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*  Intraductal papillary mucinous neoplasm
... intraductal papillary mucinous neoplasms) of the pancreas have mutations in the KRAS and/or the GNAS gene. The researchers then ... Pancreatic mucinous cystic neoplasm Pancreatic serous cystadenoma Solid pseudopapillary neoplasm "Intraductal Papillary ... Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. IPMN ... Once a doctor has reason to believe that a patient may have an intraductal papillary mucinous neoplasm, he or she can confirm ...
*  LIMA1
Epithelial Protein Lost in Neoplasm) gene reveals distinct promoters for the two EPLIN isoforms". Gene. 248 (1-2): 69-76. doi: ... "Entrez Gene: LIMA1 LIM domain and actin binding 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the ... LIM domain and actin-binding protein 1 is a protein that in humans is encoded by the LIMA1 gene. EPLIN is a cytoskeleton- ... 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. ...
*  HHIP
2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther ... Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene. This gene encodes a protein ... "Entrez Gene: HHIP hedgehog interacting protein". Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by ... 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ...
*  List of MeSH codes (G14)
... genes, neoplasm MeSH G14.340.024.340.383.249 --- genes, tumor suppressor MeSH G14.340.024.340.383.249.050 --- genes, apc MeSH ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, viral MeSH G14.340.400.500.172 --- genes, env MeSH G14.340.400.500.258 --- genes, gag MeSH G14.340.400.500.345 --- genes ... genes, helminth MeSH G14.340.357.500 --- genes, insect MeSH G14.340.365.500 --- genes, plant MeSH G14.340.375.500 --- genes, ...
*  ADAMTS8
A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. GRCh38: Ensembl release 89: ... "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8". Wågsäter D, Björk H, Zhu C, et al. (2008). " ... This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ... A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene. ...
*  STK11
2001). "STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas". Am. J. Pathol ... and other neoplasms. However, the LKB1 gene was also found to be mutated in lung cancer of sporadic origin, predominantly ... The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a ... Further, more recent studies have uncovered a large number of somatic mutations of the LKB1 gene that are present in cervical, ...
*  Index of biochemistry articles
... nef gene product - neoplasm protein - Nernst equation - nerve - nerve growth factor - nerve growth factor receptor - nerve ... gene - gene expression - gene pool - gene regulatory network - genetic carrier - genetic code - genetic drift - Genetic ... erbA gene - erbB gene - erbB-2 gene - erbB-2 receptor - erythropoietin - erythropoietin receptor - Essential amino acid - Ester ... fms gene - Formaldehyde - fos gene - free energy - freezing point - FSH receptor - functional group - fungal protein - fungi - ...
*  Tet methylcytosine dioxygenase 2
Mutations in this gene were first identified in myeloid neoplasms with deletion or uniparental disomy at 4q24. TET2 may also be ... to its target genes and activates WT1-target genes by converting methylcytosine into 5-hydroxymethylcytosine at the genes' ... as a number of non-hematopoietic malignancies appear to harbor mutations of WIT genes in a non-exclusive manner. "Entrez Gene: ... Tet methylcytosine dioxygenase 2 (TET2) is a human gene. It resides at chromosome 4q24, in a region showing recurrent ...
*  Embryoma
... s have been defined as: "Adult neoplasms expressing one or more embryo-exclusive genes", in: "Embryoma Gene Networks", ... Embryomas have been defined as: "Adult neoplasms expressing one or more embryo-exclusive genes". "embryoma" at Dorland's ...
*  JAZF1
Huang HY, Ladanyi M, Soslow RA (2004). "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with ... This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. ... "Entrez Gene: JAZF1 JAZF zinc finger 1". Manolio TA; Guttmacher, Alan E.; Manolio, Teri A. (July 2010). "Genomewide Association ... Oliva E, de Leval L, Soslow RA, Herens C (2007). "High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with ...
*  SUZ12
"Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence ... Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene. This zinc finger gene has been identified at ... Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a ... "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) ...
*  Adrenocortical carcinoma
Finally, c-myc gene expression is relatively high in neoplasms, and it is often linked to poor prognosis. Bilateral ... The genes h19, insulin-like growth factor II (IGF-II), p57kip2 are important for fetal growth and development. They are located ... There is also a loss of activity of the p57kip2 gene product in virilizing adenomas and adrenal cortical carcinomas. In ... The p53, retinoblastoma protein (RB) tumor suppressor genes located on chromosomes 17p, 13q respectively, may be changed. ...
*  Neoplasm
Some germ line mutations in DNA repair genes cause up to 100% lifetime chance of cancer (e.g., p53 mutations). These germ line ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... p. Neoplasm. ISBN 0781733901. "II Neoplasms". World Health Organization. Retrieved 19 June 2014. Abrams, Gerald. "Neoplasia I ...
*  DIDO1
2005). "Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms". J. Clin. Invest. ... This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts ... Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene. Apoptosis, a major form of cell death, is ... "Entrez Gene: DIDO1 death inducer-obliterator 1". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two ...
*  Clonal hypereosinophilia
PCM1-JAK2 gene positive patients present with features of myeloid neoplasms, lymphoid neoplasms, or features of both types of ... and the PCM1 gene, located at 12p13, create the PCM1-JAK2 fusion gene. This fusion gene encodes the chimeric PCMI-JAK2 fusion ... Patients with hematological disease related to the cited FLT3 fusion genes present with either a myeloid or lymphoid neoplasm ... The ETV6 gene (also known as translocation-Ets-leukemia) is a member of the ETS transcription factor family. The gene codes for ...
*  PDGFRB
... between the PDGFRB gene and at least any one of 30 genes on other chromosomes lead to myeloid and/or lymphoid neoplasms that ... The PDGFRB gene has been found to fuse with at least 36 other genes to form fusion genes that encode chimeric proteins that are ... The most common of these rare mutations is the translocation of PDGFRB gene with the ETV6 gene (also termed ETS variant gene 6 ... gene with the FIP1L1 gene (see FIP1L1-PDGFRA fusion gene. ... The gene is flanked by the genes for granulocyte-macrophage ...
*  Myeloproliferative neoplasm
"Rapid Molecular Profiling of Myeloproliferative Neoplasms Using Targeted Exon Resequencing of 86 Genes Involved in JAK-STAT ... Although not a malignant neoplasm like other cancers, MPNs are classified within the hematological neoplasms. There are four ... According to the WHO Classification of Hematopoietic and Lymphoid Neoplasms 2008 myeloproliferative neoplasms are divided into ... The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone ...
*  TRA (gene)
Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073-83. PMID 2546634. ... 1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): ... "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific ... T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@. It contributes ...
*  ASPSCR1
2001). "Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity ... This gene is a candidate gene for alveolar soft part sarcoma (ASPS). It has been found that ASPSCR1 can undergo oncogenic ... 2001). "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas". ... of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25". Oncogene. 20 (1 ...
*  TRD (gene)
Dyer MJ (August 1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073-83. PMID 2546634 ... T cell receptor delta locus (symbol TRD), also known as TCRD or TRD@, is a protein that in humans is encoded by the TRD gene. ... Krejci O, Prouzova Z, Horvath O, Trka J, Hrusak O (July 2003). "Cutting edge: TCR delta gene is frequently rearranged in adult ... It contributes the delta (δ) chain to the larger TCR protein (T-cell receptor). "Human PubMed Reference:". "Entrez Gene: TRD@ T ...
*  Notch signaling pathway
... the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms". Cell. 66 ... In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at least one report that ... Alleles of the two C. elegans Notch genes were identified based on developmental phenotypes: lin-12 and glp-1. The cloning and ... During development of the aortic arch and the aortic arch arteries, the Notch receptors, ligands, and target genes display a ...
*  PDGFRA
... the PDGFRA gene, are associated with an array of clinically significant neoplasms. This gene encodes a typical receptor ... The PDGFRA gene may also mutate through any one of several chromosome translocations to create fusion genes which, like the ... Somatic mutations that cause the fusion of the PDGFRA gene with certain other genes occur in hematopoietic stem cells and cause ... typically including either the CHIC2 or LNX gene. The fused gene encodes a FIP1L1-PDGFRA protein that causes: a) chronic ...
*  FIP1L1
https://www.ncbi.nlm.nih.gov/gene/81608 Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704- ... to create an in-frame fusion of the FIP1L1 gene with the platelet-derived growth factor receptor alpha gene (PGDFRA) gene. The ... An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause ... The fused gene occurs with a male/female ratio of 1.47; the reason for this male predominance is not known. The fusion gene has ...
*  Bazex-Dupré-Christol syndrome
However, no gene has been identified. Genetic testing--x linked dominant pattern associated with various neoplasm (eg. basal ... July 1995). "The gene for Bazex-Dupré-Christol syndrome maps to chromosome Xq". J. Invest. Dermatol. 105 (1): 87-91. doi: ... This means the defective gene responsible for the disorder is located on the X chromosome, and only one copy of the defective ... X-linked inheritance is determined by the gender of the parent carrying a specific gene and can often seem complex. This is ...
*  IMPDH2
... been identified as an intracellular target of the natural product sanglifehrin A This gene is up-regulated in some neoplasms, ... 2009). "Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals". Drug Metab. ... 2007). "Prognostic significance of drug-regulated genes in high-grade osteosarcoma". Mod. Pathol. 20 (10): 1085-94. doi:10.1038 ... 2010). "Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a ...
*  Tetratricopeptide repeat protein 39B
The gene for TTC39B is located on the short arm of the ninth chromosome at 9p22.3. The genomic DNA is 136,517 bases long, ... TTC39A has been tested for association to diseases like breast neoplasms and is expected to have molecular binding function and ... The TTC39B gene has five different transcript variants, each coding for a different protein. This article focuses on ... "UBC Gene - GeneCards". GeneCards. Retrieved 13 May 2013. Teslovich TM, Musunuru K, Smith AV, et al. (August 2010). "Biological ...
*  IGHV@
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations ... "Entrez Gene: IGHV@ immunoglobulin heavy variable group". Forconi F, Sozzi E, Cencini E, et al. (November 2009). "Hairy cell ... 2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL ... Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene. ...