Loading...
*  Anthelmintic
"Helminth control in school-age children" (PDF). World Health Organisation. 2011. Retrieved 28 July 2015. Hagel I, Giusti T ( ... genes. Resistant varieties accumulate and finally treatment failure occurs. Dysphania ambrosioides WHO (2006). Preventive ... The resistance is measured by the "fecal egg count reduction" value which varies for different types of helminths. Treatment ... Play media Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other ...
*  List of MeSH codes (G14)
... genes, helminth MeSH G14.340.357.500 --- genes, insect MeSH G14.340.365.500 --- genes, plant MeSH G14.340.375.500 --- genes, ... genes, fungal MeSH G14.340.024.340.320.089 --- genes, mating type, fungal MeSH G14.340.024.340.328 --- genes, helminth MeSH ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, t-cell receptor MeSH G14.340.024.340.585.050 --- genes, t-cell receptor alpha MeSH G14.340.024.340.585.080 --- genes, t- ...
*  Immunotherapy
Co-evolution with helminths has shaped some of the genes associated with Interleukin expression and immunological disorders, ... The helminths down regulate the pro-inflammatory Th1 cytokines, Interleukin-12 (IL-12), Interferon-Gamma (IFN-γ) and Tumour ... Helminth's relationship to humans as hosts should be classified as mutualistic or symbiotic.[citation needed] Biological ... Carvalho L, Sun J, Kane C, Marshall F, Krawczyk C, Pearce EJ (January 2009). "Review series on helminths, immune modulation and ...
*  Helminthic therapy
... and helminths in particular, upon genes responsible for the production of various cytokines, some involved in the regulation of ... Helminths are parasitic worms such as hookworms, whipworms, and threadworms that have evolved to live within a host organism on ... Helminth infection has emerged as one possible explanation for the low incidence of autoimmune diseases and allergies in less ... During this time, helminths compete with the host organism's cells for nutrient resources and thus possess the potential to ...
*  Tiabendazole
... and other helminth species which attack wild animals, livestock and humans. Genes responsible for the maintenance of cell walls ... TBZ works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with ...
*  Wellcome Sanger Institute
Explores human gene function by studying the impact of genome variation on cell biology. Large-scale systematic screens are ... WormBase ParaSite, a database for the genomics for parasitic helminths (both Nematodes and Platyhelminthes). Since 2000, the ... Pfam, a protein family database Rfam, an RNA family database TreeFam, a database of phylogenetic trees for animal genes Vega, a ... Adam, D (2001). "Sanger Centre welcomes gene funds with a new name". Nature. 413 (6857): 660. doi:10.1038/35099707. PMID ...
*  OX40 ligand
Maizels RM, Yazdanbakhsh M (2003). "Immune regulation by helminth parasites: cellular and molecular mechanisms" (PDF). Nat. Rev ... of the OX40L gene have been identified. For some of them association with systemic lupus erythematosus has been reported: No ...
*  20-Hydroxyecdysone
For uses in gene therapy, it may be necessary to investigate more thoroughly the natural sources of ecdysteroids in humans ( ... This would explain the mechanism behind Helminthic therapy due to the production of ecdysteroids by helminths, as mentioned ... Adding or removing ecdysteroids from the animal's diet then gives a convenient way to turn the inserted gene on or off (see ... C. S. Thummel; J. Chory (2002). "Steroid signaling in plants and insects - common themes, different pathways". Genes & ...
*  The Collapse of Nature
The first explanation, they theorized, could be the Neolutionist utilizing the worms as a form of experimental gene therapy. ... and Helminths, parasitic worms which have been used to treat autoimmune disorders, as possibilities for effectively introducing ... new genetic material into a host in order to garner a desired gene alteration. Their second theory is that the body-mod worms ...
*  Hygiene hypothesis
Recent comparative genomic studies have shown that immune response genes (protein coding and non-coding regulatory genes) have ... Autoimmune liver disease can be modulated by active helminth infections. The anti-inflammatory effects of helminth infection ... Helminths are thought to have been as old as the adaptive immune system, suggesting that they may have co-evolved, also ... Helminth therapy is one alternative. Probiotics (drinks or foods) have never been shown to reintroduce microbes to the gut. As ...
*  WormBase
The gene models of C. elegans, C. briggsae, C. remanei, and C. brenneri genes are manually curated. The majority of gene ... WormBase ParaSite is a sub-portal for approximately 100 draft genomes of parasitic helminths (nematodes and platyhelminthes) ... snRNA genes are mainly imported from Rfam. piRNA genes are from an analysis of the characteristic motif in these genes. miRNA ... There is also one scRNA gene. Transposons are not classed as genes and so do not have a parent gene object. Their structure is ...
*  Interleukin-4 receptor
IL4R is its human gene. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that ... Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y ... Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, ... Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. ...
*  Ostertagia ostertagi
Diagnosis of helminth infections in cattle : World Buiatrics Congress. Areskog, M., Ljungström, B., and Höglund, J. 2013. ... There are 7,006 identified expressed sequenced tags (ESTs), representing 2,564 genes. Clinical ostertagiosis normally occurs in ... and total worm counts are the tests most commonly employed in the diagnosis of helminth infections in ruminants. The direct ... Interspecific and host-related gene expression patterns in nematode-trapping fungi. BMC Genomics 15:968-981. http://doi.org/ ...
*  Index of biochemistry articles
... gene - gene expression - gene pool - gene regulatory network - genetic carrier - genetic code - genetic drift - Genetic ... helminth protein - helper T cell - hemopexin - hemoglobin - herpes simplex virus protein vmw65 - heterocyclic compound - ... erbA gene - erbB gene - erbB-2 gene - erbB-2 receptor - erythropoietin - erythropoietin receptor - Essential amino acid - Ester ... fms gene - Formaldehyde - fos gene - free energy - freezing point - FSH receptor - functional group - fungal protein - fungi - ...
*  ILC2
These cells lack antigen specific B or T cell receptor because of the lack of recombination activating gene. ILC2s produce type ... ILC2s play the crucial role of secreting type 2 cytokines in response to helminth infection. They have also been implicated in ...
*  Major basic protein
1990). "Cloning and sequence analysis of the human gene encoding eosinophil major basic protein". Gene. 86 (2): 285-289. doi: ... It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic ... is a protein which in humans is encoded by the PRG2 gene. The protein encoded by this gene is the predominant constituent of ... "Entrez Gene: PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)". PDB: ...
*  Taenia saginata
List of parasites (human) Eckert J. (2005). "Helminths". In Kayser, F.H.; Bienz, K.A.; Eckert, J.; Zinkernagel, R.M. Medical ... Identification often requires histological observation of the uterine branches and PCR detection of ribosomal 5.8S gene. The ...
*  Eosinophilic myocarditis
Clonal eosinophilia caused by mutations in genes that are highly susceptible to tyrosine kinase inhibitors such as PDGFRA, ... specific drug treatment of helminth and protozoan infections typically takes precedence over non-specific immunosuppressive ... Clonal hypereosinophilia due to mutations in other genes or primary malignancies: specific treatment regimens used for these ... "Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia". PLoS Neglected Tropical ...
*  Gary K. Michelson
Quinn, Gene (May 5, 2011). "Celebrating Heroes of Invention at the Temple of Innovation". IP Watchdog. Retrieved 2011-11-29. " ... Gary Michelson Funding The Development Of A Soil-Transmitted Helminth Vaccine Discovery Program. [2011] Public Advocacy as ... Gary Michelson Funding The Development Of A Soil-Transmitted Helminth Vaccine Discovery Program". Jewish Business News. ...
*  Necator americanus
It comprises 244 Mbp with 19,151 predicted protein-coding genes; these include genes whose products mediate the hookworm's ... Necator americanus is a species of hookworm (a type of helminth) commonly known as the New World hookworm. Like other hookworms ... genes encoding proteins that represent new potential drug targets against hookworms, and expanded gene families encoding likely ... Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, Diemert D, Hotez PJ (May 2006). "Soil-transmitted helminth infections: ...
*  Th 9 cells
PU.1 works by directly binding to the promoter of Il-9 gene and attract chromatin-modifying enzymes which reinforce Il9-gene ... They play a role in defense against helminth infections, in allergic responses and in autoimmunity. TH9 cells lack any specific ... IRF4 binds to the promoter of Il-9 gene in TH9 cells and it is dependent on STAT6. BATF has been also shown to bind to the Il-9 ... "Calcitonin Gene-Related Peptide and Cyclic Adenosine 5 '-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 ...
*  Nematode.net
In single organism mode this tool populates pathway images by merit of aligning transcripts or genes to KEGG Orthology (KO) ids ... Abubucker S, Martin J, Taylor CM, Mitreva M. (2011) HelmCoP: an online resource for helminth functional genomics and drug and ... Dec 11;282(5396): 2012-8. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. (2008) Helminth infections: the ... Nematode.net built on these efforts to make available the gene sequences from medically and economically relevant parasitic ...
*  Atopic dermatitis
... and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: relevant in the pathogenesis of atopic ... There is also support from epidemiological studies for a protective role for helminths against AD. Likewise children with poor ... About 30% of people with atopic dermatitis have mutations in the gene for the production of filaggrin (FLG), which increase the ...
*  TDR Targets
The output of each query will be a set of genes (e.g. all genes that produce a lethal phenotype upon a genetic knockout); and ... inclusion of helminth genomes in release 2), incorporation of new functionalities (e.g. chemical similarity and substructure ... When prioritizing genes, individual database queries are used to specify one or more desirable or undersirable criteria. ... including the possibility of weighting genes present in more than one set (this is particularly useful when calculating UNIONs ...
*  HIV disease progression rates
Wade, Nicholas (July 18, 2008). "Gene Variation May Raise Risk of H.I.V., Study Finds". New York Times. Retrieved 2008-09-06. ... Frequent exposure to helminth infections, which are endemic in Africa, activates individual immune systems, thereby shifting ... They first reviewed the role of genes in encoding chemokine receptors (CCR5 and CCR2) and chemokines (SDF-1). While CCR5 has ... The Centers for Disease Control and Prevention (CDC) has released findings that genes influence susceptibility to HIV infection ...
*  WormBook
Capitalizing on the World Wide Web, WormBook links in-text references (e.g. genes, alleles, proteins, literature citations) ... expanding to enable helminth genomic research". Nucleic Acids Research. Oxford: Oxford University Press. 44 (D1): D774-D780. ...