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*  P53-responsive gene 1
... is a protein that in humans is encoded by the PRG1 gene. "Human PubMed Reference:". "Entrez Gene: P53- ... responsive gene 1". Retrieved 2017-11-07. Ozalp S, Yalcin OT, Tanir HM, Kabukcuoglu S, Erol G (2003). "p53 overexpression as a ... "P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung ...
*  Ageing
Such variants occur in genes p53 and BRCA1. The reproductive-cell cycle theory argues that ageing is regulated specifically by ... Over-expression of the Ras2 gene increases lifespan in yeast by 30%. A yeast mutant lacking the genes sch9 and ras2 has ... Such a genetic effect is called the antagonistic pleiotropy effect when referring to a gene (pleiotropy signifying the gene has ... methylation of gene promoter regions or alterations of the DNA scaffolding which regulate gene expression), can cause abnormal ...
*  Dominance (genetics)
Such dominant-negative mutations occur in the tumor suppressor gene p53. The P53 wild-type protein is normally present as a ... The bb combination is not dominant to the A allele: rather, the B gene shows recessive epistasis to the A gene, because the B ... Males however have only one copy of each X chromosome gene locus, and are described as hemizygous for these genes. The Y ... It is now evident from molecular genetics that all gene loci are involved in complex interactions with many other genes (e.g., ...
*  Maureen Murphy (scientist)
Her research focuses on the tumor suppressor genes p53 and p14arf. Murphy's research on p53 has indicated that the gene is able ... CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53- ... "Common variant of p53 tumor suppressor gene linked to increased inflammatory responses". ScienceDaily. Retrieved 18 February ... "Committees". 16th International p53 Workshop. Retrieved 18 February 2014. "The 15th International p53 Workshop will be held ...
*  P73
Genes of the p53 family are known to be complex. The viral oncoproteins (e.g. Adenovirus E1B) that efficiently inhibit p53 ... The p73 gene encodes a protein with a significant sequence homology and a functional similarity with the tumor suppressor p53. ... The over-expression of p73 in cultured cells promotes a growth arrest and/or apoptosis similarly to p53. The p73 gene has been ... p73, also known as tumor protein 73 (TP73), protein was the first identified homologue of the tumor suppressor gene, p53. Like ...
*  P53 regulation associated lncRNA
... is a protein that in humans is encoded by the PRAL gene. "Human PubMed Reference:". "Entrez ...
*  Janus Experiments
Paunesku, Tatjana; Zhang, Yueru; Gemmell, M. Anne; Woloschak, Gayle E. (2000). "p53 gene deletions in radiation-induced tumors ...
*  Pediatric ependymoma
Further, up-regulation of p73 (TP73), a homolog of p53, and deletion of the p53 pathway gene p14arf/p16/INK4A (CDKN2A) have ... Fink, KL; Rushing, EJ; Schold Jr, SC; Nisen, PD (1996). "Infrequency of p53 gene mutations in ependymomas". Journal of Neuro- ... While p53 (TP53) mutations are not often observed in pediatric ependymoma, the p53 pathway is suggested to play a role in ... However, gene mutations linked to the familial syndromes are rarely found in sporadic cases of ependymoma. For example, NF2 ...
*  PPP1R15A
DNA damage genes and tumour suppressor gene p53 in naevi and malignant melanomas". Anticancer Res. 17 (5A): 3697-700. PMID ... The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein ... The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins ... This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions ...
*  Head and neck cancer
Gendicine is a gene therapy that employs an adenovirus to deliver the tumor suppressor gene p53 to cells. It was approved in ... E6 sequesters p53 to promote p53 degradation while pRb inhibits E7. p53 prevents cell growth when DNA is damaged by activating ... Viral integration tends to occur in or near oncogenes or tumor suppressor genes and it is for this reason that the integration ... Schmitz, M. "Loss of gene function as a consequence of human papillomavirus DNA integration". International Journal of Cancer. ...
*  Mutation
... mutations in genes p53, ATM, CEBPA and PPARgamma). Marfan syndrome is caused by mutations in the FBN1 gene, located on ... Mutations in genes can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or ... Most genes belong to larger gene families of shared ancestry, known as homology. Novel genes are produced by several methods, ... Some mutations alter a gene's DNA base sequence but do not change the function of the protein made by the gene. One study on ...
*  DUT (gene)
Notably, DUT expression is regulated by the tumor suppressor gene p53 in order to promote apoptosis of tumor cells.. Abnormal ... Wilson PM, Fazzone W, LaBonte MJ, Lenz HJ, Ladner RD (Jan 2009). "Regulation of human dUTPase gene expression and p53-mediated ... DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15. This gene ... In humans, this gene encodes a homotrimeric enzyme with two isoforms characterized by their distinct subcellular localizations ...
*  Cancer epigenetics
The tumor suppressor gene p53 regulates DNA repair and can induce apoptosis in dysregulated cells. E Soto-Reyes and F Recillas- ... a DNA repair gene; APC, a cell cycle regulator; MLH1, a DNA-repair gene; and BRCA1, another DNA-repair gene. Indeed, cancer ... Soto-Reyes E, Recillas-Targa F (April 2010). "Epigenetic regulation of the human p53 gene promoter by the CTCF transcription ... The gene designations shown in red, gray or cyan indicate genes frequently epigenetically altered in various types of cancers. ...
*  Mir-504 microRNA precursor family
"Negative regulation of the tumor suppressor p53 gene by microRNAs". Oncogene. 30 (7): 843-853. doi:10.1038/onc.2010.457. PMC ... Huang, W.; Li, M. D. (2009). "Differential Allelic Expression of Dopamine D1 Receptor Gene (DRD1) is Modulated by microRNA miR- ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms. MicroRNA 1. 2. 3. 4. 5. 6. 7. Yang, ... "Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504". Molecular Cell. 38 (5): 689-699. doi:10.1016/j.molcel.2010.05 ...
*  Mir-25 microRNA precursor family
"Negative regulation of the tumor suppressor p53 gene by microRNAs". Oncogene. 30 (7): 843-853. doi:10.1038/onc.2010.457. PMC ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-25 levels increase in human ... Gene Therapy. 15 (23): 1536-1549. doi:10.1038/gt.2008.147. PMC 3155610 . PMID 18800151. Palmieri, A.; Pezzetti, F.; Spinelli, G ... of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in ...
*  Frederick Pei Li
... p53 gene mutations led to these mutations as being linked to causing Li-Fraumeni Syndrome. The p53 gene is known as the tumor ... the tumor suppressor genes. These cancer genes are among more than 200 single-gene traits associated with the development of ... My colleagues and I are using families with inherited mutations in the p53 gene, which predisposes to breast cancer and diverse ... The goal is to identify genes that are involved in cancer development. I was attracted to studies of cancer families because ...
*  Disease gene identification
"Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas". Science. 244 (4901): 217-21. doi:10.1126/science. ... If enough of the genome sequence is known, that region is searched for candidate genes. Coding regions of these genes are then ... deletion of the entire gene, and other genetic abnormalities. Knowledge of which genes (when non-functional) cause which ... Disease gene identification is a process by which scientists identify the mutant genotypes responsible for an inherited genetic ...
*  Pseudomyxoma peritonei
The K-Ras and p53 genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. While the majority ...
*  Forkhead box d1
"Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53". ... that the tumour suppressor gene p53 and WT-1 are potential regulators of FREAC-4. FOX D1 is expressed by two kidney derived ... This gene is estimated to be approximately 2.5 kilo base pairs and, most likely introns less. The motif at NH2 terminal part is ... Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene. Forkhead d1 is a kidney expressed transcription ...
*  Bert Vogelstein
But there was no evidence that p53 played a major role in human cancers, and the gene encoding p53 (TP53) was thought to be an ... The first tumor suppressor gene validating this hypothesis was that encoding p53. The p53 protein was discovered 10 years ... "Oncogenic forms of p53 inhibit p53-regulated gene expression". Science. 256: 827-30. doi:10.1126/science.256.5058.827. PMID ... They subsequently discovered genes that are directly activated by p53 to control cell birth and cell death. His group's more ...
*  Surveyor nuclease assay
Mitani, Noriaki; Niwa, Yoshimasa; Okamoto, Yasuyuki (2007-11-01). "Surveyor nuclease-based detection of p53 gene mutations in ... For example, ATRX for X-linked mental retardation, and the HBB gene linked to β-thalassemia. The assay has also been used to ... Surveyor nuclease assay has been used to detect somatic mutations in various cancer-related genes, and as stated above, can be ... The method has been used to detect mutations in epidermal-growth-factor-receptor (EGFR), Janus Kinase 2 (JAK2), p53 and others ...
*  Fetal adenocarcinoma
Bodner SM, Koss MN (November 1996). "Mutations in the p53 gene in pulmonary blastomas: immunohistochemical and molecular ... a larger series of 12 cases revealed no p53 gene mutations. Because of its extreme rarity, there have been no controlled ... One small series of 6 cases showed that MDM2 protein was expressed in 5 of them (83%), and p53 protein was overexpressed in 50 ... June 1996). "p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas". Hum. Pathol. 27 (6): 542-6. doi: ...
*  Gendicine
... rAd-p53). This virus is designed to treat patients with tumors which have mutated p53 genes. Gendicine is the first gene ... Introgen's Advexin, a similar gene therapy that also uses adenovirus to deliver the p53 gene, was turned down by the FDA in ... This is no close correlation between p53 mutation status of the tumour cells and response to Ad-p53 treatment. Ad-p53 appears ... Gendicine enters the tumour cells by way of receptor-mediated endocytosis and begins to over-express genes coding for the p53 ...
*  Tumor antigen
Examples of tumor-specific antigens include the abnormal products of ras and p53 genes. In contrast, mutation of other genes ... Products of Mutated Oncogenes and Tumor Suppressor Genes Products of Other Mutated Genes Overexpressed or Aberrantly Expressed ... Such abnormal proteins are produced due to mutation of the concerned gene. Mutation of protooncogenes and tumor suppressors ...
*  Isochromosome
It is debated whether the loss of tumour suppressor gene p53, located on 17p, is involved in the central pathogenesis of some ... The presence of one p53 gene can be functionally active, but its relation to other oncogenes can alter its expression levels ... Consequently, there is partial trisomy of the genes present in the isochromosome and partial monosomy of the genes in the lost ... Alternatively, the increase in dosage of genes on the q arm may be involved in a 10-fold increase in risk of i(Xq) Turner's ...
*  Prostaglandin-endoperoxide synthase 2
Li Y, He W, Liu T, Zhang Q (December 2010). "A new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated ... Legan M (August 2010). "Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of ... Xie WL, Chipman JG, Robertson DL, Erikson RL, Simmons DL (April 1991). "Expression of a mitogen-responsive gene encoding ... is an enzyme that in humans is encoded by the PTGS2 gene. In humans it is one of two cyclooxygenases. It is involved in the ...