Nature. 384 (6605): 129-34. doi: ... 1992). "Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9". Cell. 69 (1): ... The Interactive Fly PTCH1 human gene location in the UCSC Genome Browser. PTCH1 human gene details in the UCSC Genome Browser. ...
*  NPRL2
"Entrez Gene: TUSC4 tumor suppressor candidate 4". Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, ... The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116-33. PMID ... also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene. GRCh38: Ensembl ... "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): ...
*  USP20
Kondo K, Kaelin WG (Mar 2001). "The von Hippel-Lindau tumor suppressor gene". Experimental Cell Research. 264 (1): 117-25. doi: ... The von Hippel-Lindau tumour suppressor protein (pVHL) ubiquitinates hypoxia-inducible factor 1α (HIF1α) when cell oxygen ... "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochemical and ... "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochemical and ...
*  Adenovirus early region 1A
It can behave as a tumour suppressor gene. "Introduction To Ad5 E1A". "Adenovirus E1A Oncogene Expression in Tumor Cells ... "E1A as a Tumor Suppressor Gene". "Adenovirus-5 E1A: paradox and paradigm". Nat Rev Mol Cell Biol. 3 (6): 441-52. Jun 2002. doi: ... Adenovirus early region 1A (E1a or E1A) is a gene expressed during adenovirus replication to produce a variety of (E1A) ...
*  Li-Fraumeni syndrome
... gene. CHK2 is also a tumor suppressor gene. CHK2 regulates the action of p53. CHK2 is activated by ATM which detects DNA damage ... The syndrome is linked to germline mutations of the p53 tumor suppressor gene, which encodes a transcription factor (p53) that ... LFS1: Mutations in TP53 Normal Conditions:[citation needed] TP53 is a tumor suppressor gene on chromosome 17 that normally ... tumor belonging to the LFS tumor spectrum - soft tissue sarcoma, osteosarcoma, pre-menopausal breast cancer, brain tumor, ...
*  Tumor promotion
"Tumor Suppressor Genes". "Oncogenes, Tumor Suppressor Genes, and Cancer" (PDF). American Cancer Society. "Oncogenes, Tumor ... it must decrease its expression of tumor suppressor genes such as p53, BRCA1, BRCA2, RB1 or the fas receptor. A tumor ... This is a step toward tumor progression In order for a tumor cell to survive, ... Tumor promotion is a process in carcinogenesis by which various factors permit the descendants of a single initiated cell to ...
*  Anticancer gene
Oncogene Tumour suppressor gene Grimm, Stefan; Noteborn, Mathieu. "Anticancer genes: inducers of tumour-specific cell death ... The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in ... Anticancer genes are genes that, when ectopically overexpressed, specifically destroy tumour cells without harming normal cells ... The first anticancer gene to be isolated was Apoptin, a gene encoded by the chicken anaemia virus genome. Brevinin-2R is a ...
*  Adenomatous polyposis coli
Mutations in the APC gene may result in colorectal cancer. APC is classified as a tumor suppressor gene. Tumor suppressor genes ... van Es JH, Giles RH, Clevers HC (March 2001). "The many faces of the tumor suppressor gene APC". Experimental Cell Research. ... Shibata T, Gotoh M, Ochiai A, Hirohashi S (August 1994). "Association of plakoglobin with APC, a tumor suppressor gene product ... Lesko AC, Goss KH, Yang FF, Schwertner A, Hulur I, Onel K, Prosperi JR (March 2015). "The APC tumor suppressor is required for ...
*  Alfred G. Knudson
"Tumor suppressor genes as a cause of cancer". The Lasker Foundation. "Kyoto Prize, Inamori Foundation". Kyoto Prize, Inamori ... These studies led to the concept of tumor suppressor genes, which Knudson called "anti-oncogenes." He received numerous prizes ... Cancer geneticist whose insights launched the search for tumour-suppressor genes". Nature. London: Springer Nature. 536 (7617 ... Humans inherit two copies of every gene, one from each parent (except for genes on the X and Y chromosomes in males). Some ...
*  FAT4
Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". ... or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene. FAT4 is associated with the ... "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)". Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, ... "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol ...
*  NKX3-1
... is a prostatic tumor suppressor gene. NKX3-1 is an androgen-regulated, prostate-specific homeobox gene whose expression ... "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in ... The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely ... Padmanabhan A, Gosc EB, Bieberich CJ (May 2013). "Stabilization of the prostate-specific tumor suppressor NKX3.1 by the ...
*  Caspase-activated DNase
... a candidate neuroblastoma tumour suppressor gene". Human Genetics. 106 (4): 406-13. doi:10.1007/s004390000257. PMID 10830907. ... Despite this gene being present in every cell, this protein is only expressed in different tissues and cell variety such as ... Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene ... Besides, Caspase 3 induces DNA breaks in the promoter of the factor p21 and this strand breakup is related to p21 gene ...