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*  ETV6
... transcriptional coactivator for nuclear hormone receptors gene NCOA2; f) Immunoglobulin heavy chain gene IGH; g) enzyme genes ... Thus, the ETV6 gene reportedly forms translocation-induced fusion genes with: a) tyrosine kinase receptor gene FGFR3; b) non- ... The following table lists the more frequently occurring genes to which ETV6 fuses, the function of these genes, these genes' ... the gene is expressed in virtually all cell types and tissues. Mice depleted of the ETV6 gene by Gene knockout die between day ...
*  Immunoglobulin heavy chain
The third teleost Ig heavy chain gene was identified very recently and does not resemble any of the heavy chains so far ... These heavy chain types vary between different animals. All heavy chains contain a series of immunoglobulin domains, usually ... The heavy chain doesn't always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in the absence of ... Heavy chains α and γ have approximately 450 amino acids. Heavy chains μ and ε have approximately 550 amino acids. Each heavy ...
*  Organization and expression of immunoglobulin genes
... a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. Here at ... Antibody (or immunoglobulin) structure is made up of two heavy-chains and two light-chains. These chains are held together by ... mμ heavy chain and surrogate light chain are formed. The final rearrangement of the light chain gene generates immature B cell ... 1979). Cloned pairs of variable region genes for immunoglobulin heavy-chains isolated from a clone library of the entire mouse ...
*  IGHV@
Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene. IGHV is the immunoglobulin heavy ... Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable ... "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene ... "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". ...
*  Enhancer (genetics)
The first discovery of a eukaryotic enhancer was in the immunoglobulin heavy chain gene in 1983. This enhancer, located in the ... "A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene ... "A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes". Cell ... "Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus". Science. 221 (4611): 663-5. PMID 6306772. ...
*  J. Donald Capra
Pascual, V.; Capra, J. D. (1991). "Human immunoglobulin heavy-chain variable region genes: Organization, polymorphism, and ... "Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes". The Journal of ... "Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes". The Journal of Experimental Medicine. ... Hurley, C. K.; Shaw, S.; Nadler, L.; Schlossman, S.; Capra, J. D. (1982). "Alpha and beta chains of SB and DR antigens are ...
*  IGHM
"Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch ... "Entrez Gene: IGHM immunoglobulin heavy constant mu". Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing ... Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form ... 1973). "Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin". Science. 182 (4109): 287-91. doi: ...
*  Susumu Tonegawa
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene ... Comparing the DNA of B cells (a type of white blood cell) in embryonic and adult mice, he observed that genes in the mature B ... Prior to Tonegawa's discovery, one early idea to explain the adaptive immune system suggested that each gene produces one ... Tonegawa's lab pioneered introductory transgenic and gene-knockout technologies in mammalian systems. He was involved in early ...
*  Cdc42 binding protein kinase beta
"Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing ... CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. This gene encodes a member of ... Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal ... "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31. Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, ...
*  Receptor editing
Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly1+ B-cell ... They can avoid apoptosis by modifying the sequence of light chain V and J genes (components of the antigen receptor) so that it ...
*  Tasuku Honjo
"Organization of the constant-region gene family of the mouse immunoglobulin heavy chain". Cell. 28 (3): 499-506. doi:10.1016/ ... Ishida, Y; Agata, Y; Shibahara, K; Honjo, T (1992). "Induced expression of PD-1, a novel member of the immunoglobulin gene ... He succeeded in cDNA clonings of IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain in 1986, and ... He presented a model explaining antibody gene rearrangement in class switch and, between 1980 and 1982, verified its validity ...
*  Laser capture microdissection
"Application of laser capture microdissection to cytologic specimens for the detection of immunoglobulin heavy chain gene ...
*  IGHE
"The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes". The ... "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National ... Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene. "Human PubMed Reference:". "Entrez Gene: ... "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". ...
*  IGHG2
Krawinkel U, Rabbitts TH (1984). "Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and ... "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National ... Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene. "Human PubMed Reference:". "Entrez Gene: ... Milstein C, Frangione B (Jan 1971). "Disulphide bridges of the heavy chain of human immunoglobulin G2". The Biochemical Journal ...
*  IGHG4
"Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National ... Ig gamma-4 chain C region is a protein that in humans is encoded by the IGHG4 gene. "Human PubMed Reference:". "Entrez Gene: ... Ellison J, Buxbaum J, Hood L (1983). "Nucleotide sequence of a human immunoglobulin C gamma 4 gene". Dna. 1 (1): 11-8. doi: ... IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker)". McLean GR, Nakouzi A, Casadevall A, Green NS (Oct 2000). "Human and ...
*  IGHA2
Flanagan JG, Rabbitts TH (Dec 1982). "Arrangement of human immunoglobulin heavy chain constant region genes implies ... "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National ... Toraño A, Putnam FW (Feb 1978). "Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the ... Ig alpha-2 chain C region is a protein that in humans is encoded by the IGHA2 gene. "Human PubMed Reference:". "Entrez Gene: ...
*  Small Maf
... of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' ... The Nrf1-sMaf heterodimers regulate genes responsible for proteasomal genes and metabolism genes. The Nrf2-sMaf heterodimers ... HUGO Gene Nomenclature Committee (HGNC)-approved gene names of MAFF, MAFG and MAFK are "v-maf avian musculoaponeurotic ... Motohashi, H (1998). "A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo". Genes Cells. ...
*  List of MeSH codes (G14)
... genes, immunoglobulin MeSH G14.340.024.340.351.300 --- genes, immunoglobulin heavy chain MeSH G14.340.024.340.351.300.249 --- ... genes, immunoglobulin light chain MeSH G14.340.024.340.353 --- genes, insect MeSH G14.340.024.340.359 --- genes, lethal MeSH ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, viral MeSH G14.340.400.500.172 --- genes, env MeSH G14.340.400.500.258 --- genes, gag MeSH G14.340.400.500.345 --- genes ...
*  CRLF2
Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8 ... "Entrez Gene: CRLF2 cytokine receptor-like factor 2". Human CRLF2 genome location and CRLF2 gene details page in the UCSC Genome ... and characterization of genomic structure of murine Tslpr gene". Gene. 284 (1-2): 161-8. doi:10.1016/S0378-1119(02)00380-3. ... Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. It forms a functional complex with ...
*  Immunoglobulin class switching
... as an inter-chromosomal translocation mixing immunoglobulin heavy chain genes from both alleles. T cell cytokines modulate ... these occur adjacent to all heavy chain constant region genes with the exception of the δ-chain. DNA is nicked and broken at ... the constant-region portion of the antibody heavy chain is changed, but the variable region of the heavy chain stays the same ( ... Naïve mature B cells produce both IgM and IgD, which are the first two heavy chain segments in the immunoglobulin locus. After ...
*  Eosinophilia
... with acute B lymphocytic leukemia resulted in the juxtaposition of the IL-3 gene and the immunoglobulin heavy-chain gene, ... Patients displaying eosinophilia overexpress a gene encoding an eosinophil hematopoietin. A translocation between chromosomes 5 ... as in lymphoblastic leukemia with a translocation between chromosomes 5 and 14 or alterations in the genes which encode ...
*  Multiple myeloma
A chromosomal translocation between the immunoglobulin heavy chain gene (on chromosome 14, locus q32) and an oncogene (often ... or λ-light chains or any of the five types of heavy chains (α-, γ-, δ-, ε- or μ-heavy chains). Patients without evidence of a ... and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain ... In addition, light and or heavy chains (the building blocks of antibodies) may be secreted in isolation: κ- ...
*  IGH@
... immunoglobulin genes: Heavy chain alpha (IgA): IGHA1, IGHA2 Heavy chain gamma (IgG): IGHG1, IGHG2, IGHG3, IGHG4 Heavy chain ... "Entrez Gene: IGH immunoglobulin heavy locus". "Gene Family: Immunoglobulin heavy locus at 14q32.33 (IGH)". HGNC: HUGO Gene ... Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of ... "A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes". Eur. J. Immunol. 18 (11): ...
*  Thereza Imanishi-Kari
"Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ... The paper, published in the scientific journal Cell, showed unexpected results on how the immune system rearranges its genes to ...
*  David Baltimore
"Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ... altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene ... "control of lg gene rearrangement might be the only mechanism that determines the specificity of heavy chain gene expression ... identified the protein pair that rearranges immunoglobulin genes, the recombination-activating gene RAG-1 and RAG-2. this was a ...
*  LILRA3
... free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles Cluster of differentiation "Human ... "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3". Jones DC, Kosmoliaptsis ... and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within ... Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), ...