P53-responsive gene 1
"Entrez Gene: P53-responsive gene 1". Retrieved 2017-11-07. Ozalp S, Yalcin OT, Tanir HM, Kabukcuoglu S, Erol G (2003). "p53 ... P53-responsive gene 1 is a protein that in humans is encoded by the PRG1 gene. "Human PubMed Reference:". National Center for ... Human genes, All stub articles, Human chromosome 19 gene stubs). ... "P53 and K-ras mutations are frequent events in microscopically ...
P53 upregulated modulator of apoptosis
Many cancers do exhibit p53 gene mutations, making gene therapies that target this gene[clarification needed] impossible, but ... PUMA can also function as an indicator of p53 mutations. Many cancers exhibit mutations in the p53 gene, but this mutation can ... "Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells". Exp ... Nakano K, Vousden KH (March 2001). "PUMA, a novel proapoptotic gene, is induced by p53". Mol. Cell. 7 (3): 683-94. doi:10.1016/ ...
P53
The p21 gene contains several p53 response elements that mediate direct binding of the p53 protein, resulting in ... Several isoforms were discovered in 2005, and so far 12 human p53 isoforms have been identified (p53α, p53β, p53γ, ∆40p53α, ∆ ... As with 95% of human genes, TP53 encodes more than one protein. All these p53 proteins are called the p53 isoforms. These ... It delivers a functional copy of the p53 gene using an engineered adenovirus. Certain pathogens can also affect the p53 protein ...
Deubiquitinating enzyme
The TP53 gene (also known as p53) is crucial in ensuring the conservation of the genome. Deubiquitinating enzymes play an ... "TP53 gene". MedlinePlus. U.S. National Library of Medicine. Retrieved May 18, 2021. "p53". Wikipedia. Retrieved May 18, 2021. ... In healthy cells, p53 activates the E3 ubiquitin ligase MDM2 which in turn ubiquitinates p53. This creates a negative feedback ... Once stabilized, p53 can exert its tumor suppression function. Downstream pathways of p53 act to either halt cell cycle ...
Tumor suppressor gene
p53. TP53, a caretaker gene, encodes the protein p53, which is nicknamed "the guardian of the genome". p53 has many different ... There are exceptions to the two-hit rule for tumor suppressors, such as certain mutations in the p53 gene product. p53 ... Gene therapy is used to reinstate the function of a mutated or deleted gene type. When tumor suppressor genes are altered in a ... TSGs can be grouped into the following categories: caretaker genes, gatekeeper genes, and more recently landscaper genes. ...
P53 regulation associated lncRNA
... is a protein that in humans is encoded by the PRAL gene. "Human PubMed Reference:". National ... "Entrez Gene: P53 regulation associated lncRNA". Retrieved 2017-06-27. v t e (Articles with short description, Short description ... matches Wikidata, Human genes, All stub articles, Human chromosome 17 gene stubs). ...
Aflatoxin B1
These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... us), National Center for Biotechnology Information (1998-01-01). The p53 tumor suppressor protein. National Center for ... March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol. 70 (3): 1253-62. Bibcode:2004ApEnM ... at several guanine residues in the 12th and 13th codons of the ras gene, a gene whose product controls cellular proliferation ...
Caretaker gene
An example of one such gene is p53. Patients with Li-Fraumeni syndrome, for example, have mutations in the p53 gene that ... genes. In contrast to caretaker genes, gatekeeper genes encode gene products that act to prevent growth of potential cancer ... Experiments with mice that have increased gatekeeper function in the p53 gene show reduced cancer incidence (due to the ... Gatekeeper genes are in fact specific to the tissues in which they reside. The probability that mutations occur in other genes ...
P73
Genes of the p53 family are known to be complex. The viral oncoproteins (e.g. Adenovirus E1B) that efficiently inhibit p53 ... The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. ... The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53. The p73 gene has been ... p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like ...
GPS2 (gene)
... has been shown to interact with: C21orf7, Cyclin A1, EP300, HDAC3, NCOR1, P53, and TBL1X. GRCh38: Ensembl release ... G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene. This gene encodes a protein involved in ... "Entrez Gene: GPS2 G protein pathway suppressor 2". Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz ... When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK ...
Morpholino
Gene knockdown is achieved by reducing the expression of a particular gene in a cell. In the case of protein-coding genes, this ... Most of these effects are due to activation of p53-mediated apoptosis and can be suppressed by co-injection of an anti-p53 ... This entire process is referred to as gene expression; it is the process by which the information in a gene, encoded as a ... a quantifiable method for gene knockdown". Genesis. 30 (3): 154-6. doi:10.1002/gene.1053. PMID 11477696. Kloosterman WP, ...
NUMB (gene)
"NUMB controls p53 tumour suppressor activity". Nature. 451 (7174): 76-80. Bibcode:2008Natur.451...76C. doi:10.1038/nature06412 ... Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in ... Four transcript variants encoding different isoforms have been found for this gene. The protein Numb is coded for by the gene, ... Among the Notch target genes are members of the HES and HEY gene families whose protein products can act as transcriptional ...
BRCA1
Ouchi T, Monteiro AN, August A, Aaronson SA, Hanafusa H (March 1998). "BRCA1 regulates p53-dependent gene expression". Proc. ... BRCA1 is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA. BRCA1 and BRCA2 ... "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes Dev. 16 (5): 583-93. doi ... "Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene". Horm. Metab. Res ...
Avery August
"BRCA1 regulates p53-dependent gene expression." (1998) Proc. Natl. Acad. Sci 95: 2302. A. August, S. Gibson, Y. Kawakami, T. ... This work was the first to show that this protein could regulate the transcription of genes and could potentially regulate the ...
Lncrna p53 regulated and esc associated 1
... is a non-coding RNA that in humans is encoded by the LNCPRESS1 gene. GRCh38: Ensembl ... "Entrez Gene: LncRNA p53 regulated and ESC associated 1". Retrieved 2018-08-22. v t e (Articles with short description, Short ... description matches Wikidata, Orphaned articles from December 2022, All orphaned articles, Genes on human chromosome 7, All ...
Janus Experiments
Paunesku, Tatjana; Zhang, Yueru; Gemmell, M. Anne; Woloschak, Gayle E. (2000). "p53 gene deletions in radiation-induced tumors ...
Pediatric ependymoma
Further, up-regulation of p73 (TP73), a homolog of p53, and deletion of the p53 pathway gene p14arf/p16/INK4A (CDKN2A) have ... Fink, KL; Rushing, EJ; Schold Jr, SC; Nisen, PD (1996). "Infrequency of p53 gene mutations in ependymomas". Journal of Neuro- ... While p53 (TP53) mutations are not often observed in pediatric ependymoma, the p53 pathway is suggested to play a role in ... However, gene mutations linked to the familial syndromes are rarely found in sporadic cases of ependymoma. For example, NF2 ...
TP53I3
This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 ... "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite ... 2004). "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation ...
Breast cancer
Roth JA, Swisher SG, Meyn RE (October 1999). "p53 tumor suppressor gene therapy for cancer". Oncology. 13 (10 Suppl 5): 148-54 ... carry a balanced genetic translocation in which part of the NTRK3 gene is fused to part of the ETV6 gene to form a fusion gene ... the ER can regulate gene expression by interacting with estrogen response elements within the promotor of specific genes. The ... This fusion gene encodes a chimeric protein termed ETV6-NTRK3. The NTRK3 part of ETV6-NTRK3 protein has up-regulated tyrosine ...
Cyclin A
Cell cycle arrest is carried out by the p53-pRb pathway. Activated p53 turns on genes for p21. P21 is a CDK inhibitor that ... Hyperphosphorylated pRb can no longer bind E2F, E2F is released and cyclin A genes, and other crucial genes for S phase, are ... Genes on human chromosome 13, Genes on human chromosome 4, Cell cycle, Proteins, Cell cycle regulators). ... Transcription of cyclin A is indirectly regulated by the tumor suppressor protein p53. P53 is activated by DNA damage and turns ...
PPP1R13B
Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene. This gene encodes a member ... They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this ... Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are ... "Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation". Oncogene. 24 (23): 3836-41. ...
PCBP4
"Entrez Gene: PCBP4 poly(rC) binding protein 4". Taylor WR, Stark GR (2001). "Regulation of the G2/M transition by p53". ... This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis ... Zhu J, Chen X (2000). "MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing ... Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene. This gene encodes a member of the KH ...
Jill Bargonetti
Armstrong, Sue (3 May 2016). P53 : the gene that cracked the cancer code. London. ISBN 978-1-4729-1052-3. OCLC 929031485.{{cite ... There, she characterized important functions of p53 needed for tumor suppression and that they were lost when p53 is mutated in ... Her research is focused on tumor suppressor protein p53 and its role as an oncogene when it is mutated in breast cancer. Born ... 1]^ Hunter, Karen (15 November 1997). "Her In-Gene-Uity Pays Work Reveals Cancer Cure". Bargonetti-Chavarria, Jill (2002-03-22 ...
USP7
... disruption of HAUSP gene stabilizes p53". Nature. 428 (6982): 1 p following 486. doi:10.1038/nature02501. PMID 15058298. S2CID ... Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. In response to oncogenic ... EBNA1 can compete with p53 for binding USP7. Stabilization by USP7 is important for the tumor suppressor function of p53. In ... HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor ...
4-Aminobiphenyl
The p53 gene codes for the tumor suppressor p53 proteins. A mutation in this gene can lead to formation of tumors. Five p53 ... One mechanism by which 4-ABP causes bladder cancer is a mutation in the p53 gene, which are seen in thirty to sixty percent of ... evidence from its DNA binding spectrum in human p53 gene". Carcinogenesis. 23 (10): 1721-1727. doi:10.1093/carcin/23.10.1721. ...
PSRC1
This gene encodes a proline-rich protein. Studies of the related mouse gene suggest that this gene is regulated by p53 and may ... Lo PK, Chen JY, Lo WC, Chen BF, Hsin JP, Tang PP, Wang FF (Feb 2000). "Identification of a novel mouse p53 target gene DDA3". ... "Entrez Gene: PSRC1 proline/serine-rich coiled-coil 1". Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci ... Lo PK, Wang FF (Nov 2002). "Cloning and characterization of human and mouse DDA3 genes". Biochim Biophys Acta. 1579 (2-3): 214- ...
AIFM2
The AIFM2 gene contains a putative p53-binding element in intron 5, suggesting that its gene expression can be activated by p53 ... is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10. This ... Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB (September 2004). "AMID is a p53-inducible gene downregulated in tumors". Oncogene. ... Wu M, Xu LG, Su T, Tian Y, Zhai Z, Shu HB (September 2004). "AMID is a p53-inducible gene downregulated in tumors". Oncogene. ...
TP53BP1
"Entrez Gene: TP53BP1 tumor protein p53 binding protein 1". Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der ... Lai H, Lin L, Nadji M, Lai S, Trapido E, Meng L (2002). "Mutations in the p53 tumor suppressor gene and early onset breast ... Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by ... "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure". Genes & Development. 16 (5): ...
Progeroid syndromes
Lehmann, AR (2001). "The xeroderma pigmentosum group D (XPD) gene: One gene, two functions, three diseases". Genes & ... its aberrant association with p53 down-regulates the function of p53, leading to a reduction in p53-dependent apoptosis and ... There are 28 genes in this pathway. Individuals with defects in these genes often have developmental defects and exhibit ... All these disorders can be caused by mutations in a single gene, XPD, or in other genes. Cockayne syndrome (CS) is a rare ...
TP53INP1
... a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85-94. doi:10.1016/S1097-2765(01)00284-2. PMID ... Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene. In mice this protein ... "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1". Tomasini, Richard; Samir Amina Azizi; Carrier Alice; ... Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are ...