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*  DAB2IP
... is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by ... 2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient ... "Entrez Gene: DAB2IP DAB2 interacting protein". Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone ... Chen H, Tu SW, Hsieh JT (2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone ...
*  Ras subfamily
Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression. The first two ras genes ... RRAS2 Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to ... The tumour suppressor gene NF1 encodes a Ras-GAP - its mutation in neurofibromatosis will mean that Ras is less likely to be ... The three human ras genes encode extremely similar proteins made up of chains of 188 to 189 amino acids. Their gene symbols are ...
*  Mariano Barbacid
Ras genes.» Annu Rev Biochem 1987; 56: 779-827. Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene ... "Ras genes." (1987). "The TRK proto-oncogene encodes a receptor for nerve growth-factor." (1991). "trkC, a new member of the trk ... Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M. «Direct mutagenesis of HA-RAS-1 oncogenes by N-Nitroso-N-Methylurea ... eventually discovering that such oncogene was the mutation of an allele of the Ras subfamily, as well as its activation ...
*  SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. RAS genes (e.g., MIM 190020) encode ... Hu Q, Milfay D, Williams LT (March 1995). "Binding of NCK to SOS and activation of ras-dependent gene expression". Mol. Cell. ... Hu Q, Milfay D, Williams LT (1995). "Binding of NCK to SOS and activation of ras-dependent gene expression". Mol. Cell. Biol. ... cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila ...
*  Parkes Weber syndrome
"RASA1 gene RAS p21 protein activator 1". "RASA1 RAS p21 protein activator 1". "RASA1 gene RAS p21 protein activator 1". ... RASA1 gene is responsible for making p120-RasGAP protein. This protein regulates the RAS/MAPK signaling pathway. RAS/MAPK ... This means that one copy of the damaged or altered gene is sufficient to elicit PWS disorder. In most cases, PWS can occur in ... Some cases of PWS are a result of mutations on the RASA1 gene which is located on chromosome 5 at position 14.3. This mutation ...
*  Karen Vousden
subscription required) Vousden, K. H.; Marshall, C. J. (1984). "Three different activated ras genes in mouse tumours; evidence ... Nakano, K; Vousden, KH (2001). "PUMA, a novel proapoptotic gene, is induced by p53". Mol Cell. 7: 683-694. doi:10.1016/S1097- ... Nakano, K.; Vousden, K. H. (2001). "PUMA, a Novel Proapoptotic Gene, is Induced by p53". Molecular Cell. 7 (3): 683-694. doi: ... Vousden, Karen (1982). Use of suppressor gene mutations to study transfer RNA redundancy in Coprinus (PhD thesis). Queen Mary ...
*  RASA4B
RAS p21 protein activator 4B is a protein that in humans is encoded by the RASA4B gene. GRCh38: Ensembl release 89: ... ENSG00000170667 - Ensembl, May 2017 "Human PubMed Reference:". "Entrez Gene: RAS p21 protein activator 4B". Retrieved 2016-10- ...
*  RASGRP4
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine ... RAS guanyl releasing protein 4 is a protein in humans that is encoded by the RASGRP4 gene in chromosome 19. ... provided by RefSeq, Apr 2009]. "Entrez Gene: RAS guanyl releasing protein 4". Retrieved 2013-01-31. ... It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to ...
*  RASAL3
RAS protein activator like 3 is a protein that in humans is encoded by the RASAL3 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: RAS protein activator like 3". Retrieved 2016-07-16. Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita- ...
*  RERG
RAS-like, estrogen-regulated, growth inhibitor is a protein in humans that is encoded by the RERG gene. RERG, a member of the ... "Entrez Gene: RAS-like, estrogen-regulated, growth inhibitor". Retrieved 2012-11-09. ... RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied ...
*  Ras association domain family member 7
... is a protein that in humans is encoded by the RASSF7 gene. ENSG00000099849 GRCh38: ... "Entrez Gene: Ras association domain family member 7". Retrieved 2017-11-03. Iarmolinskiĭ DG, Kartel NA, Ermak G, Demidchik IuE ... Djos A, Martinsson T, Kogner P, Carén H (2012). "The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA ...
*  RASEF
We can find the RAS family in the oncogene category, to which the RASEF gene belongs. RASEF or Rab 45 is classified in the Ras ... Ras and EF-hand domain-containing protein also known as Ras-related protein Rab-45 is a protein that in humans is encoded by ... Nowadays, the RASEF gene has been investigated for potential mutations and gene silencing by promoting methylation in uveal ... "Entrez Gene: RAS and EF-hand domain containing". Sweetser DA, Peniket AJ, Haaland C, Blomberg AA, Zhang Y, Zaidi ST, Dayyani F ...
*  Alfred G. Gilman
"Homologies between signal transducing G proteins and ras gene products". Science. 226 (4676): 860-2. doi:10.1126/science. ... Schleifer, LS; Kahn, RA; Hanski, E; Northup, JK; Sternweis, PC; Gilman, AG (1982). "Requirements for cholera toxin-dependent ... Brunton, LL; Maguire, ME; Anderson, HJ; Gilman, AG (1977). "Expression of genes for metabolism of cyclic adenosine 3':5'- ...
*  RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. The ... The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by ... "Entrez Gene: Ras protein-specific guanine nucleotide-releasing factor 1". Retrieved 2013-04-07. ... Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory ...
*  Clifford Tabin
... and was awarded a PhD in 1984 for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by ... "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene". Nature. 297 (5866): 474-8. doi:10.1038/ ... Burke, A. C.; Nelson, C. E.; Morgan, B. A.; Tabin, C (1995). "Hox genes and the evolution of vertebrate axial morphology". ... Comparative studies by Ann Burke in his lab showed that differences in boundaries of Hox gene expression correlated with ...
*  Luis F. Parada
"Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation." Nature. 1984 Dec 13-19;312(5995):649- ... "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene." Nature 297 (1982): 474-478. Parada, Luis F ... "Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma." Cancer Cell 2005 Aug; ...
*  Allan Balmain
Balmain, A.; Ramsden, M.; Bowden, G. T.; Smith, J. (1984). "Activation of the mouse cellular Harvey-ras gene in chemically ... Quintanilla, M; Brown, K; Ramsden, M; Balmain, A (1986). "Carcinogen-specific mutation and amplification of Ha-ras during mouse ...
*  Neuroblastoma RAS viral oncogene homolog
The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c- ... Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have ... The N-ras proto-oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a ... "Entrez Gene: NRAS neuroblastoma RAS viral (v-ras) oncogene homolog". Study Comparing the Efficacy of MEK162 Versus Dacarbazine ...
*  SPRY1
2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene". Cancer ... SPRY1 human gene location in the UCSC Genome Browser. SPRY1 human gene details in the UCSC Genome Browser.. ... "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)". Lim J, Wong ES, Ong SH, et al. (2000). " ... Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene. Neurofibromin 1 SPRED1 GRCh38: Ensembl ...
*  RRAS
"Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell. 48 (1): 137-46. doi: ... Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene. RRAS has been shown to interact with: ARAF, ... "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog". Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ...
*  KRAS
K-ras or Ki-ras) is proto-oncogene corresponding to the oncogene first identified in Kirsten rat sarcoma virus and the gene ... This proto-oncogene is a Kirsten ras oncogene homolog from the mammalian ras gene family. A single amino acid substitution, and ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... Kahn S, Yamamoto F, Almoguera C, Winter E, Forrester K, Jordano J, Perucho M (1987). "The c-K-ras gene and human cancer (review ...
*  FEZF1
"Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene". Cancer Research. 69 ... FEZ family zinc finger 1 is a protein that in humans is encoded by the FEZF1 gene. Mutations in FEZF1 cause Kallmann Syndrome ... "Entrez Gene: FEZ family zinc finger 1". Kotan LD, Hutchins BI, Ozkan Y, Demirel F, Stoner H, Cheng PJ, Esen I, Gurbuz F, ... SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in ...
*  RAB2A
Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene. Members of the Rab protein family are ... "Entrez Gene: RAB2A RAB2A, member RAS oncogene family". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, ... "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily". Nucleic Acids Research. 16 (21 ... Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale ...
*  RHOB
Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. RHOB is a ... 1990). "Chromosome localization of human ARH genes, a ras-related gene family". Genomics. 6 (2): 197-203. doi:10.1016/0888-7543 ... "Entrez Gene: RHOB ras homolog gene family, member B". Chardin P, Madaule P, Tavitian A (March 1988). "Coding sequence of human ... Madaule P, Axel R (1985). "A novel ras-related gene family". Cell. 41 (1): 31-40. doi:10.1016/0092-8674(85)90058-3. PMID ...
*  Rho family of GTPases
subscription required) Madaule P.; Axel R. (1985). "A novel ras-related gene family". Cell. 41 (1): 31-40. doi:10.1016/0092- ... After the cloning of various genes implicated in X-linked mental retardation, three genes that have effects on Rho signaling ... After finding that Ras proteins are mutated in 30% of human cancers, it was suspected that mutated Rho proteins might also be ... The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The ...
*  Phage display
Gene. 104 (2): 147-53. doi:10.1016/0378-1119(91)90244-6. PMID 1916287. Barbas CF, Kang AS, Lerner RA, Benkovic SJ (September ... In this technique, a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to " ... A versatile screening system for selective isolation of genes by specific gene-product/ligand interaction". Eur. J. Biochem. ... The phage gene and insert DNA hybrid is then inserted (a process known as "transduction") into Escherichia coli (E. coli) ...
*  RhoC
"Entrez Gene: RHOC ras homolog gene family, member C". Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin- ... RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member ... Madaule P, Axel R (1985). "A novel ras-related gene family". Cell. 41 (1): 31-40. doi:10.1016/0092-8674(85)90058-3. PMID ... It is encoded by the gene RHOC. It is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is ...